Background: Type 2 diabetes (T2D) remains a major global public health problem. This complex metabolic disorder can lead to various complications, including cardiovascular diseases (leading cause of death) in T2D. Amo...Background: Type 2 diabetes (T2D) remains a major global public health problem. This complex metabolic disorder can lead to various complications, including cardiovascular diseases (leading cause of death) in T2D. Among the biochemical markers associated with increased risk for cardiovascular disease, homocysteine is currently one of the predictive markers under evaluation. We investigate the link between hyperhomocysteinemia and diabetes complications in DT2 population in Brazzaville. Methodology: We conducted a cross-sectional analytical study, from October to December 2022. One hundred and fifty participants were included, 100 patients T2D (34 with complications, 33 with comorbidities, 33 without), and 50 patients controls. Sociodemographic and clinical characteristics were collected. Homocysteine (Hcy) serum levels were measured using Sandwich ELISA method. Results: Study population was composed of 50% males and 50% females with sex ratio of 1;mean age was 52.2 ± 10.8 years (30 - 83). The prevalence of hyperhomocysteinemia (HHcy) was 36% (20% moderate Hcy, 15% intermediate and 1% severe). Mean Hcy concentration was 31.9 μmol/l (18 - 103). Age, gender and physical inactivity were strongly correlated to Hcy (OR of 3.5;9.4 and 3 respectively). Multivariate analysis showed that HHcy was a risk accelerator for degenerative complications (stroke: OR = 6.2;ischemic heart disease: 4.9;neuropathy: 9.2;retinopathy: 4.5 and peripheral arterial disease: 4.9). Conclusion: These findings suggest that hyperhomocysteinemia can be considered as a predictive marker to be taken into account in targeting cardiovascular risk in Congolese subjects with T2D.展开更多
Human papillomaviruses (HPV) are at the origin of many mucosal, benign or malignant skin pathologies. Some so-called high-risk genotypes, especially types 16 and 18, are involved in the genesis of cervical cancer, one...Human papillomaviruses (HPV) are at the origin of many mucosal, benign or malignant skin pathologies. Some so-called high-risk genotypes, especially types 16 and 18, are involved in the genesis of cervical cancer, one of the most common cancers in women. To determine the prevalence of HPV infections and to identify oncogenic genotypes circulating in the departments of Niari and Bouenza. A total of 207 cervical samples collected between 2019 and 2020 were studied. Cervico vaginal smears were performed on all samples for cytological analysis, and HPV DNA detection and genotyping were performed on GeneXpert. The average age of the women who participated in this study was 43.67 ± 12.31 years in Niari and 38.29 ± 10.52 in Bouenza with age intervals ranging from 18 to 80 years. Cytological analysis of these samples reported the following prevalences: Normal diagnosed in 89.58% (186/207) cases, ASCUS in 5.31% (11/207) cases, LSIL in 2.89% (6/207) cases, and ICC in 1.93% (4/207) cases. The prevalence of HPV infection was detected in 83.54% (66/186) of women without lesions, 6.32% (5/11) of ASCUS women and 10.12% (8/10) of women with cytological abnormalities [5.06% (4/6) LSIL, and 5.06% (4/4) ICC]. In total, 79 of the 207 women in our study tested positive for one or more HPV-HR types, or 38.16%. In the department of Niari 37.5% (48/128) women tested positive for HPV, and in the department of Bouenza 39.24% (31/79) tested positive for HPV. Multiple infections ranged from two to more than three strains of HPV. No statistically significant association was observed between socio-demographic characteristics and genotyping (p > 0.05). On the other hand, HPV-HR prevalence varied significantly according to cervical cytology (p = 0.001). The results obtained show the predominance of HPV 16 in women in these two departments of Congo.展开更多
文摘Background: Type 2 diabetes (T2D) remains a major global public health problem. This complex metabolic disorder can lead to various complications, including cardiovascular diseases (leading cause of death) in T2D. Among the biochemical markers associated with increased risk for cardiovascular disease, homocysteine is currently one of the predictive markers under evaluation. We investigate the link between hyperhomocysteinemia and diabetes complications in DT2 population in Brazzaville. Methodology: We conducted a cross-sectional analytical study, from October to December 2022. One hundred and fifty participants were included, 100 patients T2D (34 with complications, 33 with comorbidities, 33 without), and 50 patients controls. Sociodemographic and clinical characteristics were collected. Homocysteine (Hcy) serum levels were measured using Sandwich ELISA method. Results: Study population was composed of 50% males and 50% females with sex ratio of 1;mean age was 52.2 ± 10.8 years (30 - 83). The prevalence of hyperhomocysteinemia (HHcy) was 36% (20% moderate Hcy, 15% intermediate and 1% severe). Mean Hcy concentration was 31.9 μmol/l (18 - 103). Age, gender and physical inactivity were strongly correlated to Hcy (OR of 3.5;9.4 and 3 respectively). Multivariate analysis showed that HHcy was a risk accelerator for degenerative complications (stroke: OR = 6.2;ischemic heart disease: 4.9;neuropathy: 9.2;retinopathy: 4.5 and peripheral arterial disease: 4.9). Conclusion: These findings suggest that hyperhomocysteinemia can be considered as a predictive marker to be taken into account in targeting cardiovascular risk in Congolese subjects with T2D.
文摘Human papillomaviruses (HPV) are at the origin of many mucosal, benign or malignant skin pathologies. Some so-called high-risk genotypes, especially types 16 and 18, are involved in the genesis of cervical cancer, one of the most common cancers in women. To determine the prevalence of HPV infections and to identify oncogenic genotypes circulating in the departments of Niari and Bouenza. A total of 207 cervical samples collected between 2019 and 2020 were studied. Cervico vaginal smears were performed on all samples for cytological analysis, and HPV DNA detection and genotyping were performed on GeneXpert. The average age of the women who participated in this study was 43.67 ± 12.31 years in Niari and 38.29 ± 10.52 in Bouenza with age intervals ranging from 18 to 80 years. Cytological analysis of these samples reported the following prevalences: Normal diagnosed in 89.58% (186/207) cases, ASCUS in 5.31% (11/207) cases, LSIL in 2.89% (6/207) cases, and ICC in 1.93% (4/207) cases. The prevalence of HPV infection was detected in 83.54% (66/186) of women without lesions, 6.32% (5/11) of ASCUS women and 10.12% (8/10) of women with cytological abnormalities [5.06% (4/6) LSIL, and 5.06% (4/4) ICC]. In total, 79 of the 207 women in our study tested positive for one or more HPV-HR types, or 38.16%. In the department of Niari 37.5% (48/128) women tested positive for HPV, and in the department of Bouenza 39.24% (31/79) tested positive for HPV. Multiple infections ranged from two to more than three strains of HPV. No statistically significant association was observed between socio-demographic characteristics and genotyping (p > 0.05). On the other hand, HPV-HR prevalence varied significantly according to cervical cytology (p = 0.001). The results obtained show the predominance of HPV 16 in women in these two departments of Congo.
