Rheumatoid arthritis(RA) is an autoimmune disease affecting 1% of the world population and is characterized by chronic inflammation of the joints sometimes accompanied by extra-articular manifestations. K/Bx N mice, o...Rheumatoid arthritis(RA) is an autoimmune disease affecting 1% of the world population and is characterized by chronic inflammation of the joints sometimes accompanied by extra-articular manifestations. K/Bx N mice, originally described in 1996 as a model of polyarthritis, exhibit knee joint alterations. The aim of this study was to describe temporomandibular joint(TMJ)inflammation and damage in these mice. We used relevant imaging modalities, such as micro-magnetic resonance imaging(μMRI)and micro-computed tomography(μCT), as well as histology and immunofluorescence techniques to detect TMJ alterations in this mouse model. Histology and immunofluorescence for Col-I, Col-II, and aggrecan showed cartilage damage in the TMJ of K/Bx N animals, which was also evidenced by μCT but was less pronounced than that seen in the knee joints. μMRI observations suggested an increased volume of the upper articular cavity, an indicator of an inflammatory process. Fibroblast-like synoviocytes(FLSs)isolated from the TMJ of K/Bx N mice secreted inflammatory cytokines(IL-6 and IL-1β) and expressed degradative mediators such as matrix metalloproteinases(MMPs). K/Bx N mice represent an attractive model for describing and investigating spontaneous damage to the TMJ, a painful disorder in humans with an etiology that is still poorly understood.展开更多
In this article we present our system for scalable,robust,and fast city-scale reconstruction from Internet photo collections(IPC)obtaining geo-registered dense 3D models.The major achievements of our system are the ef...In this article we present our system for scalable,robust,and fast city-scale reconstruction from Internet photo collections(IPC)obtaining geo-registered dense 3D models.The major achievements of our system are the efficient use of coarse appearance descriptors combined with strong geometric constraints to reduce the computational complexity of the image overlap search.This unique combination of recognition and geometric constraints allows our method to reduce from quadratic complexity in the number of images to almost linear complexity in the IPC size.Accordingly,our 3D-modeling framework is inherently better scalable than other state of the art methods and in fact is currently the only method to support modeling from millions of images.In addition,we propose a novel mechanism to overcome the inherent scale ambiguity of the reconstructed models by exploiting geo-tags of the Internet photo collection images and readily available StreetView panoramas for fully automatic geo-registration of the 3D model.Moreover,our system also exploits image appearance clustering to tackle the challenge of computing dense 3D models from an image collection that has significant variation in illumination between images along with a wide variety of sensors and their associated different radiometric camera parameters.Our algorithm exploits the redundancy of the data to suppress estimation noise through a novel depth map fusion.The fusion simultaneously exploits surface and free space constraints during the fusion of a large number of depth maps.Cost volume compression during the fusion achieves lower memory requirements for high-resolution models.We demonstrate our system on a variety of scenes from an Internet photo collection of Berlin containing almost three million images from which we compute dense models in less than the span of a day on a single computer.展开更多
The appearance of abnormal growths on the planarian, Dugesia dorotocephala, in response to cadmium with and without pre-exposure to L-buthionine-R, S-sulfoximine (BSO) and concurrent exposure to the polychlorinated bi...The appearance of abnormal growths on the planarian, Dugesia dorotocephala, in response to cadmium with and without pre-exposure to L-buthionine-R, S-sulfoximine (BSO) and concurrent exposure to the polychlorinated biphenyls (PCBs) Aroclor 1254, PCB 28, PCB 110 or PCB 126 is described. Pigmented rose thorn (PRT) lesions were non-invasive and appeared in response to PCBs. Post-head (PH) lesions developed in up to 100% of the animals within 6-20 days post-dosing, progressed rather rapidly and were highly invasive. Round tail tip (RTT) lesions appeared in lower frequencies within 10-30 days, but progressed extremely rapidly resulting in tail loss within 48 h. We have referred to these types of lesions as 'tumors', but they are not necessarily characteristic of vertebrate neoplasms.PCBs interacted with cadmium in a complex way, in some cases increasing total lesions and decreasing time-to-lesion and in other cases having the opposite effects. A three-factor (PCB, PCB dose, Cd dose) nested analysis of variance model was used to determine lesion rates in order to compare PCB potencies as potentiators or antagonists. The Aroclor mixture was always the least potent co-toxicant but appeared to be the most potent antagonist; the coplanar PCB 126 was the most potent co-toxicant. The complex response surfaces and the lack of stoichiometry in dose-response relationships indicate that multiple mechanisms are responsible for PH and RTT lesions in planarians. These results emphasize the complexity of PCB toxicities and suggest further studies to validate the planarian model as a screen for combinations or environmental mixtures which may have altered biological potency in other species.展开更多
文摘Rheumatoid arthritis(RA) is an autoimmune disease affecting 1% of the world population and is characterized by chronic inflammation of the joints sometimes accompanied by extra-articular manifestations. K/Bx N mice, originally described in 1996 as a model of polyarthritis, exhibit knee joint alterations. The aim of this study was to describe temporomandibular joint(TMJ)inflammation and damage in these mice. We used relevant imaging modalities, such as micro-magnetic resonance imaging(μMRI)and micro-computed tomography(μCT), as well as histology and immunofluorescence techniques to detect TMJ alterations in this mouse model. Histology and immunofluorescence for Col-I, Col-II, and aggrecan showed cartilage damage in the TMJ of K/Bx N animals, which was also evidenced by μCT but was less pronounced than that seen in the knee joints. μMRI observations suggested an increased volume of the upper articular cavity, an indicator of an inflammatory process. Fibroblast-like synoviocytes(FLSs)isolated from the TMJ of K/Bx N mice secreted inflammatory cytokines(IL-6 and IL-1β) and expressed degradative mediators such as matrix metalloproteinases(MMPs). K/Bx N mice represent an attractive model for describing and investigating spontaneous damage to the TMJ, a painful disorder in humans with an etiology that is still poorly understood.
文摘In this article we present our system for scalable,robust,and fast city-scale reconstruction from Internet photo collections(IPC)obtaining geo-registered dense 3D models.The major achievements of our system are the efficient use of coarse appearance descriptors combined with strong geometric constraints to reduce the computational complexity of the image overlap search.This unique combination of recognition and geometric constraints allows our method to reduce from quadratic complexity in the number of images to almost linear complexity in the IPC size.Accordingly,our 3D-modeling framework is inherently better scalable than other state of the art methods and in fact is currently the only method to support modeling from millions of images.In addition,we propose a novel mechanism to overcome the inherent scale ambiguity of the reconstructed models by exploiting geo-tags of the Internet photo collection images and readily available StreetView panoramas for fully automatic geo-registration of the 3D model.Moreover,our system also exploits image appearance clustering to tackle the challenge of computing dense 3D models from an image collection that has significant variation in illumination between images along with a wide variety of sensors and their associated different radiometric camera parameters.Our algorithm exploits the redundancy of the data to suppress estimation noise through a novel depth map fusion.The fusion simultaneously exploits surface and free space constraints during the fusion of a large number of depth maps.Cost volume compression during the fusion achieves lower memory requirements for high-resolution models.We demonstrate our system on a variety of scenes from an Internet photo collection of Berlin containing almost three million images from which we compute dense models in less than the span of a day on a single computer.
文摘The appearance of abnormal growths on the planarian, Dugesia dorotocephala, in response to cadmium with and without pre-exposure to L-buthionine-R, S-sulfoximine (BSO) and concurrent exposure to the polychlorinated biphenyls (PCBs) Aroclor 1254, PCB 28, PCB 110 or PCB 126 is described. Pigmented rose thorn (PRT) lesions were non-invasive and appeared in response to PCBs. Post-head (PH) lesions developed in up to 100% of the animals within 6-20 days post-dosing, progressed rather rapidly and were highly invasive. Round tail tip (RTT) lesions appeared in lower frequencies within 10-30 days, but progressed extremely rapidly resulting in tail loss within 48 h. We have referred to these types of lesions as 'tumors', but they are not necessarily characteristic of vertebrate neoplasms.PCBs interacted with cadmium in a complex way, in some cases increasing total lesions and decreasing time-to-lesion and in other cases having the opposite effects. A three-factor (PCB, PCB dose, Cd dose) nested analysis of variance model was used to determine lesion rates in order to compare PCB potencies as potentiators or antagonists. The Aroclor mixture was always the least potent co-toxicant but appeared to be the most potent antagonist; the coplanar PCB 126 was the most potent co-toxicant. The complex response surfaces and the lack of stoichiometry in dose-response relationships indicate that multiple mechanisms are responsible for PH and RTT lesions in planarians. These results emphasize the complexity of PCB toxicities and suggest further studies to validate the planarian model as a screen for combinations or environmental mixtures which may have altered biological potency in other species.
