Owing to severe agglomeration of manganese carbonate(MnCO_(3))during its synthesis,it exhibits rapid decay cycle performance when used as a cathode material in aqueous zinc ion batteries.To overcome this drawback,we s...Owing to severe agglomeration of manganese carbonate(MnCO_(3))during its synthesis,it exhibits rapid decay cycle performance when used as a cathode material in aqueous zinc ion batteries.To overcome this drawback,we synthesized a MnCO_(3)material with carbon nanotubes(CNTs)(i.e.,MnCO_(3)@CNTs)via a one-step solvothermal method using a hybrid modification strategy.MnCO_(3)nanospheres were grown in-situ on a two-dimensional(2D)plane that was orderly interwoven by tubular single fibers of carbon to form a leaf-like nanosheet structure.The surface area of the MnCO_(3)@CNTs material was enlarged enormously through the special nanosheet structure,and its stability was improved by the supporting structure of the CNTs.As a result,the MnCO_(3)@CNTs exhibited a discharge capacity of 247.6 mAh g^(-1)at a current density of 0.1 A g^(-1).The energy storage mechanism of MnCO_(3)@CNTs was further explored using a series of electrochemical kinetic analyses and ex-situ characterization tests.This modification method not only broadens the application field of MnCO_(3),but also provides the possibility of modifying more cathode materials.展开更多
This paper presents a wideband variable gain amplifier(VGA) featuring a decibel-linear gain control characteristic. The decibel-linear gain control function is realized using two VGA cells and a control signal convert...This paper presents a wideband variable gain amplifier(VGA) featuring a decibel-linear gain control characteristic. The decibel-linear gain control function is realized using two VGA cells and a control signal converter. The bandwidth is extended by using cascode architecture together with active inductive load. To achieve small parasitic and low area,direct current(DC) coupling is adopted in the circuit while a DC offset cancellation(DCOC) circuit is introduced to cancel the DC offset. Fabricated in a 0.18 μm complementary metal oxide semiconductor(CMOS) process, the chip occupies an area of 0.53 mm×0.48 mm(including pads) and draws a total current of 9 mA from a 1.8 V supply. The measurement results show that the gain of the VGA varies from-40 dB to 18 dB while the control voltage varies from 0 to 1.8 V, resulting in a total gain control range of 58 dB. The 3 dB bandwidth of the VGA is larger than 260 MHz at maximum gain.展开更多
In this paper,CaO/bio-char was synthesized by directly co-pyrolysis of Ca(OH)_(2) and rice straw,and used as catalyst to catalytic pyrolysis of soybean oil to produce high quality biofuel.In this co-pyrolysis process,...In this paper,CaO/bio-char was synthesized by directly co-pyrolysis of Ca(OH)_(2) and rice straw,and used as catalyst to catalytic pyrolysis of soybean oil to produce high quality biofuel.In this co-pyrolysis process,CaO particles has been successfully embedded on the bio-char surface.During the catalytic pyrolysis process,CaO/biochar showed a good catalytic performance on the deoxygenation of soybean oil.Pyrolysis temperature affected the pyrolysis reactions and pyrolytic products distributions dramatically,higher pyrolysis temperature lead to seriously cracking reactions,lower bio-oil yield and higher gases yield,and lower pyrolysis temperature lead to higher bio-oil yield with higher oxygenated compounds content and lower hydrocarbons contents,the suitable pyrolysis temperature was around 650℃.Under the optimal conditions(650℃ with WHSV at 6.4 h^(−1) and carrier gas flow rate at 100 ml/min),the selectivity(%)of hydrocarbons in the bio-oil was more than 90%.CaO/bio-char catalyst still shows good catalytic deoxygenation activity after 4 cycles.1 g of CaO/bio-char catalyst can catalyze pyrolysis of 32 g of soybean oil to produce high-quality liquid fuel.Bio-char based catalyst has been proved to be a promising catalyst for catalytic conversion of triglyceride-based lipids into high quality liquid biofuel.展开更多
Ultrafine-tricalcium phosphate(β-TCP)powders with good crystalline structure were produced by a new process through bone tissue engineering approach rorous β-TCPcermic was combined with recombined human bone morphog...Ultrafine-tricalcium phosphate(β-TCP)powders with good crystalline structure were produced by a new process through bone tissue engineering approach rorous β-TCPcermic was combined with recombined human bone morphogenetic proteins-2(rhBMP-2)to develop a novel composite material ,osteogenesis capacity of the composite was investigated intramuscularly in rat with histological analyses and SEM examination pureβ-TCP porous carmic wsa investigated as the control results show that the compostie materials possess good bilcompatibility biodegradation and strong osteogenesis capacity through inductive process after implantation material degradation began from 2 weeks post-implantation accompanying with the changing o pore structure with the enwrapping and separation fo materials by hyperplatic mesenchymal cells and fibroblast and with the phagocytose reaction of multinucleated giant cells early in 72h immature cartilage could be found within novel composite mature lamellar bone was induced to generate after 3 weeks with strong osteoinduction capacity and controlable bildegradation the novel rhBMP-2\β-TCP porous ceramic is expected to be a promising bone grafting substitute for bone tissue engineering展开更多
Background and Aims:To investigate the impact of MR bias field correction on response determination and survival prediction using volumetric tumor enhancement analysis in patients with infiltrative hepatocellular carc...Background and Aims:To investigate the impact of MR bias field correction on response determination and survival prediction using volumetric tumor enhancement analysis in patients with infiltrative hepatocellular carcinoma,after transcatheter arterial chemoembolization(TACE).Methods:This study included 101 patients treated with conventional or drug-eluting beads TACE between the years of 2001 and 2013.Semi-automated 3D quantification software was used to segment and calculate the enhancing tumor volume(ETV)of the liver with and without bias-field correction on multi-phasic contrast-enhanced MRI before and 1-month after initial TACE.ETV(expressed as cm3)at baseline imaging and the relative change in ETV(as%change,ETV%)before and after TACE were used to predict response and survival,respectively.Statistical survival analyses included Kaplan-Meier curve generation and Cox proportional hazards modeling.Q statistics were calculated and used to identify the best cut-off value for ETV to separate responders and non-responders(ETV cm3).The difference in survival was evaluated between responders and non-responders using Kaplan-Meier and Cox models.Results:MR bias field correction correlated with improved response calculation from baseline MR as well as survival after TACE;using a 415 cm3 cut-off for ETV at baseline(hazard ratio:2.00,95%confidence interval:1.23-3.26,p=0.01)resulted in significantly improved response prediction(median survival in patients with baseline ETV<415 cm3:19.66 months vs.≥415 cm3:9.21 months,p<0.001,log-rank test).A≥41%relative decrease in ETV(hazard ratio:0.58,95%confidence interval:0.37-0.93,p=0.02)was significant in predicting survival(ETV≥41%:19.20 months vs.ETV<41%:8.71 months,p=0.008,log-rank test).Without MR bias field correction,response from baseline ETV could be predicted but survival after TACE could not.Conclusions:MR bias field correction improves both response assessment and accuracy of survival prediction using whole liver tumor enhancement analysis from baseline MR after initi展开更多
Van der Waals(vdW)assembly of two-dimensional materials has long been recognized as a powerful tool for creating unique systems with properties that cannot be found in natural compounds[Nature 499,419(2013)].However,a...Van der Waals(vdW)assembly of two-dimensional materials has long been recognized as a powerful tool for creating unique systems with properties that cannot be found in natural compounds[Nature 499,419(2013)].However,among the variety of vdW heterostructures and their various properties,only a few have revealed metallic and ferroelectric behaviour signatures[Sci.Adv.5,eaax5080(2019);Nature 560,336(2018)].Here we show ferroelectric semimetal made of double-gated double-layer graphene separated by an atomically thin crystal of hexagonal boron nitride.The structure demonstrates high room temperature mobility of the order of 10 m2·V^(−1)·s^(−1) and exhibits ambipolar switching in response to the external electric field.The observed hysteresis is reversible and persists above room temperature.Our fabrication method expands the family of ferroelectric vdW compounds and offers a promising route for developing novel phase-changing devices.A possible microscopic model of ferroelectricity is discussed.展开更多
Rudder is an important part for the glider aircraft. In order to satisfy the long-time high-velocity for the near-space vehicle in the atmosphere, the light- weight, high-stiffness and high-strength all-composites rud...Rudder is an important part for the glider aircraft. In order to satisfy the long-time high-velocity for the near-space vehicle in the atmosphere, the light- weight, high-stiffness and high-strength all-composites rudderpost is required urgently to be prepared. The all-composites rudderpost can keep high rudder efficiency in the high temperature environment. Based on the technique require-ment of high-performance composites rudder, a 3D C/SiC rudderpost was manufactured by the CVI-CMC-SiC [1] processes. It was found during rudderpost testing that the high-temperature mechanical properties decreased and had large discretization. The analysis of the failure mechanisms was conducted by FTA method to recognize the failure modes and main reasons for rudderpost abnormal fracture and to reproduce the fracture phenomenon, which could guide production company to modify their preparation process control. Then the modified processes were proved to be validated. And the stability and reliability of the production performances were improved.展开更多
Two dimensions (2D) C/SiC laminated composites is the material with isotropic properties in laminated sheets, which is considered as a promising thermal skin for aircrafts. There are intense thermal flux and thermal i...Two dimensions (2D) C/SiC laminated composites is the material with isotropic properties in laminated sheets, which is considered as a promising thermal skin for aircrafts. There are intense thermal flux and thermal impact at the local interference region during the flight of the aircrafts. Therefore, mastering ablation and mechanical properties of 2D C/SiC laminated composite under extreme environments become the guild lines for the designs of the flight corridor and the aircraft security. This paper presents the experimental results of the ablation and thermal impact of C/SiC composites under different thermal environments (thermal flux ~5 MW/m2), which were carried out with the equipments of free-jets and conduct pipes. The effects on the ablation and mechanical properties of the C/SiC composites are studied, including gas pressure, thermal temperature, and the rates of temperature increasing and decreasing. The results show that the active oxidation and ablation behaviors of 2D C/SiC laminated composites under the thermal flux 5 MW/m2 consist with that of theoretical simulations. The critical failure conditions of 2D C/SiC laminated composite is also provided for the enveloping designs of the whole composites lightweight aircrafts.展开更多
Partial portosystemic shunts have been popularized because of a reported low rate of mortality and morbidity(especially encephalopathy,liver failure and occlusion).The results of partial portacaval shunts[small-diamet...Partial portosystemic shunts have been popularized because of a reported low rate of mortality and morbidity(especially encephalopathy,liver failure and occlusion).The results of partial portacaval shunts[small-diameter expanded polytetrafluoroethylene(ePTFE)H-graft portacaval shunt]were retrospectively reviewed to evaluate the clinical efficacy in the treatment of portal hypertension.Forty-three patients with portal hypertension were treated by small-diameter H-graft of ePTFE portacaval shunt from May 1995 to April 2006.Thirty-three had externally ringed grafts and ten had non-ringed ones.Ten had grafts of 10 mm in diameter and 33 had grafts of 8 mm.The left gastric artery and coronary vein were ligated in all the cases.Six had pericardial devascularization and splenectomy was performed in 42.An average decrease of free portal pressure(FPP)from(33.24 P4.78)cmH2O before shunting and(13.65P5.65)cmH2O after shunting was observed.The portal blood flow was reduced by one-third of that before shunt.Thirty-eight patients survived and no upper gastro-intestinal rebleeding occurred in the follow-up period(50.5 months in average).Two were out of contact.Color Doppler ultrasonography and/or portography revealed the shunts were patent in 38 cases and were occluded in three cases(3/41,7.3%).Encephalopathy developed in five cases(5/41,12.2%).Partial(small-diameter ePTFE H-graft)portacaval shunting can reduce the portal pressure effectively.Majority of the hepatic flow from the portal vein can be maintained adequately.The shunts with reinforced grafts can keep a higher rate of patency.The morbidity of encephalopathy was lower than those with total shunt.The partial portacaval shunt is effective in preventing recurrent variceal bleeding.展开更多
Background:Severe acute respiratory syndrome coronavirus 2 is a highly contagious viral infection,without any available targeted therapies.The high mortality rate of COVID-19 is speculated to be related to immune dama...Background:Severe acute respiratory syndrome coronavirus 2 is a highly contagious viral infection,without any available targeted therapies.The high mortality rate of COVID-19 is speculated to be related to immune damage.Methods:In this study,clinical bioinformatics analysis was conducted on transcriptome data of coronavirus infection.Results:Bioinformatics analysis revealed that the complex immune injury induced by coronavirus infection provoked dysfunction of numerous immune-related molecules and signaling pathways,including immune cells and toll-like receptor cascades.Production of numerous cytokines through the Th17 signaling pathway led to elevation in plasma levels of cytokines(including IL6,NF-kB,and TNF-a)followed by concurrent inflammatory storm,which mediates the autoimmune response.Several novel medications seemed to display therapeutic effects on immune damage associated with coronavirus infection.Conclusions:This study provided insights for further large-scale studies on the target therapy on reconciliation of immunological damage associated with COVID-19.展开更多
目的：探讨解剖性肝切除术治疗合并微血管侵犯（MVI）的肝细胞癌（HCC）的临床疗效。方法：采用回顾性队列研究和病例对照研究方法。收集2007年6月至2012年6月安徽医科大学附属省立医院收治的150例合并MVI的HCC手术患者的临床资料。60...目的：探讨解剖性肝切除术治疗合并微血管侵犯（MVI）的肝细胞癌（HCC）的临床疗效。方法：采用回顾性队列研究和病例对照研究方法。收集2007年6月至2012年6月安徽医科大学附属省立医院收治的150例合并MVI的HCC手术患者的临床资料。60例患者行解剖性肝切除术，设为AR组； 90例患者行非解剖性肝切除术，设为NR组。AR组患者根据术前ICG R15试验结果确定拟切除肝段，行解剖性肝切除术。NR组患者行非解剖性肝切除术。观察指标：（1）手术情况：手术时间、术中出血情况、术中输血例数。（2）术后恢复情况：术后腹腔引流管拔除时间、术后住院时间、术后30 d内并发症Clavein分级、术后30d内肝衰竭例数、术后30d内死亡例数。（3）随访情况：患者术后中位生存时间，5年总体生存率、5年无瘤生存率。（4）影响150例合并MVI的HCC手术患者预后因素分析。采用门诊和电话方式进行随访，了解患者生存情况。随访时间截至2016年4月。正态分布的计量资料以x^-±s表示，组间比较采用独立样本t检验。计数资料比较采用χ^2检验或Fisher确切概率法。采用KaplanMeier法计算生存率，采用Logrank检验进行生存分析。采用COX模型进行单因素和多因素分析。结果：（1）手术情况：150例患者均顺利完成HCC根治术。AR组患者手术时间、术中出血情况、术中输血例数分别为（165±39）min，≥500 mL 12例、〈500 mL 48例，15例；NR组患者分别为（136±30）min，≥500 mL 34例、〈500 mL 56例，38例；两组患者上述指标比较，差异均有统计学意义（t=29.172，χ^2=5.351，4.673，P〈0.05）。（2）术后恢复情况：AR组患者术后腹腔引流管拔除时间、术后住院时间分别为（2.7±1.1）d、（5.2±1.3）d，NR组患者分别为（3.8± 1.6）d、（7.1±2.3）d；两组患者上述指标比较，差异均有统计学意义（t=4.641，5.812，P〈0展开更多
基金supported by the Scientific Research Project of Hunan Provincial Department of Education(Grant No.21A0363)。
文摘Owing to severe agglomeration of manganese carbonate(MnCO_(3))during its synthesis,it exhibits rapid decay cycle performance when used as a cathode material in aqueous zinc ion batteries.To overcome this drawback,we synthesized a MnCO_(3)material with carbon nanotubes(CNTs)(i.e.,MnCO_(3)@CNTs)via a one-step solvothermal method using a hybrid modification strategy.MnCO_(3)nanospheres were grown in-situ on a two-dimensional(2D)plane that was orderly interwoven by tubular single fibers of carbon to form a leaf-like nanosheet structure.The surface area of the MnCO_(3)@CNTs material was enlarged enormously through the special nanosheet structure,and its stability was improved by the supporting structure of the CNTs.As a result,the MnCO_(3)@CNTs exhibited a discharge capacity of 247.6 mAh g^(-1)at a current density of 0.1 A g^(-1).The energy storage mechanism of MnCO_(3)@CNTs was further explored using a series of electrochemical kinetic analyses and ex-situ characterization tests.This modification method not only broadens the application field of MnCO_(3),but also provides the possibility of modifying more cathode materials.
基金supported by the Natural Science Foundation and Special Major Basic Research Program of Hebei Province(18960202D)
文摘This paper presents a wideband variable gain amplifier(VGA) featuring a decibel-linear gain control characteristic. The decibel-linear gain control function is realized using two VGA cells and a control signal converter. The bandwidth is extended by using cascode architecture together with active inductive load. To achieve small parasitic and low area,direct current(DC) coupling is adopted in the circuit while a DC offset cancellation(DCOC) circuit is introduced to cancel the DC offset. Fabricated in a 0.18 μm complementary metal oxide semiconductor(CMOS) process, the chip occupies an area of 0.53 mm×0.48 mm(including pads) and draws a total current of 9 mA from a 1.8 V supply. The measurement results show that the gain of the VGA varies from-40 dB to 18 dB while the control voltage varies from 0 to 1.8 V, resulting in a total gain control range of 58 dB. The 3 dB bandwidth of the VGA is larger than 260 MHz at maximum gain.
基金The paper was supported by the Natural Science Foundation of China(No.51906112)Natural Science Foundation of Jiangsu Province(No.BK20180548)+1 种基金China Postdoctoral Science Foundation(2019M651852)“Innovation&Entrepreneurship Talents”Introduction Plan of Jiangsu Province.
文摘In this paper,CaO/bio-char was synthesized by directly co-pyrolysis of Ca(OH)_(2) and rice straw,and used as catalyst to catalytic pyrolysis of soybean oil to produce high quality biofuel.In this co-pyrolysis process,CaO particles has been successfully embedded on the bio-char surface.During the catalytic pyrolysis process,CaO/biochar showed a good catalytic performance on the deoxygenation of soybean oil.Pyrolysis temperature affected the pyrolysis reactions and pyrolytic products distributions dramatically,higher pyrolysis temperature lead to seriously cracking reactions,lower bio-oil yield and higher gases yield,and lower pyrolysis temperature lead to higher bio-oil yield with higher oxygenated compounds content and lower hydrocarbons contents,the suitable pyrolysis temperature was around 650℃.Under the optimal conditions(650℃ with WHSV at 6.4 h^(−1) and carrier gas flow rate at 100 ml/min),the selectivity(%)of hydrocarbons in the bio-oil was more than 90%.CaO/bio-char catalyst still shows good catalytic deoxygenation activity after 4 cycles.1 g of CaO/bio-char catalyst can catalyze pyrolysis of 32 g of soybean oil to produce high-quality liquid fuel.Bio-char based catalyst has been proved to be a promising catalyst for catalytic conversion of triglyceride-based lipids into high quality liquid biofuel.
基金This study was financially supported by 863 Hi-Tech Research and Development Program of China(2002AA326080)The Fund for Youth Teacher of Education Ministry of China(2002123).
文摘Ultrafine-tricalcium phosphate(β-TCP)powders with good crystalline structure were produced by a new process through bone tissue engineering approach rorous β-TCPcermic was combined with recombined human bone morphogenetic proteins-2(rhBMP-2)to develop a novel composite material ,osteogenesis capacity of the composite was investigated intramuscularly in rat with histological analyses and SEM examination pureβ-TCP porous carmic wsa investigated as the control results show that the compostie materials possess good bilcompatibility biodegradation and strong osteogenesis capacity through inductive process after implantation material degradation began from 2 weeks post-implantation accompanying with the changing o pore structure with the enwrapping and separation fo materials by hyperplatic mesenchymal cells and fibroblast and with the phagocytose reaction of multinucleated giant cells early in 72h immature cartilage could be found within novel composite mature lamellar bone was induced to generate after 3 weeks with strong osteoinduction capacity and controlable bildegradation the novel rhBMP-2\β-TCP porous ceramic is expected to be a promising bone grafting substitute for bone tissue engineering
文摘Background and Aims:To investigate the impact of MR bias field correction on response determination and survival prediction using volumetric tumor enhancement analysis in patients with infiltrative hepatocellular carcinoma,after transcatheter arterial chemoembolization(TACE).Methods:This study included 101 patients treated with conventional or drug-eluting beads TACE between the years of 2001 and 2013.Semi-automated 3D quantification software was used to segment and calculate the enhancing tumor volume(ETV)of the liver with and without bias-field correction on multi-phasic contrast-enhanced MRI before and 1-month after initial TACE.ETV(expressed as cm3)at baseline imaging and the relative change in ETV(as%change,ETV%)before and after TACE were used to predict response and survival,respectively.Statistical survival analyses included Kaplan-Meier curve generation and Cox proportional hazards modeling.Q statistics were calculated and used to identify the best cut-off value for ETV to separate responders and non-responders(ETV cm3).The difference in survival was evaluated between responders and non-responders using Kaplan-Meier and Cox models.Results:MR bias field correction correlated with improved response calculation from baseline MR as well as survival after TACE;using a 415 cm3 cut-off for ETV at baseline(hazard ratio:2.00,95%confidence interval:1.23-3.26,p=0.01)resulted in significantly improved response prediction(median survival in patients with baseline ETV<415 cm3:19.66 months vs.≥415 cm3:9.21 months,p<0.001,log-rank test).A≥41%relative decrease in ETV(hazard ratio:0.58,95%confidence interval:0.37-0.93,p=0.02)was significant in predicting survival(ETV≥41%:19.20 months vs.ETV<41%:8.71 months,p=0.008,log-rank test).Without MR bias field correction,response from baseline ETV could be predicted but survival after TACE could not.Conclusions:MR bias field correction improves both response assessment and accuracy of survival prediction using whole liver tumor enhancement analysis from baseline MR after initi
基金supported by the National Key R&D Program of China(Grant Nos.SQ2018YFA030066 and SQ2018YFA030143)the National Natural Science Foundation of China(No.11974169)+1 种基金the Fundamental Research Funds for the Central Universities(Nos.020414380087 and 020414913201)and the Basic Research Program of Jiangsu Province(Grant No.BK20190283).
文摘Van der Waals(vdW)assembly of two-dimensional materials has long been recognized as a powerful tool for creating unique systems with properties that cannot be found in natural compounds[Nature 499,419(2013)].However,among the variety of vdW heterostructures and their various properties,only a few have revealed metallic and ferroelectric behaviour signatures[Sci.Adv.5,eaax5080(2019);Nature 560,336(2018)].Here we show ferroelectric semimetal made of double-gated double-layer graphene separated by an atomically thin crystal of hexagonal boron nitride.The structure demonstrates high room temperature mobility of the order of 10 m2·V^(−1)·s^(−1) and exhibits ambipolar switching in response to the external electric field.The observed hysteresis is reversible and persists above room temperature.Our fabrication method expands the family of ferroelectric vdW compounds and offers a promising route for developing novel phase-changing devices.A possible microscopic model of ferroelectricity is discussed.
文摘Rudder is an important part for the glider aircraft. In order to satisfy the long-time high-velocity for the near-space vehicle in the atmosphere, the light- weight, high-stiffness and high-strength all-composites rudderpost is required urgently to be prepared. The all-composites rudderpost can keep high rudder efficiency in the high temperature environment. Based on the technique require-ment of high-performance composites rudder, a 3D C/SiC rudderpost was manufactured by the CVI-CMC-SiC [1] processes. It was found during rudderpost testing that the high-temperature mechanical properties decreased and had large discretization. The analysis of the failure mechanisms was conducted by FTA method to recognize the failure modes and main reasons for rudderpost abnormal fracture and to reproduce the fracture phenomenon, which could guide production company to modify their preparation process control. Then the modified processes were proved to be validated. And the stability and reliability of the production performances were improved.
文摘Two dimensions (2D) C/SiC laminated composites is the material with isotropic properties in laminated sheets, which is considered as a promising thermal skin for aircrafts. There are intense thermal flux and thermal impact at the local interference region during the flight of the aircrafts. Therefore, mastering ablation and mechanical properties of 2D C/SiC laminated composite under extreme environments become the guild lines for the designs of the flight corridor and the aircraft security. This paper presents the experimental results of the ablation and thermal impact of C/SiC composites under different thermal environments (thermal flux ~5 MW/m2), which were carried out with the equipments of free-jets and conduct pipes. The effects on the ablation and mechanical properties of the C/SiC composites are studied, including gas pressure, thermal temperature, and the rates of temperature increasing and decreasing. The results show that the active oxidation and ablation behaviors of 2D C/SiC laminated composites under the thermal flux 5 MW/m2 consist with that of theoretical simulations. The critical failure conditions of 2D C/SiC laminated composite is also provided for the enveloping designs of the whole composites lightweight aircrafts.
文摘Partial portosystemic shunts have been popularized because of a reported low rate of mortality and morbidity(especially encephalopathy,liver failure and occlusion).The results of partial portacaval shunts[small-diameter expanded polytetrafluoroethylene(ePTFE)H-graft portacaval shunt]were retrospectively reviewed to evaluate the clinical efficacy in the treatment of portal hypertension.Forty-three patients with portal hypertension were treated by small-diameter H-graft of ePTFE portacaval shunt from May 1995 to April 2006.Thirty-three had externally ringed grafts and ten had non-ringed ones.Ten had grafts of 10 mm in diameter and 33 had grafts of 8 mm.The left gastric artery and coronary vein were ligated in all the cases.Six had pericardial devascularization and splenectomy was performed in 42.An average decrease of free portal pressure(FPP)from(33.24 P4.78)cmH2O before shunting and(13.65P5.65)cmH2O after shunting was observed.The portal blood flow was reduced by one-third of that before shunt.Thirty-eight patients survived and no upper gastro-intestinal rebleeding occurred in the follow-up period(50.5 months in average).Two were out of contact.Color Doppler ultrasonography and/or portography revealed the shunts were patent in 38 cases and were occluded in three cases(3/41,7.3%).Encephalopathy developed in five cases(5/41,12.2%).Partial(small-diameter ePTFE H-graft)portacaval shunting can reduce the portal pressure effectively.Majority of the hepatic flow from the portal vein can be maintained adequately.The shunts with reinforced grafts can keep a higher rate of patency.The morbidity of encephalopathy was lower than those with total shunt.The partial portacaval shunt is effective in preventing recurrent variceal bleeding.
基金supported by the 2017 National Geriatrics Clinical Medical Research Center Bidding Project(NCRCG-PLAGH-2017011)the Translational Medicine Project of Chinese PLA General Hospital(2017TM-020)+2 种基金Pudong New Area Health and Health Committee Subject Leader Program(PWRd2019-04)Pudong New Area TCM Peak Disease Subject(PDZY-2018-0603)the Innovation Project of Chinese PLA General Hospital(CX19028).
文摘Background:Severe acute respiratory syndrome coronavirus 2 is a highly contagious viral infection,without any available targeted therapies.The high mortality rate of COVID-19 is speculated to be related to immune damage.Methods:In this study,clinical bioinformatics analysis was conducted on transcriptome data of coronavirus infection.Results:Bioinformatics analysis revealed that the complex immune injury induced by coronavirus infection provoked dysfunction of numerous immune-related molecules and signaling pathways,including immune cells and toll-like receptor cascades.Production of numerous cytokines through the Th17 signaling pathway led to elevation in plasma levels of cytokines(including IL6,NF-kB,and TNF-a)followed by concurrent inflammatory storm,which mediates the autoimmune response.Several novel medications seemed to display therapeutic effects on immune damage associated with coronavirus infection.Conclusions:This study provided insights for further large-scale studies on the target therapy on reconciliation of immunological damage associated with COVID-19.
文摘目的：探讨解剖性肝切除术治疗合并微血管侵犯（MVI）的肝细胞癌（HCC）的临床疗效。方法：采用回顾性队列研究和病例对照研究方法。收集2007年6月至2012年6月安徽医科大学附属省立医院收治的150例合并MVI的HCC手术患者的临床资料。60例患者行解剖性肝切除术，设为AR组； 90例患者行非解剖性肝切除术，设为NR组。AR组患者根据术前ICG R15试验结果确定拟切除肝段，行解剖性肝切除术。NR组患者行非解剖性肝切除术。观察指标：（1）手术情况：手术时间、术中出血情况、术中输血例数。（2）术后恢复情况：术后腹腔引流管拔除时间、术后住院时间、术后30 d内并发症Clavein分级、术后30d内肝衰竭例数、术后30d内死亡例数。（3）随访情况：患者术后中位生存时间，5年总体生存率、5年无瘤生存率。（4）影响150例合并MVI的HCC手术患者预后因素分析。采用门诊和电话方式进行随访，了解患者生存情况。随访时间截至2016年4月。正态分布的计量资料以x^-±s表示，组间比较采用独立样本t检验。计数资料比较采用χ^2检验或Fisher确切概率法。采用KaplanMeier法计算生存率，采用Logrank检验进行生存分析。采用COX模型进行单因素和多因素分析。结果：（1）手术情况：150例患者均顺利完成HCC根治术。AR组患者手术时间、术中出血情况、术中输血例数分别为（165±39）min，≥500 mL 12例、〈500 mL 48例，15例；NR组患者分别为（136±30）min，≥500 mL 34例、〈500 mL 56例，38例；两组患者上述指标比较，差异均有统计学意义（t=29.172，χ^2=5.351，4.673，P〈0.05）。（2）术后恢复情况：AR组患者术后腹腔引流管拔除时间、术后住院时间分别为（2.7±1.1）d、（5.2±1.3）d，NR组患者分别为（3.8± 1.6）d、（7.1±2.3）d；两组患者上述指标比较，差异均有统计学意义（t=4.641，5.812，P〈0
