DNA甲基化是一种常见的表观遗传修饰,与基因的表达调控、转座子的沉默及异染色质的形成等紧密相关.DNA从头甲基化是指在新位点建立甲基化修饰的过程.植物中存在多个DNA从头甲基化通路,主要分为RNA介导的DNA甲基化(RNA-directed DNA meth...DNA甲基化是一种常见的表观遗传修饰,与基因的表达调控、转座子的沉默及异染色质的形成等紧密相关.DNA从头甲基化是指在新位点建立甲基化修饰的过程.植物中存在多个DNA从头甲基化通路,主要分为RNA介导的DNA甲基化(RNA-directed DNA methylation,Rd DM)及CMTs(CHROMOMETHYLASEs)参与的从头甲基化.Rd DM通路在非编码RNA的介导下靶向建立甲基化修饰,可调控植物多类生长发育过程.伴随着研究的深入,多条非经典的Rd DM通路得以发现,这些通路在转座子的识别和沉默方面有着重要作用.此外,非模式植物中的研究还对CMT3参与从头甲基化的机理进行了探索.基于DNA从头甲基化机制,最近的研究开发了多种靶向DNA甲基化操控工具,这些工具将推进对DNA甲基化功能的认识,并有望进一步用于遗传操控进行作物改良.本文综述了植物DNA从头甲基化机制的最新研究进展,并针对该机制的应用进行了讨论.展开更多
Over the past few years,quantum computation based on superconducting circuits has achieved remarkable progress.A milestone occurred in 2019 when Google released Sycamore,a processor with 54 qubits,and claimed quantum ...Over the past few years,quantum computation based on superconducting circuits has achieved remarkable progress.A milestone occurred in 2019 when Google released Sycamore,a processor with 54 qubits,and claimed quantum supremacy by performing in just 100 s a specific computation which would take a classical supercomputer,as stated by Google’s team,10000 years to complete.[1]In 2021,a strong quantum advantage was demonstrated by Pan and his colleagues from the University of Science and Technology of China,using a quantum processor named Zuchongzhi,which has 66 functional qubits.[2]This year,the record of the number of quantum qubits has been lifted to 127 qubits.[3]Indeed,the number of qubits is limited to a few hundreds due to the finite space of dilution refrigerators,where the superconducting qubits must be placed to be isolated from thermal noise.However,this number is still several orders of magnitude away from the requirement of quantum error correction,which is essential for general-purpose quantum computers.[4–8].展开更多
<strong>Objective:</strong> To explore the level of soluble growth-stimulated expression gene 2 (sST2) in patients with atrial fibrillation (AF) and its relationship with atrial remodeling. <strong>M...<strong>Objective:</strong> To explore the level of soluble growth-stimulated expression gene 2 (sST2) in patients with atrial fibrillation (AF) and its relationship with atrial remodeling. <strong>Methods:</strong> From December 2018 to July 2019, 86 patients were enrolled in the cardiovascular department of Jingzhou Central Hospital in Hubei Province. AF group was 60 patients with AF diagnosed according to the diagnostic criteria of electrophysiology and pacing branch of Chinese Medical Association, while the control group was 26 normal ECG patients with sinus rhythm examined by ECG and/or DCG. Clinical data, NT proBNP and birth rate of all patients were collected chemical indicators. All the patients in the groups were examined by ECG and color Doppler echocardiography. The serum level of ST2 was detected by enzyme-linked immunosorbent assay (ELISA), and the indexes related to atrial remodeling in echocardiography, left atrial diameter (LAD), were collected, compared and analyzed. <strong>Results:</strong> Serum sST2 levels and LAD and RAD values in the AF group were higher than those in the control group (P < 0.05 or P < 0.01). Serum sST2 levels were higher in the AF group than in the paroxysmal atrial fibrillation group (P = 0.031). 1) The sST2 level was positively correlated with LAD and RAD measured by cardiac ultrasound (r = 0.388, P = 0.029). <strong>Conclusion:</strong> Serum sST2 levels have early recognition value in patients with high-risk atrial fibrillation, which contributes to the stratification of risk of atrial fibrillation and the prediction of disease activity. Elevated serum sST2 levels may be associated with atrial remodeling. sST2 may be an objective biomarker that predicts the risk of emergency admission in patients with atrial fibrillation. Elevated sST2 levels may be associated with atrial fibrillation progression.展开更多
基金国家自然科学基金(9102403091324013)资助+1 种基金Supported by Military Project of National Social Science Fund of China(15GJ003-184)National Natural Science Foundation of China(61271152)
基金The authors thank Gang-Qin Liu for useful discussions and acknowledge funding support from the National Natural Science Foundation of China(Gant Nos.62222515 and 12174438)the Basic Frontier Science Research Program of Chinese Academy of Sciences(Gant No.ZDBS-LY-JSC003)CAS Project for Young Scientists in Basic Research(Gant No.YSBR-100).
文摘Over the past few years,quantum computation based on superconducting circuits has achieved remarkable progress.A milestone occurred in 2019 when Google released Sycamore,a processor with 54 qubits,and claimed quantum supremacy by performing in just 100 s a specific computation which would take a classical supercomputer,as stated by Google’s team,10000 years to complete.[1]In 2021,a strong quantum advantage was demonstrated by Pan and his colleagues from the University of Science and Technology of China,using a quantum processor named Zuchongzhi,which has 66 functional qubits.[2]This year,the record of the number of quantum qubits has been lifted to 127 qubits.[3]Indeed,the number of qubits is limited to a few hundreds due to the finite space of dilution refrigerators,where the superconducting qubits must be placed to be isolated from thermal noise.However,this number is still several orders of magnitude away from the requirement of quantum error correction,which is essential for general-purpose quantum computers.[4–8].
文摘<strong>Objective:</strong> To explore the level of soluble growth-stimulated expression gene 2 (sST2) in patients with atrial fibrillation (AF) and its relationship with atrial remodeling. <strong>Methods:</strong> From December 2018 to July 2019, 86 patients were enrolled in the cardiovascular department of Jingzhou Central Hospital in Hubei Province. AF group was 60 patients with AF diagnosed according to the diagnostic criteria of electrophysiology and pacing branch of Chinese Medical Association, while the control group was 26 normal ECG patients with sinus rhythm examined by ECG and/or DCG. Clinical data, NT proBNP and birth rate of all patients were collected chemical indicators. All the patients in the groups were examined by ECG and color Doppler echocardiography. The serum level of ST2 was detected by enzyme-linked immunosorbent assay (ELISA), and the indexes related to atrial remodeling in echocardiography, left atrial diameter (LAD), were collected, compared and analyzed. <strong>Results:</strong> Serum sST2 levels and LAD and RAD values in the AF group were higher than those in the control group (P < 0.05 or P < 0.01). Serum sST2 levels were higher in the AF group than in the paroxysmal atrial fibrillation group (P = 0.031). 1) The sST2 level was positively correlated with LAD and RAD measured by cardiac ultrasound (r = 0.388, P = 0.029). <strong>Conclusion:</strong> Serum sST2 levels have early recognition value in patients with high-risk atrial fibrillation, which contributes to the stratification of risk of atrial fibrillation and the prediction of disease activity. Elevated serum sST2 levels may be associated with atrial remodeling. sST2 may be an objective biomarker that predicts the risk of emergency admission in patients with atrial fibrillation. Elevated sST2 levels may be associated with atrial fibrillation progression.
