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Active tectonic blocks and strong earthquakes in the continent of China 被引量:262
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作者 ZHANG Peizhen (张培震) DENG Qidong (邓起东) ZHANG Guomin (张国民) MA Jin (马 瑾) gan Weijun (甘卫军) MIN Wei (闵 伟) MAO Fengying (毛凤英) WANG Qi (王 琪) 《Science China Earth Sciences》 SCIE EI CAS 2003年第z2期13-24,共12页
The primary pattern of the late Cenozoic to the present tectonic deformation of China is characterized by relative movements and interactions of tectonic blocks. Active tectonic blocks are geological units that have b... The primary pattern of the late Cenozoic to the present tectonic deformation of China is characterized by relative movements and interactions of tectonic blocks. Active tectonic blocks are geological units that have been separated from each other by active tectonic zones. Boundaries between blocks are the highest gradient of differential movement. Most of tectonic activity occurs on boundaries of the blocks. Earthquakes are results of abrupt releases of accumulated strain energy that reaches the threshold of strength of the earth's crust. Boundaries of tectonic blocks are the locations of most discontinuous deformation and highest gradient of stress accumulation, thus are the most likely places for strain energy accumulation and releases, and in turn, devastating earthquakes. Almost all earthquakes of magnitude greater than 8 and 80%-90% of earthquakes of magnitude over 7 occur along boundaries of active tectonic blocks. This fact indicates that differential movements and interactions of active tectonic blocks are the primary mechanism for the occurrences of devastating earthquakes. 展开更多
关键词 active TECTONIC block interactions of blocks differential movement STRONG EARTHQUAKE activity.
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A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01) 被引量:122
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作者 QIN E'de ZHU Qingyu +44 位作者 YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan gan Yonghua LI Xiaoyu L Fushuang TAN gang CAO Wuchun YANG Ruifu WANG Jian LI Wei XU Zuyuan LI Yan WU Qingfa LIN Wei CHEN Weijun TANG Lin DENG Yajun HAN Yujun LI Changfeng LEI Meng LI Guoqing LI Wenjie L Hong SHI Jianping TONG Zongzhong ZHANG Feng LI Songgang LIU Bin LIU Siqi DONG Wei WANG Jun gane K-S Wong YU Jun YANG Huanming 《Chinese Science Bulletin》 SCIE EI CAS 2003年第10期941-948,共8页
The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of trans... The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). 展开更多
关键词 比较分析 SARS 非典型肺炎 冠状病毒 病因学 发病机理 诊断学 疫苗
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Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer 被引量:92
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作者 An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book. 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第3期403-406,共4页
INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 a... INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . 展开更多
关键词 APOPTOSIS FEMALE Humans Male Middle Aged Precancerous Conditions Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-myc Research Support Non-U.S. Gov't Stomach Neoplasms Tumor Suppressor Protein p53
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GPS-constrained inversion of present-day slip rates along major faults of the Sichuan-Yunnan region, China 被引量:74
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作者 WANG YanZhao WANG EnNing +9 位作者 SHEN ZhengKang WANG Min gan WeiJun QIAO XueJun MENG GuoJie LI TieMing TAO Wei YANG YongLin CHENG Jia LI Peng 《Science China Earth Sciences》 SCIE EI CAS 2008年第9期1267-1283,共17页
A linked-fault-element model is employed to invert for contemporary slip rates along major active faults in the Sichuan-Yunnan region (96°-108°E, 21°-35°N) using the least squares method. The model... A linked-fault-element model is employed to invert for contemporary slip rates along major active faults in the Sichuan-Yunnan region (96°-108°E, 21°-35°N) using the least squares method. The model is based on known fault geometry, and constrained by a GPS-derived horizontal velocity field. Our results support a model attributing the eastward extrusion of the Tibetan Plateau driven mainly by the north-northeastward indentation of the Indian plate into Tibet and the gravitational collapse of the plateau. Resisted by a relatively stable south China block, materials of the Sichuan-Yunnan region rotate clockwise around the eastern Himalayan tectonic syntaxis. During the process the Garzê-Yushu, Xianshuihe, Anninghe, Zemuhe, Daliangshan, and Xiaojiang faults, the southwest extension of the Xiaojiang fault, and the Daluo-Jinghong and Mae Chan faults constitute the northeast and east boundaries of the eastward extrusion, with their left slip rates being 0.3-14.7, 8.9-17.1, 5.1 ± 2.5, 2.8 ± 2.3, 7.1 ± 2.1, 9.4 ± 1.2, 10.1 ± 2.0, 7.3 ± 2.6, and 4.9 ± 3.0 mm/a respectively. The southwestern boundary consists of a widely distributed dextral transpressional zone other than a single fault. Right slip rates of 4.2 ± 1.3, 4.3 ± 1.1, and 8.5 ± 1.7 mm/a are detected across the Nanhua-Chuxiong-Jianshui, Wuliangshan, and Longling-Lancang faults. Crustal deformation across the Longmenshan fault is weak, with short-ening rates of 1.4 ± 1.0 and 1.6 ± 1.3 mm/a across the Baoxing-Beichuan and Beichuan-Qingchuan segments. Northwest of the Longmenshan fault lies an active deformation zone (the Longriba fault) with 5.1±1.2 mm/a right slip across. Relatively large slip rates are detected across a few faults within the Sichuan-Yunnan block: 4.4±1.3 mm/a left slip and 2.7±1.1 mm/a shortening across the Litang fault, and 2.7±2.3 mm/a right-lateral shearing and 6.7±2.3 mm/a shortening across the Yunongxi fault and its surrounding regions. In conclusion, we find that the Sichuan-Yunnan region is divided into more than a doz 展开更多
关键词 Sichuan-Yunnan region GPS linked-fault-element SLIP rate
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Plasma exchange-centered artificial liver support system in hepatitis B virus-related acute-onchronic liver failure:a nationwide prospective multicenter study in China 被引量:52
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作者 Jia-Jia Chen Jian-Rong Huang +13 位作者 Qian Yang Xiao-Wei Xu Xiao-Li Liu Shao-Rui Hao Hui-Fen Wang Tao Han Jing Zhang Jian-He gan Zhi-Liang Gao Yu-Ming Wang Shu-Mei Lin Qing Xie Chen Pan Lan-Juan Li 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2016年第3期275-281,共7页
BACKGROUND: Plasma exchange (PE)-centered artificial liver support system reduced the high mortality rate of hepa titis B virus (HBV)-related acute-on-chronic liver failure (ACLF). But the data were diverse in ... BACKGROUND: Plasma exchange (PE)-centered artificial liver support system reduced the high mortality rate of hepa titis B virus (HBV)-related acute-on-chronic liver failure (ACLF). But the data were diverse in different medical centers. The present prospective nationwide study was to evaluate the effects of PE on patients with HBV-ACLF at different stages. 展开更多
关键词 liver failure artificial liver support plasma exchange acute-on-chronic liver failure
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Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018 被引量:49
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作者 Rei Ogawa Sadanori Akita +19 位作者 Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi 《Burns & Trauma》 SCIE 2019年第1期356-395,共40页
There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.... There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physi 展开更多
关键词 KELOID Hypertrophic scars Pathological scars GUIDELINE PATHOLOGY Surgery Radiotherapy STEROID Laser
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Effects of thymol and carvacrol supplementation on intestinal integrity and immune responses of broiler chickens challenged with Clostridium perfringens 被引量:48
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作者 Encun Du Weiwei Wang +3 位作者 Liping gan Zhui Li Shuangshuang Guo Yuming Guo 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2016年第4期522-531,共10页
Background: Necrotic enteritis caused by Clostfidium perffingens infection leads to serious economic losses in the global poultry production. In the present study, we investigated the protective effects of essential ... Background: Necrotic enteritis caused by Clostfidium perffingens infection leads to serious economic losses in the global poultry production. In the present study, we investigated the protective effects of essential oils (EO, which contained 25 % thymol and 25 % carvacrol as active components) supplementation on growth performance, gut lesions, intestinal morphology, and immune responses of the broiler chickens infected with C. perfringens. A total of 448 1-day-old male broiler chicks were allocated into eight treatment groups following a 4 x 2 factorial arrangement with four dietary EO dosages (0, 60, 120, or 240 mg/kg) and two infection status (with or without C. perfringens challenge from d 14 to 20). Results: The challenge did not impair the growth performance of birds, but induced gut lesions and increased crypt depth in the ileum (P ≤ 0.05). It also down-regulated the claudin-1 and occludin mRNA expression (P ≤0.05), up-regulated the mRNA expression of interleukin-113 (P≤ 0.05), tended to increase the toll-like receptor (TLR) 2 mRNA expression (P 〈 0.10) in the ileum, and enhanced the mucosal secretory IgA production (P 〈 0.05). In the challenged birds, dietary EO supplementation linearly alleviated the gut lesions and improved the ratio of villus height to crypt depth (P ≤0.05), and the supplementation of 120 and 240 mg/kg EO increased the serum antibody titers against Newcastle disease virus (P≤ 0.05). Regardless of challenge, the EO supplementation showed a tendency to linearly elevate the feed conversion efficiency between 14 and 28 d of age as well as the occludin mRNA expression (P〈 0.10), and linearly inhibited the mRNA expression of TLR2 and tumor necrotic factor-o in the ileum (P≤ 0.05). Conclusions: The dietary supplementation of EO could alleviate the intestinal injury by improving intestinal integrity and modulating immune responses in the C. perffingens-challenged broiler chickens. 展开更多
关键词 Broiler chicken Clostridium peffringens Essential oils Immune response Intestinal integrity
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Comparing the Diagnostic Criteria for Gestational Diabetes Mellitus of World Health Organization 2013 with 1999 in Chinese Population 被引量:46
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作者 Weiwei Zhu Huixia Yang +13 位作者 Yumei Wei Zilian Wang Xuelan Li Hairong Wu Nan Li Meihua Zhang Xinghui Liu Hua Zhang Yunhui Wang Jianmin Niu Yujie gan Liruo Zhong Yunfeng Wang Anil Kapur 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第1期125-127,共3页
INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as "hyperglycemia first recognized during pregnancy" and has more recently been described by American Diabetes Association (ADA) (2012) as d... INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as "hyperglycemia first recognized during pregnancy" and has more recently been described by American Diabetes Association (ADA) (2012) as diabetes diagnosed during pregnancy that is not clearly overt diabetes. The hyperglycemia and adverse pregnancy outcomes study (HAPO) demonstrated that the risk of adverse maternal,fetal,and neonatal outcomes continuously increase as a function of maternal glycemia at 24-28 weeks,even within ranges previously considered normal for pregnancy. 展开更多
关键词 CRITERIA Gestational Diabetes Mellitus Oral Glucose Tolerance Test
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Colorectal cancer in Guangdong Province of China:A demographic and anatomic survey 被引量:40
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作者 Xu, An-Gao Yu, Zhi-Jin +5 位作者 Jiang, Bo Wang, Xin-Ying Zhong, Xu-Hui Liu, Ji-Hong Lou, Qiu-Yun gan, Ai-Hua 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第8期960-965,共6页
AIM:To determine the basic demographic features of colorectal cancer (CRC) in five hospitals located in four different areas of Guangdong Province,China.METHODS:A review of patient records from 1986 to 2006 from five ... AIM:To determine the basic demographic features of colorectal cancer (CRC) in five hospitals located in four different areas of Guangdong Province,China.METHODS:A review of patient records from 1986 to 2006 from five hospitals was conducted. Patient data was obtained,including age,gender,location of le-sions,staging and histological type of CRC. The Chi-square test was used to assess differences in rates and a significance level of 0.05 was used. Univariate com-parisons were made via Fisher's exact tests.RESULTS:Analysis was carried out on 8172 CRC patents,6.1% (499/8172) of the patients were aged ≤ 30 years. The peak incidence was between the ages 61-70 years (27.8%). The mean age at CRC diagnosis increased from 52 years (1986-1988) to 60 years(2004-2006) and the proportion of young CRC patients decreased from 8.0% to 5.9% over the same period. Of 8172 lesions,4434 (54.3%) were located in rectum and 3738 (45.7%) in colon. The incidence of rectal cancer decreased significantly from 59.4% (1989-1991) to 51.8% (2004-2006) and right sided colon cancer increased from 40.6% to 48.2%. The mean age,ana-tomic distribution,histological type and differentiation degree were significantly different among the four geographical areas (P < 0.05).CONCLUSION:The hospitalization rate for CRC has increased in Guangdong in recent years. The characteristics of CRC from the five hospitals located in the four different areas of Guangdong Province are also different. Further studies are needed to assess more recent trend in the incidence and prevalence of CRC as well as the respective roles of genetic and environ-mental factors in CRC. 展开更多
关键词 Colorectal cancer SURVEY CHARACTERISTICS DIFFERENTIATION
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Atomically dispersed materials:Ideal catalysts in atomic era 被引量:35
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作者 Tao gan Dingsheng Wang 《Nano Research》 SCIE EI CSCD 2024年第1期18-38,共21页
Catalysts can accelerate the chemical reaction rate and effectively promote the molecules transformation,which is of great significance in the research of chemical industry and material science.The extreme utilization... Catalysts can accelerate the chemical reaction rate and effectively promote the molecules transformation,which is of great significance in the research of chemical industry and material science.The extreme utilization of reactive sites has led to the emergence and development of atomically dispersed materials(ADMs).The highly active coordination unsaturated metal sites and fully utilized metal atoms make ADMs show great potential in catalytic reactions.The adjustment of coordination environment and electronic structure provides more possibilities for constructing reactive centers with different properties.This review summarized the application and research progress of ADMs in different fields.The design strategy and structure–activity relationship of ADMs for specific reactions were summarized and analyzed.Moreover,we also provided advices for the challenges and opportunities faced by ADMs in catalytic reactions. 展开更多
关键词 atomically dispersed materials CATALYSIS organic synthesis battery sensor ENZYME
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Hypertriglyceridemia-induced pancreatitis: A case-based review 被引量:37
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作者 S Ian gan Alun L Edwards +1 位作者 Christopher J Symonds Paul L Beck 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第44期7197-7202,共6页
Hypertriglyceridemia is an established cause of pancreatitis. In a case-based approach, we present a review of hypertriglyceridemJa and how it can cause pancreatitis. We outline how to investigate and manage such pati... Hypertriglyceridemia is an established cause of pancreatitis. In a case-based approach, we present a review of hypertriglyceridemJa and how it can cause pancreatitis. We outline how to investigate and manage such patients. A 35 year old man presented to the emergency department with abdominal pain and biochemical evidence of acute pancreatitis. There was no history of alcohol consumption and biliary imaging was normal. The only relevant past medical history was that of mild hyperlipidemia, treated with diet alone. Physical exam revealed epigastric tenderness, right lateral rectus palsy, lipemia retinalis, bitemporal hemianopsia and a delay in the relaxation phase of his ankle reflexes. Subsequent laboratory investigation revealed marked hypertriglyceridemia and panhypopituarism. An enhanced CT scan of the head revealed a large suprasellar mass impinging on the optic chiasm and hypothalamus. The patient was treated supportively; thyroid replacement and lipid lowering agents were started. He underwent a successful resection of a craniopharyngioma. Postoperatively, the patient did well on hormone replacement therapy. He has had no further attacks of pancreatitis. This case highlights many of the factors involved in the regulation of triglyceride metabolism. We review the common causes of hypertriglyceridemia and the proposed mechanisms resulting in pancreatitis. The incidence and management of hypertriglyceridemiainduced pancreatitis are also discussed. 展开更多
关键词 HYPERTRIGLYCERIDEMIA PANCREATITIS HYPERLIPIDEMIA
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Contemporary crustal deformation of the Chinese continent and tectonic block model 被引量:34
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作者 WANG Min (王 敏) SHEN Zhengkang (沈正康) NIU Zhijun (牛之俊) ZHANG Zusheng (张祖胜) SUN Hanrong (孙汉荣) gan Weijun (甘卫军) WANG Qi (王 琪) REN Qun (任 群) 《Science China Earth Sciences》 SCIE EI CAS 2003年第z2期25-40,共12页
We obtain the preliminary result of crustal deformation velocity field for the Chinese con-tinent by analyzing GPS data from the Crustal Motion Observation Network of China (CMONOC), particularly the data from the reg... We obtain the preliminary result of crustal deformation velocity field for the Chinese con-tinent by analyzing GPS data from the Crustal Motion Observation Network of China (CMONOC), particularly the data from the regional networks of CMONOC observed in 1999 and 2001. We de-lineate 9 tectonically active blocks and 2 broadly distributed deformation zones out of a denseGPS velocity field, and derive block motion Euler poles for the blocks and their relative motionrates. Our result reveals that there are 3 categories of deformation patterns in the Chinese conti-nent. The first category, associated with the interior of the Tibetan Plateau and the Tianshan oro-genic belt, shows broadly distributed deformation within the regions. The third category, associatedwith the Tarim Basin and the region east of the north-south seismic belt of China, shows block-likemotion, with deformation accommodated along the block boundaries only. The second category, mainly associated with the borderland of the Tibetan Plateau, such as the Qaidam, Qilian, Xining(in eastern Qinghai), and the Diamond-shaped (in western Sichuan and Yunnan) blocks, has thedeformation pattern between the first and the third, i.e. these regions appear to deform block-like,but with smaller sizes and less strength for the blocks. Based on the analysis of the lithosphericstructures and the deformation patterns of the regions above, we come to the inference that thedeformation modes of the Chinese continental crust are mainly controlled by the crustal structure.The crust of the eastern China and the Tarim Basin is mechanically strong, and its deformationtakes the form of relative motion between rigid blocks. On the other hand, the northward indentation of the Indian plate into the Asia continent has created the uplift of the Tibetan Plateau and the Tianshan Mountains, thickened their crust, and raised the temperature in the crust. The lower crust thus has become ductile, evidenced in low seismic velocity and high electric conductivity observed. The brittle part of t 展开更多
关键词 GPS CONTINENTAL CRUSTAL motion TECTONIC blocks significance test.
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转基因(SAG12-IPT)青菜的迟衰特性 被引量:20
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作者 袁政 潘爱虎 +4 位作者 简志英 徐淑平 gan Su-Sheng 黄海 张大兵 《植物生理与分子生物学学报》 CAS CSCD 2002年第5期379-384,共6页
利用根癌农杆菌感染方法将融合基因SAG12 IPT导入青菜 ,转基因植株明显表现出衰老延迟的生理现象。SAG12 IPT的抗衰老作用表现为 :在衰老过程中转基因青菜叶片中叶绿素含量高于未转基因的青菜 ,PCR分析结果表明该融合基因已经转入青... 利用根癌农杆菌感染方法将融合基因SAG12 IPT导入青菜 ,转基因植株明显表现出衰老延迟的生理现象。SAG12 IPT的抗衰老作用表现为 :在衰老过程中转基因青菜叶片中叶绿素含量高于未转基因的青菜 ,PCR分析结果表明该融合基因已经转入青菜中。激素检测结果表明转基因青菜叶片中细胞分裂素含量高于未转基因植株 ,说明抗衰老与叶片内细胞分裂素含量提高有关。另外 ,转基因植株不仅表现出活体植株衰老延迟 ,而且长在植株上的与离体的叶片滞绿时间延长。这些为蔬菜的耐储存育种提供了新的思路 ,同时为该融合基因在十字花科经济作物中的应用提供了理论依据。 展开更多
关键词 迟衰特性 抑制衰老 SAG12-IPT 转基因青菜
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Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy 被引量:33
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作者 gan Xie Qian Zhou +9 位作者 Chuang-Zhao Qiu Wen-Kui Dai He-Ping Wang Yin-Hu Li Jian-Xiang Liao Xin-Guo Lu Su-Fang Lin Jing-Hua Ye Zhuo-Ya Ma Wen-Jian Wang 《World Journal of Gastroenterology》 SCIE CAS 2017年第33期6164-6171,共8页
AIM To investigate whether patients with refractory epilepsy and healthy infants differ in gut microbiota(GM),and how ketogenic diet(KD) alters GM.METHODS A total of 14 epileptic and 30 healthy infants were recruited ... AIM To investigate whether patients with refractory epilepsy and healthy infants differ in gut microbiota(GM),and how ketogenic diet(KD) alters GM.METHODS A total of 14 epileptic and 30 healthy infants were recruited and seizure frequencies were recorded. Stool samples were collected for 16 S r DNA sequencing using the Illumina Miseq platform. The composition of GM in each sample was analyzed with MOTHUR,and intergroup comparison was conducted by R software.RESULTS After being on KD treatment for a week,64% of epileptic infants showed an obvious improvement,with a 50% decrease in seizure frequency. GM structure in epileptic infants(P1 group) differed dramatically from that in healthy infants(Health group). Proteobacteria,which had accumulated significantly in the P1 group,decreased dramatically after KD treatment(P2 group). Cronobacter predominated in the P1 group and remained at a low level both in the Health and P2 groups. Bacteroides increased significantly in the P2 group,in which Prevotella and Bifidobacterium also grew in numbers and kept increasing.CONCLUSION GM pattern in healthy infants differed dramatically from that of the epileptic group. KD could significantly modify symptoms of epilepsy and reshape the GM of epileptic infants. 展开更多
关键词 Ketogenic diet CRONOBACTER Seizures Gut microbiota EPILEPSY
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Recent progress in drug delivery 被引量:30
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作者 Chong Li Jiancheng Wang +11 位作者 Yiguang Wang Huile Gao gang Wei Yongzhuo Huang Haijun Yu Yong gan Yongjun Wang Lin Mei Huabing Chen Haiyan Hu Zhiping Zhang Yiguang Jin 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2019年第6期1145-1162,共18页
Drug delivery systems(DDS)are defined as methods by which drugs are delivered to desired tissues,organs,cells and subcellular organs for drug release and absorption through a variety of drug carriers.Its usual purpose... Drug delivery systems(DDS)are defined as methods by which drugs are delivered to desired tissues,organs,cells and subcellular organs for drug release and absorption through a variety of drug carriers.Its usual purpose to improve the pharmacological activities of therapeutic drugs and to overcome problems such as limited solubility,drug aggregation,low bioavailability,poor biodistribution,lack of selectivity,or to reduce the side effects of therapeutic drugs.During 2015-2018,significant progress in the research on drug delivery systems has been achieved along with advances in related fields,such as pharmaceutical sciences,material sciences and biomedical sciences.This review provides a conciseoverview of current progress in this research area through its focus on the delivery strategies,construction techniques and specific examples.It is a valuable reference for pharmaceutical scientists who want to learn more about the design of drug delivery systems. 展开更多
关键词 PHARMACEUTICS DRUG delivery SYSTEM Basic RESEARCH APPLICATION Delivery STRATEGY
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Advanced Space-based Solar Observatory(ASO-S):an overview 被引量:29
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作者 Wei-Qun gan Cheng Zhu +37 位作者 Yuan-Yong Deng Hui Li Yang Su Hai-Ying Zhang Bo Chen Zhe Zhang Jian Wu Lei Deng Yu Huang Jian-Feng Yang Ji-Jun Cui Jin Chang Chi Wang Ji Wu Zeng-Shan Yin Wen Chen Cheng Fang Yi-Hua Yan Jun Lin Wei-Ming Xiong Bin Chen Hai-Chao Bao Cai-Xia Cao Yan-Ping Bai Tao Wang Bing-Long Chen Xin-Yu Li Ye Zhang Li Feng Jiang-Tao Su Ying Li Wei Chen You-Ping Li Ying-Na Su Hai-Yan Wu Mei Gu Lei Huang Xue-Jun Tang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2019年第11期3-10,共8页
The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic fie... The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C. 展开更多
关键词 space vehicles instruments-Sun magnetic fields-Sun flares-Sun CMEs-Sun UV radiation-Sun X-ray gamma-rays
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Morphological study on colonic pathology in ulcerative colitis treated by moxibustion 被引量:29
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作者 Huan gan Wu Li Bin Zhou +5 位作者 Da Ren Shi Shi Min Liu Hui Rong Liu Bi Meng Zhang Han Ping Chen Lin Shan Zhang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2000年第6期861-865,共5页
AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustion ... AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustion with herbal medicine underneathgroup and the western medicine group.Thirtypatients were treated with the abovemoxibustion and 16 patients with Salicylayefapyridine(SASP).The colonic mucosa of 13patients in the moxibustion group was observedby colonoscopy before and after the treatment.Mucin was also analyzed by H.E and AB-PASstaining.RESULTS Seventeen patients were clinicallycured,12 were improved and 1 unchanged in themoxibustion group.In the control group,5patients were clinically cured,7 improved and 4unchanged.Thirteen patients with active UCwere taken as the subjects for histopathologicanalysis in this study.The colonic mucosallesions were remarkably improved and thecharacteristic of the mucin also changed.Inmost sections,the chronic inflammation ofmucosa was geatly ameliorated(P【0.01).Theinflammatory cell infiltratation much decreased and neutrophils,disapeared in most sections(P【0.001).The goblet cells significantlyincreased(P【0.001);crypt paracrypt abscessor mucosal ulceration was seen(P【0.001).CONCLUSION The rate of cure of ulcerative colitis by moxibustion with herbal medicine beneath is superior to that by SASP. This sort of moxibustion can effectively improve the colonic mucosal lesions and restore the proportion of mucoprotein to near normal. 展开更多
关键词 COLITIS ulcerative/therapy MOXIBUSTION intestinal MUCOSA morphological study
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Lattice Boltzmann modeling and simulation of compressible flows 被引量:28
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作者 Ai-Guo Xu Guang-Cai Zhang +2 位作者 Yan-Biao gan Feng Chen Xi-Jun Yu 《Frontiers in Biology》 CAS CSCD 2012年第5期582-600,共19页
In this mini-review we summarize the progress of Lattice Boltzmann (LB) modeling and simulating compressible flows in our group in recent years. Main contents include (i) Single-Relaxation-Time (SRT) LB model su... In this mini-review we summarize the progress of Lattice Boltzmann (LB) modeling and simulating compressible flows in our group in recent years. Main contents include (i) Single-Relaxation-Time (SRT) LB model supplemented by additional viscosity, (ii) Multiple-Relaxation-Time (MRT) LB model, and (iii) LB study on hydrodynamic instabilities. The former two belong to improvements of physical modeling and the third belongs to simulation or application. The SRT-LB model sup- plemented by additional viscosity keeps the original framework of Lattice Bhatnagar-Gross Krook (LBGK). So, it is easier and more convenient for previous SRT-LB users. The MRT-LB is a com- pletely new framework for physical modeling. It significantly extends the range of LB applications. The cost is longer computational time. The developed SRT-LB and MRT-LB are complementary from the sides of convenience and applicability. 展开更多
关键词 lattice Boltzmann modeling compressible flows shock waves hydrodynamic instability
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The influence of the Madden-Julian Oscillation activity anomalies on Yunnan's extreme drought of 2009-2010 被引量:27
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作者 LU JunMei JU JianHua +1 位作者 REN JuZhang gan WeiWei 《Science China Earth Sciences》 SCIE EI CAS 2012年第1期98-112,共15页
Yunnan Province of China suffered a record-breaking drought that persisted from autumn 2009 into spring 2010. The present study examined the physical causes of this extreme drought event in terms of persistent anomali... Yunnan Province of China suffered a record-breaking drought that persisted from autumn 2009 into spring 2010. The present study examined the physical causes of this extreme drought event in terms of persistent anomalies of intraseasonal oscillation in the tropical atmosphere (the Madden-Julian Oscillation hereafter the MJO). The results show that the occurrence of severe drought in Yunnan was caused directly by deficient rainfall lasting from the summer of 2009 to the spring of 2010. Further ex- ploration reveals a persistent positive variation of MJO index 1 from June to October. Accordingly, the convective activity over the Bay of Bengal (BOB) weakened continuously, and then an anomalous descending airflow was induced over the tropi- cal Indian Ocean, resulted in the anomalous weakening of vertical Asian monsoon circulation in South Asia. Consequently, the transport of water vapor from the tropical Indian Ocean to Yunnan decreased abnormally, leading to persistent below-normai rainfall over Yunnan from summer to autumn in 2009. As a result, a severe drought began to appear in autumn. In the winter of 2009-2010, MJO index 1 remained persistently positive, indicating the continuous weakening of convective activity over the BOB. The atmospheric circulation associated with the persistent positive anomalies in the MJO also demonstrated anomalous patterns. Specifically, there was an anomalous high-pressure ridge stretching from South Asia through the Tibetan Plateau and into the western part of southwestem China. This indicates that the atmospheric circulation over Yunnan was dominated by vertical descending airflow in the high-pressure ridge. Simultaneously, the India-Burma trough was weakened, which resulted in unfavorable conditions for the transport of water vapor from the BOB to Yunnan, causing the observed persistent deficient precipitation in winter and the subsequently intensified drought. Therefore, the persistent anomalies in MJO activity in the tropical atmosphere played an important role in the oc 展开更多
关键词 YUNNAN extreme drought MJO persistent anomalies
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Natural history of covert hepatic encephalopathy: An observational study of 366 cirrhotic patients 被引量:27
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作者 An-Jiang Wang A-Ping Peng +7 位作者 Bi-Min Li Na gan Li Pei Xue-Lian Zheng Jun-Bo Hong Hai-Ying Xiao Jia-Wei Zhong Xuan Zhu 《World Journal of Gastroenterology》 SCIE CAS 2017年第34期6321-6329,共9页
AIM To explore the natural history of covert hepatic encephalopathy(CHE) in absence of medication intervention.METHODS Consecutive outpatient cirrhotic patients in a Chinese tertiary care hospital were enrolled and ev... AIM To explore the natural history of covert hepatic encephalopathy(CHE) in absence of medication intervention.METHODS Consecutive outpatient cirrhotic patients in a Chinese tertiary care hospital were enrolled and evaluated for CHE diagnosis. They were followed up for a mean of 11.2 ± 1.3 mo. Time to the first cirrhosis-related complications requiring hospitalization, including overt HE(OHE), resolution of CHE and death/transplantation, were compared between CHE and no-CHE patients. Predictors for complication(s) and death/transplantation were also analyzed.RESULTS A total of 366 patients(age: 47.2 ± 8.6 years, male: 73.0%) were enrolled. CHE was identified in 131 patients(35.8%). CHE patients had higher rates of death and incidence of complications requiring hospitalization, including OHE, compared to unimpaired patients. Moreover, 17.6% of CHE patients developed OHE, 42.0% suffered persistent CHE, and 19.8% of CHE spontaneously resolved. In CHE patients, serum albumin < 30 g/L(HR = 5.22, P = 0.03) was the sole predictor for developing OHE, and blood creatinine > 133 μmol/L(HR = 4.75, P = 0.036) predicted mortality. Child-Pugh B/C(HR = 0.084, P < 0.001) and OHE history(HR = 0.15, P = 0.014) were predictors of spontaneous resolution of CHE.CONCLUSION CHE exacerbates, persists or resolves without medication intervention in clinically stable cirrhosis. Triage of patients based on these predictors will allow for more cost-effect management of CHE. 展开更多
关键词 Covert hepatic encephalopathy Overt hepatic encephalopathy Natural history Liver cirrhosis
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