仙灵骨葆口服制剂是我国治疗骨病的中药大品种,但近年来国家食品药品监督管理总局通报其易引起肝损伤。传统毒理学研究很难评价其肝损伤作用,我们前期发现仙灵骨葆肝损伤具有特异质属性,拆方研究发现补骨脂和淫羊藿是其导致特异质肝损...仙灵骨葆口服制剂是我国治疗骨病的中药大品种,但近年来国家食品药品监督管理总局通报其易引起肝损伤。传统毒理学研究很难评价其肝损伤作用,我们前期发现仙灵骨葆肝损伤具有特异质属性,拆方研究发现补骨脂和淫羊藿是其导致特异质肝损伤的主要药味,且配伍后其特异质肝损伤加重,呈现七情配伍中“相反”的特点。进一步研究发现,TNF-α介导的免疫应激是其重要诱因,免疫促进成分和肝损伤易感成分存在是其另一重要诱因。然而,具体机制尚不清楚。本研究通过建立动物模型,考察了免疫促进淫羊藿次苷Ⅱ联合肝损伤易感成分补骨脂甲素对小鼠肝损伤的影响;借助非靶向代谢组学技术评价了两个成分联合对肝损伤代谢标志物的影响;利用16S r RNA测序技术探讨了肠道菌群的物种组成和相对丰度的变化。结果表明在TNF-α诱导的免疫应激小鼠模型上发现,单独给药补骨脂甲素能够引起明显肝损伤,而淫羊藿次苷Ⅱ组却无明显变化,但是淫羊藿次苷Ⅱ能够协同补骨脂甲素导致特异质肝损伤;同时代谢组学结果揭示补骨脂甲素联合淫羊藿次苷Ⅱ能够引起小鼠肝脏中甲基氨基甲酰PAF、吲哚-3-醋酸甲酯等代谢物的水平升高,而甘氨酸-酪氨酸(Gly-Tyr)、L-亮氨酰-L-甘氨酸(Leu-Gly)和L-色氨酸-L-丝氨酸(Trp-Ser)等代谢物的水平则下降。这些与肝损伤相关的差异表达代谢物主要富集在鞘脂代谢、鞘脂信号通路和坏死等代谢途径。值得注意的是,补骨脂甲素联合淫羊藿次苷Ⅱ可以诱导肝损伤小鼠肠道中的乳酸杆菌和脱硫弧菌科丰度显著增加。相关性分析结果表明,类杆菌科和脱硫弧菌科与甲基氨基甲酰基PAF和吲哚-3-醋酸甲酯呈正相关,而与Gly-Tyr、Leu-Gly和Trp-Ser呈负相关。本研究初步阐明了补骨脂配伍淫羊藿引起特异质型药物性肝损伤的物质基础和机制,为中成药临床合理�展开更多
具有低温升的高效散热方案是实现电泵浦激光的关键因素之一.高导热金刚石有望克服钙钛矿激光的散热限制.本文中,我们展示了一种可以将光泵浦过程中产生热量高效耗散的金刚石基底钙钛矿纳米片激光.此外,紧密光学束缚可以通过在纳米片和...具有低温升的高效散热方案是实现电泵浦激光的关键因素之一.高导热金刚石有望克服钙钛矿激光的散热限制.本文中,我们展示了一种可以将光泵浦过程中产生热量高效耗散的金刚石基底钙钛矿纳米片激光.此外,紧密光学束缚可以通过在纳米片和金刚石基底之间引入一层薄SiO_(2)间隔层而实现.该激光的品质因子高达~1962,激光阈值为52.19μJ cm^(-2).受益于金刚石基底,其泵浦能量密度相关温度灵敏度较低(~0.56±0.01 K cm~2μJ^(-1)).本工作有望促进电泵浦钙钛矿激光的发展.展开更多
A scheme of hybrid light source using lasers and LEDs for projection display is presented;the si-mulation results show that projectors with the proposed scheme can achieve high brightness of over 1000 lm, good uniform...A scheme of hybrid light source using lasers and LEDs for projection display is presented;the si-mulation results show that projectors with the proposed scheme can achieve high brightness of over 1000 lm, good uniformity of illumination and chromaticity. It also provides an improved me-thod for light source with longer life, wider color garment and higher adaptability to environment which can replace UHP in traditional projectors.展开更多
基金supported by the National Natural Science Foundation of China (82174071)。
文摘仙灵骨葆口服制剂是我国治疗骨病的中药大品种,但近年来国家食品药品监督管理总局通报其易引起肝损伤。传统毒理学研究很难评价其肝损伤作用,我们前期发现仙灵骨葆肝损伤具有特异质属性,拆方研究发现补骨脂和淫羊藿是其导致特异质肝损伤的主要药味,且配伍后其特异质肝损伤加重,呈现七情配伍中“相反”的特点。进一步研究发现,TNF-α介导的免疫应激是其重要诱因,免疫促进成分和肝损伤易感成分存在是其另一重要诱因。然而,具体机制尚不清楚。本研究通过建立动物模型,考察了免疫促进淫羊藿次苷Ⅱ联合肝损伤易感成分补骨脂甲素对小鼠肝损伤的影响;借助非靶向代谢组学技术评价了两个成分联合对肝损伤代谢标志物的影响;利用16S r RNA测序技术探讨了肠道菌群的物种组成和相对丰度的变化。结果表明在TNF-α诱导的免疫应激小鼠模型上发现,单独给药补骨脂甲素能够引起明显肝损伤,而淫羊藿次苷Ⅱ组却无明显变化,但是淫羊藿次苷Ⅱ能够协同补骨脂甲素导致特异质肝损伤;同时代谢组学结果揭示补骨脂甲素联合淫羊藿次苷Ⅱ能够引起小鼠肝脏中甲基氨基甲酰PAF、吲哚-3-醋酸甲酯等代谢物的水平升高,而甘氨酸-酪氨酸(Gly-Tyr)、L-亮氨酰-L-甘氨酸(Leu-Gly)和L-色氨酸-L-丝氨酸(Trp-Ser)等代谢物的水平则下降。这些与肝损伤相关的差异表达代谢物主要富集在鞘脂代谢、鞘脂信号通路和坏死等代谢途径。值得注意的是,补骨脂甲素联合淫羊藿次苷Ⅱ可以诱导肝损伤小鼠肠道中的乳酸杆菌和脱硫弧菌科丰度显著增加。相关性分析结果表明,类杆菌科和脱硫弧菌科与甲基氨基甲酰基PAF和吲哚-3-醋酸甲酯呈正相关,而与Gly-Tyr、Leu-Gly和Trp-Ser呈负相关。本研究初步阐明了补骨脂配伍淫羊藿引起特异质型药物性肝损伤的物质基础和机制,为中成药临床合理�
基金supported by the National Natural Science Foundation of China(U21A20496,61922060,61775156,61805172,12104334,62174117,and 61905173)the Key Research and Development Program of Shanxi Province(202102150101007)+5 种基金Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Program(2022SX-TD020)the Natural Science Foundation of Shanxi Province(20210302123154 and 20210302123169)the Research Project Supported by Shanxi Scholarship Council of China(2021-033)the Research Project Supported by Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(2021SXFR008)the Introduction of Talents Special Project of Lvliang City(Rc2020206 and Rc2020207)support from China Scholarship Council(202006935009)。
文摘具有低温升的高效散热方案是实现电泵浦激光的关键因素之一.高导热金刚石有望克服钙钛矿激光的散热限制.本文中,我们展示了一种可以将光泵浦过程中产生热量高效耗散的金刚石基底钙钛矿纳米片激光.此外,紧密光学束缚可以通过在纳米片和金刚石基底之间引入一层薄SiO_(2)间隔层而实现.该激光的品质因子高达~1962,激光阈值为52.19μJ cm^(-2).受益于金刚石基底,其泵浦能量密度相关温度灵敏度较低(~0.56±0.01 K cm~2μJ^(-1)).本工作有望促进电泵浦钙钛矿激光的发展.
基金supported by the National Natural Science Foundation of China (U21A20496,61922060,62205235,62204157,61805172,12104334,62174117,and 61905173)the Graduate Innovation Project of Shanxi Province (2020BY117)+9 种基金the Key Research and Development (International Cooperation)Program of Shanxi Province (201803D421044)the Natural Science Foundation of Shanxi Province (20210302123154 and 20210302123169)Research Project Supported by Shanxi Scholarship Council of China (2021-033)Research Project Supported by Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering (2021SX-FR008 and 2022SX-TD020)Introduction of Talents Special Project of Lvliang City (Rc2020206,Rc2020207)Transformation Cultivation Project of University Scientific and Technological Achievements of Shanxi Province (2020CG013)the Key Research and Development Program of Shanxi Province (202102150101007)the support from the Research Grants Council,University Grants Committee,Hong Kong,General Research Fund (12303920)SZ-HK-Macao Science and Technology Plan Project (SGDX2020110309540000)Guangdong Basic and Applied Basic Research Fund (2022A1515010020)。
文摘A scheme of hybrid light source using lasers and LEDs for projection display is presented;the si-mulation results show that projectors with the proposed scheme can achieve high brightness of over 1000 lm, good uniformity of illumination and chromaticity. It also provides an improved me-thod for light source with longer life, wider color garment and higher adaptability to environment which can replace UHP in traditional projectors.
