Insert Snakebite is a global public health issue, and in majority of cases it is undermined. Tropical and subtropical countries are most effected, Bangladesh being one of them. There is scarcity of countries’ epidemi...Insert Snakebite is a global public health issue, and in majority of cases it is undermined. Tropical and subtropical countries are most effected, Bangladesh being one of them. There is scarcity of countries’ epidemiological situation in relation to snakebite poisoning. This study has looked at the epidemiological status of snakebite poisoning from national representative survey findings. Methods: A nationwide cross-sectional survey was conducted in 12 randomly selected districts of Bangladesh in 2003. A total of 171,366 households were surveyed and information was collected from 819,429 populations by face to face interview. Multi-stage cluster sampling methods were used in this survey and covered urban, rural and slum populations. Results: Annually an estimated 15,372 (10.98/100,000) individuals were bitten by snakes and of them 1709 (1.22/100,000) died every year. Males were found to be most vulnerable with a risk of 1.51 times higher than female. Rural populations were also 10.54 times higher at risk than the populations living in the urban areas. Among the victims 94% were from the poor socio economic conditions. Around 43.9% of the incidences occurred during evening to midnight. Home was found the most common area for snake bite (33.6%), and the Leg was found to be the most common site for biting (63.1%). A total of 96.6% victims sought treatment, of them 61% sought immediate treatment from traditional healing methods. Conclusions: Present incidence of snakebite in Bangladesh has clearly shown that there is emerging public health needs for intervention that can reduce the mortality and burden of the disease in the country.展开更多
In common property studies,increasing number of users has been considered as a major threat for the long-term sustainability of natural resources. This perception has been true in a few cases. However,the 40-years emp...In common property studies,increasing number of users has been considered as a major threat for the long-term sustainability of natural resources. This perception has been true in a few cases. However,the 40-years empirical research conducted in a variety of environmental settings,reveals that population pressure is not the only factor responsible for the degradation of natural resources. In remote areas,where the local inhabitants highly depend on available natural resources for subsistence livelihood,the economically important resources are kept under different ownership regimes. The local inhabitants have established autochthonous insti-tutions,and formulated rules and regulations for proper management of these resources. In this paper an attempt has been made to explore the response of a small fodder user community to the increasing population. For this purpose a micro-level study has been conducted in a remote mountain environment in the eastern Hindu Kush. For this research,data has been collected through fieldwork and focus group discussion. The results of this study reveal that fodder user communities have responded very well to the problem of population pressure. To maintain equity and long-term sustainability they have adopted a number of strategies including changing the ownership,and a resource kept under private ownership at the time of low population has been changed to a common property with increase in population. Based on this study it can be concluded that in mountainous areas and fragile environment the local inhabitant have both the capacity and capability to change their behaviour with regard to changing resource productivity as well as increasing number of users,and this situation does not always lead to the tragedy of commons.展开更多
Pakistan is predominantly a mountainous country where rural development activities are characterised by inconsistency, politically motivated short-term projects without proper feedback. Since the inception of the coun...Pakistan is predominantly a mountainous country where rural development activities are characterised by inconsistency, politically motivated short-term projects without proper feedback. Since the inception of the country, the top-down approach has been followed, and the same development plans that were formulated for the plain areas have been extended to the mountains without any modification. In doing so, neither the participation of the local communities was cared for, nor the mountain specificities were considered in the planning process. Moreover, the representation of the local inhabitants was improper and contradictory to the facts. This biased approach has been one of the main causes for the failure of development projects carried out by different agencies of the Government. Contrary to the perception of the state authorities, the mountain communities proved to be more open to accept new approaches and demonstrated the capacity and capability of being a dependable development partner. In this paper, a detailed account of the Aga Khan Rural Support Programme （AKRSP） has been presented to assess and evaluate the approach followed by this non-governmental organisation （NGO）, and the response of the local inhabitants as collaborators in the development process. The achievements of the AKRSP from project planning, implementation and monitoring can be adopted as a model for rural development not only in the plains, but also in the mountainous areas of the developing countries in the world.展开更多
A series of indazol-2-yl（pyridin-4-yl）methanones, 4 were acquired from 2,6-bisbenzylidene cyclohex- anones, 3 and anti-tubercular drug （isoniazid）, and their anti-tubercular impacts were screened. Among the test c...A series of indazol-2-yl（pyridin-4-yl）methanones, 4 were acquired from 2,6-bisbenzylidene cyclohex- anones, 3 and anti-tubercular drug （isoniazid）, and their anti-tubercular impacts were screened. Among the test compounds used against Mycobacterium tuberculosis H37 Ra cell line in the microplate alamar blue assay, the compounds 4g-j revealed moderate anti-tubercular activity with MIC 12.5 μg/mL, comparable to standard drugs （streptomycin, MIC, 6.25 μg/mL, pyrazinamide, isoniazid and ciprofloxacin with MICs of 3.125 μg/mL）.展开更多
The Suzuki-Miyaura reaction of methyl-5-bromo-8-（tosyloxy）-1,6-naphthyridine-7-carboxylate（5）,with 2 equiv. of arylboronic acids gave diarylated product, 5,8–diaryl-1,6-naphthyridine-7-carboxylate（7）, whereas 1...The Suzuki-Miyaura reaction of methyl-5-bromo-8-（tosyloxy）-1,6-naphthyridine-7-carboxylate（5）,with 2 equiv. of arylboronic acids gave diarylated product, 5,8–diaryl-1,6-naphthyridine-7-carboxylate（7）, whereas 1 equiv. of arylboronic acid resulted in site-selective formation of 5-aryl-8-（tosyloxy）-1,6-naphthyridine-7-carboxylate（8）. The reactions proceeded with excellent chemo-selectivity in favor of the bromide group. Likewise, one-pot reaction with completely different boronic acids by sequential addition produced 1,6-naphthyridine-7-carboxylates,（10） containing two different aryl groups at 5 and 8 positions.展开更多
文摘Insert Snakebite is a global public health issue, and in majority of cases it is undermined. Tropical and subtropical countries are most effected, Bangladesh being one of them. There is scarcity of countries’ epidemiological situation in relation to snakebite poisoning. This study has looked at the epidemiological status of snakebite poisoning from national representative survey findings. Methods: A nationwide cross-sectional survey was conducted in 12 randomly selected districts of Bangladesh in 2003. A total of 171,366 households were surveyed and information was collected from 819,429 populations by face to face interview. Multi-stage cluster sampling methods were used in this survey and covered urban, rural and slum populations. Results: Annually an estimated 15,372 (10.98/100,000) individuals were bitten by snakes and of them 1709 (1.22/100,000) died every year. Males were found to be most vulnerable with a risk of 1.51 times higher than female. Rural populations were also 10.54 times higher at risk than the populations living in the urban areas. Among the victims 94% were from the poor socio economic conditions. Around 43.9% of the incidences occurred during evening to midnight. Home was found the most common area for snake bite (33.6%), and the Leg was found to be the most common site for biting (63.1%). A total of 96.6% victims sought treatment, of them 61% sought immediate treatment from traditional healing methods. Conclusions: Present incidence of snakebite in Bangladesh has clearly shown that there is emerging public health needs for intervention that can reduce the mortality and burden of the disease in the country.
文摘In common property studies,increasing number of users has been considered as a major threat for the long-term sustainability of natural resources. This perception has been true in a few cases. However,the 40-years empirical research conducted in a variety of environmental settings,reveals that population pressure is not the only factor responsible for the degradation of natural resources. In remote areas,where the local inhabitants highly depend on available natural resources for subsistence livelihood,the economically important resources are kept under different ownership regimes. The local inhabitants have established autochthonous insti-tutions,and formulated rules and regulations for proper management of these resources. In this paper an attempt has been made to explore the response of a small fodder user community to the increasing population. For this purpose a micro-level study has been conducted in a remote mountain environment in the eastern Hindu Kush. For this research,data has been collected through fieldwork and focus group discussion. The results of this study reveal that fodder user communities have responded very well to the problem of population pressure. To maintain equity and long-term sustainability they have adopted a number of strategies including changing the ownership,and a resource kept under private ownership at the time of low population has been changed to a common property with increase in population. Based on this study it can be concluded that in mountainous areas and fragile environment the local inhabitant have both the capacity and capability to change their behaviour with regard to changing resource productivity as well as increasing number of users,and this situation does not always lead to the tragedy of commons.
文摘Pakistan is predominantly a mountainous country where rural development activities are characterised by inconsistency, politically motivated short-term projects without proper feedback. Since the inception of the country, the top-down approach has been followed, and the same development plans that were formulated for the plain areas have been extended to the mountains without any modification. In doing so, neither the participation of the local communities was cared for, nor the mountain specificities were considered in the planning process. Moreover, the representation of the local inhabitants was improper and contradictory to the facts. This biased approach has been one of the main causes for the failure of development projects carried out by different agencies of the Government. Contrary to the perception of the state authorities, the mountain communities proved to be more open to accept new approaches and demonstrated the capacity and capability of being a dependable development partner. In this paper, a detailed account of the Aga Khan Rural Support Programme （AKRSP） has been presented to assess and evaluate the approach followed by this non-governmental organisation （NGO）, and the response of the local inhabitants as collaborators in the development process. The achievements of the AKRSP from project planning, implementation and monitoring can be adopted as a model for rural development not only in the plains, but also in the mountainous areas of the developing countries in the world.
基金VIT University for providing us with research funding and laboratory facilitiesMaratha Mandal Dental College,Belgaum for biological screening support
文摘A series of indazol-2-yl（pyridin-4-yl）methanones, 4 were acquired from 2,6-bisbenzylidene cyclohex- anones, 3 and anti-tubercular drug （isoniazid）, and their anti-tubercular impacts were screened. Among the test compounds used against Mycobacterium tuberculosis H37 Ra cell line in the microplate alamar blue assay, the compounds 4g-j revealed moderate anti-tubercular activity with MIC 12.5 μg/mL, comparable to standard drugs （streptomycin, MIC, 6.25 μg/mL, pyrazinamide, isoniazid and ciprofloxacin with MICs of 3.125 μg/mL）.
基金the VIT University Vellore for the support and facilitiesSIF-VIT for their support of NMR(DST-FIST Fund)
文摘The Suzuki-Miyaura reaction of methyl-5-bromo-8-（tosyloxy）-1,6-naphthyridine-7-carboxylate（5）,with 2 equiv. of arylboronic acids gave diarylated product, 5,8–diaryl-1,6-naphthyridine-7-carboxylate（7）, whereas 1 equiv. of arylboronic acid resulted in site-selective formation of 5-aryl-8-（tosyloxy）-1,6-naphthyridine-7-carboxylate（8）. The reactions proceeded with excellent chemo-selectivity in favor of the bromide group. Likewise, one-pot reaction with completely different boronic acids by sequential addition produced 1,6-naphthyridine-7-carboxylates,（10） containing two different aryl groups at 5 and 8 positions.
