In the frequency band of the Laser Interferometer Space Antenna(LISA),extensive research has been conducted on the impact of foreground confusion noise generated by galactic binaries within the Milky Way Galaxy.Additi...In the frequency band of the Laser Interferometer Space Antenna(LISA),extensive research has been conducted on the impact of foreground confusion noise generated by galactic binaries within the Milky Way Galaxy.Additionally,recent evidence of a stochastic signal,announced by the NANOGrav,EPTA,PPTA,CPTA,and InPTA,indicates that the stochastic gravitational-wave background(SGWB)generated by supermassive black hole binaries(SMBHBs)can contribute strong background noise within the LISA band.Given the presence of such strong noise,it is expected to have significant impacts on LISA's scientific missions.In this study,we investigate the impacts of the SGWB generated by SMBHBs on the detection of individual massive black hole binaries,verified galactic binaries,and extreme mass ratio inspirals in the context of LISA.We find it essential to resolve and eliminate the excess noise from the SGWB to guarantee the success of LISA's missions.展开更多
目的:评估托伐普坦治疗利尿剂抵抗心力衰竭患者的临床效果及安全性。方法:回顾性分析2014年1月-2016年8月在重庆医科大学附属第一医院心血管内科病房住院的21例利尿剂抵抗心力衰竭患者的临床资料。所有患者在接受大剂量袢利尿剂(呋塞米...目的:评估托伐普坦治疗利尿剂抵抗心力衰竭患者的临床效果及安全性。方法:回顾性分析2014年1月-2016年8月在重庆医科大学附属第一医院心血管内科病房住院的21例利尿剂抵抗心力衰竭患者的临床资料。所有患者在接受大剂量袢利尿剂(呋塞米和/或托拉塞米)治疗后,心力衰竭改善不明显;后改为托伐普坦治疗,其中19例患者口服托伐普坦片7.5 mg,qd,2例患者口服托伐普坦片15 mg,qd,均连续治疗直至出院。比较21例患者治疗前后的心功能、水肿程度、结局及体质量、血压、血钠、血肌酐、血N末端B型利钠肽原(NT-proBNP)水平和单位时间尿量的变化,并观察不良反应发生情况。结果:治疗后,21例患者心功能明显改善、水肿程度明显减轻、收缩压明显降低、血钠明显升高、单位时间尿量明显增多,与治疗前比较差异均有统计学意义(P<0.05);但治疗前后体质量、舒张压、血肌酐和血NT-proBNP水平比较,差异均无统计学意义(P>0.05)。21例患者中有1例出现口干,3例收缩压较基础值降低20 mm Hg及以上,4例舒张压较基础值降低10 mm Hg及以上。结论:对出现利尿剂抵抗的患者,托伐普坦能显著增加其尿量、改善心功能、纠正低钠血症,且对收缩压有降低作用。展开更多
基金Supported by the NSFC(12250010,11991052)Key Research Program of Frontier Sciences,CAS,(ZDBS-LY-7009)。
文摘In the frequency band of the Laser Interferometer Space Antenna(LISA),extensive research has been conducted on the impact of foreground confusion noise generated by galactic binaries within the Milky Way Galaxy.Additionally,recent evidence of a stochastic signal,announced by the NANOGrav,EPTA,PPTA,CPTA,and InPTA,indicates that the stochastic gravitational-wave background(SGWB)generated by supermassive black hole binaries(SMBHBs)can contribute strong background noise within the LISA band.Given the presence of such strong noise,it is expected to have significant impacts on LISA's scientific missions.In this study,we investigate the impacts of the SGWB generated by SMBHBs on the detection of individual massive black hole binaries,verified galactic binaries,and extreme mass ratio inspirals in the context of LISA.We find it essential to resolve and eliminate the excess noise from the SGWB to guarantee the success of LISA's missions.
基金the National Natural Science Foundation of China(42171306,42001270,and 42201337)for providing support for this current studythe support from the National Youth Talent Support Program of Chinasupported by Coastal Observations,Mechanisms,and Predictions Across Systems and Scales-Great Lakes Modeling(COMPASS-GLM),a multi-institutional project supported by the U.S.Department of Energy,Office of Science,Office of Biological and Environmental Research as part of the Earth and Environmental Systems Modeling program。
文摘目的:评估托伐普坦治疗利尿剂抵抗心力衰竭患者的临床效果及安全性。方法:回顾性分析2014年1月-2016年8月在重庆医科大学附属第一医院心血管内科病房住院的21例利尿剂抵抗心力衰竭患者的临床资料。所有患者在接受大剂量袢利尿剂(呋塞米和/或托拉塞米)治疗后,心力衰竭改善不明显;后改为托伐普坦治疗,其中19例患者口服托伐普坦片7.5 mg,qd,2例患者口服托伐普坦片15 mg,qd,均连续治疗直至出院。比较21例患者治疗前后的心功能、水肿程度、结局及体质量、血压、血钠、血肌酐、血N末端B型利钠肽原(NT-proBNP)水平和单位时间尿量的变化,并观察不良反应发生情况。结果:治疗后,21例患者心功能明显改善、水肿程度明显减轻、收缩压明显降低、血钠明显升高、单位时间尿量明显增多,与治疗前比较差异均有统计学意义(P<0.05);但治疗前后体质量、舒张压、血肌酐和血NT-proBNP水平比较,差异均无统计学意义(P>0.05)。21例患者中有1例出现口干,3例收缩压较基础值降低20 mm Hg及以上,4例舒张压较基础值降低10 mm Hg及以上。结论:对出现利尿剂抵抗的患者,托伐普坦能显著增加其尿量、改善心功能、纠正低钠血症,且对收缩压有降低作用。
