Waterborne organic pollutants pose significant threats to ecosystems and the health of billions worldwide,presenting a pressing global challenge.Advanced oxidation processes(AOPs)offer promise for efficient wastewater...Waterborne organic pollutants pose significant threats to ecosystems and the health of billions worldwide,presenting a pressing global challenge.Advanced oxidation processes(AOPs)offer promise for efficient wastewater treatment,yet the efficacy and the reliability of current environmental catalysts hinder their widespread adoption.This study developed an as-cast nanostructured glassy fiber capable of rapidly activating persulfate and achieved the degradation of diverse organic contaminants within 60 s using the as-prepared fiber.The material is relatively robust and can be reused about 40 times.The exceptional catalytic performance of the fibers stemmed from their low atomic coordination numbers,which facilitated the generation of numerous unsaturated active sites and accelerated radical production rates through a one-electron transfer mechanism.Additionally,the glassy-nanocrystalline heterogeneous interface,achieved through our proposed nanostructur-alization approach,exhibited electron delocalization behavior.This enhanced persulfate adsorption and reduced the energy barrier for heterolytic cleavage of peroxy bonds.These findings present a novel avenue for the rational structural design of high-performance environmental catalysts for advanced water remediation.展开更多
Background Iron overload is frequently observed in non-alcoholic fatty liver disease(NAFLD).Transferrin receptor 2(TFR2)is an important key factor in iron regulation.We aimed to investigate whether TFR2 single nucleot...Background Iron overload is frequently observed in non-alcoholic fatty liver disease(NAFLD).Transferrin receptor 2(TFR2)is an important key factor in iron regulation.We aimed to investigate whether TFR2 single nucleotide polymorphisms(SNPs)contribute to susceptibility to NAFLD in a Chinese Han population.Methods Five tag SNPs(rs10247962,rs4434553,rs2075672,rs1052897,and rs3757859)in the TFR2 gene were selected and genotyped in a case–control study on participants who visited two affiliated hospitals of Fujian Medical University between June 2011 and August 2017.Propensity score matching and inverse probability of treatment weighting analyses were used to verify the risk associated with TFR2 SNPs.Results Logistic regression analyses suggested that subjects with the rs4434553 GA or GG genotype had a lower risk of NAFLD than those carrying the AA genotype(odds ratio=0.630,95%confidence interval=0.504–0.788).Moreover,the rs4434553 GA or GG genotype was negatively correlated with body mass index,hepatic steatosis index,and serum ferritin(b=-0.363,P=0.008;b=-1.040,P=0.009;b=-35.258,P=0.015,respectively),and positively associated with serum hepcidin level(b=35.308,P<0.001).Moreover,rs10247962 and rs1052897 had multiplicative interactions with age in relation to the risk of NAFLD(P for interactions,0.041 and 0.034,respectively).The cumulative effects of the rs10247962,rs1052897,and rs4434553 SNPs were positively associated with the risk of NAFLD(adjusted P_(trend)=0.012).Conclusions In this Chinese Han population,the rs4434553 polymorphism in TFR2 may be an independent influencing factor associated with the susceptibility to NAFLD.The ageing effect on the development of NAFLD may be inhibited by SNPs rs10247962 and rs1052897.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.52271028,52201174,12002108,52071118,51827801)the China Postdoctoral Science Foundation(Grant Nos.2019M661275 and 2020T130030ZX)+5 种基金the National Key Research and Development Program of China(Grant No.2022YFA1604600)the Funds of Frontier Research Center of Space Environment Interacting with Matter(Harbin Institute of Technology)the Natural Science Foundation of Heilongjian Province(Grant No.LH2022D017)the Natural Science Foundation of Jiangsu Province(Grant No.BK20220858)the Guangdong Basic and Applied Basic Research Foundation(Grant No.2022A1515011402)the Fundamental Research Funds for the Central Universities(Grant No.HIT.BRET.2023FRFK06001).
文摘Waterborne organic pollutants pose significant threats to ecosystems and the health of billions worldwide,presenting a pressing global challenge.Advanced oxidation processes(AOPs)offer promise for efficient wastewater treatment,yet the efficacy and the reliability of current environmental catalysts hinder their widespread adoption.This study developed an as-cast nanostructured glassy fiber capable of rapidly activating persulfate and achieved the degradation of diverse organic contaminants within 60 s using the as-prepared fiber.The material is relatively robust and can be reused about 40 times.The exceptional catalytic performance of the fibers stemmed from their low atomic coordination numbers,which facilitated the generation of numerous unsaturated active sites and accelerated radical production rates through a one-electron transfer mechanism.Additionally,the glassy-nanocrystalline heterogeneous interface,achieved through our proposed nanostructur-alization approach,exhibited electron delocalization behavior.This enhanced persulfate adsorption and reduced the energy barrier for heterolytic cleavage of peroxy bonds.These findings present a novel avenue for the rational structural design of high-performance environmental catalysts for advanced water remediation.
基金supported by the National Natural Science Foundation of China[grant number 81473047]the Natural Science Foundation of Fujian Province[grant number 2019J01316].
文摘Background Iron overload is frequently observed in non-alcoholic fatty liver disease(NAFLD).Transferrin receptor 2(TFR2)is an important key factor in iron regulation.We aimed to investigate whether TFR2 single nucleotide polymorphisms(SNPs)contribute to susceptibility to NAFLD in a Chinese Han population.Methods Five tag SNPs(rs10247962,rs4434553,rs2075672,rs1052897,and rs3757859)in the TFR2 gene were selected and genotyped in a case–control study on participants who visited two affiliated hospitals of Fujian Medical University between June 2011 and August 2017.Propensity score matching and inverse probability of treatment weighting analyses were used to verify the risk associated with TFR2 SNPs.Results Logistic regression analyses suggested that subjects with the rs4434553 GA or GG genotype had a lower risk of NAFLD than those carrying the AA genotype(odds ratio=0.630,95%confidence interval=0.504–0.788).Moreover,the rs4434553 GA or GG genotype was negatively correlated with body mass index,hepatic steatosis index,and serum ferritin(b=-0.363,P=0.008;b=-1.040,P=0.009;b=-35.258,P=0.015,respectively),and positively associated with serum hepcidin level(b=35.308,P<0.001).Moreover,rs10247962 and rs1052897 had multiplicative interactions with age in relation to the risk of NAFLD(P for interactions,0.041 and 0.034,respectively).The cumulative effects of the rs10247962,rs1052897,and rs4434553 SNPs were positively associated with the risk of NAFLD(adjusted P_(trend)=0.012).Conclusions In this Chinese Han population,the rs4434553 polymorphism in TFR2 may be an independent influencing factor associated with the susceptibility to NAFLD.The ageing effect on the development of NAFLD may be inhibited by SNPs rs10247962 and rs1052897.
