生态系统服务价值(ecosystem service value,ESV)是区域生态福祉的重要测度指标,探析ESV演变规律对区域生态保护政策制定和绿色发展具有重要参考意义.以大娄山区水源涵养与生物多样性保护重要区(简称“大娄山区”)为研究区,基于土地利...生态系统服务价值(ecosystem service value,ESV)是区域生态福祉的重要测度指标,探析ESV演变规律对区域生态保护政策制定和绿色发展具有重要参考意义.以大娄山区水源涵养与生物多样性保护重要区(简称“大娄山区”)为研究区,基于土地利用数据和修正系数的当量因子法,评估2000—2018年大娄山区ESV空间格局及演变特征,同时结合10项土地利用驱动因素和斑块生成土地利用变化模拟(patch-generating land use simulation,PLUS)模型预测大娄山区2036年自然演变、经济优先和生态保护3种情景下土地利用变化及其ESV演变和转移特征.结果表明:(1)2000—2018年大娄山区ESV呈微弱增加趋势,由2000年的1988.41×10^(8)元/a增至2018年的1994.20×10^(8)元/a,增幅为0.29%;其中,湿地面积增加致使水文调节ESV增加4.75×10^(8)元/a.(2)总体上,夜间灯光指数、人口密度、高程等因素对耕地、林地和草地的土地发展潜力驱动贡献较高.就耕地土地发展潜力来说,以高程、夜间灯光指数、地形湿度指数(topographic wetness index,TWI)驱动贡献率较高,分别为14.41%、11.83%和10.44%.(3)从ESV模拟结果来看,到2036年,经济优先情景下大娄山区ESV为1955.8×10^(8)元/a,相比2018年下降38.4×10^(8)元/a;生态保护情景下,林地、水域面积均有较大增幅,导致气候调节和水文调节分别提升4.77×10^(8)和3.35×10^(8)元/a,其中在金沙县、习水县、叙永县和大方县耕地转化为林地较为集中.研究显示,退耕还林是大娄山区生态保护的主要途径,湿地水域土地利用变化是影响大娄山区ESV的重要因素.展开更多
Nanotechnology-based photothermal therapy has attracted great attention in the past decade. Nevertheless, photothermal therapy has some inherent drawbacks, such as the uneven heat production and limited laser penetrat...Nanotechnology-based photothermal therapy has attracted great attention in the past decade. Nevertheless, photothermal therapy has some inherent drawbacks, such as the uneven heat production and limited laser penetration, often leading to insufficient treatment outcomes. Here, we developed a combination strategy to improve cancer therapy. The biomimetic albumin-modified gold nanorods(AuNRs) were prepared with incorporation of paclitaxel(PTX). This therapeutic system was characterized by several features. First, the albumin modification enhanced the biocompatibility and colloidal stability. Second, the surface-coated albumin promoted cellular uptake via the albumin-binding protein pathway. Third, PTX was incorporated via hydrophobic interaction between PTX and the albumin lipophilic domain. Fourth, the system can be used for combined photothermo-chemotherapy for yielding synergistic effects. The antitumor activity of the system was evaluated both in vitro and in vivo using the HCT116 colon cancer cell and tumor model. The combination therapy was found with an enhanced treatment efficiency and no obvious side effect. Most importantly, the thermal effect was also discovered with the ability to modulate the tumor microenvironments and suppress the macrophages polarization towards the M2 pro-tumor phenotype. It could be a mechanism for photothermal immunotherapy. The combination strategy and the system provide a potential method for cancer therapy.展开更多
The enhanced permeability retention(EPR)effect based nanomedicine has been widely used for tumor targeting during the past decades.Here we unexpectedly observed the similar"EPR effect"at the site of iniury.W...The enhanced permeability retention(EPR)effect based nanomedicine has been widely used for tumor targeting during the past decades.Here we unexpectedly observed the similar"EPR effect"at the site of iniury.We found that the temporary dilated and leaky blood vessels caused by the potent vasodilator histamine in response to injury allowed the injected nanoparticles to pass through the vasculature and reached the injured tissue.Our finding shows the potential underline mechanism of"EPR effect"at the injured site.By loading with antibiotics,we further demonstrated a new strategy for prevention of infection at the site of injury.展开更多
文摘针对膜下滴灌种植过程中外界水压变化造成的变频器过载现象,设计了一种棉田水肥一体化控制系统。系统以三菱FX2N PLC为核心,能够实时监测外部水压,依据外部水压的变化量和水肥调整函数关系式,优化水肥溶液排量设定值,保证施肥过程中PID闭环控制系统的稳定运行。使用Samkoon AK 070 MG触摸屏搭建了物联网云平台,完成了开机界面、手动控制界面、自动控制界面、历史数据界面、动态监控界面和触摸屏远程监控界面的编写,可以直观地查询设备的实时运行参数。试验结果表明:当系统水压为0.1~0.4MPa、变频器初始设定频率为35Hz时,可以实现施肥频率的自调整和施肥流速的稳定输出,提高了水肥利用效率,保证了设备的高效运行。
文摘生态系统服务价值(ecosystem service value,ESV)是区域生态福祉的重要测度指标,探析ESV演变规律对区域生态保护政策制定和绿色发展具有重要参考意义.以大娄山区水源涵养与生物多样性保护重要区(简称“大娄山区”)为研究区,基于土地利用数据和修正系数的当量因子法,评估2000—2018年大娄山区ESV空间格局及演变特征,同时结合10项土地利用驱动因素和斑块生成土地利用变化模拟(patch-generating land use simulation,PLUS)模型预测大娄山区2036年自然演变、经济优先和生态保护3种情景下土地利用变化及其ESV演变和转移特征.结果表明:(1)2000—2018年大娄山区ESV呈微弱增加趋势,由2000年的1988.41×10^(8)元/a增至2018年的1994.20×10^(8)元/a,增幅为0.29%;其中,湿地面积增加致使水文调节ESV增加4.75×10^(8)元/a.(2)总体上,夜间灯光指数、人口密度、高程等因素对耕地、林地和草地的土地发展潜力驱动贡献较高.就耕地土地发展潜力来说,以高程、夜间灯光指数、地形湿度指数(topographic wetness index,TWI)驱动贡献率较高,分别为14.41%、11.83%和10.44%.(3)从ESV模拟结果来看,到2036年,经济优先情景下大娄山区ESV为1955.8×10^(8)元/a,相比2018年下降38.4×10^(8)元/a;生态保护情景下,林地、水域面积均有较大增幅,导致气候调节和水文调节分别提升4.77×10^(8)和3.35×10^(8)元/a,其中在金沙县、习水县、叙永县和大方县耕地转化为林地较为集中.研究显示,退耕还林是大娄山区生态保护的主要途径,湿地水域土地利用变化是影响大娄山区ESV的重要因素.
基金the National Basic Research Program of China (973 Program 2014CB931900 and 2013CB932503)NSFC, China (81373357, 81422048, 81673382 and 81521005) for the supportNational Center for Protein Science Shanghai, CAS, for the technical support at Electron Microscopy Facility
文摘Nanotechnology-based photothermal therapy has attracted great attention in the past decade. Nevertheless, photothermal therapy has some inherent drawbacks, such as the uneven heat production and limited laser penetration, often leading to insufficient treatment outcomes. Here, we developed a combination strategy to improve cancer therapy. The biomimetic albumin-modified gold nanorods(AuNRs) were prepared with incorporation of paclitaxel(PTX). This therapeutic system was characterized by several features. First, the albumin modification enhanced the biocompatibility and colloidal stability. Second, the surface-coated albumin promoted cellular uptake via the albumin-binding protein pathway. Third, PTX was incorporated via hydrophobic interaction between PTX and the albumin lipophilic domain. Fourth, the system can be used for combined photothermo-chemotherapy for yielding synergistic effects. The antitumor activity of the system was evaluated both in vitro and in vivo using the HCT116 colon cancer cell and tumor model. The combination therapy was found with an enhanced treatment efficiency and no obvious side effect. Most importantly, the thermal effect was also discovered with the ability to modulate the tumor microenvironments and suppress the macrophages polarization towards the M2 pro-tumor phenotype. It could be a mechanism for photothermal immunotherapy. The combination strategy and the system provide a potential method for cancer therapy.
基金This work was supported by grants from startup supports of Soochow University and the Program for Jiangsu Specially-Appointed Professors.This work was also supported by the National Natural Science Foundation of China(No.31900988)the Natural Science Foundation of Jiangsu Province(No.SBK2019040088).
文摘The enhanced permeability retention(EPR)effect based nanomedicine has been widely used for tumor targeting during the past decades.Here we unexpectedly observed the similar"EPR effect"at the site of iniury.We found that the temporary dilated and leaky blood vessels caused by the potent vasodilator histamine in response to injury allowed the injected nanoparticles to pass through the vasculature and reached the injured tissue.Our finding shows the potential underline mechanism of"EPR effect"at the injured site.By loading with antibiotics,we further demonstrated a new strategy for prevention of infection at the site of injury.
