<span style="font-family:Verdana;">Several androgenic steroids have been biotransformed by fungi into metabolites with numerous biological properties. Incubation of norandrostenedione (</span><...<span style="font-family:Verdana;">Several androgenic steroids have been biotransformed by fungi into metabolites with numerous biological properties. Incubation of norandrostenedione (</span><b><span style="font-family:Verdana;">1</span></b><span style="font-family:Verdana;">) with </span><i><span style="font-family:Verdana;">Fusarium lini</span></i><span> </span><span style="font-family:Verdana;">NRRL 2204 was carried out for the first time, yielding two new metabolites, 3,7</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-dihydroxy-19-norandrost-1,3,5-trien-17-one</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">(</span><b><span style="font-family:Verdana;">3</span></b><span style="font-family:Verdana;">) and 6</span><i><span style="font-family:Verdana;">α</span></i></span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;">10</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;">17</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-trihydroxy-19-nor-4-androsten-3-one</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">(</span><b><span style="font-family:Verdana;">4</span></b><span style="font-family:Verdana;">), along</span></span><span style="font-family:Verdana;"> with three known compounds, </span><span style="font-family:""><span style="font-family:Verdana;">3</span><b><span style="font-family:Verdana;">-</span></b><span style="font-family:Verdana;">hydroxy-19-norandrost-1,3,5-trien-17-one (</span><b><span style="font-family:Verdana;">2</span></b><span style="font-family:Verdana;">), 10</span></span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:""><span style="font-family:Verdana;">,</span><i> </i></span><span style="font-family:Verdana;">17</span><i><span style="font-family:Ver展开更多
文摘<span style="font-family:Verdana;">Several androgenic steroids have been biotransformed by fungi into metabolites with numerous biological properties. Incubation of norandrostenedione (</span><b><span style="font-family:Verdana;">1</span></b><span style="font-family:Verdana;">) with </span><i><span style="font-family:Verdana;">Fusarium lini</span></i><span> </span><span style="font-family:Verdana;">NRRL 2204 was carried out for the first time, yielding two new metabolites, 3,7</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-dihydroxy-19-norandrost-1,3,5-trien-17-one</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">(</span><b><span style="font-family:Verdana;">3</span></b><span style="font-family:Verdana;">) and 6</span><i><span style="font-family:Verdana;">α</span></i></span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;">10</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;">17</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-trihydroxy-19-nor-4-androsten-3-one</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">(</span><b><span style="font-family:Verdana;">4</span></b><span style="font-family:Verdana;">), along</span></span><span style="font-family:Verdana;"> with three known compounds, </span><span style="font-family:""><span style="font-family:Verdana;">3</span><b><span style="font-family:Verdana;">-</span></b><span style="font-family:Verdana;">hydroxy-19-norandrost-1,3,5-trien-17-one (</span><b><span style="font-family:Verdana;">2</span></b><span style="font-family:Verdana;">), 10</span></span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:""><span style="font-family:Verdana;">,</span><i> </i></span><span style="font-family:Verdana;">17</span><i><span style="font-family:Ver
