Objective: To determine the role of CD4+ and CD8+ T lymphocytes in the onset of stroke in people living with HIV. Methodology: This was a descriptive, cross-sectional study from January to July 2019, in the neurology ...Objective: To determine the role of CD4+ and CD8+ T lymphocytes in the onset of stroke in people living with HIV. Methodology: This was a descriptive, cross-sectional study from January to July 2019, in the neurology department of loandjili general hospital, including any patient hospitalized for a first episode of stroke confirmed by brain scan. The study variables were: age, sex, CRP value, serum T cell CD4+, CD8+. The statistical analysis was carried out using the EPI info 7 software. Results: Twenty stroke patients were included. The relative frequency of HIV was 20%. The risk factors were potentiated by immunosuppression of CD4+ T cells. Sixty percent (60%) of the patients had a CD4+ count < 200/mm<sup>3</sup> and the mean CD4+ count was ±191/mm<sup>3</sup>. Stroke was the predominant mechanism of injury with a frequency of 70%, the only injury mechanism of stroke in patients with CD8+ T cell count > 800/mm<sup>3</sup> (p = 0.04). Conclusion: Risk factors are potentiated by TCD4+ lymphocyte immunosupression, also CD8+ lymphocytes of immune system activation marker are a cardiovascular risk factor for living people with HIV.展开更多
<strong>Introduction:</strong> The role of immunosuppression of TCD4<sup>+</sup> lymphocytes in the onset of stroke in people living with HIV has been reported in numerous studies examining the...<strong>Introduction:</strong> The role of immunosuppression of TCD4<sup>+</sup> lymphocytes in the onset of stroke in people living with HIV has been reported in numerous studies examining the co-morbidity of stroke and HIV. Objective: To determine the correlation between the viral load and the type of stroke. <strong>Methodology:</strong> This was a 7-month cross-sectional descriptive study carried out in the Neurology Department of Loandjili General Hospital in Pointe-Noire. The study population consisted of patients living with HIV who had a stroke confirmed by brain scan. The sero-immunological investigation consisted of looking for T lymphocyte typing from two kits: a CD4<sup>+</sup> T lymphocyte typing reagent kit (BD FACS Presto TM) and a GeneXpert kit for viral load (Xpert<sup><span style="color:#000000;font-family:Roboto, "white-space:normal;background-color:#D46399;">®</span></sup>HIV-1 Viral Load). The database was made from the 2010 version of Microsoft Excel. <strong>Results:</strong> We included 16 patients living with HIV, 56% of whom were women with a sex ration of 0.78. The mean age was 56.92 ± 11.21. The mean number of TCD4<sup>+</sup> lymphocytes was 413.44 ± 677.95/mm<sup>3</sup>;minimum: 93/mm<sup>3</sup>;maximum: 2854/mm<sup>3</sup>. The mean viral load was 17,996.31 ± 20,982.22/mm<sup>3</sup>;minimum: 1002/mm<sup>3</sup>;maximum: 67,229/mm<sup>3</sup>. No significant difference between the viral load and the occurrence of the stroke (p = 0.13). <strong>Conclusion:</strong> Our study did not show a causal link between viral load, immunosuppression of TCD4<sup>+</sup> lymphocytes and the onset of stroke.展开更多
文摘Objective: To determine the role of CD4+ and CD8+ T lymphocytes in the onset of stroke in people living with HIV. Methodology: This was a descriptive, cross-sectional study from January to July 2019, in the neurology department of loandjili general hospital, including any patient hospitalized for a first episode of stroke confirmed by brain scan. The study variables were: age, sex, CRP value, serum T cell CD4+, CD8+. The statistical analysis was carried out using the EPI info 7 software. Results: Twenty stroke patients were included. The relative frequency of HIV was 20%. The risk factors were potentiated by immunosuppression of CD4+ T cells. Sixty percent (60%) of the patients had a CD4+ count < 200/mm<sup>3</sup> and the mean CD4+ count was ±191/mm<sup>3</sup>. Stroke was the predominant mechanism of injury with a frequency of 70%, the only injury mechanism of stroke in patients with CD8+ T cell count > 800/mm<sup>3</sup> (p = 0.04). Conclusion: Risk factors are potentiated by TCD4+ lymphocyte immunosupression, also CD8+ lymphocytes of immune system activation marker are a cardiovascular risk factor for living people with HIV.
文摘<strong>Introduction:</strong> The role of immunosuppression of TCD4<sup>+</sup> lymphocytes in the onset of stroke in people living with HIV has been reported in numerous studies examining the co-morbidity of stroke and HIV. Objective: To determine the correlation between the viral load and the type of stroke. <strong>Methodology:</strong> This was a 7-month cross-sectional descriptive study carried out in the Neurology Department of Loandjili General Hospital in Pointe-Noire. The study population consisted of patients living with HIV who had a stroke confirmed by brain scan. The sero-immunological investigation consisted of looking for T lymphocyte typing from two kits: a CD4<sup>+</sup> T lymphocyte typing reagent kit (BD FACS Presto TM) and a GeneXpert kit for viral load (Xpert<sup><span style="color:#000000;font-family:Roboto, "white-space:normal;background-color:#D46399;">®</span></sup>HIV-1 Viral Load). The database was made from the 2010 version of Microsoft Excel. <strong>Results:</strong> We included 16 patients living with HIV, 56% of whom were women with a sex ration of 0.78. The mean age was 56.92 ± 11.21. The mean number of TCD4<sup>+</sup> lymphocytes was 413.44 ± 677.95/mm<sup>3</sup>;minimum: 93/mm<sup>3</sup>;maximum: 2854/mm<sup>3</sup>. The mean viral load was 17,996.31 ± 20,982.22/mm<sup>3</sup>;minimum: 1002/mm<sup>3</sup>;maximum: 67,229/mm<sup>3</sup>. No significant difference between the viral load and the occurrence of the stroke (p = 0.13). <strong>Conclusion:</strong> Our study did not show a causal link between viral load, immunosuppression of TCD4<sup>+</sup> lymphocytes and the onset of stroke.
