目的:比较阿柏西普玻璃体内注射联合曲安奈德后部眼球筋膜下注射治疗抗血管内皮生长因子(VEGF)药物雷珠单抗应答不良的湿性年龄相关性黄斑变性(ARMD)的效果及安全性。方法:回顾性队列研究。2018-06/2020-05对抗VEGF药物雷珠单抗治疗应...目的:比较阿柏西普玻璃体内注射联合曲安奈德后部眼球筋膜下注射治疗抗血管内皮生长因子(VEGF)药物雷珠单抗应答不良的湿性年龄相关性黄斑变性(ARMD)的效果及安全性。方法:回顾性队列研究。2018-06/2020-05对抗VEGF药物雷珠单抗治疗应答不良的难治性ARMD 60例60眼,随机分为阿柏西普对照组及曲安奈德联合阿柏西普观察组,每组30例30眼。两组患者每月1次分别行单纯阿柏西普玻璃体内注射或阿柏西普玻璃内注射联合曲安奈德后部眼球筋膜下注射,连续注射3次。分别于注射前和注射第3次后1、3、6mo进行复查视力(BCVA)、黄斑中心凹厚度(CMT)及眼压的改变。结果:两组患者在治疗后1、3、6mo的BCVA及CMT均明显好转(P<0.05)。观察组治疗后1mo平均眼压较前升高,但仍在正常范围,两组眼压比较有差异(17.50±4.60 vs 18.30±3.73mmHg,P<0.05)。结论:曲安奈德后部眼球筋膜下注射联合阿柏西普玻璃体内注射治疗湿性ARMD,有效地减轻黄斑区水肿并改善视力,更加安全可靠。展开更多
We propose a new method to generate terahertz perfect vortex beam with integer-order and fractional-order. A new optical diffractive element composed of the phase combination of a spherical harmonic axicon and a spira...We propose a new method to generate terahertz perfect vortex beam with integer-order and fractional-order. A new optical diffractive element composed of the phase combination of a spherical harmonic axicon and a spiral phase plate is designed and called spiral spherical harmonic axicon. A terahertz Gaussian beam passes through the spiral spherical harmonic axicon to generate a terahertz vortex beam. When only the topological charge number carried by spiral spherical harmonic axicon increases, the ring radius of terahertz vortex beam increases slightly, so the beam is shaped into a terahertz quasi-perfect vortex beam. Importantly, the terahertz quasi-perfect vortex beam can carry not only integer-order topological charge number but also fractional-order topological charge number. This is the first time that vortex beam and quasi-perfect vortex beam with fractional-order have been successfully realized in terahertz domain and experiment.展开更多
A novel scheme to suppress both stimulated Brillouin scattering(SBS) and stimulated Raman scattering(SRS) by combining an alternating frequency(AF) laser and a transverse magnetic field is proposed. The AF laser allow...A novel scheme to suppress both stimulated Brillouin scattering(SBS) and stimulated Raman scattering(SRS) by combining an alternating frequency(AF) laser and a transverse magnetic field is proposed. The AF laser allows the laser frequency to change discretely and alternately over time. The suppression of SBS is significant as long as the AF difference is greater than the linear growth rate of SBS or the alternating time of the laser frequency is shorter than the linear growth time of SBS. However, the AF laser proves ineffective in suppressing SRS, which usually has a much higher linear growth rate than SBS. To remedy that, a transverse magnetic field is included to suppress the SRS instability. The electrons trapped in the electron plasma waves(EPWs) of SRS can be accelerated by the surfatron mechanism in a transverse magnetic field and eventually detrapped. While continuously extracting energy from EPWs, the EPWs are dissipated and the kinetic inflation of SRS is suppressed. The one-dimensional particle-in-cell simulation results show that both SBS and SRS can be effectively suppressed by combining the AF laser with a transverse magnetic field with tens of Tesla. The total reflectivity can be dramatically reduced by more than one order of magnitude. These results provide a potential reference for controlling SBS and SRS under the related parameters of inertial confinement fusion.展开更多
近年来,病原体引起的流行病频发,对含能杀菌剂提出了迫切需求;它们可通过爆炸性反应快速地大面积抛洒以单质碘为主的高效广谱杀菌物质,但其高碘含量与高爆性能难以同时兼得.在此,我们报道了一类新型含能杀菌剂——多碘分子钙钛矿:(H_(2)...近年来,病原体引起的流行病频发,对含能杀菌剂提出了迫切需求;它们可通过爆炸性反应快速地大面积抛洒以单质碘为主的高效广谱杀菌物质,但其高碘含量与高爆性能难以同时兼得.在此,我们报道了一类新型含能杀菌剂——多碘分子钙钛矿:(H_(2)dabco)M(IO_(4))_(3)(dabco=1,4-二氮杂双环[2.2.2]辛烷,M=Na^(+)/K^(+)/Rb^(+)/NH_(4)^(+)分别对应DAI-1/2/3/4)和(H_(2)dabco)Na(H_(4)IO_(6))_(3)(DAI-X1).这些化合物具有立方钙钛矿结构,不仅具有高碘含量(49–54wt%),而且具有较高的爆速(6.331–6.558 km s^(-1))和爆压(30.69–30.88 GPa).特别地,DAI-4具有高达54.0 wt%的碘含量,以及6.558 km s^(-1)的爆速.激光扫描共聚焦显微镜观察和标准微量肉汤稀释法实验表明,DAI-4的爆炸产物对细菌(大肠杆菌、金黄色葡萄球菌和铜绿假单胞菌)具有广谱杀菌性.这类基于高碘酸根的分子钙钛矿具有易于放大合成、低成本、高爆轰性能和高碘含量的优点,是极具潜力的新型含能杀菌剂.展开更多
文摘目的:比较阿柏西普玻璃体内注射联合曲安奈德后部眼球筋膜下注射治疗抗血管内皮生长因子(VEGF)药物雷珠单抗应答不良的湿性年龄相关性黄斑变性(ARMD)的效果及安全性。方法:回顾性队列研究。2018-06/2020-05对抗VEGF药物雷珠单抗治疗应答不良的难治性ARMD 60例60眼,随机分为阿柏西普对照组及曲安奈德联合阿柏西普观察组,每组30例30眼。两组患者每月1次分别行单纯阿柏西普玻璃体内注射或阿柏西普玻璃内注射联合曲安奈德后部眼球筋膜下注射,连续注射3次。分别于注射前和注射第3次后1、3、6mo进行复查视力(BCVA)、黄斑中心凹厚度(CMT)及眼压的改变。结果:两组患者在治疗后1、3、6mo的BCVA及CMT均明显好转(P<0.05)。观察组治疗后1mo平均眼压较前升高,但仍在正常范围,两组眼压比较有差异(17.50±4.60 vs 18.30±3.73mmHg,P<0.05)。结论:曲安奈德后部眼球筋膜下注射联合阿柏西普玻璃体内注射治疗湿性ARMD,有效地减轻黄斑区水肿并改善视力,更加安全可靠。
基金Project supported by the Fundamental Research Funds for the Central Universities,China (Grant No.2017KFYXJJ029)。
文摘We propose a new method to generate terahertz perfect vortex beam with integer-order and fractional-order. A new optical diffractive element composed of the phase combination of a spherical harmonic axicon and a spiral phase plate is designed and called spiral spherical harmonic axicon. A terahertz Gaussian beam passes through the spiral spherical harmonic axicon to generate a terahertz vortex beam. When only the topological charge number carried by spiral spherical harmonic axicon increases, the ring radius of terahertz vortex beam increases slightly, so the beam is shaped into a terahertz quasi-perfect vortex beam. Importantly, the terahertz quasi-perfect vortex beam can carry not only integer-order topological charge number but also fractional-order topological charge number. This is the first time that vortex beam and quasi-perfect vortex beam with fractional-order have been successfully realized in terahertz domain and experiment.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.11975059 and 12005021)。
文摘A novel scheme to suppress both stimulated Brillouin scattering(SBS) and stimulated Raman scattering(SRS) by combining an alternating frequency(AF) laser and a transverse magnetic field is proposed. The AF laser allows the laser frequency to change discretely and alternately over time. The suppression of SBS is significant as long as the AF difference is greater than the linear growth rate of SBS or the alternating time of the laser frequency is shorter than the linear growth time of SBS. However, the AF laser proves ineffective in suppressing SRS, which usually has a much higher linear growth rate than SBS. To remedy that, a transverse magnetic field is included to suppress the SRS instability. The electrons trapped in the electron plasma waves(EPWs) of SRS can be accelerated by the surfatron mechanism in a transverse magnetic field and eventually detrapped. While continuously extracting energy from EPWs, the EPWs are dissipated and the kinetic inflation of SRS is suppressed. The one-dimensional particle-in-cell simulation results show that both SBS and SRS can be effectively suppressed by combining the AF laser with a transverse magnetic field with tens of Tesla. The total reflectivity can be dramatically reduced by more than one order of magnitude. These results provide a potential reference for controlling SBS and SRS under the related parameters of inertial confinement fusion.
基金supported by the National Natural Science Foundation of China(22071273 and 21821003)the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01C161)the Fundamental Innovation Team Fund(CXTD202001)。
文摘近年来,病原体引起的流行病频发,对含能杀菌剂提出了迫切需求;它们可通过爆炸性反应快速地大面积抛洒以单质碘为主的高效广谱杀菌物质,但其高碘含量与高爆性能难以同时兼得.在此,我们报道了一类新型含能杀菌剂——多碘分子钙钛矿:(H_(2)dabco)M(IO_(4))_(3)(dabco=1,4-二氮杂双环[2.2.2]辛烷,M=Na^(+)/K^(+)/Rb^(+)/NH_(4)^(+)分别对应DAI-1/2/3/4)和(H_(2)dabco)Na(H_(4)IO_(6))_(3)(DAI-X1).这些化合物具有立方钙钛矿结构,不仅具有高碘含量(49–54wt%),而且具有较高的爆速(6.331–6.558 km s^(-1))和爆压(30.69–30.88 GPa).特别地,DAI-4具有高达54.0 wt%的碘含量,以及6.558 km s^(-1)的爆速.激光扫描共聚焦显微镜观察和标准微量肉汤稀释法实验表明,DAI-4的爆炸产物对细菌(大肠杆菌、金黄色葡萄球菌和铜绿假单胞菌)具有广谱杀菌性.这类基于高碘酸根的分子钙钛矿具有易于放大合成、低成本、高爆轰性能和高碘含量的优点,是极具潜力的新型含能杀菌剂.
