Several catalysts comprising Pt supported on octahedral Fe3O4（Pt/Fe3O4） were prepared by a facile method involving co-precipitation followed by thermal treatment at different temperatures. A variety of characterizat...Several catalysts comprising Pt supported on octahedral Fe3O4（Pt/Fe3O4） were prepared by a facile method involving co-precipitation followed by thermal treatment at different temperatures. A variety of characterization results revealed that this preparation process afforded highly crystalline octahedral Fe3O4 with a uniform distribution of Pt nanoparticles on its surface. The thermal-treatment temperature significantly influenced the redox properties of the Pt/Fe3O4 catalysts. All the Pt/Fe3O4 catalysts were found to be catalytically active and stable for the oxidation of low-concentration formaldehyde（HCHO） with oxygen. The catalyst prepared by thermal treatment at 80 °C（labelled Pt/Fe3O4-80） exhibited the highest catalytic activity, efficiently converting HCHO to CO2 and H2 O under ambient temperature and moisture conditions. The excellent performance of Pt/Fe3O4-80 was mainly attributed to beneficial interactions between the Pt and Fe species that result in the formation a higher density of active interface sites（e.g., Pt-O-FeO x and Pt-OH-FeO x）. The introduction of water vapor improves the catalytic activity of the Pt/Fe3O4 catalysts as it participates in a water-assisted dissociation process.展开更多
Dental caries is the most common oral disease with high incidence, widely spread and can seriously affect the health of oral cavity and the whole body. Current caries prevention measures such as fluoride treatment, an...Dental caries is the most common oral disease with high incidence, widely spread and can seriously affect the health of oral cavity and the whole body. Current caries prevention measures such as fluoride treatment, antimicrobial agents, and traditional Chinese herbal, have limitations to some extent. Here we design and synthesize a novel peptide based on the amelogenin, and assess its ability to promote the remineralization of initial enamel caries lesions. We used enamel blocks to form initial lesions, and then subjected to 12-day pH cycling in the presence of peptide, NaF and HEPES buffer. Enamel treated with peptide or NaF had shallower, narrower lesions, thicker remineralized surfaces and less mineral loss than enamel treated with HEPES. This peptide can promote the remineralization of initial enamel caries and inhibit the progress of caries. It is a promising anti-caries agent with various research prospects and practical application value.展开更多
Insufficient early osteogenesis seriously affects the later stage osteogenic quality and osseointegration of dental implants.To promote early osteogenesis,we first designed a Ti dental implant with a built-in magnet(m...Insufficient early osteogenesis seriously affects the later stage osteogenic quality and osseointegration of dental implants.To promote early osteogenesis,we first designed a Ti dental implant with a built-in magnet(mTi)to produce a local static magnetic field(SMF).Then,a dental implantation system comprising the mTi implant and the superparamagnetic hydroxyapatite(HA:Yb/Ho-Fe,named HYH-Fe)particles was implanted into the alveolar bone of beagles.The results showed that the mTi+HYH-Fe group displayed better early osteogenesis and later stage osseointegration than the Ti+HA and mTi+HA groups.A combination of the local SMF(mTi)and superparamagnetic HYH-Fe particles had a positive effect on the pro-osteogenesis of Ti implants.The results also indicated that week 10 could be adopted as the key time point to evaluate the early osteogenic effect of the mTi+HYH-Fe implantation system,which would be a promising prospect for promotion of osteogenesis,in vivo tracking investigation of material-bone relationships,and clinical applications.展开更多
耳鸣严重影响患者的生活质量,目前认为其产生机制与听觉通路信号改变所引起的神经元可塑性变化有关,其中可能涉及神经元兴奋性和抑制性传导失衡。A型γ-氨基丁酸受体(γ-aminobutyric acid a receptor,GABAAR)和N-甲基-D天冬氨酸受体(N-...耳鸣严重影响患者的生活质量,目前认为其产生机制与听觉通路信号改变所引起的神经元可塑性变化有关,其中可能涉及神经元兴奋性和抑制性传导失衡。A型γ-氨基丁酸受体(γ-aminobutyric acid a receptor,GABAAR)和N-甲基-D天冬氨酸受体(N-methyl-D-aspartic acid receptor,NMDAR)是重要的神经元抑制性和兴奋性受体,NMDAR功能亢进和GABAAR功能抑制可能是耳鸣发生中的关键性事件。钙/钙调蛋白激酶Ⅱ(Ca^2+/calmodulin-dependent protein kinaseⅡ,Ca^2+/CaMKⅡ)是一种丝氨酸/苏氨酸蛋白激酶,介导NMDAR和GABAAR的磷酸化及其相互作用,在神经突触受体活性调节过程中发挥重要作用,并可能参与耳鸣的发生发展过程。本文就Ca^2+/CaMKⅡ介导NMDAR与GABAAR的相互作用及其与耳鸣的关系展开综述,并结合临床试验介绍相关耳鸣治疗最新研究成果,以期为临床耳鸣的治疗提供新的作用靶点和干预思路。展开更多
文摘Several catalysts comprising Pt supported on octahedral Fe3O4（Pt/Fe3O4） were prepared by a facile method involving co-precipitation followed by thermal treatment at different temperatures. A variety of characterization results revealed that this preparation process afforded highly crystalline octahedral Fe3O4 with a uniform distribution of Pt nanoparticles on its surface. The thermal-treatment temperature significantly influenced the redox properties of the Pt/Fe3O4 catalysts. All the Pt/Fe3O4 catalysts were found to be catalytically active and stable for the oxidation of low-concentration formaldehyde（HCHO） with oxygen. The catalyst prepared by thermal treatment at 80 °C（labelled Pt/Fe3O4-80） exhibited the highest catalytic activity, efficiently converting HCHO to CO2 and H2 O under ambient temperature and moisture conditions. The excellent performance of Pt/Fe3O4-80 was mainly attributed to beneficial interactions between the Pt and Fe species that result in the formation a higher density of active interface sites（e.g., Pt-O-FeO x and Pt-OH-FeO x）. The introduction of water vapor improves the catalytic activity of the Pt/Fe3O4 catalysts as it participates in a water-assisted dissociation process.
文摘Dental caries is the most common oral disease with high incidence, widely spread and can seriously affect the health of oral cavity and the whole body. Current caries prevention measures such as fluoride treatment, antimicrobial agents, and traditional Chinese herbal, have limitations to some extent. Here we design and synthesize a novel peptide based on the amelogenin, and assess its ability to promote the remineralization of initial enamel caries lesions. We used enamel blocks to form initial lesions, and then subjected to 12-day pH cycling in the presence of peptide, NaF and HEPES buffer. Enamel treated with peptide or NaF had shallower, narrower lesions, thicker remineralized surfaces and less mineral loss than enamel treated with HEPES. This peptide can promote the remineralization of initial enamel caries and inhibit the progress of caries. It is a promising anti-caries agent with various research prospects and practical application value.
基金The authors acknowledge the support of funds from the National Natural Science Foundation of China(Grant No.31700828,32071335)the Research Funding from West China School/Hospital of Stomatology,Sichuan University(Grant No.RCDWJS2020-9,SKLOD202022).Special thanks to Dr.Li Chen for micro-CT analysis.
文摘Insufficient early osteogenesis seriously affects the later stage osteogenic quality and osseointegration of dental implants.To promote early osteogenesis,we first designed a Ti dental implant with a built-in magnet(mTi)to produce a local static magnetic field(SMF).Then,a dental implantation system comprising the mTi implant and the superparamagnetic hydroxyapatite(HA:Yb/Ho-Fe,named HYH-Fe)particles was implanted into the alveolar bone of beagles.The results showed that the mTi+HYH-Fe group displayed better early osteogenesis and later stage osseointegration than the Ti+HA and mTi+HA groups.A combination of the local SMF(mTi)and superparamagnetic HYH-Fe particles had a positive effect on the pro-osteogenesis of Ti implants.The results also indicated that week 10 could be adopted as the key time point to evaluate the early osteogenic effect of the mTi+HYH-Fe implantation system,which would be a promising prospect for promotion of osteogenesis,in vivo tracking investigation of material-bone relationships,and clinical applications.
文摘耳鸣严重影响患者的生活质量,目前认为其产生机制与听觉通路信号改变所引起的神经元可塑性变化有关,其中可能涉及神经元兴奋性和抑制性传导失衡。A型γ-氨基丁酸受体(γ-aminobutyric acid a receptor,GABAAR)和N-甲基-D天冬氨酸受体(N-methyl-D-aspartic acid receptor,NMDAR)是重要的神经元抑制性和兴奋性受体,NMDAR功能亢进和GABAAR功能抑制可能是耳鸣发生中的关键性事件。钙/钙调蛋白激酶Ⅱ(Ca^2+/calmodulin-dependent protein kinaseⅡ,Ca^2+/CaMKⅡ)是一种丝氨酸/苏氨酸蛋白激酶,介导NMDAR和GABAAR的磷酸化及其相互作用,在神经突触受体活性调节过程中发挥重要作用,并可能参与耳鸣的发生发展过程。本文就Ca^2+/CaMKⅡ介导NMDAR与GABAAR的相互作用及其与耳鸣的关系展开综述,并结合临床试验介绍相关耳鸣治疗最新研究成果,以期为临床耳鸣的治疗提供新的作用靶点和干预思路。
