Dynamic response analysis of damper connected adjacent multi-story structures with uncertain parameters is carried out.A formula of the multi degree of freedom(MDOF) for the structure-damper system with stochastic par...Dynamic response analysis of damper connected adjacent multi-story structures with uncertain parameters is carried out.A formula of the multi degree of freedom(MDOF) for the structure-damper system with stochastic parameters is derived.The uncertainties of mass and stiffness are taken into consideration firstly.The ground acceleration is represented by Kanai-Tajimi filtered non-stationary process.The mean square random responses of structural displacement and story drift are chosen as the optimization objective.The variations of mean square responses of top floor displacements and bottom story drifts in neighboring structures with the damper stiffness and damping coefficient are analyzed in detail.Through the parametric study,the acquiring optimum parameters of damper are regarded as numerical results.Then,a reducing order model of the MDOF system for adjacent structures with mean parameters is presented.The explicit expressions for determining optimal parameters of Kelvin model-defined damper which is used to connect adjacent single degree of freedom(SDOF) structures subjected to a white-noise excitation are employed to achieve the appropriate damper parameters,which are called theory results.Through a comparative study,it can be found that the theory values of damper parameters are consistent with the results based on extensive parametric studies.The analytical results can be obtained by using the first natural frequencies and the total mass of the adjacent deterministic structures with mean parameters.The analytical formulas can be used to find appropriate parameters of damper between adjacent structures for engineering applications.The performance of damper is investigated on the basis of mitigations of mean square random responses of inter-story drifts,displacements and accelerations in adjacent structures.The numerical results demonstrate the robustness of coupled building control strategies.展开更多
BACKGROUND Treatment-resistant schizophrenia is a severe form of schizophrenia characterized by poor response to at least two antipsychotic drugs and is typically treated with clozapine.However,clozapine lowers the ep...BACKGROUND Treatment-resistant schizophrenia is a severe form of schizophrenia characterized by poor response to at least two antipsychotic drugs and is typically treated with clozapine.However,clozapine lowers the epileptic threshold,leading to seizures,which are severe side effects of antipsychotics that result in multiple complications.Clozapine-related seizures are generally considered to be dose-dependent and especially rare in the low-dose(150-300 mg/d)clozapine treated population.Due to clinical rarity,little is known about its clinical characteristics and treatment.CASE SUMMARY A 62-year-old Chinese man with a 40-year history of treatment-resistant schizophrenia presented to the Emergency Department with symptoms of myoclonus,consciousness disturbance and vomiting after taking 125 mg clozapine.Upon admission,the patient had a suddenly generalized tonic-clonic seizure lasting for about half a minute with persistent disturbance of consciousness,fever,cough and bloody sputum,which was considered to be low-dose clozapine-related seizure.After antiepileptic and multiple anti-infection treatments,the patient was discharged without epileptic or psychotic symptoms.CONCLUSION Our aim is to highlight the early prevention and optimal treatment of clozapine related seizure through case analysis and literature review.展开更多
The paper proves that, if f（x） ∈ L^p[-1,1],1≤p〈∞ ,changes sign I times in （-1, 1）,then there exists a real rational function r（x） ∈ Rn^（2μ-1）l which is eopositive with f（x）, such that the following Ja...The paper proves that, if f（x） ∈ L^p[-1,1],1≤p〈∞ ,changes sign I times in （-1, 1）,then there exists a real rational function r（x） ∈ Rn^（2μ-1）l which is eopositive with f（x）, such that the following Jackson type estimate ｜｜f-r｜｜p≤Cδl^2μωφ（f,1/n）p holds, where μ is a natural number ≥3/2＋1/p, and Cδ is a positive constant depending only on δ.展开更多
基金supported by the National Natural Science Foundation of China (No. 50778077)the National Science Foundation for Distinguished Young Scholars of China (No. 50925828)
文摘Dynamic response analysis of damper connected adjacent multi-story structures with uncertain parameters is carried out.A formula of the multi degree of freedom(MDOF) for the structure-damper system with stochastic parameters is derived.The uncertainties of mass and stiffness are taken into consideration firstly.The ground acceleration is represented by Kanai-Tajimi filtered non-stationary process.The mean square random responses of structural displacement and story drift are chosen as the optimization objective.The variations of mean square responses of top floor displacements and bottom story drifts in neighboring structures with the damper stiffness and damping coefficient are analyzed in detail.Through the parametric study,the acquiring optimum parameters of damper are regarded as numerical results.Then,a reducing order model of the MDOF system for adjacent structures with mean parameters is presented.The explicit expressions for determining optimal parameters of Kelvin model-defined damper which is used to connect adjacent single degree of freedom(SDOF) structures subjected to a white-noise excitation are employed to achieve the appropriate damper parameters,which are called theory results.Through a comparative study,it can be found that the theory values of damper parameters are consistent with the results based on extensive parametric studies.The analytical results can be obtained by using the first natural frequencies and the total mass of the adjacent deterministic structures with mean parameters.The analytical formulas can be used to find appropriate parameters of damper between adjacent structures for engineering applications.The performance of damper is investigated on the basis of mitigations of mean square random responses of inter-story drifts,displacements and accelerations in adjacent structures.The numerical results demonstrate the robustness of coupled building control strategies.
文摘BACKGROUND Treatment-resistant schizophrenia is a severe form of schizophrenia characterized by poor response to at least two antipsychotic drugs and is typically treated with clozapine.However,clozapine lowers the epileptic threshold,leading to seizures,which are severe side effects of antipsychotics that result in multiple complications.Clozapine-related seizures are generally considered to be dose-dependent and especially rare in the low-dose(150-300 mg/d)clozapine treated population.Due to clinical rarity,little is known about its clinical characteristics and treatment.CASE SUMMARY A 62-year-old Chinese man with a 40-year history of treatment-resistant schizophrenia presented to the Emergency Department with symptoms of myoclonus,consciousness disturbance and vomiting after taking 125 mg clozapine.Upon admission,the patient had a suddenly generalized tonic-clonic seizure lasting for about half a minute with persistent disturbance of consciousness,fever,cough and bloody sputum,which was considered to be low-dose clozapine-related seizure.After antiepileptic and multiple anti-infection treatments,the patient was discharged without epileptic or psychotic symptoms.CONCLUSION Our aim is to highlight the early prevention and optimal treatment of clozapine related seizure through case analysis and literature review.
基金supported by the National Natural Science Foundation of China (10901044)Research Project of Hangzhou Normal University (YS05203154)
文摘The paper proves that, if f（x） ∈ L^p[-1,1],1≤p〈∞ ,changes sign I times in （-1, 1）,then there exists a real rational function r（x） ∈ Rn^（2μ-1）l which is eopositive with f（x）, such that the following Jackson type estimate ｜｜f-r｜｜p≤Cδl^2μωφ（f,1/n）p holds, where μ is a natural number ≥3/2＋1/p, and Cδ is a positive constant depending only on δ.
