This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elev...This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence.展开更多
Augmented reality head-mounted displays(AR-HMDs)enable users to see real images of the outside world and visualize virtual information generated by a computer at any time and from any location,making them useful for v...Augmented reality head-mounted displays(AR-HMDs)enable users to see real images of the outside world and visualize virtual information generated by a computer at any time and from any location,making them useful for various applications.The manufacture of AR-HMDs combines the fields of optical engineering,optical materials,optical coating,precision manufacturing,electronic science,computer science,physiology,ergonomics,etc.This paper primarily focuses on the optical engineering of AR-HMDs.Optical combiners and display devices are used to combine real-world and virtual-world objects that are visible to the human eye.In this review,existing AR-HMD optical solutions employed for optical combiners are divided into three categories:optical solutions based on macro-,micro-,and nanooptics.The physical principles,optical structure,performance parameters,and manufacturing process of different types of AR-HMD optical solutions are subsequently analyzed.Moreover,their advantages and disadvantages are investigated and evaluated.In addition,the bottlenecks and future development trends in the case of AR-HMD optical solutions are discussed.展开更多
Large scale synthesis of high-efficiency bifunctional electrocatalyst based on cost-effective and earth-abundant transition metal for overall water splitting in the alkaline environment is indispensable for renewable ...Large scale synthesis of high-efficiency bifunctional electrocatalyst based on cost-effective and earth-abundant transition metal for overall water splitting in the alkaline environment is indispensable for renewable energy conversion.In this regard,meticulous design of active sites and probing their catalytic mechanism on both cathode and anode with different reaction environment at molecular-scale are vitally necessary.Herein,a coordination environment inheriting strategy is presented for designing low-coordination Ni^(2+)octahedra(L-Ni-8)atomic interface at a high concentration(4.6 at.%).Advanced spectroscopic techniques and theoretical calculations reveal that the self-matching electron delocalization and localization state at L-Ni-8 atomic interface enable an ideal reaction environment at both cathode and anode.To improve the efficiency of using the self-modification reaction environment at L-Ni-8,all of the structural features,including high atom economy,mass transfer,and electron transfer,are integrated together from atomic-scale to macro-scale.At high current density of 500 mA/cm2,the samples synthesized at gram-scale can deliver low hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)overpotentials of 262 and 348 mV,respectively.展开更多
Electrochemical nitrogen reduction reaction(NRR)is considered as an alternative to the industrial Haber-Bosch process for NH3 production due to both low energy consumption and environment friendliness.However,the majo...Electrochemical nitrogen reduction reaction(NRR)is considered as an alternative to the industrial Haber-Bosch process for NH3 production due to both low energy consumption and environment friendliness.However,the major problem of electrochemical NRR is the unsatisfied efficiency and selectivity of electrocatalyst.As one group of the cheapest and most abundant transition metals,iron-group(Fe,Co,Ni and Cu)electrocatalysts show promising potential on cost and performance advantages as ideal substitute for traditional noble-metal catalysts.In this minireview,we summarize recent advances of iron-group-based materials(including their oxides,hydroxides,nitrides,sulfides and phosphides,etc.)as non-noble metal electrocatalysts towards ambient N2-to-NH3 conversion in aqueous media.Strategies to boost NRR performances and perspectives for future developments are discussed to provide guidance for the field of NRR studies.展开更多
Alhagi sparsifolia Shap. （Fabaceae） is a spiny, perennial herb. The species grows in the salinized, arid regions in North China. This study investigated the response characteristics of the root growth and the dis- t...Alhagi sparsifolia Shap. （Fabaceae） is a spiny, perennial herb. The species grows in the salinized, arid regions in North China. This study investigated the response characteristics of the root growth and the dis- tribution of one-year-old A. sparsifolia seedlings to different groundwater depths in controlled plots. The eco- logical adaptability of the root systems of A. sparsifolia seedlings was examined using the artificial digging method. Results showed that： （1） A. sparsifolia seedlings adapted to an increase in groundwater depth mainly through increasing the penetration depth and growth rate of vertical roots. The vertical roots grew rapidly when soil moisture content reached 3%-9%, but slowly when soil moisture content was 13%-20%. The vertical roots stopped growing when soil moisture content reached 30% （the critical soil moisture point）. （2） The morphological plasticity of roots is an important strategy used by A. sparsifolia seedlings to obtain water and adapt to dry soil conditions. When the groundwater table was shallow, horizontal roots quickly expanded and tillering increased in order to compete for light resources, whereas when the groundwater table was deeper, vertical roots developed quickly to exploit space in the deeper soil layers. （3） The decrease in groundwater depth was probably respon- sible for the root distribution in the shallow soil layers. Root biomass and surface area both decreased with soil depth. One strategy of A. sparsifolia seedlings in dealing with the increase in groundwater depth is to increase root biomass in the deep soil layers. The relationship between the root growth/distribution of A. sparsifolia and the depth of groundwater table can be used as guidance for harvesting A. sparsifolia biomass and managing water resources for forage grasses. It is also of ecological significance as it reveals how desert plants adapt to arid environments.展开更多
Vegetation fractional coverage （VFC） is an important index to describe and evaluate the ecological system. The vegetation index is widely used to monitor vegetation coverage in the field of remote sensing （RS）. In...Vegetation fractional coverage （VFC） is an important index to describe and evaluate the ecological system. The vegetation index is widely used to monitor vegetation coverage in the field of remote sensing （RS）. In this paper, the author conducted a case study of the delta oasis of Weigan and Kuqa rivers, which is a typical saline area in the Tarim River Watershed. The current study was based on the TM/ETM＋ images of 1989, 2001, and 2006, and supported by Geographic Information System （GIS） spatial analysis, vegetation index, and dimidiate pixel model. In addition, VBSl （vegetation, bare soil and shadow indices） suitable for TM/ETM＋ irrlages, constructed with FCD （forest canopy density） model principle and put forward by ITTO （International Tropical Timber Organization）, was used, and it was applied to estimate the VFC. The estimation accuracy was later prow^n to be up to 83.52%. Further, the study analyzed and appraised the changes in vegetation patterns and revealed a pattern of spatial change in the vegetation coverage of the study area by producing the map of VFC levels in the delta oasis. Forest, grassland, and farmland were the three main land-use types with high and extremely-high coverage, and they played an important role in maintaining the vegetation. The forest area determined the changes of the coverage area, whereas the other two land types affected the directions of change. Therefore, planting trees, protecting grasslands, reclaiming farmlands, and controlling unused lands should be included in a long-term program because of their importance in keeping regional vegetation coverage. Finally, the dynamic variation of VFC in the study area was evaluated according to the quantity and spatial distribution rendered by plant cover diigital images to deeply analyze the reason behind the variation.展开更多
The Aral Sea Basin in Central Asia is an important geographical environment unit in the center of Eurasia.It is of great significance to the ecological protection and sustainable development of Central Asia to carry o...The Aral Sea Basin in Central Asia is an important geographical environment unit in the center of Eurasia.It is of great significance to the ecological protection and sustainable development of Central Asia to carry out dynamic monitoring and effective evaluation of the eco-environmental quality of the Aral Sea Basin.In this study,the arid remote sensing ecological index(ARSEI)for large-scale arid areas was developed,which coupled the information of the greenness index,the salinity index,the humidity index,the heat index,and the land degradation index of arid areas.The ARSEI was used to monitor and evaluate the eco-environmental quality of the Aral Sea Basin from 2000 to 2019.The results show that the greenness index,the humidity index and the land degradation index had a positive impact on the quality of the ecological environment in the Aral Sea Basin,while the salinity index and the heat index exerted a negative impact on the quality of the ecological environment.The eco-environmental quality of the Aral Sea Basin demonstrated a trend of initial improvement,followed by deterioration,and finally further improvement.The spatial variation of these changes was significant.From 2000 to 2019,grassland and wasteland(saline alkali land and sandy land)in the central and western parts of the basin had the worst ecological environment quality.The areas with poor ecological environment quality are mainly distributed in rivers,wetlands,and cultivated land around lakes.During the period from 2000 to 2019,except for the surrounding areas of the Aral Sea,the ecological environment quality in other areas of the Aral Sea Basin has been improved in general.The correlation coefficients between the change in the eco-environmental quality and the heat index and between the change in the eco-environmental quality and the humidity index were–0.593 and 0.524,respectively.Climate conditions and human activities have led to different combinations of heat and humidity changes in the eco-environmental quality of the Aral Sea Basin.Howev展开更多
Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has quickly spread worldwide and has affected more than 10 million individuals.A typical feature of COVID-19 is ...Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has quickly spread worldwide and has affected more than 10 million individuals.A typical feature of COVID-19 is the suppression of type I and III interferon(IFN)-mediated antiviral immunity.However,the molecular mechanism by which SARS-CoV-2 evades antiviral immunity remains elusive.Here,we reported that the SARS-CoV-2 membrane(M)protein inhibits the production of type I and III IFNs induced by the cytosolic dsRNA-sensing pathway mediated by RIG-I/MDA-5–MAVS signaling.In addition,the SARS-CoV-2 M protein suppresses type I and III IFN induction stimulated by SeV infection or poly(I:C)transfection.Mechanistically,the SARS-CoV-2 M protein interacts with RIG-I,MAVS,and TBK1,thus preventing the formation of the multiprotein complex containing RIG-I,MAVS,TRAF3,and TBK1 and subsequently impeding the phosphorylation,nuclear translocation,and activation of IRF3.Consequently,ectopic expression of the SARS-CoV-2 M protein facilitates the replication of vesicular stomatitis virus.Taken together,these results indicate that the SARS-CoV-2 M protein antagonizes type I and III IFN production by targeting RIG-I/MDA-5 signaling,which subsequently attenuates antiviral immunity and enhances viral replication.This study provides insight into the interpretation of SARS-CoV-2-induced antiviral immune suppression and illuminates the pathogenic mechanism of COVID-19.展开更多
With the classical statistical and geostatistical methods, the study of the spatial distribution and its in- fluence factors of soil water, salinity and organic matter was carried out for 0-70 cm soil layers in Manas ...With the classical statistical and geostatistical methods, the study of the spatial distribution and its in- fluence factors of soil water, salinity and organic matter was carried out for 0-70 cm soil layers in Manas River watershed. The results showed that the soil moisture data from all soil layers exhibited a normal distribution, with average values of 14.08%-21.55%. Geostatistical analysis revealed that the content of soil moisture had a moder- ate spatial autocorrelation with the ratios of nugget/sill ranging from 0.500 to 0.718, which implies that the spatial pattern of soil moisture is influenced by the combined effects of structural factors and random factors. Remarkable spatial distributions with stripped and mottled features were found for soil moisture in all different soil layers. The landform and crop planting had a relatively big influence on the spatial distribution of soil moisture; total soil salinity was high in east but low in west, and non-salinized soil and lightly salinized soil appeared at the northwest and southwest of the study area. Under the effect of reservoir leakage, the heavily salinized soils are widely distributed in the middle of the study area. The areas of the non-salinized and lightly salinized soils decreased gradually with soil depth increment, which is contrary to the case for saline soils that reached a maximum of 245.67 km2 at the layer of 50-70 cm. The types of soil salinization in Manas River watershed were classified into four classes： the sulfate, chloride-sulfate, sulfate-chloride and chloride. The sulfate salinized soil is most widely distributed in the surface layer. The areas of chloride-sulfate, sulfate-chloride, and chloride salinized soils increased gradually along with the increment of soil depth; the variation range of the average values of soil organic matter content was be- tween 7.48%-11.33%. The ratios of nugget/sill reduced gradually from 0.698 to 0.299 with soil depth increment, which shows that the content of soil organic matter has a moderate spatia展开更多
Melamine formaldehyde (MF) foam is kind of fire-retardant material and has great potential in acoustic and thermal insulation area. In this article, MF resin foam was prepared by microwave radiation. We discussed the ...Melamine formaldehyde (MF) foam is kind of fire-retardant material and has great potential in acoustic and thermal insulation area. In this article, MF resin foam was prepared by microwave radiation. We discussed the thermal stability of MF foam and the effect of different emulsifiers on its morphology, apparent density, fire-retardancy and mechanical property. The decomposition temperature of MF foam we prepared is nearly 400℃ and the constitution of residue after combustion is made up of carbon and graphite. Emulsifier influenced the apparent density of MF foam and using coemulsifiers can get flexible foam with uniform cell size, good morphology and low apparent density. When the fire-retardant MF foam’s apparent density is low of 5.53 kg/cm-3, its value of LOI can reach 32.4. The mechanical property of foam is consistent with apparent density.展开更多
Electrocatalytic N_(2) reduction provides an attractive alternative to Haber-Bosch process for artificial NH_(3) synthesis.The difficulty of suppressing competing proton reduction,however,largely impedes its practical...Electrocatalytic N_(2) reduction provides an attractive alternative to Haber-Bosch process for artificial NH_(3) synthesis.The difficulty of suppressing competing proton reduction,however,largely impedes its practical use.Herein,we design a hydrophobic octadecanethiol-modified Fe_(3)P nanoarrays supported on carbon paper(C18@Fe_(3)P/CP)to effectively repel water,concentrate N_(2),and enhance N_(2)-to-NH_(3) conversion.Such catalyst achieves an NH_(3) yield of 1.80×10^(-10) mol s^(-1)·cm^(-2) and a high Faradaic efficiency of 11.22%in 0.1 M Na_(2)SO_(4),outperforming the non-modified Fe_(3)P/CP(2.16×10^(-11) mol s^(-1)·cm^(-2),0.9%)counterpart.Significantly,C18@Fe_(3)P/CP renders steady Nrfixing activlty/selectivity in cycling test and exhibits durability for at least 25 h.First-principles calculations suggest that the surface electronic structure and chemical activity of Fe_(3)P can be well tuned by the thiol modification,which facilitates N_(2) electroreduction activity and catalytic formation of NH_(3).展开更多
First-Input-First-Output (FIFO) buffers are extensively used in contemporary digital processors and System-on-Chips (SoC). There are synchronous FIFOs and asycnrhonous FIFOs. And different sized FIFOs should be implem...First-Input-First-Output (FIFO) buffers are extensively used in contemporary digital processors and System-on-Chips (SoC). There are synchronous FIFOs and asycnrhonous FIFOs. And different sized FIFOs should be implemented in different ways. FIFOs are used not only for the pipeline design within a processor, for the inter-processor communication networks, for example Network-on-Chips (NoCs), but also for the peripherals and the clock domain crossing at the whole SoC level. In this paper, we review the interface, the circuit implementation, and the various usages of FIFOs in various levels of the digital design. We can find that the usage of FIFOs could greatly facilitate the signal storage, signal decoupling, signal transfer, power domain separation and power domain crossing in digital systems. We hope that more attentions are paid to the usages of synchronous and asynchronous FIFOs and more sophististicated usages are discovered by the digital design communities.展开更多
Central Asia(CA)occupies the hinterland of the Eurasian continent,containing the countries of Uzbekistan,Kyrgyzstan,Turkmenistan,Tajikistan,and Kazakhstan[1,2].Being isolated by the Pamir Mountains in Tajikistan,the T...Central Asia(CA)occupies the hinterland of the Eurasian continent,containing the countries of Uzbekistan,Kyrgyzstan,Turkmenistan,Tajikistan,and Kazakhstan[1,2].Being isolated by the Pamir Mountains in Tajikistan,the Tibetan Plateau and the Tian Shan Mountains on the border between China and Kyrgyzstan.展开更多
Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.Herein,we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 ...Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.Herein,we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative examples in different strategies from the medicinal chemistry perspective.展开更多
Background Mycophenolate mofetil （MMF） and cyclophosphamide （CTX） are widely used in treating various kidney diseases.However,whether they are effective and which one is better for treating IgA nephropathy patient...Background Mycophenolate mofetil （MMF） and cyclophosphamide （CTX） are widely used in treating various kidney diseases.However,whether they are effective and which one is better for treating IgA nephropathy patients with proliferative pathological phenotype in renal diseases,such as endocapillary proliferation,cellular crescents,and/or capillary loops fibrinoid necrosis is still unknown.We,therefore,initiated a study to compare the effects of MMF and CTX in treating IgA nephropathy with the above pathological lesions.Methods One hundred and nineteen patients with IgA nephropathy who had at least one of the three aforementioned lesions were enrolled.All patients were treated with prednisone; 48 patients received prednisone only （Pred group）,40 received MMF and prednisone （MMF ＋ Pred group）,and 31 were treated with CTX and prednisone （CTX ＋ Pred group）.The median time of follow-up was 30 months （maximum：96 months）.The primary endpoint was defined as renal survival.The incidence of remission of proteinuria was the secondary endpoint.Results Serum creatinine in all groups declined significantly at different follow-up times （P=0.002）,and the differences among the three groups were significant （P＜0.001）.At 24 months of follow-up,the decline rates were 12.35％,32.95％,and 24.14％ in the Pred,MMF ＋ Pred,and CTX ＋ Pred groups respectively.For urine protein excretion,the decline rates were 49.12％ （Pred）,73.67％ （MMF ＋ Pred）,and 63.53％ （CTX ＋ Pred） respectively at 24 months of follow-up.The differences among the three groups were not significant （P=0.714）.Renal survival （the primary endpoint） was significantly different （P=0.027）; however,the sencondary endpoint was similar for all the three groups （P=0.100）.Conclusions For IgA nephropathy patients with endocapillary proliferation,cellular crescents,and/or fibrinoid necrosis of capillary loops,prednisone combined with MMF was more effective in lowering the serum creatinine than with CTX.Combi展开更多
Plant height(PH)is an essential trait in maize(Zea mays)that is tightly associated with planting density,biomass,lodging resistance,and grain yield in the field.Dissecting the dynamics of maize plant architecture will...Plant height(PH)is an essential trait in maize(Zea mays)that is tightly associated with planting density,biomass,lodging resistance,and grain yield in the field.Dissecting the dynamics of maize plant architecture will be beneficial for ideotype-based maize breeding and prediction,as the genetic basis controlling PH in maize remains largely unknown.In this study,we developed an automated high-throughput phenotyping platform(HTP)to systematically and noninvasively quantify 77 image-based traits(i-traits)and 20 field traits(f-traits)for 228 maize inbred lines across all developmental stages.Time-resolved i-traits with novel digital phenotypes and complex correlations with agronomic traits were characterized to reveal the dynamics of maize growth.An i-trait-based genome-wide association study identified 4945 traitassociated SNPs,2603 genetic loci,and 1974 corresponding candidate genes.We found that rapid growth of maize plants occurs mainly at two developmental stages,stage 2(S2)to S3 and S5 to S6,accounting for the final PH indicators.By integrating the PH-association network with the transcriptome profiles of specific internodes,we revealed 13 hub genes that may play vital roles during rapid growth.The candidate genes and novel i-traits identified at multiple growth stages may be used as potential indicators for final PH in maize.One candidate gene,ZmVATE,was functionally validated and shown to regulate PH-related traits in maize using genetic mutation.Furthermore,machine learning was used to build predictive models for final PH based on i-traits,and their performancewas assessed across developmental stages.Moderate,strong,and very strong correlations between predictions and experimental datasets were achieved from the early S4(tenth-leaf)stage.Colletively,our study provides a valuable tool for dissecting the spatiotemporal formation of specific internodes and the genetic architecture of PH,as well as resources and predictive models that are useful for molecular design breeding and predicting maize varieties with i展开更多
A reliable mathematical model of urea-water-solution(UWS) droplet evaporation and thermolysis is developed.The well known Abramzon–Sirignano evaporation model is corrected by introducing an adjustment coefficient con...A reliable mathematical model of urea-water-solution(UWS) droplet evaporation and thermolysis is developed.The well known Abramzon–Sirignano evaporation model is corrected by introducing an adjustment coefficient considering the different evaporation behaviors of UWS droplet at different ambient temperatures. A semidetailed kinetic scheme of urea thermolysis is developed based on Ebrahimian's work. Sequentially, the evaporation characteristics, decomposition efficiency of a single UWS droplet and deposit formation are simulated. As a result, the relation of evaporation time, relative velocity, exhaust temperature and droplet initial diameter is presented. Synchronously, it indicates that temperature is the decisive factor for urea thermolysis. Different temperatures result in different deposit components, and deposit yield is significantly influenced by temperature and decomposition time. The current work can provide guidance for designing urea injection strategy of SCR systems.展开更多
Background and Aims:Chronic hepatitis caused by hepatitis B virus(HBV)infection is a leading cause of hepatocellular carcinoma(HCC).We investigated the roles of oncogenic HBV infection-associated long noncoding RNAs i...Background and Aims:Chronic hepatitis caused by hepatitis B virus(HBV)infection is a leading cause of hepatocellular carcinoma(HCC).We investigated the roles of oncogenic HBV infection-associated long noncoding RNAs in HCC.Methods:Bioinformatics analysis of data from the Cancer Genome Atlas(TCGA)was performed to screen potential oncogenic HBV-related lncRNAs.Next,we assessed their expression in clinical samples and investigated their correlation with clinical characteristics.The detailed oncogenic effects were analyzed by performing in vitro and in vivo studies.Results:RP11-40C6.2,an HBV infection-related lncRNA,was identified by analysis of the TCGA–Liver Hepatocellular Carcinoma database.Gene Set Enrichment Analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis of differentially expressed genes revealed a strong association of RP11-40C6.2 with the Hippo signaling pathway.RP11-40C6.2 was overexpressed in HCC patients with HBV infection compared to those without HBV infection.RP11-40C6.2 transcription showed a positive association with HBV-X protein(HBx),but not HBV core protein(HBc)expression,both of which are carcinogenic proteins.Luciferase gene reporter and ChIP assays revealed that YAP1/TAZ/TEADs complex enhanced RP11-40C6.2 transcription by binding to its promoter area.RP11-40C6.2 showed oncogenic characteristics in HCC cell lines and in animal models that were mediated via activation of YAP1.In vitro ubiquitylation assay revealed that RP11-40C6.2 can promote the stabilization of YAP1 by stopping phosphorylation at its s127 residue and further stopping its degradation through binding to 14-3-3.Conclusions:RP11-40C6.2 is an HBV infection-related lncRNA that exerts its oncogenic effects by targeting the Hippo signaling pathway.展开更多
基金supported by the National Key Research and Development Program of China(Grant Nos.2021YFC2203501,2021YFC2203502,2021YFC2203503,and 2021YFC2203600)the National Natural Science Foundation of China(Grant Nos.12173077,11873082,11803080,and 12003062)+3 种基金the Scientific Instrument Developing Project of the Chinese Academy of Sciences(Grant No.PTYQ2022YZZD01)the Operation,Maintenance and Upgrading Fund for Astronomical Telescopes and Facility Instrumentsbudgeted from the Ministry of Finance of China and Administrated by the Chinese Academy of Sciencesthe Chinese Academy of Sciences“Light of West China”Program(Grant No.2021-XBQNXZ-030)。
文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence.
文摘Augmented reality head-mounted displays(AR-HMDs)enable users to see real images of the outside world and visualize virtual information generated by a computer at any time and from any location,making them useful for various applications.The manufacture of AR-HMDs combines the fields of optical engineering,optical materials,optical coating,precision manufacturing,electronic science,computer science,physiology,ergonomics,etc.This paper primarily focuses on the optical engineering of AR-HMDs.Optical combiners and display devices are used to combine real-world and virtual-world objects that are visible to the human eye.In this review,existing AR-HMD optical solutions employed for optical combiners are divided into three categories:optical solutions based on macro-,micro-,and nanooptics.The physical principles,optical structure,performance parameters,and manufacturing process of different types of AR-HMD optical solutions are subsequently analyzed.Moreover,their advantages and disadvantages are investigated and evaluated.In addition,the bottlenecks and future development trends in the case of AR-HMD optical solutions are discussed.
基金supported by the National Natural Science Foundation of China(No.21676300)the Shandong Provincial Natural Science Foundation(No.ZR2018MB035)+3 种基金the Fundamental Research Funds for the Central Universities(Nos.19CX02008A and 16CX06007A)PetroChina Innovation Foundation(No.2019D-5007-0401)Taishan Scholars Program of Shandong Province(No.tsqn201909065)Tsinghua University Initiative Scientific Research Program.
文摘Large scale synthesis of high-efficiency bifunctional electrocatalyst based on cost-effective and earth-abundant transition metal for overall water splitting in the alkaline environment is indispensable for renewable energy conversion.In this regard,meticulous design of active sites and probing their catalytic mechanism on both cathode and anode with different reaction environment at molecular-scale are vitally necessary.Herein,a coordination environment inheriting strategy is presented for designing low-coordination Ni^(2+)octahedra(L-Ni-8)atomic interface at a high concentration(4.6 at.%).Advanced spectroscopic techniques and theoretical calculations reveal that the self-matching electron delocalization and localization state at L-Ni-8 atomic interface enable an ideal reaction environment at both cathode and anode.To improve the efficiency of using the self-modification reaction environment at L-Ni-8,all of the structural features,including high atom economy,mass transfer,and electron transfer,are integrated together from atomic-scale to macro-scale.At high current density of 500 mA/cm2,the samples synthesized at gram-scale can deliver low hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)overpotentials of 262 and 348 mV,respectively.
文摘Electrochemical nitrogen reduction reaction(NRR)is considered as an alternative to the industrial Haber-Bosch process for NH3 production due to both low energy consumption and environment friendliness.However,the major problem of electrochemical NRR is the unsatisfied efficiency and selectivity of electrocatalyst.As one group of the cheapest and most abundant transition metals,iron-group(Fe,Co,Ni and Cu)electrocatalysts show promising potential on cost and performance advantages as ideal substitute for traditional noble-metal catalysts.In this minireview,we summarize recent advances of iron-group-based materials(including their oxides,hydroxides,nitrides,sulfides and phosphides,etc.)as non-noble metal electrocatalysts towards ambient N2-to-NH3 conversion in aqueous media.Strategies to boost NRR performances and perspectives for future developments are discussed to provide guidance for the field of NRR studies.
基金supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (KZCX2-EW-316)the National Natural Science Foundation of China (31070477,30870471)the West Light Foundation of the Chinese Academy of Sciences (XBBS201105)
文摘Alhagi sparsifolia Shap. （Fabaceae） is a spiny, perennial herb. The species grows in the salinized, arid regions in North China. This study investigated the response characteristics of the root growth and the dis- tribution of one-year-old A. sparsifolia seedlings to different groundwater depths in controlled plots. The eco- logical adaptability of the root systems of A. sparsifolia seedlings was examined using the artificial digging method. Results showed that： （1） A. sparsifolia seedlings adapted to an increase in groundwater depth mainly through increasing the penetration depth and growth rate of vertical roots. The vertical roots grew rapidly when soil moisture content reached 3%-9%, but slowly when soil moisture content was 13%-20%. The vertical roots stopped growing when soil moisture content reached 30% （the critical soil moisture point）. （2） The morphological plasticity of roots is an important strategy used by A. sparsifolia seedlings to obtain water and adapt to dry soil conditions. When the groundwater table was shallow, horizontal roots quickly expanded and tillering increased in order to compete for light resources, whereas when the groundwater table was deeper, vertical roots developed quickly to exploit space in the deeper soil layers. （3） The decrease in groundwater depth was probably respon- sible for the root distribution in the shallow soil layers. Root biomass and surface area both decreased with soil depth. One strategy of A. sparsifolia seedlings in dealing with the increase in groundwater depth is to increase root biomass in the deep soil layers. The relationship between the root growth/distribution of A. sparsifolia and the depth of groundwater table can be used as guidance for harvesting A. sparsifolia biomass and managing water resources for forage grasses. It is also of ecological significance as it reveals how desert plants adapt to arid environments.
基金supported by the National Basic Research Program of China (2009CB421302)the Joint Fundsof the National Natural Science Foundation of China(U1138303)+4 种基金the National Natural Science Foundation of China(41261090,41161063)the Open Foundation of State Key Laboratory of Resources and Environment Information Systems (2010KF0003SA)Scientific Research Foundation for Doctor (BS110125)Xinjiang Natural Science Foundation for Young Scholars (2012211B04)Research Fund for Training Young Teachers (XJEDU2012S03)
文摘Vegetation fractional coverage （VFC） is an important index to describe and evaluate the ecological system. The vegetation index is widely used to monitor vegetation coverage in the field of remote sensing （RS）. In this paper, the author conducted a case study of the delta oasis of Weigan and Kuqa rivers, which is a typical saline area in the Tarim River Watershed. The current study was based on the TM/ETM＋ images of 1989, 2001, and 2006, and supported by Geographic Information System （GIS） spatial analysis, vegetation index, and dimidiate pixel model. In addition, VBSl （vegetation, bare soil and shadow indices） suitable for TM/ETM＋ irrlages, constructed with FCD （forest canopy density） model principle and put forward by ITTO （International Tropical Timber Organization）, was used, and it was applied to estimate the VFC. The estimation accuracy was later prow^n to be up to 83.52%. Further, the study analyzed and appraised the changes in vegetation patterns and revealed a pattern of spatial change in the vegetation coverage of the study area by producing the map of VFC levels in the delta oasis. Forest, grassland, and farmland were the three main land-use types with high and extremely-high coverage, and they played an important role in maintaining the vegetation. The forest area determined the changes of the coverage area, whereas the other two land types affected the directions of change. Therefore, planting trees, protecting grasslands, reclaiming farmlands, and controlling unused lands should be included in a long-term program because of their importance in keeping regional vegetation coverage. Finally, the dynamic variation of VFC in the study area was evaluated according to the quantity and spatial distribution rendered by plant cover diigital images to deeply analyze the reason behind the variation.
基金This work was funded by the National Natural Science Foundation of China(U1603242)the Major Science and Technology Projects in Inner Mongolia,China(ZDZX2018054).
文摘The Aral Sea Basin in Central Asia is an important geographical environment unit in the center of Eurasia.It is of great significance to the ecological protection and sustainable development of Central Asia to carry out dynamic monitoring and effective evaluation of the eco-environmental quality of the Aral Sea Basin.In this study,the arid remote sensing ecological index(ARSEI)for large-scale arid areas was developed,which coupled the information of the greenness index,the salinity index,the humidity index,the heat index,and the land degradation index of arid areas.The ARSEI was used to monitor and evaluate the eco-environmental quality of the Aral Sea Basin from 2000 to 2019.The results show that the greenness index,the humidity index and the land degradation index had a positive impact on the quality of the ecological environment in the Aral Sea Basin,while the salinity index and the heat index exerted a negative impact on the quality of the ecological environment.The eco-environmental quality of the Aral Sea Basin demonstrated a trend of initial improvement,followed by deterioration,and finally further improvement.The spatial variation of these changes was significant.From 2000 to 2019,grassland and wasteland(saline alkali land and sandy land)in the central and western parts of the basin had the worst ecological environment quality.The areas with poor ecological environment quality are mainly distributed in rivers,wetlands,and cultivated land around lakes.During the period from 2000 to 2019,except for the surrounding areas of the Aral Sea,the ecological environment quality in other areas of the Aral Sea Basin has been improved in general.The correlation coefficients between the change in the eco-environmental quality and the heat index and between the change in the eco-environmental quality and the humidity index were–0.593 and 0.524,respectively.Climate conditions and human activities have led to different combinations of heat and humidity changes in the eco-environmental quality of the Aral Sea Basin.Howev
基金supported by grants from the COVID-19 emergency tackling research project of Shandong University(Grant No.2020XGB03 to P.-H.W)grants from the Natural Science Foundation of Jiangsu Province(SBK2020042706 to P.-H.W)+3 种基金grants from the Natural Science Foundation of China(81930039,31730026,81525012)awarded to C.G.,and the Fundamental Research Funds of Shandong University(21510078614099)the Fundamental Research Funds of Cheeloo College of Medicine(21510089393109)China Postdoctoral Science Foundation(2018M642662)the Natural Science Foundation of China(81901604)awarded to Y.Z.,and grants from the Key Research and Development Project of Shandong Province(2020SFXGFY08).
文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has quickly spread worldwide and has affected more than 10 million individuals.A typical feature of COVID-19 is the suppression of type I and III interferon(IFN)-mediated antiviral immunity.However,the molecular mechanism by which SARS-CoV-2 evades antiviral immunity remains elusive.Here,we reported that the SARS-CoV-2 membrane(M)protein inhibits the production of type I and III IFNs induced by the cytosolic dsRNA-sensing pathway mediated by RIG-I/MDA-5–MAVS signaling.In addition,the SARS-CoV-2 M protein suppresses type I and III IFN induction stimulated by SeV infection or poly(I:C)transfection.Mechanistically,the SARS-CoV-2 M protein interacts with RIG-I,MAVS,and TBK1,thus preventing the formation of the multiprotein complex containing RIG-I,MAVS,TRAF3,and TBK1 and subsequently impeding the phosphorylation,nuclear translocation,and activation of IRF3.Consequently,ectopic expression of the SARS-CoV-2 M protein facilitates the replication of vesicular stomatitis virus.Taken together,these results indicate that the SARS-CoV-2 M protein antagonizes type I and III IFN production by targeting RIG-I/MDA-5 signaling,which subsequently attenuates antiviral immunity and enhances viral replication.This study provides insight into the interpretation of SARS-CoV-2-induced antiviral immune suppression and illuminates the pathogenic mechanism of COVID-19.
基金funded by the National Basic Research Program of China(2009CB825101)the National Natural Science Foundation of China(41071139)
文摘With the classical statistical and geostatistical methods, the study of the spatial distribution and its in- fluence factors of soil water, salinity and organic matter was carried out for 0-70 cm soil layers in Manas River watershed. The results showed that the soil moisture data from all soil layers exhibited a normal distribution, with average values of 14.08%-21.55%. Geostatistical analysis revealed that the content of soil moisture had a moder- ate spatial autocorrelation with the ratios of nugget/sill ranging from 0.500 to 0.718, which implies that the spatial pattern of soil moisture is influenced by the combined effects of structural factors and random factors. Remarkable spatial distributions with stripped and mottled features were found for soil moisture in all different soil layers. The landform and crop planting had a relatively big influence on the spatial distribution of soil moisture; total soil salinity was high in east but low in west, and non-salinized soil and lightly salinized soil appeared at the northwest and southwest of the study area. Under the effect of reservoir leakage, the heavily salinized soils are widely distributed in the middle of the study area. The areas of the non-salinized and lightly salinized soils decreased gradually with soil depth increment, which is contrary to the case for saline soils that reached a maximum of 245.67 km2 at the layer of 50-70 cm. The types of soil salinization in Manas River watershed were classified into four classes： the sulfate, chloride-sulfate, sulfate-chloride and chloride. The sulfate salinized soil is most widely distributed in the surface layer. The areas of chloride-sulfate, sulfate-chloride, and chloride salinized soils increased gradually along with the increment of soil depth; the variation range of the average values of soil organic matter content was be- tween 7.48%-11.33%. The ratios of nugget/sill reduced gradually from 0.698 to 0.299 with soil depth increment, which shows that the content of soil organic matter has a moderate spatia
文摘Melamine formaldehyde (MF) foam is kind of fire-retardant material and has great potential in acoustic and thermal insulation area. In this article, MF resin foam was prepared by microwave radiation. We discussed the thermal stability of MF foam and the effect of different emulsifiers on its morphology, apparent density, fire-retardancy and mechanical property. The decomposition temperature of MF foam we prepared is nearly 400℃ and the constitution of residue after combustion is made up of carbon and graphite. Emulsifier influenced the apparent density of MF foam and using coemulsifiers can get flexible foam with uniform cell size, good morphology and low apparent density. When the fire-retardant MF foam’s apparent density is low of 5.53 kg/cm-3, its value of LOI can reach 32.4. The mechanical property of foam is consistent with apparent density.
基金supported by the National Natural Science Foundation of China(No.22072015)Shanghai Scientific and Technological Innovation Project(No.18JC 1410604)Program for Science&Technology Innovation Talents in Universities of Henan Province(No.20HASTIT028).
文摘Electrocatalytic N_(2) reduction provides an attractive alternative to Haber-Bosch process for artificial NH_(3) synthesis.The difficulty of suppressing competing proton reduction,however,largely impedes its practical use.Herein,we design a hydrophobic octadecanethiol-modified Fe_(3)P nanoarrays supported on carbon paper(C18@Fe_(3)P/CP)to effectively repel water,concentrate N_(2),and enhance N_(2)-to-NH_(3) conversion.Such catalyst achieves an NH_(3) yield of 1.80×10^(-10) mol s^(-1)·cm^(-2) and a high Faradaic efficiency of 11.22%in 0.1 M Na_(2)SO_(4),outperforming the non-modified Fe_(3)P/CP(2.16×10^(-11) mol s^(-1)·cm^(-2),0.9%)counterpart.Significantly,C18@Fe_(3)P/CP renders steady Nrfixing activlty/selectivity in cycling test and exhibits durability for at least 25 h.First-principles calculations suggest that the surface electronic structure and chemical activity of Fe_(3)P can be well tuned by the thiol modification,which facilitates N_(2) electroreduction activity and catalytic formation of NH_(3).
文摘First-Input-First-Output (FIFO) buffers are extensively used in contemporary digital processors and System-on-Chips (SoC). There are synchronous FIFOs and asycnrhonous FIFOs. And different sized FIFOs should be implemented in different ways. FIFOs are used not only for the pipeline design within a processor, for the inter-processor communication networks, for example Network-on-Chips (NoCs), but also for the peripherals and the clock domain crossing at the whole SoC level. In this paper, we review the interface, the circuit implementation, and the various usages of FIFOs in various levels of the digital design. We can find that the usage of FIFOs could greatly facilitate the signal storage, signal decoupling, signal transfer, power domain separation and power domain crossing in digital systems. We hope that more attentions are paid to the usages of synchronous and asynchronous FIFOs and more sophististicated usages are discovered by the digital design communities.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA20060303)the Fund“Light of West China”Program of Chinese Academy of Sciences(2018-XBQNXZ-B-017)+1 种基金the High-level Talents Project in Xinjiang(Y942171)“One Hundred Person Project of Chinese Academy of Sciences”(Y931201)。
文摘Central Asia(CA)occupies the hinterland of the Eurasian continent,containing the countries of Uzbekistan,Kyrgyzstan,Turkmenistan,Tajikistan,and Kazakhstan[1,2].Being isolated by the Pamir Mountains in Tajikistan,the Tibetan Plateau and the Tian Shan Mountains on the border between China and Kyrgyzstan.
基金financial support from the Shandong Provincial Key Research and Development Project(No.2019JZZY021011,China)Foreign Cultural and Educational Experts Project(GXL20200015001,China)+1 种基金Outstanding Youth Fund of Shandong Province(ZR2020JQ31,China)Qilu Young Scholars Program of Shandong University and the Taishan Scholar Program at Shandong Province。
文摘Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.Herein,we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative examples in different strategies from the medicinal chemistry perspective.
文摘Background Mycophenolate mofetil （MMF） and cyclophosphamide （CTX） are widely used in treating various kidney diseases.However,whether they are effective and which one is better for treating IgA nephropathy patients with proliferative pathological phenotype in renal diseases,such as endocapillary proliferation,cellular crescents,and/or capillary loops fibrinoid necrosis is still unknown.We,therefore,initiated a study to compare the effects of MMF and CTX in treating IgA nephropathy with the above pathological lesions.Methods One hundred and nineteen patients with IgA nephropathy who had at least one of the three aforementioned lesions were enrolled.All patients were treated with prednisone; 48 patients received prednisone only （Pred group）,40 received MMF and prednisone （MMF ＋ Pred group）,and 31 were treated with CTX and prednisone （CTX ＋ Pred group）.The median time of follow-up was 30 months （maximum：96 months）.The primary endpoint was defined as renal survival.The incidence of remission of proteinuria was the secondary endpoint.Results Serum creatinine in all groups declined significantly at different follow-up times （P=0.002）,and the differences among the three groups were significant （P＜0.001）.At 24 months of follow-up,the decline rates were 12.35％,32.95％,and 24.14％ in the Pred,MMF ＋ Pred,and CTX ＋ Pred groups respectively.For urine protein excretion,the decline rates were 49.12％ （Pred）,73.67％ （MMF ＋ Pred）,and 63.53％ （CTX ＋ Pred） respectively at 24 months of follow-up.The differences among the three groups were not significant （P=0.714）.Renal survival （the primary endpoint） was significantly different （P=0.027）; however,the sencondary endpoint was similar for all the three groups （P=0.100）.Conclusions For IgA nephropathy patients with endocapillary proliferation,cellular crescents,and/or fibrinoid necrosis of capillary loops,prednisone combined with MMF was more effective in lowering the serum creatinine than with CTX.Combi
基金supported by the National Key Research and Development Program of China(2021YFF1000301 and 2021YFF1000304)the National Natural Science Foundation of China(32172091)+4 种基金the National Key Research and Development Program of China(2016YFD0100103)the Fundamental Research Funds for Central Non-Profit of Chinese Academy of Agricultural Sciences(CAAS-ZDRW202109 and Y2020PT06)the Innovation Program of the Chinese Academy of Agricultural Sciences(CAAS-ZDRW202004)the 2020 Research Program of Sanya Yazhou Bay Science and Technology City(SKJC-2020-02-005)the Nanfan special project of the Chinese Academy of Agricultural Sciences(YBXM15).
文摘Plant height(PH)is an essential trait in maize(Zea mays)that is tightly associated with planting density,biomass,lodging resistance,and grain yield in the field.Dissecting the dynamics of maize plant architecture will be beneficial for ideotype-based maize breeding and prediction,as the genetic basis controlling PH in maize remains largely unknown.In this study,we developed an automated high-throughput phenotyping platform(HTP)to systematically and noninvasively quantify 77 image-based traits(i-traits)and 20 field traits(f-traits)for 228 maize inbred lines across all developmental stages.Time-resolved i-traits with novel digital phenotypes and complex correlations with agronomic traits were characterized to reveal the dynamics of maize growth.An i-trait-based genome-wide association study identified 4945 traitassociated SNPs,2603 genetic loci,and 1974 corresponding candidate genes.We found that rapid growth of maize plants occurs mainly at two developmental stages,stage 2(S2)to S3 and S5 to S6,accounting for the final PH indicators.By integrating the PH-association network with the transcriptome profiles of specific internodes,we revealed 13 hub genes that may play vital roles during rapid growth.The candidate genes and novel i-traits identified at multiple growth stages may be used as potential indicators for final PH in maize.One candidate gene,ZmVATE,was functionally validated and shown to regulate PH-related traits in maize using genetic mutation.Furthermore,machine learning was used to build predictive models for final PH based on i-traits,and their performancewas assessed across developmental stages.Moderate,strong,and very strong correlations between predictions and experimental datasets were achieved from the early S4(tenth-leaf)stage.Colletively,our study provides a valuable tool for dissecting the spatiotemporal formation of specific internodes and the genetic architecture of PH,as well as resources and predictive models that are useful for molecular design breeding and predicting maize varieties with i
基金Supported by the National High Technology Research and Development Program of China(2013AA065301)the Fundamental Research Funds for the Central Universities(2016QNA4014)the State Key Laboratory of Clean Energy Utilization at Zhejiang University(ZJUCEU2016006)
文摘A reliable mathematical model of urea-water-solution(UWS) droplet evaporation and thermolysis is developed.The well known Abramzon–Sirignano evaporation model is corrected by introducing an adjustment coefficient considering the different evaporation behaviors of UWS droplet at different ambient temperatures. A semidetailed kinetic scheme of urea thermolysis is developed based on Ebrahimian's work. Sequentially, the evaporation characteristics, decomposition efficiency of a single UWS droplet and deposit formation are simulated. As a result, the relation of evaporation time, relative velocity, exhaust temperature and droplet initial diameter is presented. Synchronously, it indicates that temperature is the decisive factor for urea thermolysis. Different temperatures result in different deposit components, and deposit yield is significantly influenced by temperature and decomposition time. The current work can provide guidance for designing urea injection strategy of SCR systems.
基金supported by grants from the National Natural Science Foundation (Grant Number 81972675 to T.Z.M.)。
文摘Background and Aims:Chronic hepatitis caused by hepatitis B virus(HBV)infection is a leading cause of hepatocellular carcinoma(HCC).We investigated the roles of oncogenic HBV infection-associated long noncoding RNAs in HCC.Methods:Bioinformatics analysis of data from the Cancer Genome Atlas(TCGA)was performed to screen potential oncogenic HBV-related lncRNAs.Next,we assessed their expression in clinical samples and investigated their correlation with clinical characteristics.The detailed oncogenic effects were analyzed by performing in vitro and in vivo studies.Results:RP11-40C6.2,an HBV infection-related lncRNA,was identified by analysis of the TCGA–Liver Hepatocellular Carcinoma database.Gene Set Enrichment Analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis of differentially expressed genes revealed a strong association of RP11-40C6.2 with the Hippo signaling pathway.RP11-40C6.2 was overexpressed in HCC patients with HBV infection compared to those without HBV infection.RP11-40C6.2 transcription showed a positive association with HBV-X protein(HBx),but not HBV core protein(HBc)expression,both of which are carcinogenic proteins.Luciferase gene reporter and ChIP assays revealed that YAP1/TAZ/TEADs complex enhanced RP11-40C6.2 transcription by binding to its promoter area.RP11-40C6.2 showed oncogenic characteristics in HCC cell lines and in animal models that were mediated via activation of YAP1.In vitro ubiquitylation assay revealed that RP11-40C6.2 can promote the stabilization of YAP1 by stopping phosphorylation at its s127 residue and further stopping its degradation through binding to 14-3-3.Conclusions:RP11-40C6.2 is an HBV infection-related lncRNA that exerts its oncogenic effects by targeting the Hippo signaling pathway.
