Due to the spatial characteristics of orbital angular momentum,vortex fields can be applied in the fields of quantum storage and quantum information.We study the realization of spatially modulated vortex fields based ...Due to the spatial characteristics of orbital angular momentum,vortex fields can be applied in the fields of quantum storage and quantum information.We study the realization of spatially modulated vortex fields based on four-wave mixing in a four-level atomic system with a diamond structure.The intensity and spiral phase of the vortex field are effectively transferred to the generated four-wave mixing field.By changing the detuning of the probe field,the phase and intensity of the generated vertex four-wave mixing field can be changed.When the probe field takes a large detuning value,the spatial distribution of the intensity and phase of the vertex four-wave mixing field can be effectively tuned by adjusting the Rabi frequency or detuning value of the coupled field.At the same time,we also provide a detailed explanation based on the dispersion relationship,and the results agree well with our simulation results.展开更多
A high-power CW Yb:YAG slab laser amplifier with no adaptive optics correction has been experimentally established.At room temperature,the amplifier emits a power of 22 kW with an average beam quality(β)of less than ...A high-power CW Yb:YAG slab laser amplifier with no adaptive optics correction has been experimentally established.At room temperature,the amplifier emits a power of 22 kW with an average beam quality(β)of less than 3 in 0.5 min.To our knowledge,this is the brightest slab laser without closed-loop adaptive optics demonstrated to date.In addition,an extracted power of 17 kW with an optical extraction efficiency of 33%,corresponding to a residual optical path difference of less than 0.5μm,is achieved with the single Yb:YAG slab gain module.The slab gain module has the potential to be scalable to higher powers while maintaining good beam quality.This makes a high-power solid-state laser system simpler and more robust.展开更多
Background: With the development of high quality nursing service, hospitals put forward higher requirements for nurses’ service level. In recent years, the number and quality of specialized nurses remain to be improv...Background: With the development of high quality nursing service, hospitals put forward higher requirements for nurses’ service level. In recent years, the number and quality of specialized nurses remain to be improved despite the remarkable achievements in the construction of specialized nurses. Objective: This study intended to explore a standardized training mode for nurses oriented by training and assessment of nursespecialty knowledge and to summarize the practical experience of this mode. Methods: The training and assessment program was formulated by starting from the objectives of training clinical front-line nursing staff in our hospital, and the standard training and assessment were carried out from four aspects: the specialized disease knowledge, the condition observation and reporting ability, emergency and severe disease nursing, and perioperative accelerated rehabilitation guidance. These four items are hereinafter referred to as “Four Passes” training and assessment, and it was practiced in the assessment and training of nurses in our hospital from 2020 to 2022. Results: A total of 915 front-line caregivers were surveyed in our study, including 772 nurses and 143 doctors. After two years of implementation, the self-evaluation of nurses increased from (2.96 ± 0.79) points to (3.64 ± 0.78) points, and the evaluation score by doctors increased from (3.94 ± 0.74) points to (4.26 ± 0.72) points. The core competence of specialty increased from (69.22 ± 16.53) points to (85.42 ± 14.44) points. The scores of all dimensions after training were higher than those before training, with statistical significances. Conclusion: The “Four Passes” training and assessment of nurse specialty knowledge can fully mobilize the enthusiasm of managers and nurses in all departments, ensure solid specialty knowledge, improve nurses’ core competence, improve nursing quality, and create a harmonious relationship between nurses and patients as well as between doctors and patients.展开更多
[目的]筛选出在肺癌组织中特异性表达的长链非编码RNA(lncRNA),并探讨其在肺癌中的表达水平与患者预后的相关性。[方法]从癌症基因组图谱(the cancer genome atlas,TCGA)下载肺癌临床病理和基因表达谱信息。以|Fold Change|>2和校正...[目的]筛选出在肺癌组织中特异性表达的长链非编码RNA(lncRNA),并探讨其在肺癌中的表达水平与患者预后的相关性。[方法]从癌症基因组图谱(the cancer genome atlas,TCGA)下载肺癌临床病理和基因表达谱信息。以|Fold Change|>2和校正后的P值(FDR)<0.05为标准筛选差异表达的lncRNA。对差异表达显著的FOXD3-AS1进行RNA结合蛋白(RBP)预测,并用关联矩阵法构建差异表达的lncRNA-RBP-mRNA共表达网络,继而对共表达mRNA进行Kyoto Encyclopedia of Genes and Genomes(KEGG)通路富集分析;通过Kaplan-Meier Plotter方法研究FOXD3-AS1与预后相关性。[结果]共筛选出1 362个在肺癌中差异表达的lncRNA,其中表达上调的1 184个,表达下调的178个。与FOXD3-AS1具有共表达关系的mRNA共有11个。KEGG分析这些共表达的mRNA主要富集在黏着连接、结肠直肠癌和松弛素信号通路,RBP预测发现FOXD3-AS1可以与人丝氨酸/精氨酸富有剪接因子SRSF1结合。FOXD3-AS1与肺癌患者生存曲线具有极显著相关性(P<0.01)。[结论]SRSF1居于lncRNA-RBP-mRNA共表达网络的核心位置,在肺癌的发生、发展中起到重要的调控作用,有望成为肺癌免疫治疗的分子靶标。差异表达的FOXD3-AS1可以很好地判断肺癌患者的预后,因此,可以作为潜在的肺癌检测分子标志物。展开更多
We demonstrate coherent optical frequency dissemination over a distance of 972 km by cascading two spans where the phase noise is passively compensated for.Instead of employing a phase discriminator and a phase lockin...We demonstrate coherent optical frequency dissemination over a distance of 972 km by cascading two spans where the phase noise is passively compensated for.Instead of employing a phase discriminator and a phase locking loop in the conventional active phase control scheme,the passive phase noise cancellation is realized by feeding double-trip beat-note frequency to the driver of the acoustic optical modulator at the local site.This passive scheme exhibits fine robustness and reliability,making it suitable for long-distance and noisy fiber links.An optical regeneration station is used in the link for signal amplification and cascaded transmission.The phase noise cancellation and transfer instability of the 972-km link is investigated,and transfer instability of 1.1×10^(-19)at 10^(4)s is achieved.This work provides a promising method for realizing optical frequency distribution over thousands of kilometers by using fiber links.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant Nos.11704151 and 11247201)the Twelfth Five-year Program for Science and Technology of Education Department of Jilin Province (Grant No.20150215)。
文摘Due to the spatial characteristics of orbital angular momentum,vortex fields can be applied in the fields of quantum storage and quantum information.We study the realization of spatially modulated vortex fields based on four-wave mixing in a four-level atomic system with a diamond structure.The intensity and spiral phase of the vortex field are effectively transferred to the generated four-wave mixing field.By changing the detuning of the probe field,the phase and intensity of the generated vertex four-wave mixing field can be changed.When the probe field takes a large detuning value,the spatial distribution of the intensity and phase of the vertex four-wave mixing field can be effectively tuned by adjusting the Rabi frequency or detuning value of the coupled field.At the same time,we also provide a detailed explanation based on the dispersion relationship,and the results agree well with our simulation results.
基金supported by the National Key Research and Development Project(2018YFB1502401 and 2018YFA0702002)the Program for Changjiang Scholars and Innovation Research Team in the University(IRT1205)+1 种基金the Fundamental Research Funds for the Central Universitiesthe long-term subsidy mechanism from the Ministry of Finance and the Ministry of Education of China。
基金supported by the Joint Fund of the National Natural Science Foundation of China and the China Academy of Engineering Physics(No.U1830132)the National Natural Science Foundation of China(No.62105313)。
文摘A high-power CW Yb:YAG slab laser amplifier with no adaptive optics correction has been experimentally established.At room temperature,the amplifier emits a power of 22 kW with an average beam quality(β)of less than 3 in 0.5 min.To our knowledge,this is the brightest slab laser without closed-loop adaptive optics demonstrated to date.In addition,an extracted power of 17 kW with an optical extraction efficiency of 33%,corresponding to a residual optical path difference of less than 0.5μm,is achieved with the single Yb:YAG slab gain module.The slab gain module has the potential to be scalable to higher powers while maintaining good beam quality.This makes a high-power solid-state laser system simpler and more robust.
文摘Background: With the development of high quality nursing service, hospitals put forward higher requirements for nurses’ service level. In recent years, the number and quality of specialized nurses remain to be improved despite the remarkable achievements in the construction of specialized nurses. Objective: This study intended to explore a standardized training mode for nurses oriented by training and assessment of nursespecialty knowledge and to summarize the practical experience of this mode. Methods: The training and assessment program was formulated by starting from the objectives of training clinical front-line nursing staff in our hospital, and the standard training and assessment were carried out from four aspects: the specialized disease knowledge, the condition observation and reporting ability, emergency and severe disease nursing, and perioperative accelerated rehabilitation guidance. These four items are hereinafter referred to as “Four Passes” training and assessment, and it was practiced in the assessment and training of nurses in our hospital from 2020 to 2022. Results: A total of 915 front-line caregivers were surveyed in our study, including 772 nurses and 143 doctors. After two years of implementation, the self-evaluation of nurses increased from (2.96 ± 0.79) points to (3.64 ± 0.78) points, and the evaluation score by doctors increased from (3.94 ± 0.74) points to (4.26 ± 0.72) points. The core competence of specialty increased from (69.22 ± 16.53) points to (85.42 ± 14.44) points. The scores of all dimensions after training were higher than those before training, with statistical significances. Conclusion: The “Four Passes” training and assessment of nurse specialty knowledge can fully mobilize the enthusiasm of managers and nurses in all departments, ensure solid specialty knowledge, improve nurses’ core competence, improve nursing quality, and create a harmonious relationship between nurses and patients as well as between doctors and patients.
文摘[目的]筛选出在肺癌组织中特异性表达的长链非编码RNA(lncRNA),并探讨其在肺癌中的表达水平与患者预后的相关性。[方法]从癌症基因组图谱(the cancer genome atlas,TCGA)下载肺癌临床病理和基因表达谱信息。以|Fold Change|>2和校正后的P值(FDR)<0.05为标准筛选差异表达的lncRNA。对差异表达显著的FOXD3-AS1进行RNA结合蛋白(RBP)预测,并用关联矩阵法构建差异表达的lncRNA-RBP-mRNA共表达网络,继而对共表达mRNA进行Kyoto Encyclopedia of Genes and Genomes(KEGG)通路富集分析;通过Kaplan-Meier Plotter方法研究FOXD3-AS1与预后相关性。[结果]共筛选出1 362个在肺癌中差异表达的lncRNA,其中表达上调的1 184个,表达下调的178个。与FOXD3-AS1具有共表达关系的mRNA共有11个。KEGG分析这些共表达的mRNA主要富集在黏着连接、结肠直肠癌和松弛素信号通路,RBP预测发现FOXD3-AS1可以与人丝氨酸/精氨酸富有剪接因子SRSF1结合。FOXD3-AS1与肺癌患者生存曲线具有极显著相关性(P<0.01)。[结论]SRSF1居于lncRNA-RBP-mRNA共表达网络的核心位置,在肺癌的发生、发展中起到重要的调控作用,有望成为肺癌免疫治疗的分子靶标。差异表达的FOXD3-AS1可以很好地判断肺癌患者的预后,因此,可以作为潜在的肺癌检测分子标志物。
基金funded by the National Natural Science Foundation of China(grant number:72204209)the China Health Talents Training Project(grant number:RCLX2320050).
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12103059,12033007,12303077,and 12303076)the Fund from the Xi’an Science and Technology Bureau,China(Grant No.E019XK1S04)the Fund from the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Grant No.1188000XGJ).
文摘We demonstrate coherent optical frequency dissemination over a distance of 972 km by cascading two spans where the phase noise is passively compensated for.Instead of employing a phase discriminator and a phase locking loop in the conventional active phase control scheme,the passive phase noise cancellation is realized by feeding double-trip beat-note frequency to the driver of the acoustic optical modulator at the local site.This passive scheme exhibits fine robustness and reliability,making it suitable for long-distance and noisy fiber links.An optical regeneration station is used in the link for signal amplification and cascaded transmission.The phase noise cancellation and transfer instability of the 972-km link is investigated,and transfer instability of 1.1×10^(-19)at 10^(4)s is achieved.This work provides a promising method for realizing optical frequency distribution over thousands of kilometers by using fiber links.
