Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell c...Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell carcinoma have been changing. Research into HPVrelated oropharyngeal squamous cell carcinoma is rapidly expanding, however many molecular pathological and clinical aspects of the role of HPV remain uncertain and are the subject of ongoing investigation. A detailed search of the literature pertaining to HPV-related oropharyngeal squamous cell carcinoma was performed and information on the topic was gathered. In this article, we present an extensive review of the current literature on the role of HPV in oropharyngeal squamous cell carcinoma, particularly in relation to epidemiology, risk factors, carcinogenesis, biomarkers and clinicalimplications. HPV has been established as a causative agent in oropharyngeal squamous cell carcinoma and biologically active HPV can act as a prognosticator with better overall survival than HPV-negative tumours. A distinct group of younger patients with limited tobacco and alcohol exposure have emerged as characteristic of this HPV-related subset of squamous cell carcinoma of the head and neck. However, the exact molecular mechanisms of carcinogenesis are not completely understood and further studies are needed to assist development of optimal prevention and treatment modalities.展开更多
BACKGROUND Incidental pulmonary nodules are an increasingly common finding on computed tomography(CT)scans of the thorax due to the exponential rise in CT examin-ations in everyday practice.The majority of incidental ...BACKGROUND Incidental pulmonary nodules are an increasingly common finding on computed tomography(CT)scans of the thorax due to the exponential rise in CT examin-ations in everyday practice.The majority of incidental pulmonary nodules are benign and correctly identifying the small number of malignant nodules is cha-llenging.Ultra-low-dose CT(ULDCT)has been shown to be effective in diagnosis of respiratory pathology in comparison with traditional standard dose techniques.Our hypothesis was that ULDCT chest combined with model-based iterative reconstruction(MBIR)is comparable to standard dose CT(SDCT)chest in the analysis of pulmonary nodules with significant reduction in radiation dose.AIM To prospectively compare ULDCT chest combined with MBIR with SDCT chest in the analysis of solid pulmonary nodules.METHODS A prospective cohort study was conducted on adult patients(n=30)attending a respiratory medicine outpatient clinic in a tertiary referral university hospital for surveillance of previously detected indeterminate pulmonary nodules on SDCT chest.This study involved the acquisition of a reference SDCT chest followed immediately by an ULDCT chest.Nodule identification,nodule characterisation,nodule measurement,objective and subjective image quality and radiation dose were compared between ULDCT with MBIR and SDCT chest.RESULTS One hundred solid nodules were detected on ULDCT chest and 98 on SDCT chest.There was no significant difference in the characteristics of correctly identified nodules when comparing SDCT chest to ULDCT chest protocols.Signal-to-noise ratio was significantly increased in the ULDCT chest in all areas except in the paraspinal muscle at the maximum cardiac diameter level(P<0.001).The mean subjective image quality score for overall diagnostic acceptability was 8.9/10.The mean dose length product,computed tomography volume dose index and effective dose for the ULDCT chest protocol were 5.592 mGy.cm,0.16 mGy and 0.08 mSv respectively.These were significantly less than the SDCT chest protocol(P<0.展开更多
The existence of common fixed points and invariant approximations for pointwise R- subweakly commuting and compatible maps is established. Our results unify and generalize various known results to a more general class...The existence of common fixed points and invariant approximations for pointwise R- subweakly commuting and compatible maps is established. Our results unify and generalize various known results to a more general class of noncommuting mappings.展开更多
Nonlinear delay Caputo fractional differential equations with non-instantaneous impulses are studied and we consider the general case of delay,depending on both the time and the state variable.The case when the lower ...Nonlinear delay Caputo fractional differential equations with non-instantaneous impulses are studied and we consider the general case of delay,depending on both the time and the state variable.The case when the lower limit of the Caputo fractional derivative is fixed at the initial time,and the case when the lower limit of the fractional derivative is changed at the end of each interval of action of the impulse are studied.Practical stability properties,based on the modified Razumikhin method are investigated.Several examples are given in this paper to illustrate the results.展开更多
In this paper,we study some new fractional-order multi-agent systems with current and delay states (FMASCD).Using the generalized Nyquist's stability criterion and Gerschgorin's circle theorem,we obtain the bo...In this paper,we study some new fractional-order multi-agent systems with current and delay states (FMASCD).Using the generalized Nyquist's stability criterion and Gerschgorin's circle theorem,we obtain the bounded input-bounded output (BIBO) stability and asymptotical consensus of the FMASCD under mild conditions.Moreover,we give some numerical examples to illustrate our main results.展开更多
A new upper and lower solution theory is presented for the second order problem （G＇（y））＇＋ f（t, y） = 0 on finite and infinite intervals. The theory on finite intervals is based on a Leray-Schauder alternative,...A new upper and lower solution theory is presented for the second order problem （G＇（y））＇＋ f（t, y） = 0 on finite and infinite intervals. The theory on finite intervals is based on a Leray-Schauder alternative, where as the theory on infinite intervals is based on results on the finite interval and a diagonalization process.展开更多
Differential tigated. We study the properties of solutions sufficient conditions for equations with impulses at random moments are set up and invescase of Gamma distributed random moments of impulses. Several are stud...Differential tigated. We study the properties of solutions sufficient conditions for equations with impulses at random moments are set up and invescase of Gamma distributed random moments of impulses. Several are studied based on properties of Gammma distributions. Some p-moment exponential stability of the solutions are given.展开更多
This paper discusses both the nonexistence of positive solutions for second-order three-point boundary value problems when the nonlinear term f（t, x, y） is superlinear in y at y = 0 and the existence of multiple pos...This paper discusses both the nonexistence of positive solutions for second-order three-point boundary value problems when the nonlinear term f（t, x, y） is superlinear in y at y = 0 and the existence of multiple positive solutions for second-order three-point boundary value problems when the nonlinear term f（t, x,y） is superlinear in x at ＋∞.展开更多
By employing the generalized Riccati transformation technique,we will establish some new oscillation criteria and study the asymptotic behavior of the nonoscillatory solutions of the second-order nonlinear neutral del...By employing the generalized Riccati transformation technique,we will establish some new oscillation criteria and study the asymptotic behavior of the nonoscillatory solutions of the second-order nonlinear neutral delay dynamic equation [r(t)[y(t)+p(t)y(■(t))]~Δ]~Δ+q(t)f(y((δ(t)))=0 on a time scale■.The results improve some oscillation results for neutral delay dynamic equations and in the special case when■our results cover and improve the oscillation results for second- order neutral delay differential equations established by Li and Liu[Canad.J.Math.,48(1996), 871 886].When■,our results cover and improve the oscillation results for second order neutral delay difference equations established by Li and Yeh[Comp.Math.Appl.,36(1998),123-132].When ■ ■our results are essentially new.Some examples illustrating our main results are given.展开更多
AIM: To review the use of the Months Backwards Test(MBT) in clinical and research contexts.METHODS: We conducted a systematic review of reports relating to the MBT based upon a search of Psych INFO and MEDLINE between...AIM: To review the use of the Months Backwards Test(MBT) in clinical and research contexts.METHODS: We conducted a systematic review of reports relating to the MBT based upon a search of Psych INFO and MEDLINE between January 1980 and December 2014. Only reports that specifically described findings pertaining to the MBT were included. Findings were considered in terms of rating procedures, testing performance, psychometric properties, neuropsychological studies and use in clinical populations.RESULTS: We identified 22 data reports. The MBT is administered and rated in a variety of ways with very little consistency across studies. It has been used to assess various cognitive functions including focused and sustained attention as well as central processingspeed. Performance can be assessed in terms of the ability to accurately complete the test without errors("MB accuracy"), and time taken to complete the test("MB duration"). Completion time in cognitively intact subjects is usually < 20 s with upper limits of 60-90 s typically applied in studies. The majority of cognitively intact adults can complete the test without error such that any errors of omission are strongly suggestive of cognitive dysfunction. Coverage of clinical populations, including those with significant cognitive difficulties is high with the majority of subjects able to engage with MBT procedures. Performance correlates highly with other cognitive tests, especially of attention, including the digit span backwards, trailmaking test B, serial threes and sevens, tests of simple and complex choice reaction time, delayed story recall and standardized list learning measures. Test-retest and inter-rater reliability are high(both > 0.90). Functional magnetic resonance imaging studies comparing the months forward test and MBT indicate greater involvement of more complex networks(bilateral middle and inferior frontal gyri, the posterior parietal cortex and the left anterior cingulate gyrus) for backwards cognitive processing. The MBT has been usefully appl展开更多
New oscillation criteria for general differential equations of the form x^（n）（t）＋pn-1 （t）x^（n-1）（t）＋…＋P1（t）x′（t）＋p0（t）x（t）＋q1（t）x^μ （t） = q2 （t）x^λ （t）＋e（t） where λ,μ are the ra...New oscillation criteria for general differential equations of the form x^（n）（t）＋pn-1 （t）x^（n-1）（t）＋…＋P1（t）x′（t）＋p0（t）x（t）＋q1（t）x^μ （t） = q2 （t）x^λ （t）＋e（t） where λ,μ are the ratios of positive odd integers, 0 〈 μ 〈 1 and λ 〉 1 are established.展开更多
Some coincidence point theorems satisfying a general contractive condition are proved. As applications, some invariant approximation results are also obtained and several related results in the literature are either e...Some coincidence point theorems satisfying a general contractive condition are proved. As applications, some invariant approximation results are also obtained and several related results in the literature are either extended or improved.展开更多
In this paper we establish some new dynamic inequalities on time scales which contain in particular generalizations of integral and discrete inequalities due to Hardy, Littlewood, Polya, D＇Apuzzo, Sbordone and Popoli...In this paper we establish some new dynamic inequalities on time scales which contain in particular generalizations of integral and discrete inequalities due to Hardy, Littlewood, Polya, D＇Apuzzo, Sbordone and Popoli. We also apply these inequalities to prove a higher integrability theorem for decreasing functions on time scales.展开更多
文摘Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell carcinoma have been changing. Research into HPVrelated oropharyngeal squamous cell carcinoma is rapidly expanding, however many molecular pathological and clinical aspects of the role of HPV remain uncertain and are the subject of ongoing investigation. A detailed search of the literature pertaining to HPV-related oropharyngeal squamous cell carcinoma was performed and information on the topic was gathered. In this article, we present an extensive review of the current literature on the role of HPV in oropharyngeal squamous cell carcinoma, particularly in relation to epidemiology, risk factors, carcinogenesis, biomarkers and clinicalimplications. HPV has been established as a causative agent in oropharyngeal squamous cell carcinoma and biologically active HPV can act as a prognosticator with better overall survival than HPV-negative tumours. A distinct group of younger patients with limited tobacco and alcohol exposure have emerged as characteristic of this HPV-related subset of squamous cell carcinoma of the head and neck. However, the exact molecular mechanisms of carcinogenesis are not completely understood and further studies are needed to assist development of optimal prevention and treatment modalities.
文摘BACKGROUND Incidental pulmonary nodules are an increasingly common finding on computed tomography(CT)scans of the thorax due to the exponential rise in CT examin-ations in everyday practice.The majority of incidental pulmonary nodules are benign and correctly identifying the small number of malignant nodules is cha-llenging.Ultra-low-dose CT(ULDCT)has been shown to be effective in diagnosis of respiratory pathology in comparison with traditional standard dose techniques.Our hypothesis was that ULDCT chest combined with model-based iterative reconstruction(MBIR)is comparable to standard dose CT(SDCT)chest in the analysis of pulmonary nodules with significant reduction in radiation dose.AIM To prospectively compare ULDCT chest combined with MBIR with SDCT chest in the analysis of solid pulmonary nodules.METHODS A prospective cohort study was conducted on adult patients(n=30)attending a respiratory medicine outpatient clinic in a tertiary referral university hospital for surveillance of previously detected indeterminate pulmonary nodules on SDCT chest.This study involved the acquisition of a reference SDCT chest followed immediately by an ULDCT chest.Nodule identification,nodule characterisation,nodule measurement,objective and subjective image quality and radiation dose were compared between ULDCT with MBIR and SDCT chest.RESULTS One hundred solid nodules were detected on ULDCT chest and 98 on SDCT chest.There was no significant difference in the characteristics of correctly identified nodules when comparing SDCT chest to ULDCT chest protocols.Signal-to-noise ratio was significantly increased in the ULDCT chest in all areas except in the paraspinal muscle at the maximum cardiac diameter level(P<0.001).The mean subjective image quality score for overall diagnostic acceptability was 8.9/10.The mean dose length product,computed tomography volume dose index and effective dose for the ULDCT chest protocol were 5.592 mGy.cm,0.16 mGy and 0.08 mSv respectively.These were significantly less than the SDCT chest protocol(P<0.
基金Supported by the National Natural Science Foundation of China(11601048) Natural Science Foundation of Chongqing(cstc2016jcyj A0181)+1 种基金 the Science and Technology Research Program of Chongqing Municipal Education Commission(KJ1703050) Natural Science Found
文摘The existence of common fixed points and invariant approximations for pointwise R- subweakly commuting and compatible maps is established. Our results unify and generalize various known results to a more general class of noncommuting mappings.
基金supported by Portuguese funds through the CIDMA-Center for Research and Development in Mathematics and Applicationsthe Portuguese Foundation for Science and Technology(FCT-Fundação para a Ciência e a Tecnologia),within project UIDB/04106/2020Fund Scientific Research MU21FMI007,University of Plovdiv"Paisii Hilendarski".
文摘Nonlinear delay Caputo fractional differential equations with non-instantaneous impulses are studied and we consider the general case of delay,depending on both the time and the state variable.The case when the lower limit of the Caputo fractional derivative is fixed at the initial time,and the case when the lower limit of the fractional derivative is changed at the end of each interval of action of the impulse are studied.Practical stability properties,based on the modified Razumikhin method are investigated.Several examples are given in this paper to illustrate the results.
基金Project supported by the National Natural Science Foundation of China(Nos.11471230 and11671282)
文摘In this paper,we study some new fractional-order multi-agent systems with current and delay states (FMASCD).Using the generalized Nyquist's stability criterion and Gerschgorin's circle theorem,we obtain the bounded input-bounded output (BIBO) stability and asymptotical consensus of the FMASCD under mild conditions.Moreover,we give some numerical examples to illustrate our main results.
基金Supported by Grant No.201/01/1451 of the Grant Agency of Czech Republicthe Council of Czech Government J14/98:153100011
文摘A new upper and lower solution theory is presented for the second order problem （G＇（y））＇＋ f（t, y） = 0 on finite and infinite intervals. The theory on finite intervals is based on a Leray-Schauder alternative, where as the theory on infinite intervals is based on results on the finite interval and a diagonalization process.
基金partially supported by Fund Scientific Research MU15FMIIT008,Plovdiv University
文摘Differential tigated. We study the properties of solutions sufficient conditions for equations with impulses at random moments are set up and invescase of Gamma distributed random moments of impulses. Several are studied based on properties of Gammma distributions. Some p-moment exponential stability of the solutions are given.
基金Supported by the National Natural Science Foundation of China(No.10571111)the fund of Shandong Education Committee(J07WH08).
文摘This paper discusses both the nonexistence of positive solutions for second-order three-point boundary value problems when the nonlinear term f（t, x, y） is superlinear in y at y = 0 and the existence of multiple positive solutions for second-order three-point boundary value problems when the nonlinear term f（t, x,y） is superlinear in x at ＋∞.
文摘By employing the generalized Riccati transformation technique,we will establish some new oscillation criteria and study the asymptotic behavior of the nonoscillatory solutions of the second-order nonlinear neutral delay dynamic equation [r(t)[y(t)+p(t)y(■(t))]~Δ]~Δ+q(t)f(y((δ(t)))=0 on a time scale■.The results improve some oscillation results for neutral delay dynamic equations and in the special case when■our results cover and improve the oscillation results for second- order neutral delay differential equations established by Li and Liu[Canad.J.Math.,48(1996), 871 886].When■,our results cover and improve the oscillation results for second order neutral delay difference equations established by Li and Yeh[Comp.Math.Appl.,36(1998),123-132].When ■ ■our results are essentially new.Some examples illustrating our main results are given.
基金Supported by Health Research Board(Ireland)Funding(HRA-POR-2011-48)
文摘AIM: To review the use of the Months Backwards Test(MBT) in clinical and research contexts.METHODS: We conducted a systematic review of reports relating to the MBT based upon a search of Psych INFO and MEDLINE between January 1980 and December 2014. Only reports that specifically described findings pertaining to the MBT were included. Findings were considered in terms of rating procedures, testing performance, psychometric properties, neuropsychological studies and use in clinical populations.RESULTS: We identified 22 data reports. The MBT is administered and rated in a variety of ways with very little consistency across studies. It has been used to assess various cognitive functions including focused and sustained attention as well as central processingspeed. Performance can be assessed in terms of the ability to accurately complete the test without errors("MB accuracy"), and time taken to complete the test("MB duration"). Completion time in cognitively intact subjects is usually < 20 s with upper limits of 60-90 s typically applied in studies. The majority of cognitively intact adults can complete the test without error such that any errors of omission are strongly suggestive of cognitive dysfunction. Coverage of clinical populations, including those with significant cognitive difficulties is high with the majority of subjects able to engage with MBT procedures. Performance correlates highly with other cognitive tests, especially of attention, including the digit span backwards, trailmaking test B, serial threes and sevens, tests of simple and complex choice reaction time, delayed story recall and standardized list learning measures. Test-retest and inter-rater reliability are high(both > 0.90). Functional magnetic resonance imaging studies comparing the months forward test and MBT indicate greater involvement of more complex networks(bilateral middle and inferior frontal gyri, the posterior parietal cortex and the left anterior cingulate gyrus) for backwards cognitive processing. The MBT has been usefully appl
文摘New oscillation criteria for general differential equations of the form x^（n）（t）＋pn-1 （t）x^（n-1）（t）＋…＋P1（t）x′（t）＋p0（t）x（t）＋q1（t）x^μ （t） = q2 （t）x^λ （t）＋e（t） where λ,μ are the ratios of positive odd integers, 0 〈 μ 〈 1 and λ 〉 1 are established.
文摘Some coincidence point theorems satisfying a general contractive condition are proved. As applications, some invariant approximation results are also obtained and several related results in the literature are either extended or improved.
文摘In this paper we establish some new dynamic inequalities on time scales which contain in particular generalizations of integral and discrete inequalities due to Hardy, Littlewood, Polya, D＇Apuzzo, Sbordone and Popoli. We also apply these inequalities to prove a higher integrability theorem for decreasing functions on time scales.
