Ternary Ti-B-N coatings were synthesized on AISI 304 and Si wafer by plasma-enhanced chemical vapor deposition (PECVD) technique using a gaseous mixture of TiCl4,BCl3,H2,N2,and Ar.By virtue of X-ray diffraction analys...Ternary Ti-B-N coatings were synthesized on AISI 304 and Si wafer by plasma-enhanced chemical vapor deposition (PECVD) technique using a gaseous mixture of TiCl4,BCl3,H2,N2,and Ar.By virtue of X-ray diffraction analysis,X-ray photoelectron spectroscopy,scanning electron microscope,and high-resolution transmission electron microscope,the influences of B content on the microstructure and properties of Ti B N coatings were investigated systematically.The results indicated that the microstructure and mechanical properties of Ti-B-N coatings largely depend on the transformation from FCC-TiN phase to HCP-TiB2 phase.With increasing B content and decreasing N content in the coatings,the coating microstructure evolves gradually from FCC-TiN/a-BN to HCP-TiB2 /a-BN via FCC-TiN+HCP-TiB2/a-BN.The highest microhardness of about 34 GPa is achieved,which corresponds to the nanocomposite Ti-63%B-N (mole fraction) coating consisting of the HCP-TiB2 nano-crystallites and amorphous BN phase.The lowest friction-coefficient was observed for the nanocomposite Ti-41%B-N (mole fraction) coating consisting of the FCC-TiN nanocrystallites and amorphous BN展开更多
The CrN and Cr-Al-Si-N films were deposited on Si wafer and SUS 304 substrates by a hybrid coating system with high power impulse magnetron sputtering (HIPIMS) and a DC pulse sputtering using Cr and AlSi targets under...The CrN and Cr-Al-Si-N films were deposited on Si wafer and SUS 304 substrates by a hybrid coating system with high power impulse magnetron sputtering (HIPIMS) and a DC pulse sputtering using Cr and AlSi targets under N2/Ar atmosphere.By varying the sputtering current of the AlSi target in the range of 0-2.5 A,both the Al and Si contents in the films increased gradually from 0 to 19.1% and 11.1% (mole fraction),respectively.The influences of the AlSi cathode DC pulse current on the microstructure,phase constituents,mechanical properties,and oxidation behaviors of the Cr-Al-Si-N films were investigated systematically.The results indicate that the as-deposited Cr-Al-Si-N films possess the typical nanocomposite structure,namely the face centered cubic (Cr,Al)N nano-crystallites are embedded in the amorphous Si3N4 matrix.With increasing the Al and Si contents,the hardness of the film first increases from 20.8 GPa for the CrN film to the peak value of 29.4 GPa for the Cr0.23Al0.14Si0.07 N film,and then decreases gradually.In the meanwhile,the Cr0.23Al0.14Si0.07N film also possesses excellent high-temperature oxidation resistance that is much better than that of the CrN film at 900 or 1000 °C.展开更多
AIM:To explore the impact of fecal incontinence (FI) on quality of life (QOL) of patients attending urogynecology and colorectal clinics (CCs).METHODS:Cross-sectional study of 154 patients (27 male) with FI,who attend...AIM:To explore the impact of fecal incontinence (FI) on quality of life (QOL) of patients attending urogynecology and colorectal clinics (CCs).METHODS:Cross-sectional study of 154 patients (27 male) with FI,who attended the clinics at a regional hospital in North Queensland,Australia in 2003 and 2004,and completed the Fecal Incontinence Quality of Life Scale (FIQL:1=very affected;4=not affected).RESULTS:More than 22% of patients had their QOL affected severely by FI.Patients reported that they had not previously been asked about FI by a medical practitioner nor did they voluntarily disclose its presence.The median FIQL scores for all participants were:lifestyle=3.24;coping=2.23;depression=2.42;and embarrassment=2.33.Increasing frequency of soiling had a negative effect on all four FIQL scales (P < 0.001) as did the quantity of soiling (P < 0.01).Female CC patients had poorer FIQL scores than urogynecology clinic patients for lifestyle (P=0.015),coping (P=0.004) and embarrassment (P=0.009),but not depression (P=0.062),despite having experienced FI for a shorter period.CONCLUSION:Failure to seek treatment for FI degrades the quality of patients' lives over time.FI assessment tools should incorporate the quantity of fecal loss.展开更多
AIM: To evaluate the diagnostic efficiency of endoscopic ultrasound (EUS) as the main imaging modality in patients with moderate suspicion of common bile duct stones (CBDS).METHODS: 55 patients with moderate clinical ...AIM: To evaluate the diagnostic efficiency of endoscopic ultrasound (EUS) as the main imaging modality in patients with moderate suspicion of common bile duct stones (CBDS).METHODS: 55 patients with moderate clinical suspicion of CBDS were prospectively included to the study and evaluated with EUS. This study was done in single blind method in the clinical and biochemical data of patients. EUS was done with echo-endoscope Pentax FG 32-UA (f=5-7,5 MHz) and Hitachi EUB 405 ultrasound machine. Patients diagnosed with CBDS by EUS were excluded from this study and treated with ERC. All the other patients were included to the follow up study obtained by mail every 6 months for clinical evaluation (need of ERC or surgery).RESULTS: CBDS was found in 4 patients by EUS. Diagnosis was confirmed in all cases on ERC. The remaining 51 patients without CBDS on EUS were followed up for 6-26 months (meanly 13 months) There were: 40 women, 42cholecystectomized patients, aged: 55 (mean). Biochemical values (mean values) were as follows: bilirubin: 14,9 μmol.L-1,alkaline phosphatase: 95 IU.L-,1 γ-GTP: 131 IU.L-1, ALT: 50IU.L-1, AST: 49 IU.L-1, Only 1 patient was lost for follow up.In the remaining 50 patients with follow up, there was only 1 (2 %) patient with persistent biliary symptoms in whom CBDS was finally diagnosed by ERC with ES. All other patients remained symptoms free on follow up and did not require ERC or biliary surgery.CONCLUSION: Vast majority of patients with moderate suspicion of CBDS and no stones on EUS with linear array can avoid invasive evaluation of biliary tree with ERC.展开更多
New clinical approaches are imperative beyond the widely adopted National Comprehensive Cancer Network (NCCN) guidelines, utilized by prominent cancer institutions. Cancer is the leading cause of death among individua...New clinical approaches are imperative beyond the widely adopted National Comprehensive Cancer Network (NCCN) guidelines, utilized by prominent cancer institutions. Cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical Centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical Centers over a two-year period. Compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.展开更多
The structure and electrochemical properties of nanocrystalline LaNi_5-type alloys were studied. These materials were prepared by mechanical alloying (MA) followed by annealing. The properties of hydrogen host materia...The structure and electrochemical properties of nanocrystalline LaNi_5-type alloys were studied. These materials were prepared by mechanical alloying (MA) followed by annealing. The properties of hydrogen host materials can be modified substantially by alloying to obtain the desired storage characteristics. It was found that the partial substitution of Ni by Al or Mn in LaNi_(5-x)M_x alloy leads to an increase in discharge capacity. The alloying elements such as Al, Mn and Co greatly improved the cycle life of LaNi_5 material. For example, in the nanocrystalline LaNi_(3.75)Mn_(0.75)Al_(0.25)Co_(0.25) powder, discharge capacity up to 258 mAh·g^(-1) was measured (at 40 mA·g^(-1) discharge current). Furthermore, the effect of the graphite coating on the structure of some nanocrystalline alloys and the electrodes characteristics were investigated. The mechanical coating with graphite effectively reduced the degradation rate of the studied electrode materials. The combination of a nanocrystalline LaNi_5-type hydride electrodes and a nickel positive electrode to form a Ni-MH battery, was successful.展开更多
BACKGROUND:Anaphylaxis is characterized by acute episodes of potentially life-threatening symptoms that are often treated in the emergency setting.Current guidelines recommend:1) quick diagnosis using standard criteri...BACKGROUND:Anaphylaxis is characterized by acute episodes of potentially life-threatening symptoms that are often treated in the emergency setting.Current guidelines recommend:1) quick diagnosis using standard criteria;2) first-line treatment with epinephrine;and 3) discharge with a prescription for an epinephrine auto-injector,written instructions regarding long-term management,and a referral(preferably,allergy) for follow-up.However,studies suggest low concordance with guideline recommendations by emergency medicine(EM) providers.The study aimed to evaluate how emergency departments(EDs) in the United States(US) manage anaphylaxis in relation to guideline recommendations.METHODS:This was an online anonymous survey of a random sample of EM health providers in US EDs.RESULTS:Data analysis included 207 EM providers.For respondent EDs,approximately 9%reported using agreed-upon clinical criteria to diagnose anaphylaxis;42%reported administering epinephrine in the ED for most anaphylaxis episodes;and <50%provided patients with a prescription for an epinephrine auto-injector and/or an allergist referral on discharge.Most provided some written materials,and follow-up with a primary care clinician was recommended.CONCLUSIONS:This is the first cross-sectional survey to provide "real-world" data showing that practice in US EDs is discordant with current guideline recommendations for the diagnosis,treatment,and follow-up of patients with anaphylaxis.The primary gaps are low(or no) utilization of standard criteria for defining anaphylaxis and inconsistent use of epinephrine.Prospective research is recommended.展开更多
Purpose: To estimate the prevalence and risk factors for dry eye disease (DED) in a sample population of Polish older adults. Material and methods: Cross-sectional and observational study of 1107 men and women of Euro...Purpose: To estimate the prevalence and risk factors for dry eye disease (DED) in a sample population of Polish older adults. Material and methods: Cross-sectional and observational study of 1107 men and women of European Caucasian origin aged 35 - 97 years, who were interviewed and underwent detailed ophthalmic examinations. DED was defined as presence of a previous clinical diagnosis of dry eye with concomitant dry eye treatment. Results: The overall prevalence of DED in the researched population was 6.7% (95% CI 5.2 - 8.2). The prevalence of DED increased with age from 4.8% in age group 35 - 59 years to 8.3% in group aged ≥60 years. The prevalence of DED was also higher in women 8.1% than in men 4.7%. In multiple logistic regression modelling with age, gender, presence of cataract surgery and glaucoma or ocular hypertension (OHT) treatment, DED was significantly associated with older age (OR 1.99, 95% CI 1.21 - 3.30) and with female gender (OR 1.76, 95% CI 1.05 - 2.96). Conclusions: The prevalence of DED in our study population was comparable with the findings of other studies from Europe and the United States, with significantly higher rates among women and elderly subjects.展开更多
Fusarium populations were investigated on 53 samples of wheat grains and husks collected approximately three weeks before harvest in 53 wheat fields in south-eastern Poland. A limited area of sample collection was cho...Fusarium populations were investigated on 53 samples of wheat grains and husks collected approximately three weeks before harvest in 53 wheat fields in south-eastern Poland. A limited area of sample collection was chosen intentionally to avoid the effect of climate and weather variability. The study was conducted to assess the occurrence of 13 Fusarium species using species-specific PCR assays separately on grains and husks of winter wheat. The obtained data suggest that husks could take a protective role of wheat grain against Fusarium spp. The incidence of Fusarium species decreased in grains vs. husks from 29 to 100%. While Fusarium species were present in husks at 11.32% and less, they were absent in the grain. The presence of Fusarium species on husks is inversely proportional to the percentage reduction of Fusarium spp. in grain. There was a correlation of the presence of certain species of Fusarium in husks and in grains. The number of Fusarium species found on husks was about three times higher in comparison to wheat grain. In conclusion, the presented data indicate the importance of Fusarium populations analysis on wheat husk in seeds pathological studies.展开更多
Mechanical alloying and annealing at 1150 °C for 2 h under an argon atmosphere were used to prepare Ti-45S5 bioglass nanocomposites. Ti-45S5 bioglass material was chemically modified by silver. The antibacterial ...Mechanical alloying and annealing at 1150 °C for 2 h under an argon atmosphere were used to prepare Ti-45S5 bioglass nanocomposites. Ti-45S5 bioglass material was chemically modified by silver. The antibacterial activity of Ti-10% 45S5 bioglass nanocomposite containing silver against Streptococcus mutans and Staphylococcus aureus was studied. Nanocomposites were characterized by X-ray diffraction, scanning electron microscopy equipped with an electron energy dispersive spectrometer and transmission electron microscopy to evaluate phase composition, crystal structure and grain size. In vitro bacterial adhesion study indicated a significantly reduced number of Streptococcus mutans and Staphylococcus aureus on the bulk nanostructured Ti-45S5 bioglass-Ag plate surface in comparison to that on microcrystalline Ti plate surface. Nanostructured Ti-based biomaterials can be considered to be the future generation of dental implants.展开更多
Ecological adsorption technology is becoming a focus of attention by industry due to the utilization of low grade thermal energy sources for cooling production. It can be a promising part of sustainable development co...Ecological adsorption technology is becoming a focus of attention by industry due to the utilization of low grade thermal energy sources for cooling production. It can be a promising part of sustainable development concept of the global economy. Therefore, research aiming at improving their performance i.e. Coefficient of Performance(COP) by optimizing the construction of sorption beds with a built in heat exchanger system is crucial. The heat transfer characteristics between the bed of porous media(sorbent) and surface of the heat exchanger system determine the heating power of an adsorption chiller. The HP increase can be obtained by heat transfer intensification due to the increase in the thermal conductivity of the sorbent layer in the vicinity of the heat exchanger's surface. The novel modification of the sorbent layer structure is proposed in the paper in order to improve the heat transfer processes in the heat exchanger boundary layer. The analysis of desorption process conditions in the parametric model of a coated and fixed adsorption bed design is presented in the paper. The computational fluid dynamics(CFD) with conjugate heat transfer analysis is used to determine the crucial input parameters(temperature distribution in the sorbent bed) for further analytical calculations. The commercial code Ansys Fluent was used to perform numerical simulations. The developed computational model consisted of three subdomains representing heating water, heat exchanger material(copper) and sorbent(silica gel). The comparison of a novel coated design and a conventional fixed bed is discussed in the paper. The numerical analysis is based on experimental thermal conductivity measurements of the sorbent layer in different configurations, which were performed using Laser Flash Method.展开更多
BACKGROUND Frailty is associated with adverse events in elderly patients with acute coronary syndrome(ACS).Our aim was to compare the prognostic value of four frailty scales in patients aged≥65 years hospitalized wit...BACKGROUND Frailty is associated with adverse events in elderly patients with acute coronary syndrome(ACS).Our aim was to compare the prognostic value of four frailty scales in patients aged≥65 years hospitalized with ACS in a cardiac care unit(CCU).METHODS Patients aged≥65 years with ACS were included.Frailty was assessed using the Fried frailty scale(reference standard),the Edmonton Frail Scale(EFS),the FRAIL scale,and the Clinical frailty scale(CFS).The primary end point was all-cause mortality and the secondary end point was unscheduled rehospitalization.RESULTS One hundred and seventy four patients aged≥65 years with ACS were recruited.The median follow-up was 637.5 days.Frailty was identified in 41.4%,40.2%,39.1%and 36.3%patients by the Fried frailty scale,EFS,FRAIL scale and CFS,re-spectively.The agreement coefficients were 0.88,0.86,and 0.79 for the FRAIL scale,EFS and CFS,respectively.In the Cox regres-sion model,frailty was associated with all-cause mortality regardless of the scale used(univariate:hazard ratio[HR]95%CI=10.5,2.4-46.8 Fried frailty scale;12.0,2.7-53.4 FRAIL scale;7.1,2.0-25.2 EFS;8.3,2.4-29.6 CFS.Multivariate:HR=5.1,1.1-23.8 Fried frailty scale;5.7,1.2-26.8 FRAIL scale;3.7,1.0-14.0 EFS;4.2,1.1-15.9 CFS).The FRAIL scale had the highest HR.In the uni-variate analysis,frailty was associated with unscheduled rehospitalization(HR=3.2,1.7-6.0 Fried frailty scale;3.4,1.8-6.3 FRAIL scale;3.5,1.8-6.6 EFS;3.1,1.7-5.8 CFS).In the multivariate analysis,only the EFS independently predicted unscheduled rehospit-alization(HR=2.2,1.1-4.63).CONCLUSIONS Frailty assessed by the Fried frailty scale,FRAIL scale,EFS and CFS is associated with all-cause mortality and unscheduled rehospitalization in elderly patients hospitalized in a CCU with ACS.The adjusted HR of the FRAIL scale for all-cause mortality was the highest among the scales compared,whereas the EFS was an independent predictor of unscheduled re-hospitalization.These data should be taken into consideration when choosing a frailty assessment t展开更多
Contemporary villages of the mountain region are subject to uncontrolled structural and spatial transformations,which cause deformation of centuries-old spatial systems of high cultural and natural value.The aim of th...Contemporary villages of the mountain region are subject to uncontrolled structural and spatial transformations,which cause deformation of centuries-old spatial systems of high cultural and natural value.The aim of the study is to confront the opinions of the inhabitants and experts regarding the condition of the cultural landscape of the villages in south-eastern Poland.This area belongs to the Carpathian region of Central Europe.The historical and economic conditions of the studied region,related to the functioning in the post-war period,and then its breakdown and the development of the free market economy,constitute an interesting background for the proposed research.Local communities still remembering the period of difficulties related to the period of systemic transformations,are currently experiencing a relative prosperity,many difficulties related to the period of systemic transformations,are currently experiencing a relative prosperity,which is also expressed in a completely new,previously unknown way of managing the landscape.Investments implemented in villages are associated by the inhabitants with the improvement of the standards and quality of life.They assess them rather positively.An expert assessment of these landscape transformations indicates their negative dimension and the risk of losing timeless values.The discrepancy in the assessment of experts and local residents creates difficulties in the protection of the rural landscape.Therefore,high-quality visual landscape features among rural residents is necessary from the point of view of its multi-faceted and effective protection.Local initiatives and actions in the field of industry policy should play a significant role in this respect by consolidating the images of a harmonious landscape in the public awareness.展开更多
BACKGROUND Acute coronary syndrome(ACS)is linked to a range of in-hospital complications,and age is recognized as risk factor for adverse events.Discrepancies between physiological and chronological age are explained ...BACKGROUND Acute coronary syndrome(ACS)is linked to a range of in-hospital complications,and age is recognized as risk factor for adverse events.Discrepancies between physiological and chronological age are explained by frailty.However,the relationship between frailty and in-hospital complications is not clear.METHODS Assessment of frailty in patients was carried out using the FRAIL scale.In-hospital complications assessed included,bleeding,infection,arrhythmia,acute kidney injury(AKI),delirium,stroke/transient ischemic attack(TIA),liver injury,hypoglycemia,length of stay in the cardiac care unit(CCU).RESULTS Of the 174 patients,frailty was identified in 39.1%and pre-frailty in 29.9%.Frailty was associated with a higher incidence of all types of bleeding(frail vs.robust:45.5%vs.16.7%,P<0.001)and infection(54.4%vs.11.1%,P<0.001),including pneumonia/lower respiratory tract infections(LRTI)and urinary tract infections(UTI).Incidence of antibiotic therapy(52.9%vs.13.0%,P<0.001),atrial fibrillation(AF)(47.1%vs.9.3%,P<0.001),AKI(57.3%vs.20.4%,P<0.001),delirium(52.9%vs.3.7%,P<0.001),liver injury,were higher in frail patients(17.6%vs.0,P=0.001),whilst their length of stay in the CCU was longer(4 days(2-6.5)vs.2 days(2-3),P<0.001).Infections,pneumonia/LRTI,antibiotic therapy during hospitalization,the incidence of AF and liver injury were more often in patients with pre-frailty compared to the robust group.After adjustment for potential confounders,frailty remained independently associated with an increased risk of infection(OR:3.3[1.6-7.0]),including pneumonia/LRTI(OR:2.5[1.1-5.8])and UTI(OR:4.8[1.8-12.5]).Frail individuals had an increased requirement for antibiotic therapy(OR:3.9[1.9-8.1]),and greater risk of AF(OR:3.5[1.3-9.3]),AKI(OR:2.6[1.2-5.3])delirium(OR:11.7[4.8-28.7]),as well as having to stay longer in the CCU(>3 days)(OR:3.7[1.9-7.3]).CONCLUSIONS Frailty was associated with an increased risk of numerous in-hospital complications in elderly patients who had been hospitalized with ACS.展开更多
Flood wave propagation modeling is of critical importance to advancing water resources management and protecting human life and property. In this study, we investigated how the advection-diffusion routing model perfor...Flood wave propagation modeling is of critical importance to advancing water resources management and protecting human life and property. In this study, we investigated how the advection-diffusion routing model performed in flood wave propagation on a 16 km long downstream section of the Big Piney River, MO. Model performance was based on gaging station data at the upstream and downstream cross sections. We demonstrated with advection-diffusion theory that for small differences in watershed drainage area between the two river cross sections, inflow along the reach mainly contributes to the downstream hydrograph＇s rising limb and not to the falling limb. The downstream hydrograph＇s falling limb is primarily determined by the propagated flood wave originating at the upstream cross section. This research suggests the parameter for the advectiondiffusion routing model can be calibrated by fitting the hydrograph falling limb. Application of the advection diffusion model to the flood wave of January 29, 2013 supports our theoretical finding that the propagated flood wave determines the downstream cross section falling limb, and the model has good performance in our test examples.展开更多
The instability of coal ribs in underground mines continues to result in the injuries and fatalities of mine workers.The proper esti-mation and evaluation of primary and secondary support for coal ribs is still a chal...The instability of coal ribs in underground mines continues to result in the injuries and fatalities of mine workers.The proper esti-mation and evaluation of primary and secondary support for coal ribs is still a challenging problem in the field of ground control science and requires further research and study.Although mining operations have various support design criteria and support methodologies for strata control,most rib support designs are still based on experience and local practices.This review study is intended to summarize the currently applied practices for rib support and control in various countries and mining conditions.Firstly,critical parameters that con-trol the amount and type of required rib support are considered and evaluated.The study revealed that among these parameters that control the stability of coal ribs,mining depth,rib height,cleat orientation/condition,and coal strength are the most significant param-eters.Secondly,current rib support application methods were also summarized.Similar to rock mass classification systems,some studies proposed a rib control rating system for practical estimation of the current rib condition and to estimate primary support requirements.These studies are classified and summarized into two groups(categorical and empirical)based on the required inputs and methodologies.Empirically based coal rib rating systems were closely examined,and the usefulness and intuitive aspects of each rating system were com-pared.This comprehensive literature review demonstrates that the Australian rating system,Analysis and Design of Rib Support(ADRS),and the new U.S.rating system,Coal Pillar Rib Rating(CPRR),are highly applicable for their regions.展开更多
The issue of bonding formation in liquid metal/open-celled carbon foam(C_(of))systems was examined,taking into account the practical aspects of the synthesis of a new type of Mg-C metal material composite.The problem ...The issue of bonding formation in liquid metal/open-celled carbon foam(C_(of))systems was examined,taking into account the practical aspects of the synthesis of a new type of Mg-C metal material composite.The problem is complex due to the strong oxidation and intense evaporation of liquid magnesium,as well as the 3D geometry of the carbon component,where metal transport occurred through the foam cells’windows.Laboratory experiments performed at 700℃ in ceramic crucibles showed that spontaneous carbon foam infiltration by liquid metal is impossible under the applied conditions,either in an air atmosphere coupled with flux protection or under argon protection.Comparative tests performed in a UHV chamber filled with static pure Ar by a sessile drop method,coupled with non-contact heating and capillary purification at a test temperature of 700℃ directly in the UHV chamber,showed non-wetting behavior of the Mg/C_(of)couple with a correspondingly high contact angle of about 135°.The graphite capillary was then moved down,the liquid drop being slightly pressed into the foam,but these changes did not induce effective foam penetration.Despite the short contact time for the sessile drop test under an argon atmosphere,SEM+WDS analysis of the solidified Mg/C_(of)couple revealed the formation of an MgO interlayer at the interface,with a thickness of approx.1μm.The experimentally demonstrated presence of oxygen in the carbon foam sample,both before and after its contact with magnesium,points to oxide-type bonding being established between Mg and C_(of).This observation is in a good agreement with previous reports on the interface characterization of magnesium matrix composites reinforced with glassy carbon materials and carbon fibers by stir casting and pressure infiltration.Based on the findings of this study,a general structural scheme of the bonding process between carbon foam and liquid magnesium,as an important stage in the syntheses of Mg-C composites,was proposed.展开更多
基金funded by a grant from the National Core Research Center(NCRC)Program through the National Research Foundation of Korea funded by the Ministry of Education,Science and Technology(No.2012-0000-957)by a grant from the Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy,Republic of Korea
文摘Ternary Ti-B-N coatings were synthesized on AISI 304 and Si wafer by plasma-enhanced chemical vapor deposition (PECVD) technique using a gaseous mixture of TiCl4,BCl3,H2,N2,and Ar.By virtue of X-ray diffraction analysis,X-ray photoelectron spectroscopy,scanning electron microscope,and high-resolution transmission electron microscope,the influences of B content on the microstructure and properties of Ti B N coatings were investigated systematically.The results indicated that the microstructure and mechanical properties of Ti-B-N coatings largely depend on the transformation from FCC-TiN phase to HCP-TiB2 phase.With increasing B content and decreasing N content in the coatings,the coating microstructure evolves gradually from FCC-TiN/a-BN to HCP-TiB2 /a-BN via FCC-TiN+HCP-TiB2/a-BN.The highest microhardness of about 34 GPa is achieved,which corresponds to the nanocomposite Ti-63%B-N (mole fraction) coating consisting of the HCP-TiB2 nano-crystallites and amorphous BN phase.The lowest friction-coefficient was observed for the nanocomposite Ti-41%B-N (mole fraction) coating consisting of the FCC-TiN nanocrystallites and amorphous BN
基金supported by a 2-Year Research Grant of Pusan National University,Korea
文摘The CrN and Cr-Al-Si-N films were deposited on Si wafer and SUS 304 substrates by a hybrid coating system with high power impulse magnetron sputtering (HIPIMS) and a DC pulse sputtering using Cr and AlSi targets under N2/Ar atmosphere.By varying the sputtering current of the AlSi target in the range of 0-2.5 A,both the Al and Si contents in the films increased gradually from 0 to 19.1% and 11.1% (mole fraction),respectively.The influences of the AlSi cathode DC pulse current on the microstructure,phase constituents,mechanical properties,and oxidation behaviors of the Cr-Al-Si-N films were investigated systematically.The results indicate that the as-deposited Cr-Al-Si-N films possess the typical nanocomposite structure,namely the face centered cubic (Cr,Al)N nano-crystallites are embedded in the amorphous Si3N4 matrix.With increasing the Al and Si contents,the hardness of the film first increases from 20.8 GPa for the CrN film to the peak value of 29.4 GPa for the Cr0.23Al0.14Si0.07 N film,and then decreases gradually.In the meanwhile,the Cr0.23Al0.14Si0.07N film also possesses excellent high-temperature oxidation resistance that is much better than that of the CrN film at 900 or 1000 °C.
基金Supported by A James Cook University Program Grant (2003) and A Cancer Council Queensland scholarship
文摘AIM:To explore the impact of fecal incontinence (FI) on quality of life (QOL) of patients attending urogynecology and colorectal clinics (CCs).METHODS:Cross-sectional study of 154 patients (27 male) with FI,who attended the clinics at a regional hospital in North Queensland,Australia in 2003 and 2004,and completed the Fecal Incontinence Quality of Life Scale (FIQL:1=very affected;4=not affected).RESULTS:More than 22% of patients had their QOL affected severely by FI.Patients reported that they had not previously been asked about FI by a medical practitioner nor did they voluntarily disclose its presence.The median FIQL scores for all participants were:lifestyle=3.24;coping=2.23;depression=2.42;and embarrassment=2.33.Increasing frequency of soiling had a negative effect on all four FIQL scales (P < 0.001) as did the quantity of soiling (P < 0.01).Female CC patients had poorer FIQL scores than urogynecology clinic patients for lifestyle (P=0.015),coping (P=0.004) and embarrassment (P=0.009),but not depression (P=0.062),despite having experienced FI for a shorter period.CONCLUSION:Failure to seek treatment for FI degrades the quality of patients' lives over time.FI assessment tools should incorporate the quantity of fecal loss.
文摘AIM: To evaluate the diagnostic efficiency of endoscopic ultrasound (EUS) as the main imaging modality in patients with moderate suspicion of common bile duct stones (CBDS).METHODS: 55 patients with moderate clinical suspicion of CBDS were prospectively included to the study and evaluated with EUS. This study was done in single blind method in the clinical and biochemical data of patients. EUS was done with echo-endoscope Pentax FG 32-UA (f=5-7,5 MHz) and Hitachi EUB 405 ultrasound machine. Patients diagnosed with CBDS by EUS were excluded from this study and treated with ERC. All the other patients were included to the follow up study obtained by mail every 6 months for clinical evaluation (need of ERC or surgery).RESULTS: CBDS was found in 4 patients by EUS. Diagnosis was confirmed in all cases on ERC. The remaining 51 patients without CBDS on EUS were followed up for 6-26 months (meanly 13 months) There were: 40 women, 42cholecystectomized patients, aged: 55 (mean). Biochemical values (mean values) were as follows: bilirubin: 14,9 μmol.L-1,alkaline phosphatase: 95 IU.L-,1 γ-GTP: 131 IU.L-1, ALT: 50IU.L-1, AST: 49 IU.L-1, Only 1 patient was lost for follow up.In the remaining 50 patients with follow up, there was only 1 (2 %) patient with persistent biliary symptoms in whom CBDS was finally diagnosed by ERC with ES. All other patients remained symptoms free on follow up and did not require ERC or biliary surgery.CONCLUSION: Vast majority of patients with moderate suspicion of CBDS and no stones on EUS with linear array can avoid invasive evaluation of biliary tree with ERC.
文摘New clinical approaches are imperative beyond the widely adopted National Comprehensive Cancer Network (NCCN) guidelines, utilized by prominent cancer institutions. Cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical Centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical Centers over a two-year period. Compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.
文摘The structure and electrochemical properties of nanocrystalline LaNi_5-type alloys were studied. These materials were prepared by mechanical alloying (MA) followed by annealing. The properties of hydrogen host materials can be modified substantially by alloying to obtain the desired storage characteristics. It was found that the partial substitution of Ni by Al or Mn in LaNi_(5-x)M_x alloy leads to an increase in discharge capacity. The alloying elements such as Al, Mn and Co greatly improved the cycle life of LaNi_5 material. For example, in the nanocrystalline LaNi_(3.75)Mn_(0.75)Al_(0.25)Co_(0.25) powder, discharge capacity up to 258 mAh·g^(-1) was measured (at 40 mA·g^(-1) discharge current). Furthermore, the effect of the graphite coating on the structure of some nanocrystalline alloys and the electrodes characteristics were investigated. The mechanical coating with graphite effectively reduced the degradation rate of the studied electrode materials. The combination of a nanocrystalline LaNi_5-type hydride electrodes and a nickel positive electrode to form a Ni-MH battery, was successful.
基金supported in part by an unrestricted educational grant from Mylan Specialty Pharmaceuticals(Basking Ridge,NJ)
文摘BACKGROUND:Anaphylaxis is characterized by acute episodes of potentially life-threatening symptoms that are often treated in the emergency setting.Current guidelines recommend:1) quick diagnosis using standard criteria;2) first-line treatment with epinephrine;and 3) discharge with a prescription for an epinephrine auto-injector,written instructions regarding long-term management,and a referral(preferably,allergy) for follow-up.However,studies suggest low concordance with guideline recommendations by emergency medicine(EM) providers.The study aimed to evaluate how emergency departments(EDs) in the United States(US) manage anaphylaxis in relation to guideline recommendations.METHODS:This was an online anonymous survey of a random sample of EM health providers in US EDs.RESULTS:Data analysis included 207 EM providers.For respondent EDs,approximately 9%reported using agreed-upon clinical criteria to diagnose anaphylaxis;42%reported administering epinephrine in the ED for most anaphylaxis episodes;and <50%provided patients with a prescription for an epinephrine auto-injector and/or an allergist referral on discharge.Most provided some written materials,and follow-up with a primary care clinician was recommended.CONCLUSIONS:This is the first cross-sectional survey to provide "real-world" data showing that practice in US EDs is discordant with current guideline recommendations for the diagnosis,treatment,and follow-up of patients with anaphylaxis.The primary gaps are low(or no) utilization of standard criteria for defining anaphylaxis and inconsistent use of epinephrine.Prospective research is recommended.
文摘Purpose: To estimate the prevalence and risk factors for dry eye disease (DED) in a sample population of Polish older adults. Material and methods: Cross-sectional and observational study of 1107 men and women of European Caucasian origin aged 35 - 97 years, who were interviewed and underwent detailed ophthalmic examinations. DED was defined as presence of a previous clinical diagnosis of dry eye with concomitant dry eye treatment. Results: The overall prevalence of DED in the researched population was 6.7% (95% CI 5.2 - 8.2). The prevalence of DED increased with age from 4.8% in age group 35 - 59 years to 8.3% in group aged ≥60 years. The prevalence of DED was also higher in women 8.1% than in men 4.7%. In multiple logistic regression modelling with age, gender, presence of cataract surgery and glaucoma or ocular hypertension (OHT) treatment, DED was significantly associated with older age (OR 1.99, 95% CI 1.21 - 3.30) and with female gender (OR 1.76, 95% CI 1.05 - 2.96). Conclusions: The prevalence of DED in our study population was comparable with the findings of other studies from Europe and the United States, with significantly higher rates among women and elderly subjects.
基金supported by the internal funds of University of Life Sciences in Lublin,Poland
文摘Fusarium populations were investigated on 53 samples of wheat grains and husks collected approximately three weeks before harvest in 53 wheat fields in south-eastern Poland. A limited area of sample collection was chosen intentionally to avoid the effect of climate and weather variability. The study was conducted to assess the occurrence of 13 Fusarium species using species-specific PCR assays separately on grains and husks of winter wheat. The obtained data suggest that husks could take a protective role of wheat grain against Fusarium spp. The incidence of Fusarium species decreased in grains vs. husks from 29 to 100%. While Fusarium species were present in husks at 11.32% and less, they were absent in the grain. The presence of Fusarium species on husks is inversely proportional to the percentage reduction of Fusarium spp. in grain. There was a correlation of the presence of certain species of Fusarium in husks and in grains. The number of Fusarium species found on husks was about three times higher in comparison to wheat grain. In conclusion, the presented data indicate the importance of Fusarium populations analysis on wheat husk in seeds pathological studies.
文摘Mechanical alloying and annealing at 1150 °C for 2 h under an argon atmosphere were used to prepare Ti-45S5 bioglass nanocomposites. Ti-45S5 bioglass material was chemically modified by silver. The antibacterial activity of Ti-10% 45S5 bioglass nanocomposite containing silver against Streptococcus mutans and Staphylococcus aureus was studied. Nanocomposites were characterized by X-ray diffraction, scanning electron microscopy equipped with an electron energy dispersive spectrometer and transmission electron microscopy to evaluate phase composition, crystal structure and grain size. In vitro bacterial adhesion study indicated a significantly reduced number of Streptococcus mutans and Staphylococcus aureus on the bulk nanostructured Ti-45S5 bioglass-Ag plate surface in comparison to that on microcrystalline Ti plate surface. Nanostructured Ti-based biomaterials can be considered to be the future generation of dental implants.
基金the project:"The development of innovative technology of adsorption chiller NETI?,using special,glued construction of the adsorption beds"(number:POIR.01.01.01-00-1659/15)partially supported by National Science Centre of Poland (Narodowe Centrum Nauki) grant number 2017/01/X/ST8/00019granted by the Faculty of Mathematics and Natural Sciences of Jan Dlugosz University in Czestochowa.
文摘Ecological adsorption technology is becoming a focus of attention by industry due to the utilization of low grade thermal energy sources for cooling production. It can be a promising part of sustainable development concept of the global economy. Therefore, research aiming at improving their performance i.e. Coefficient of Performance(COP) by optimizing the construction of sorption beds with a built in heat exchanger system is crucial. The heat transfer characteristics between the bed of porous media(sorbent) and surface of the heat exchanger system determine the heating power of an adsorption chiller. The HP increase can be obtained by heat transfer intensification due to the increase in the thermal conductivity of the sorbent layer in the vicinity of the heat exchanger's surface. The novel modification of the sorbent layer structure is proposed in the paper in order to improve the heat transfer processes in the heat exchanger boundary layer. The analysis of desorption process conditions in the parametric model of a coated and fixed adsorption bed design is presented in the paper. The computational fluid dynamics(CFD) with conjugate heat transfer analysis is used to determine the crucial input parameters(temperature distribution in the sorbent bed) for further analytical calculations. The commercial code Ansys Fluent was used to perform numerical simulations. The developed computational model consisted of three subdomains representing heating water, heat exchanger material(copper) and sorbent(silica gel). The comparison of a novel coated design and a conventional fixed bed is discussed in the paper. The numerical analysis is based on experimental thermal conductivity measurements of the sorbent layer in different configurations, which were performed using Laser Flash Method.
基金found by statutory work number 3.19/III/18, National Institute of Cardiology, Warsaw, Poland.
文摘BACKGROUND Frailty is associated with adverse events in elderly patients with acute coronary syndrome(ACS).Our aim was to compare the prognostic value of four frailty scales in patients aged≥65 years hospitalized with ACS in a cardiac care unit(CCU).METHODS Patients aged≥65 years with ACS were included.Frailty was assessed using the Fried frailty scale(reference standard),the Edmonton Frail Scale(EFS),the FRAIL scale,and the Clinical frailty scale(CFS).The primary end point was all-cause mortality and the secondary end point was unscheduled rehospitalization.RESULTS One hundred and seventy four patients aged≥65 years with ACS were recruited.The median follow-up was 637.5 days.Frailty was identified in 41.4%,40.2%,39.1%and 36.3%patients by the Fried frailty scale,EFS,FRAIL scale and CFS,re-spectively.The agreement coefficients were 0.88,0.86,and 0.79 for the FRAIL scale,EFS and CFS,respectively.In the Cox regres-sion model,frailty was associated with all-cause mortality regardless of the scale used(univariate:hazard ratio[HR]95%CI=10.5,2.4-46.8 Fried frailty scale;12.0,2.7-53.4 FRAIL scale;7.1,2.0-25.2 EFS;8.3,2.4-29.6 CFS.Multivariate:HR=5.1,1.1-23.8 Fried frailty scale;5.7,1.2-26.8 FRAIL scale;3.7,1.0-14.0 EFS;4.2,1.1-15.9 CFS).The FRAIL scale had the highest HR.In the uni-variate analysis,frailty was associated with unscheduled rehospitalization(HR=3.2,1.7-6.0 Fried frailty scale;3.4,1.8-6.3 FRAIL scale;3.5,1.8-6.6 EFS;3.1,1.7-5.8 CFS).In the multivariate analysis,only the EFS independently predicted unscheduled rehospit-alization(HR=2.2,1.1-4.63).CONCLUSIONS Frailty assessed by the Fried frailty scale,FRAIL scale,EFS and CFS is associated with all-cause mortality and unscheduled rehospitalization in elderly patients hospitalized in a CCU with ACS.The adjusted HR of the FRAIL scale for all-cause mortality was the highest among the scales compared,whereas the EFS was an independent predictor of unscheduled re-hospitalization.These data should be taken into consideration when choosing a frailty assessment t
文摘Contemporary villages of the mountain region are subject to uncontrolled structural and spatial transformations,which cause deformation of centuries-old spatial systems of high cultural and natural value.The aim of the study is to confront the opinions of the inhabitants and experts regarding the condition of the cultural landscape of the villages in south-eastern Poland.This area belongs to the Carpathian region of Central Europe.The historical and economic conditions of the studied region,related to the functioning in the post-war period,and then its breakdown and the development of the free market economy,constitute an interesting background for the proposed research.Local communities still remembering the period of difficulties related to the period of systemic transformations,are currently experiencing a relative prosperity,many difficulties related to the period of systemic transformations,are currently experiencing a relative prosperity,which is also expressed in a completely new,previously unknown way of managing the landscape.Investments implemented in villages are associated by the inhabitants with the improvement of the standards and quality of life.They assess them rather positively.An expert assessment of these landscape transformations indicates their negative dimension and the risk of losing timeless values.The discrepancy in the assessment of experts and local residents creates difficulties in the protection of the rural landscape.Therefore,high-quality visual landscape features among rural residents is necessary from the point of view of its multi-faceted and effective protection.Local initiatives and actions in the field of industry policy should play a significant role in this respect by consolidating the images of a harmonious landscape in the public awareness.
文摘BACKGROUND Acute coronary syndrome(ACS)is linked to a range of in-hospital complications,and age is recognized as risk factor for adverse events.Discrepancies between physiological and chronological age are explained by frailty.However,the relationship between frailty and in-hospital complications is not clear.METHODS Assessment of frailty in patients was carried out using the FRAIL scale.In-hospital complications assessed included,bleeding,infection,arrhythmia,acute kidney injury(AKI),delirium,stroke/transient ischemic attack(TIA),liver injury,hypoglycemia,length of stay in the cardiac care unit(CCU).RESULTS Of the 174 patients,frailty was identified in 39.1%and pre-frailty in 29.9%.Frailty was associated with a higher incidence of all types of bleeding(frail vs.robust:45.5%vs.16.7%,P<0.001)and infection(54.4%vs.11.1%,P<0.001),including pneumonia/lower respiratory tract infections(LRTI)and urinary tract infections(UTI).Incidence of antibiotic therapy(52.9%vs.13.0%,P<0.001),atrial fibrillation(AF)(47.1%vs.9.3%,P<0.001),AKI(57.3%vs.20.4%,P<0.001),delirium(52.9%vs.3.7%,P<0.001),liver injury,were higher in frail patients(17.6%vs.0,P=0.001),whilst their length of stay in the CCU was longer(4 days(2-6.5)vs.2 days(2-3),P<0.001).Infections,pneumonia/LRTI,antibiotic therapy during hospitalization,the incidence of AF and liver injury were more often in patients with pre-frailty compared to the robust group.After adjustment for potential confounders,frailty remained independently associated with an increased risk of infection(OR:3.3[1.6-7.0]),including pneumonia/LRTI(OR:2.5[1.1-5.8])and UTI(OR:4.8[1.8-12.5]).Frail individuals had an increased requirement for antibiotic therapy(OR:3.9[1.9-8.1]),and greater risk of AF(OR:3.5[1.3-9.3]),AKI(OR:2.6[1.2-5.3])delirium(OR:11.7[4.8-28.7]),as well as having to stay longer in the CCU(>3 days)(OR:3.7[1.9-7.3]).CONCLUSIONS Frailty was associated with an increased risk of numerous in-hospital complications in elderly patients who had been hospitalized with ACS.
基金supported by funding from the USDA Forest Service Northern Research Station iTree Spatial Simulation (No. PL-5937)the National Urban and Community Forest Advisory Council iT ree Tool (No. 11-DG-11132544340)The SUNY ESF Department of Environmental Resources Engineering provided computing facilities and logistical support
文摘Flood wave propagation modeling is of critical importance to advancing water resources management and protecting human life and property. In this study, we investigated how the advection-diffusion routing model performed in flood wave propagation on a 16 km long downstream section of the Big Piney River, MO. Model performance was based on gaging station data at the upstream and downstream cross sections. We demonstrated with advection-diffusion theory that for small differences in watershed drainage area between the two river cross sections, inflow along the reach mainly contributes to the downstream hydrograph＇s rising limb and not to the falling limb. The downstream hydrograph＇s falling limb is primarily determined by the propagated flood wave originating at the upstream cross section. This research suggests the parameter for the advectiondiffusion routing model can be calibrated by fitting the hydrograph falling limb. Application of the advection diffusion model to the flood wave of January 29, 2013 supports our theoretical finding that the propagated flood wave determines the downstream cross section falling limb, and the model has good performance in our test examples.
文摘The instability of coal ribs in underground mines continues to result in the injuries and fatalities of mine workers.The proper esti-mation and evaluation of primary and secondary support for coal ribs is still a challenging problem in the field of ground control science and requires further research and study.Although mining operations have various support design criteria and support methodologies for strata control,most rib support designs are still based on experience and local practices.This review study is intended to summarize the currently applied practices for rib support and control in various countries and mining conditions.Firstly,critical parameters that con-trol the amount and type of required rib support are considered and evaluated.The study revealed that among these parameters that control the stability of coal ribs,mining depth,rib height,cleat orientation/condition,and coal strength are the most significant param-eters.Secondly,current rib support application methods were also summarized.Similar to rock mass classification systems,some studies proposed a rib control rating system for practical estimation of the current rib condition and to estimate primary support requirements.These studies are classified and summarized into two groups(categorical and empirical)based on the required inputs and methodologies.Empirically based coal rib rating systems were closely examined,and the usefulness and intuitive aspects of each rating system were com-pared.This comprehensive literature review demonstrates that the Australian rating system,Analysis and Design of Rib Support(ADRS),and the new U.S.rating system,Coal Pillar Rib Rating(CPRR),are highly applicable for their regions.
基金This research was funded by the Silesian University of Technology,Faculty of Materials Engineering as a part of statutory research for 2020.
文摘The issue of bonding formation in liquid metal/open-celled carbon foam(C_(of))systems was examined,taking into account the practical aspects of the synthesis of a new type of Mg-C metal material composite.The problem is complex due to the strong oxidation and intense evaporation of liquid magnesium,as well as the 3D geometry of the carbon component,where metal transport occurred through the foam cells’windows.Laboratory experiments performed at 700℃ in ceramic crucibles showed that spontaneous carbon foam infiltration by liquid metal is impossible under the applied conditions,either in an air atmosphere coupled with flux protection or under argon protection.Comparative tests performed in a UHV chamber filled with static pure Ar by a sessile drop method,coupled with non-contact heating and capillary purification at a test temperature of 700℃ directly in the UHV chamber,showed non-wetting behavior of the Mg/C_(of)couple with a correspondingly high contact angle of about 135°.The graphite capillary was then moved down,the liquid drop being slightly pressed into the foam,but these changes did not induce effective foam penetration.Despite the short contact time for the sessile drop test under an argon atmosphere,SEM+WDS analysis of the solidified Mg/C_(of)couple revealed the formation of an MgO interlayer at the interface,with a thickness of approx.1μm.The experimentally demonstrated presence of oxygen in the carbon foam sample,both before and after its contact with magnesium,points to oxide-type bonding being established between Mg and C_(of).This observation is in a good agreement with previous reports on the interface characterization of magnesium matrix composites reinforced with glassy carbon materials and carbon fibers by stir casting and pressure infiltration.Based on the findings of this study,a general structural scheme of the bonding process between carbon foam and liquid magnesium,as an important stage in the syntheses of Mg-C composites,was proposed.
