It is critical to regulate the senescence-associated secretory phenotype(SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that mar...It is critical to regulate the senescence-associated secretory phenotype(SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M(Mar-M, a naturally occurring bisbibenzyl) suppressed proinflammatory SASP components which were elevated in chemotherapy-resistant cells. Mar-M treatment attenuated the pro-tumorigenic effects of SASP and enhanced survival in drug-resistant mouse models.No toxicity was detected on normal fibroblast cells or in animals following this treatment. Inactivation of transcription factor EB(TFEB) and nuclear factor-k B(NF-k B) by Mar-M significantly accounted for its suppression on the components of SASP. Furthermore, inhibition of SASP by Mar-M contributed to a synergistic effect during co-treatment with doxorubicin to lower toxicity and enhance antitumor efficacy. Thus, chemotherapy-driven pro-inflammatory activity, seen to contribute to drug-resistance, is an important target for Mar-M. By decreasing SASP, Mar-M may be a potential approach to overcome tumor malignancy.展开更多
Purpose: Despite many scientific advances, Regenerative Medicine is still in the preclinical stages in many areas. In this article, we intend to discuss the role of microsurgery in the bench-to-bedside transition of s...Purpose: Despite many scientific advances, Regenerative Medicine is still in the preclinical stages in many areas. In this article, we intend to discuss the role of microsurgery in the bench-to-bedside transition of such primary findings. Method: By searching the papers related to the history of Regenerative Medicine (RM) and the news of Tissue Engineering (TE) in orthopedics in Pubmed, Scopus, and Google Scholar databases, we accessed a complete archive of various topics related to this field. Result: We first assessed the history and achievements of regenerative medicine, then we realized the importance of translational medical sciences and the role of animal models in this incipient phenomenon. Finally, after mastering the capabilities of microsurgery and the useful contribution of this technique to the advancement of clinical applications of regenerative medicine in various branches such as skin, skeletal system, nerves, and blood vessels, we decided to express the gist of our studies through this article. Conclusion: Considering the widespread use of small animals in regenerative medicine projects and the inevitable role of microsurgery in performing the best intervention on these animal models, the significant progress of regenerative medicine clinical application requires special attention to microsurgery in associated research.展开更多
Mosquito-borne diseases,particularly dengue and chikungunya have become global threats,infecting millions of people worldwide,including developing countries of Southeast Asia and Latin America.Bangladesh,like many oth...Mosquito-borne diseases,particularly dengue and chikungunya have become global threats,infecting millions of people worldwide,including developing countries of Southeast Asia and Latin America.Bangladesh,like many other developing countries,is experiencing frequent dengue outbreaks.This article,therefore,critically discussed the current status of dengue disease,vector control approaches,and the need for Wolbachia-mediated intervention in Bangladesh and other dengue-endemic developing countries.In this narrative review study,rel-evant literature was searched from major databases and search engines such as PubMed,BanglaJol,World Health Organization(WHO)/European Centre for Disease Prevention and Control(ECDC)and Google Scholar.Considering the selection criteria,our search strategies finally involved 55 related literature for further investigation.Findings showed that current vector control strategies could not render protection for an extended period,and the disease burden of arboviruses is increasing.The impoverished outbreak preparedness,urbanization,climate change,and less efficacy of existing control methods have made people susceptible to vector-borne diseases.Hence,Wolbachia,a naturally occurring endosymbiont of many mosquito species that can potentially limit virus transmission through several host genetic alterations,would be a potential alterna-tive for dengue prevention.We also critically discussed the challenges and prospects of Wolbachia-based den-gue control in developing countries.The evidence supporting the efficacy and safety of this intervention and its mechanism have also been elucidated.Empirical evidence suggests that this introgression method could be an eco-friendly and long-lasting dengue control method.This review would help the policymakers and health experts devise a scheme of Wolbachia-based dengue control that can control mosquito-borne diseases,partic-ularly dengue in Bangladesh and other developing countries.展开更多
Wireless Sensor Networks (WSNs) are one of the fastest growing and emerging technologies in the field of Wireless Networking today. The applications of WSNs are extensively spread over areas like Military, En-vironmen...Wireless Sensor Networks (WSNs) are one of the fastest growing and emerging technologies in the field of Wireless Networking today. The applications of WSNs are extensively spread over areas like Military, En-vironment, Health Care, Communication and many more. These networks are powered by batteries and hence energy optimization is a major concern. One of the factors that reduce the energy efficiency of the WSN is collision which occurs due to the high density of data packets in a typical communication channel. This paper aims at minimizing the effects of congestion leading to collision in the network by proposing an effective algorithm. This can be done by optimizing the size of the contention window by introducing pa-rameters like source count and α. If the contention window of a node is low, it results in collision. If the size of the contention window of a node is high then it results in a medium access delay. Thus minimizing colli-sion and medium access delay of data packets conserve energy.展开更多
In answer to the important technological deployment, consumers express a need of physical reassuring and tangible contact. The perceived quality exceeds the role of brand image’s vector by perceptions’ differentiati...In answer to the important technological deployment, consumers express a need of physical reassuring and tangible contact. The perceived quality exceeds the role of brand image’s vector by perceptions’ differentiation to constitute an irrational link between objective characteristics (power engine, resistance) and subjective perceptions (facilitated hand grip, hardness of a steering wheel). The emotional expectations’ controls turn out many fields. It supposed to know and understand the perceptions of its customers. Its feelings must be objectively identified and quantified to be reproduced. The touch is the most solicited sense after the sight during the exploration of a product but it still undertaken in account. After an explication of sensory data’s integration to products’ conception, we resume different techniques to objectivize perceptions and how to link them to consumers’ preference. Then we present a new philosophy Touch design, which attest that the characterisation of the tactile feeling transmitted by a product is an important challenge. At least, we insist on the necessary coordination between design and technical engineering leading to the development of sensory communication tools and sensory-instrumental correlations.展开更多
Nursing is a very intense and focused career, so picking the right time and its proper management can help to relieve personal stress, manage tasks properly and achieve patients and organizational outcome. Objective: ...Nursing is a very intense and focused career, so picking the right time and its proper management can help to relieve personal stress, manage tasks properly and achieve patients and organizational outcome. Objective: This study aimed to explore perceived time management skill of the clinical nurses. Methods: This was a descriptive correlational study design using simple random sampling. A total of 77 clinical nurses working in Mugda Medical College Hospital, Dhaka, Bangladesh were selected as study participants. The data were collected through structure questionnaire which consisted of demographic questionnaire and five dimensions of Time Management Skill Questionnaire (TMSQ). Results: The overall mean score of time management skill was 2.63 (SD = 0.28) reflecting a medium level of nurses perceived time management skill. The results also revealed that nurses age (r = 0.39, p = 0.000), monthly income (r = 0.294, p = 0.017) and service experience (r = 0.248, p = 0.030) were statistically significant correlated with nurses’ perceived time management skill. Conclusion: The outcome of this research would add to develop a strategy for nurse administrators to take an initiative for how nurses could improve the time management and utilize their limited time effectively. It specifies that proper time management can influence to provide quality care and achieving organizational goal.展开更多
Forecasting the COVID‐19 confirmed cases,deaths,and recoveries demands time to know the severity of the novel coronavirus.This research aims to predict all types of COVID‐19 cases(verified people,deaths,and recoveri...Forecasting the COVID‐19 confirmed cases,deaths,and recoveries demands time to know the severity of the novel coronavirus.This research aims to predict all types of COVID‐19 cases(verified people,deaths,and recoveries)from the deadliest 3rd wave data of the COVID‐19 pandemic in Bangladesh.We used the official website of the Directorate General of Health Services as our data source.To identify and predict the upcoming trends of the COVID‐19 situation of Bangladesh,we fit the Auto‐Regressive Integrated Moving Average(ARIMA)model on the data from Mar.01,2021 to Jul.31,2021.The finding of the ARIMA model(forecast model)reveals that infected,deaths,and recoveries number will have experienced exponential growth in Bangladesh to October 2021.Our model reports that confirmed cases and deaths will escalate by four times,and the recoveries will improve by five times at a later point in October 2021 if the trend of the three scenarios of COVID‐19 from March to July lasts.The prediction of the COVID‐19 scenario for the next three months is very frightening in Bangladesh,so the strategic planner and field‐level personnel need to search for suitable policies and strategies and adopt these for controlling the mass transmission of the virus.展开更多
The polycrystalline MgCrxFe2-xO4 ferrites (0.0 ? x ? 1.0) were prepared by conventional solid state ceramic sintering technique in air at 1300?C. X-ray diffraction experiments were carried out on all the samples in or...The polycrystalline MgCrxFe2-xO4 ferrites (0.0 ? x ? 1.0) were prepared by conventional solid state ceramic sintering technique in air at 1300?C. X-ray diffraction experiments were carried out on all the samples in order to characterize the materials at room temperature. The X-ray diffraction patterns showed sharp peaks indicating the formation of single phased cubic spinel structure. The lattice parameters of the samples were determined from the X-ray diffraction data using Nelson-Riley extrapolation method. It was found that the lattice parameter decreased with increasing Cr concen- tration obeying Vegard’s law. Magnetic properties of the samples were measured using an Impedance Analyzer. Real and imaginary parts of the complex permeability, loss factor and quality factor were measured as the function of frequency at three different sintering temperatures 1250?C, 1300?C and 1350?C for all the samples in the frequency range 1 kHz to 13 MHz. Frequency stability of the real part of permeability increases with increasing Cr concentration and also with sintering temperature. Imaginary part of permeability decreases with increasing frequency and increased with increasing both of the Cr content and sintering temperature. Loss factor decreased with increasing frequency while the quality factor (Q) increased with increasing frequency for all the samples. The temperature de- pendence of initial permeability was measured for all the samples sintered at 1300?C. The Curie temperature (Tc) was determined from the -T curves. The values of Tc were found to be 733 K, 657 K, 583 K, 468 K, 400 K and 317 K for x = 0.0, 0.2, 0.4, 0.6, 0.8 and 1.0, respectively.展开更多
基金supported by the National Natural Science Foundation of China(81473238,81872896,and 81874293)the Shandong Key Innovative Research Program(2018CXGC1216,China)
文摘It is critical to regulate the senescence-associated secretory phenotype(SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M(Mar-M, a naturally occurring bisbibenzyl) suppressed proinflammatory SASP components which were elevated in chemotherapy-resistant cells. Mar-M treatment attenuated the pro-tumorigenic effects of SASP and enhanced survival in drug-resistant mouse models.No toxicity was detected on normal fibroblast cells or in animals following this treatment. Inactivation of transcription factor EB(TFEB) and nuclear factor-k B(NF-k B) by Mar-M significantly accounted for its suppression on the components of SASP. Furthermore, inhibition of SASP by Mar-M contributed to a synergistic effect during co-treatment with doxorubicin to lower toxicity and enhance antitumor efficacy. Thus, chemotherapy-driven pro-inflammatory activity, seen to contribute to drug-resistance, is an important target for Mar-M. By decreasing SASP, Mar-M may be a potential approach to overcome tumor malignancy.
文摘Purpose: Despite many scientific advances, Regenerative Medicine is still in the preclinical stages in many areas. In this article, we intend to discuss the role of microsurgery in the bench-to-bedside transition of such primary findings. Method: By searching the papers related to the history of Regenerative Medicine (RM) and the news of Tissue Engineering (TE) in orthopedics in Pubmed, Scopus, and Google Scholar databases, we accessed a complete archive of various topics related to this field. Result: We first assessed the history and achievements of regenerative medicine, then we realized the importance of translational medical sciences and the role of animal models in this incipient phenomenon. Finally, after mastering the capabilities of microsurgery and the useful contribution of this technique to the advancement of clinical applications of regenerative medicine in various branches such as skin, skeletal system, nerves, and blood vessels, we decided to express the gist of our studies through this article. Conclusion: Considering the widespread use of small animals in regenerative medicine projects and the inevitable role of microsurgery in performing the best intervention on these animal models, the significant progress of regenerative medicine clinical application requires special attention to microsurgery in associated research.
文摘Mosquito-borne diseases,particularly dengue and chikungunya have become global threats,infecting millions of people worldwide,including developing countries of Southeast Asia and Latin America.Bangladesh,like many other developing countries,is experiencing frequent dengue outbreaks.This article,therefore,critically discussed the current status of dengue disease,vector control approaches,and the need for Wolbachia-mediated intervention in Bangladesh and other dengue-endemic developing countries.In this narrative review study,rel-evant literature was searched from major databases and search engines such as PubMed,BanglaJol,World Health Organization(WHO)/European Centre for Disease Prevention and Control(ECDC)and Google Scholar.Considering the selection criteria,our search strategies finally involved 55 related literature for further investigation.Findings showed that current vector control strategies could not render protection for an extended period,and the disease burden of arboviruses is increasing.The impoverished outbreak preparedness,urbanization,climate change,and less efficacy of existing control methods have made people susceptible to vector-borne diseases.Hence,Wolbachia,a naturally occurring endosymbiont of many mosquito species that can potentially limit virus transmission through several host genetic alterations,would be a potential alterna-tive for dengue prevention.We also critically discussed the challenges and prospects of Wolbachia-based den-gue control in developing countries.The evidence supporting the efficacy and safety of this intervention and its mechanism have also been elucidated.Empirical evidence suggests that this introgression method could be an eco-friendly and long-lasting dengue control method.This review would help the policymakers and health experts devise a scheme of Wolbachia-based dengue control that can control mosquito-borne diseases,partic-ularly dengue in Bangladesh and other developing countries.
文摘Wireless Sensor Networks (WSNs) are one of the fastest growing and emerging technologies in the field of Wireless Networking today. The applications of WSNs are extensively spread over areas like Military, En-vironment, Health Care, Communication and many more. These networks are powered by batteries and hence energy optimization is a major concern. One of the factors that reduce the energy efficiency of the WSN is collision which occurs due to the high density of data packets in a typical communication channel. This paper aims at minimizing the effects of congestion leading to collision in the network by proposing an effective algorithm. This can be done by optimizing the size of the contention window by introducing pa-rameters like source count and α. If the contention window of a node is low, it results in collision. If the size of the contention window of a node is high then it results in a medium access delay. Thus minimizing colli-sion and medium access delay of data packets conserve energy.
文摘In answer to the important technological deployment, consumers express a need of physical reassuring and tangible contact. The perceived quality exceeds the role of brand image’s vector by perceptions’ differentiation to constitute an irrational link between objective characteristics (power engine, resistance) and subjective perceptions (facilitated hand grip, hardness of a steering wheel). The emotional expectations’ controls turn out many fields. It supposed to know and understand the perceptions of its customers. Its feelings must be objectively identified and quantified to be reproduced. The touch is the most solicited sense after the sight during the exploration of a product but it still undertaken in account. After an explication of sensory data’s integration to products’ conception, we resume different techniques to objectivize perceptions and how to link them to consumers’ preference. Then we present a new philosophy Touch design, which attest that the characterisation of the tactile feeling transmitted by a product is an important challenge. At least, we insist on the necessary coordination between design and technical engineering leading to the development of sensory communication tools and sensory-instrumental correlations.
文摘Nursing is a very intense and focused career, so picking the right time and its proper management can help to relieve personal stress, manage tasks properly and achieve patients and organizational outcome. Objective: This study aimed to explore perceived time management skill of the clinical nurses. Methods: This was a descriptive correlational study design using simple random sampling. A total of 77 clinical nurses working in Mugda Medical College Hospital, Dhaka, Bangladesh were selected as study participants. The data were collected through structure questionnaire which consisted of demographic questionnaire and five dimensions of Time Management Skill Questionnaire (TMSQ). Results: The overall mean score of time management skill was 2.63 (SD = 0.28) reflecting a medium level of nurses perceived time management skill. The results also revealed that nurses age (r = 0.39, p = 0.000), monthly income (r = 0.294, p = 0.017) and service experience (r = 0.248, p = 0.030) were statistically significant correlated with nurses’ perceived time management skill. Conclusion: The outcome of this research would add to develop a strategy for nurse administrators to take an initiative for how nurses could improve the time management and utilize their limited time effectively. It specifies that proper time management can influence to provide quality care and achieving organizational goal.
文摘Forecasting the COVID‐19 confirmed cases,deaths,and recoveries demands time to know the severity of the novel coronavirus.This research aims to predict all types of COVID‐19 cases(verified people,deaths,and recoveries)from the deadliest 3rd wave data of the COVID‐19 pandemic in Bangladesh.We used the official website of the Directorate General of Health Services as our data source.To identify and predict the upcoming trends of the COVID‐19 situation of Bangladesh,we fit the Auto‐Regressive Integrated Moving Average(ARIMA)model on the data from Mar.01,2021 to Jul.31,2021.The finding of the ARIMA model(forecast model)reveals that infected,deaths,and recoveries number will have experienced exponential growth in Bangladesh to October 2021.Our model reports that confirmed cases and deaths will escalate by four times,and the recoveries will improve by five times at a later point in October 2021 if the trend of the three scenarios of COVID‐19 from March to July lasts.The prediction of the COVID‐19 scenario for the next three months is very frightening in Bangladesh,so the strategic planner and field‐level personnel need to search for suitable policies and strategies and adopt these for controlling the mass transmission of the virus.
文摘The polycrystalline MgCrxFe2-xO4 ferrites (0.0 ? x ? 1.0) were prepared by conventional solid state ceramic sintering technique in air at 1300?C. X-ray diffraction experiments were carried out on all the samples in order to characterize the materials at room temperature. The X-ray diffraction patterns showed sharp peaks indicating the formation of single phased cubic spinel structure. The lattice parameters of the samples were determined from the X-ray diffraction data using Nelson-Riley extrapolation method. It was found that the lattice parameter decreased with increasing Cr concen- tration obeying Vegard’s law. Magnetic properties of the samples were measured using an Impedance Analyzer. Real and imaginary parts of the complex permeability, loss factor and quality factor were measured as the function of frequency at three different sintering temperatures 1250?C, 1300?C and 1350?C for all the samples in the frequency range 1 kHz to 13 MHz. Frequency stability of the real part of permeability increases with increasing Cr concentration and also with sintering temperature. Imaginary part of permeability decreases with increasing frequency and increased with increasing both of the Cr content and sintering temperature. Loss factor decreased with increasing frequency while the quality factor (Q) increased with increasing frequency for all the samples. The temperature de- pendence of initial permeability was measured for all the samples sintered at 1300?C. The Curie temperature (Tc) was determined from the -T curves. The values of Tc were found to be 733 K, 657 K, 583 K, 468 K, 400 K and 317 K for x = 0.0, 0.2, 0.4, 0.6, 0.8 and 1.0, respectively.
