On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS...On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at https://bigd.big.ac.cn/ncov/.展开更多
Resorbable polymer electrospun nanofiber-based materials/devices have high surface-to-volume ratio and often have a porous structure with excellent pore interconnectivity,which are suitable for growth and development ...Resorbable polymer electrospun nanofiber-based materials/devices have high surface-to-volume ratio and often have a porous structure with excellent pore interconnectivity,which are suitable for growth and development of different types of cells.Due to the huge advantages of both resorbable polymers and electrospun nano fibers,re sorbable polymer electrospun nanofibers(RPENs)have been widely applied in the field of tissue engineering.In this paper,we will mainly introduce RPENs for tissue engineering.Firstly,the electrospinning technique and electrospun nanofiber architectures are briefly introduced.Secondly,the application of RPENs in the field of tissue engineering is mainly reviewed.Finally,the advantages and disadvantages of RPENs for tissue engineering are discussed.This review will provide a comprehensive guide to apply resorbable polymer electrospun nanofibers for tissue engineering.展开更多
The rapid advancement in electronic devices,electric vehicles,and grid storage stations have lead to a high demand for energy storage devices with enhanced power and energy densities as well as extended lifespans.Lith...The rapid advancement in electronic devices,electric vehicles,and grid storage stations have lead to a high demand for energy storage devices with enhanced power and energy densities as well as extended lifespans.Lithium ion hybrid capacitors are constructed with battery-type anodes and capacitor-type cathodes,which enables the direct integration of the high energy from lithium ion batteries and high power and long lifetime from supercapacitors,making lithium ion hybrid capacitor one of the most promising energy storage devices.In the past two decades,tremendous efforts have been put into the search for suitable battery-type anode materials with improved Faradaic reaction kinetics so that it can match with the fast non-Faradaic charging rate of the capacitive cathodes.This review aims to provide an up-to-date and comprehensive summary of the battery-type anode materials for high-performance lithium ion hybrid capacitors.To date,a large variety of battery-type anode materials have been explored with smart material design strategies,such as carbonaceous materials,metal oxides,alloys,sulfides,nitirdes,and Mxenes,etc.,which will be discussed in detail.A perspective to the challenges and future developing trends of lithium ion hybrid capacitors is proposed to close.展开更多
Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 dia...Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 diabetes mellitus （T 1DM）. The Diabetes Behavior Rating Scale （DBRS） has a potential to be the first mature instrument. The purpose of this study is to cross-culturally adapt the DBRS, and preliminarily evaluate its psychometric properties. The instrument translation included translation, back translation and culture adaptation. Psychometric properties were assessed in a sample of 116 young patients with T1DM adapting insulin injection therapy. The Chinese version of the DBRS was divided to four subscales. Cronbaeh＇s α for the total scale was 0.92. The mean inter-item and item-total correlations were 0.35 and 0.54 respectively. Test-retest reliability showed good temporal stability （r=0.81, P=0.001）. Negative correlations were found between DBRS scores with the Diabetes Distress Scale scores （r=-0.32, P=-0.003） and hemoglobin Ale （HbAlc） levels （r=-0.36, P=0.002）. Higher DBRS scores correlated with better glycemic control. The Chinese insulin injection therapy version of the DBRS is well translated and culturally adapted. It shows good overall reliability and validity and appears to be a valuable tool for assessing the diabetic self-care behaviors for young patients with T 1DM.展开更多
目的:汉化冠心病患者运动恐惧量表(Fear of Activity in Patients with Coronary Artery Disease,Fact-CAD),为国内冠心病患者运动恐惧的评估提供科学、可靠的特异性工具。方法:遵循Brislin翻译模型对量表进行翻译、回译和文化调适,形...目的:汉化冠心病患者运动恐惧量表(Fear of Activity in Patients with Coronary Artery Disease,Fact-CAD),为国内冠心病患者运动恐惧的评估提供科学、可靠的特异性工具。方法:遵循Brislin翻译模型对量表进行翻译、回译和文化调适,形成中文版Fact-CAD量表。于2022年10月至2023年2月,采用便利抽样法,选取杭州市某三级甲等医院的334例冠心病患者进行调查,结合Rasch模型分析和经典测量理论对问卷的信度、效度进行评价。结果:中文版Fact-CAD为单维度,包括19个条目。各条目的未加权均方拟合统计量值为0.72~2.10,加权均方拟合统计量为0.88~1.29,条目-总分的相关系数为0.04~0.58,各条目拟合结果符合Rasch模型。以中文版多维度运动自我效能量表作为聚合效度指标,相关系数为-0.636(P<0.01),量表平均内容效度指数为0.951。总量表的Cronbach’sα系数为0.901,Guttman折半信度为0.885,重测信度为0.893。结论:中文版Fact-CAD具有良好的信度、效度,量表条目少,评估时间短,难度适中,适用于我国冠心病患者运动恐惧的评估。展开更多
Antisense oligonucleotide(ASO)for anti-apoptosis is emerging as a highly promising therapeutic agents for ischemic stroke with complex pathological environment.However,its therapeutic efficacy is seriously limited by ...Antisense oligonucleotide(ASO)for anti-apoptosis is emerging as a highly promising therapeutic agents for ischemic stroke with complex pathological environment.However,its therapeutic efficacy is seriously limited by a number of challenges including inefficient internalization,low blood-brain barrier(BBB)penetration,poor stability,and potential toxicity of the carrier.Herein,a carrier-free programmed spherical nucleic acid nanostructure is developed for effective ischemic stroke therapy via integrating multifunctional modules into one DNA structure.By co-encoding caspase-3-ASO and transferrin receptor(TfR)aptamer into circle template,the spherical nucleic acid nanostructure(TD)was obtained via self-assembly.The experimental results demonstrated that the developed TD displayed efficient BBB penetration capability(6.4 times)and satisfactory caspase-3 silence effect(2.3 times)due to the dense DNA packaging in TD.Taken together,our study demonstrated that the carrier-free programmed spherical nucleic acid nanostructure could significantly improve the therapeutic efficacy of ischemic stroke and was a promising therapeutic tool for various brain damage-related diseases.展开更多
基金This work was supported by grants from the Strategic PriorityResearch Program of Chinese Academy of Sciences(GrantNos.XDA19090116,XDA19050302,and XDB38030400)awarded to SS,ZZ,and MLthe National Key R&D Programof China(Grant Nos.2020YFC0848900,2020YFC0847000,2016YFE0206600,and 2017YFC0907502)+5 种基金the 13th Five-yearInformatization Plan of Chinese Academy of Sciences(GrantNo.XXH13505-05)Genomics Data Center Construction ofChinese Academy of Sciences(Grant No.XXH-13514-0202)the Open Biodiversity and Health Big Data Programme ofInternational Union of Biological Sciences,International Part-nership Program of Chinese Academy of Sciences(Grant No.153F11KYSB20160008)the Professional Association of theAlliance of International Science Organizations(Grant No.ANSO-PA-2020-07)This work was also supported by KCWong Education Foundation to ZZthe YouthInnovation Promotion Association of Chinese Academy ofSciences(Grant Nos.2017141 and 2019104)awarded to SSand ML.
文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at https://bigd.big.ac.cn/ncov/.
基金supported by research grants from the National Key R&D Program of China(No.2016YFD0400202-8)Scientific Instruments Development Project of the Science and Technology Commission of Shanghai Municipality(No.17142202800)。
文摘Resorbable polymer electrospun nanofiber-based materials/devices have high surface-to-volume ratio and often have a porous structure with excellent pore interconnectivity,which are suitable for growth and development of different types of cells.Due to the huge advantages of both resorbable polymers and electrospun nano fibers,re sorbable polymer electrospun nanofibers(RPENs)have been widely applied in the field of tissue engineering.In this paper,we will mainly introduce RPENs for tissue engineering.Firstly,the electrospinning technique and electrospun nanofiber architectures are briefly introduced.Secondly,the application of RPENs in the field of tissue engineering is mainly reviewed.Finally,the advantages and disadvantages of RPENs for tissue engineering are discussed.This review will provide a comprehensive guide to apply resorbable polymer electrospun nanofibers for tissue engineering.
基金This work was supported by National Key Basic Research Program of China(No.2014CB932400)Joint Fund of the National Natural Science Foundation of China(No.U1401243)+2 种基金National Nature Science Foundation of China(No.51232005,51571144)Shenzhen Tech-nical Plan Project(No.JCYJ20150529164918735,JCYJ20170412170911187,KQJSCX20160226191136)Guangdong Technical Plan Project(No.2015T X01N011).
文摘The rapid advancement in electronic devices,electric vehicles,and grid storage stations have lead to a high demand for energy storage devices with enhanced power and energy densities as well as extended lifespans.Lithium ion hybrid capacitors are constructed with battery-type anodes and capacitor-type cathodes,which enables the direct integration of the high energy from lithium ion batteries and high power and long lifetime from supercapacitors,making lithium ion hybrid capacitor one of the most promising energy storage devices.In the past two decades,tremendous efforts have been put into the search for suitable battery-type anode materials with improved Faradaic reaction kinetics so that it can match with the fast non-Faradaic charging rate of the capacitive cathodes.This review aims to provide an up-to-date and comprehensive summary of the battery-type anode materials for high-performance lithium ion hybrid capacitors.To date,a large variety of battery-type anode materials have been explored with smart material design strategies,such as carbonaceous materials,metal oxides,alloys,sulfides,nitirdes,and Mxenes,etc.,which will be discussed in detail.A perspective to the challenges and future developing trends of lithium ion hybrid capacitors is proposed to close.
基金supported by the National Natural Science Foundation of China(81530026)the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education
文摘Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 diabetes mellitus （T 1DM）. The Diabetes Behavior Rating Scale （DBRS） has a potential to be the first mature instrument. The purpose of this study is to cross-culturally adapt the DBRS, and preliminarily evaluate its psychometric properties. The instrument translation included translation, back translation and culture adaptation. Psychometric properties were assessed in a sample of 116 young patients with T1DM adapting insulin injection therapy. The Chinese version of the DBRS was divided to four subscales. Cronbaeh＇s α for the total scale was 0.92. The mean inter-item and item-total correlations were 0.35 and 0.54 respectively. Test-retest reliability showed good temporal stability （r=0.81, P=0.001）. Negative correlations were found between DBRS scores with the Diabetes Distress Scale scores （r=-0.32, P=-0.003） and hemoglobin Ale （HbAlc） levels （r=-0.36, P=0.002）. Higher DBRS scores correlated with better glycemic control. The Chinese insulin injection therapy version of the DBRS is well translated and culturally adapted. It shows good overall reliability and validity and appears to be a valuable tool for assessing the diabetic self-care behaviors for young patients with T 1DM.
文摘目的:汉化冠心病患者运动恐惧量表(Fear of Activity in Patients with Coronary Artery Disease,Fact-CAD),为国内冠心病患者运动恐惧的评估提供科学、可靠的特异性工具。方法:遵循Brislin翻译模型对量表进行翻译、回译和文化调适,形成中文版Fact-CAD量表。于2022年10月至2023年2月,采用便利抽样法,选取杭州市某三级甲等医院的334例冠心病患者进行调查,结合Rasch模型分析和经典测量理论对问卷的信度、效度进行评价。结果:中文版Fact-CAD为单维度,包括19个条目。各条目的未加权均方拟合统计量值为0.72~2.10,加权均方拟合统计量为0.88~1.29,条目-总分的相关系数为0.04~0.58,各条目拟合结果符合Rasch模型。以中文版多维度运动自我效能量表作为聚合效度指标,相关系数为-0.636(P<0.01),量表平均内容效度指数为0.951。总量表的Cronbach’sα系数为0.901,Guttman折半信度为0.885,重测信度为0.893。结论:中文版Fact-CAD具有良好的信度、效度,量表条目少,评估时间短,难度适中,适用于我国冠心病患者运动恐惧的评估。
基金This work was funded by the National Natural Science Foundation of China(Nos.82073395 and 319009919)Postdoctoral Science Foundation of China(Nos.2020TQ0288).
文摘Antisense oligonucleotide(ASO)for anti-apoptosis is emerging as a highly promising therapeutic agents for ischemic stroke with complex pathological environment.However,its therapeutic efficacy is seriously limited by a number of challenges including inefficient internalization,low blood-brain barrier(BBB)penetration,poor stability,and potential toxicity of the carrier.Herein,a carrier-free programmed spherical nucleic acid nanostructure is developed for effective ischemic stroke therapy via integrating multifunctional modules into one DNA structure.By co-encoding caspase-3-ASO and transferrin receptor(TfR)aptamer into circle template,the spherical nucleic acid nanostructure(TD)was obtained via self-assembly.The experimental results demonstrated that the developed TD displayed efficient BBB penetration capability(6.4 times)and satisfactory caspase-3 silence effect(2.3 times)due to the dense DNA packaging in TD.Taken together,our study demonstrated that the carrier-free programmed spherical nucleic acid nanostructure could significantly improve the therapeutic efficacy of ischemic stroke and was a promising therapeutic tool for various brain damage-related diseases.
