目的多中心横断面调查中青年出血性脑卒中患者康复运动依从性现状并分析其影响因素。方法采用便利抽样法,多中心合作研究,于2021年7月—2022年1月选取中国中、东、北部3所三级甲等医院的397例中青年出血性脑卒中住院患者作为调查对象。...目的多中心横断面调查中青年出血性脑卒中患者康复运动依从性现状并分析其影响因素。方法采用便利抽样法,多中心合作研究,于2021年7月—2022年1月选取中国中、东、北部3所三级甲等医院的397例中青年出血性脑卒中住院患者作为调查对象。依据健康行动过程取向(the health action process approach,HAPA)模型,采用一般资料调查量表、脑卒中功能锻炼依从性量表、运动自我效能量表、锻炼计划量表、脑卒中健康信念量表及Barthel指数量表进行横断面调查。结果中青年脑卒中患者功能锻炼依从性量表得分为(43.46±9.58)分,平均依从率为77.60%,康复运动依从性总体较高。多因素回归分析结果显示,运动自我效能、锻炼计划、感知到的易感性、感知到的严重性、感知到的益处、感知到的障碍、健康动力、自我效能是中青年脑卒中患者康复运动依从性的影响因素(P<0.05)。结论临床医护人员应依据HAPA模型,精准评估患者所处的康复运动阶段,根据患者的实际状况和各种可能的影响因素,制订和实施卒中康复运动策略,从而提高患者的康复运动依从性,改善其功能状态,进一步提高其生活质量。展开更多
In vitro maturation(IVM), the maturation in culture of immature oocytes, has been used in clinic for more than 20 years.Although IVM has the specific advantages of low cost and minor side effects over controlled ovari...In vitro maturation(IVM), the maturation in culture of immature oocytes, has been used in clinic for more than 20 years.Although IVM has the specific advantages of low cost and minor side effects over controlled ovarian stimulation, the prevalence of IVM is less than 1% of routine in vitro fertilization and embryo transfer techniques in many reproductive centers. In this review, we searched the MEDLINE database for all full texts and/or abstract articles published in English with content related to oocyte IVM mainly between 2000 and 2016. Many different aspects of the IVM method may influence oocyte potential,including priming, gonadotrophin, growth factors, and culture times. The culture conditions of IVM result in alterations in the oocyte or cumulus cell transcriptome that are not observed under in vivo culture conditions. Additionally, epigenetic modifications, such as DNA methylation or acetylation, are also different between in vitro and in vivo cultured oocytes. In sum,current IVM technique is still not popular and requires more systematic and intensive research to improve its effects and applications. This review will help point our problems, supply evidence or clues for future improving IVM technique, thus assist patients for fertility treatment or preservation as an additional option.展开更多
In the applications of COX regression models, we always encounter data sets t<span>hat contain too many variables that only a few of them contribute to the</span> model. Therefore, it will waste much more ...In the applications of COX regression models, we always encounter data sets t<span>hat contain too many variables that only a few of them contribute to the</span> model. Therefore, it will waste much more samples to estimate the “noneffective” variables in the inference. In this paper, we use a sequential procedure for constructing<span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">the fixed size confidence set for the “effective” parameters to the model based on an adaptive shrinkage estimate such that the “effective” coefficients can be efficiently identified with the minimum sample size. Fixed design is considered for numerical simulation. The strong consistency, asymptotic distributions and convergence rates of estimates under the fixed design are obtained. In addition, the sequential procedure is shown to be asymptotically optimal in the sense of Chow and Robbins (1965).</span></span></span>展开更多
<span style="font-family:Verdana;">In the applications of Tobit regression models we always encounter the data sets which contain too many variables that only a few of them contribute to the model. The...<span style="font-family:Verdana;">In the applications of Tobit regression models we always encounter the data sets which contain too many variables that only a few of them contribute to the model. Therefore, it will waste much more samples to estimate the “non-effective” variables in the inference. In this paper, we use a sequential procedure for constructing the fixed size confidence set for the “effective” parameters to the model by using an adaptive shrinkage estimate such that the “effective” coefficients can be efficiently identified with the minimum sample size based on Tobit regression model. Fixed design is considered for numerical simulation.</span>展开更多
文摘目的多中心横断面调查中青年出血性脑卒中患者康复运动依从性现状并分析其影响因素。方法采用便利抽样法,多中心合作研究,于2021年7月—2022年1月选取中国中、东、北部3所三级甲等医院的397例中青年出血性脑卒中住院患者作为调查对象。依据健康行动过程取向(the health action process approach,HAPA)模型,采用一般资料调查量表、脑卒中功能锻炼依从性量表、运动自我效能量表、锻炼计划量表、脑卒中健康信念量表及Barthel指数量表进行横断面调查。结果中青年脑卒中患者功能锻炼依从性量表得分为(43.46±9.58)分,平均依从率为77.60%,康复运动依从性总体较高。多因素回归分析结果显示,运动自我效能、锻炼计划、感知到的易感性、感知到的严重性、感知到的益处、感知到的障碍、健康动力、自我效能是中青年脑卒中患者康复运动依从性的影响因素(P<0.05)。结论临床医护人员应依据HAPA模型,精准评估患者所处的康复运动阶段,根据患者的实际状况和各种可能的影响因素,制订和实施卒中康复运动策略,从而提高患者的康复运动依从性,改善其功能状态,进一步提高其生活质量。
基金supported by the National Natural Science Foundation of China(81300456)the Joint Research Fund for Overseas Natural Science of China(31429004)
文摘In vitro maturation(IVM), the maturation in culture of immature oocytes, has been used in clinic for more than 20 years.Although IVM has the specific advantages of low cost and minor side effects over controlled ovarian stimulation, the prevalence of IVM is less than 1% of routine in vitro fertilization and embryo transfer techniques in many reproductive centers. In this review, we searched the MEDLINE database for all full texts and/or abstract articles published in English with content related to oocyte IVM mainly between 2000 and 2016. Many different aspects of the IVM method may influence oocyte potential,including priming, gonadotrophin, growth factors, and culture times. The culture conditions of IVM result in alterations in the oocyte or cumulus cell transcriptome that are not observed under in vivo culture conditions. Additionally, epigenetic modifications, such as DNA methylation or acetylation, are also different between in vitro and in vivo cultured oocytes. In sum,current IVM technique is still not popular and requires more systematic and intensive research to improve its effects and applications. This review will help point our problems, supply evidence or clues for future improving IVM technique, thus assist patients for fertility treatment or preservation as an additional option.
文摘目的评价虚拟现实(virtual reality,VR)技术对卒中后失语(post-stroke aphasia,PSA)患者语言功能的康复疗效,比较该方法与常规语言康复训练的疗效差异,为临床更规范有效地应用VR技术提供证据。方法检索PubMed、CINAHL等9个数据库及临床试验注册平台中关于VR语言训练治疗PSA的随机对照试验,检索时限为建库至2022年3月。由2名研究者独立筛选文献,评价文献质量及提取信息。采用RevMan 5.4软件进行Meta分析,并采用推荐分级的评价、制订与评估(grades of recommendations assessment,development and evaluation,GRADE)系统进行证据质量评级。结果共纳入9篇文献,包括311例患者。Meta分析结果显示:VR语言训练能提高PSA患者的自发言语能力[SMD=0.88,95%CI(0.57,1.20),P<0.001],命名能力[SMD=0.60,95%CI(0.30,0.90),P=0.001],听理解能力[SMD=0.81,95%CI(0.40,1.22),P=0.001],复述能力[SMD=0.55,95%CI(0.30,0.80),P<0.001],PSA治疗有效率[RR=1.43,95%CI(1.06,1.95),P=0.020],但在失语严重程度[SMD=0.70,95%CI(0.01,1.39),P=0.050]方面的干预效果尚不明确。结论VR语言训练有助于改善PSA患者的语言功能,对改善自发言语、命名、听理解、复述能力均有效,并能提高PSA治疗有效率,但对失语严重程度的干预效果尚不明确。由于总体样本量较小及结果存在异质性,仍需开展高质量随机对照试验,进一步验证VR语言训练对PSA患者语言功能的疗效。
文摘In the applications of COX regression models, we always encounter data sets t<span>hat contain too many variables that only a few of them contribute to the</span> model. Therefore, it will waste much more samples to estimate the “noneffective” variables in the inference. In this paper, we use a sequential procedure for constructing<span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">the fixed size confidence set for the “effective” parameters to the model based on an adaptive shrinkage estimate such that the “effective” coefficients can be efficiently identified with the minimum sample size. Fixed design is considered for numerical simulation. The strong consistency, asymptotic distributions and convergence rates of estimates under the fixed design are obtained. In addition, the sequential procedure is shown to be asymptotically optimal in the sense of Chow and Robbins (1965).</span></span></span>
文摘<span style="font-family:Verdana;">In the applications of Tobit regression models we always encounter the data sets which contain too many variables that only a few of them contribute to the model. Therefore, it will waste much more samples to estimate the “non-effective” variables in the inference. In this paper, we use a sequential procedure for constructing the fixed size confidence set for the “effective” parameters to the model by using an adaptive shrinkage estimate such that the “effective” coefficients can be efficiently identified with the minimum sample size based on Tobit regression model. Fixed design is considered for numerical simulation.</span>
