In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some ...In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development.展开更多
Clay minerals have played a significant role in the study of the East Asian monsoon evolution in the South China Sea by being able to track oceanic current variations and to reveal contemporaneous pa- leoclimatic chan...Clay minerals have played a significant role in the study of the East Asian monsoon evolution in the South China Sea by being able to track oceanic current variations and to reveal contemporaneous pa- leoclimatic changes prevailing in continental source areas.As one of the most important rivers input- ting terrigenous matters to the northern South China Sea,the Pearl River was not previously paid at- tention to from the viewpoint of clay mineralogy.This paper presents a detailed study on clay minerals in surface sediments collected from the Pearl River drainage basin(including all three main channels, various branches,and the Lingdingyang in the estuary)by using the X-ray diffraction(XRD)method. The results indicate that the clay mineral assemblage consists dominantly of kaolinite(35%-65%), lesser abundance of chlorite(20%-35%)and illite(12%-42%),and very scare smectite occurrences (generally<5%).Their respective distribution does not present any obvious difference throughout the Pearl River drainage basin.However,downstream the Pearl River to the northern South China Sea,the clay mineral assemblage varies significantly:kaolinite decreases gradually,smectite and illite increase gradually.Additionally,illite chemistry index steps down and illite crystallinity steps up.These varia- tions indicate the contribution of major kaolinite,lesser illite and chlorite,and very scarce smectite to the northern South China Sea from the Pearl River drainage basin.The maximum contribution of clay minerals from the Pearl River is 72%to the northern margin and only 15%to the northern slope of the South China Sea.In both glacials and interglacials,kaolinite indicates that the ability of mechanical erosion occurred in the Pearl River drainage basin.展开更多
The use of ultra-high intensity laser beams to achieve extreme material states in the laboratory has become almost routine with the development of the petawatt laser. Petawatt class lasers have been constructed for sp...The use of ultra-high intensity laser beams to achieve extreme material states in the laboratory has become almost routine with the development of the petawatt laser. Petawatt class lasers have been constructed for specific research activities,including particle acceleration, inertial confinement fusion and radiation therapy, and for secondary source generation(x-rays, electrons, protons, neutrons and ions). They are also now routinely coupled, and synchronized, to other large scale facilities including megajoule scale lasers, ion and electron accelerators, x-ray sources and z-pinches. The authors of this paper have tried to compile a comprehensive overview of the current status of petawatt class lasers worldwide.The definition of ‘petawatt class' in this context is a laser that delivers >200 TW.展开更多
High-resolution clay mineral records combined with oxygen isotopic stratigraphy over the past 450 ka during late Quaternary from Core MD05-2901 off Middle Vietnam in the western South China Sea are re-ported to recons...High-resolution clay mineral records combined with oxygen isotopic stratigraphy over the past 450 ka during late Quaternary from Core MD05-2901 off Middle Vietnam in the western South China Sea are re-ported to reconstruct a history of East Asian monsoon evolution. Variations in Illite, chlorite, and kaolinite contents indicate a strong glacial-interglacial cyclicity, while changes in smectite content present a higher frequency cyclicity. The provenance analysis indicates a mixture of individual clay minerals from various sources surrounding the South China Sea. Smectite derived mainly from the Sunda shelf and its major source area of the Indonesian islands. Illite and chlorite originated mainly from the Mekong and Red rivers. Kaolinite was provided mainly by the Pearl River. Spectral analysis of the kaolin-ite/(illite+chlorite) ratio displays a strong eccentricity period of 100 ka, implying the ice sheet-forced win-ter monsoon evolution; whereas higher frequency changes in the smectite content show an ice sheet-forced obliquity period of 41 ka, and precession periods of 23 and 19 ka and a semi-precession period of 13 ka as well, implying the tropical-forced summer monsoon evolution. The winter monsoon evolution is generally in coherence with the glacial-interglacial cyclicity, with intensified winter monsoon winds during glacials and weakened winter monsoon winds during interglacials; whereas the summer monsoon evolution provides an almost linear response to the summer insolation of low latitude in the Northern Hemisphere, with strengthened summer monsoon during higher insolation and weakened summer monsoon during lower insolation. The result suggests that the high-latitude ice sheet and low-latitude tropical factor could drive the late Quaternary evolution of East Asian winter and summer monsoons, respectively, implying their diplex and self-contained forcing mechanism.展开更多
High-resolution clay mineralogical analysis of Core MD05-2904 in the northern South China Sea(SCS) covering the period since the Last Glacial Maximum shows that illite(29%-48%),smectite(14%-45%),chlorite(17%-28%),and ...High-resolution clay mineralogical analysis of Core MD05-2904 in the northern South China Sea(SCS) covering the period since the Last Glacial Maximum shows that illite(29%-48%),smectite(14%-45%),chlorite(17%-28%),and minor kaolinite(6%-14%) comprise the clay mineral assemblage,and that time series variation does not present glacial-interglacial cyclicity.Provenance analysis indicates three end-member sources:almost all smectite derives from Luzon,all kaolinite is sourced from the Pearl River,and illite and chlorite originate from both the Pearl River and Taiwan.By comparing clay mineral compositions in surface sediments from the three major source areas and of the SCS,we reconstructed a time series of clay mineral contribution from the major provenances to the northern slope of the SCS using the linear separation method for illite crystallinity.There were three stages of provenance change.(1) During 24.1-17.5 ka BP,contributions from Taiwan and Luzon were similar(30%-40%),while that from the Pearl River was only 25%.(2) During 17.5-14.0 ka BP,the contribution from Luzon decreased rapidly to 20%-25%,while that from Taiwan increased to 35% from an average of 25% at 18 ka BP,and that from the Pearl River increased largely to 40%.(3) During the Holocene,differences in contributions from the three major provenances increased:the contribution from Luzon increased slightly and then remained at 27%-35%,that from Taiwan increased rapidly and then remained at 55%-60%,and that from the Pearl River decreased to 15%.The change in clay mineral contributions from different provenances is influenced mainly by clay mineral production,monsoon rainfall denudation,oceanic current transport,and sea-level change.展开更多
Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capac...Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy.展开更多
文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development.
基金Supported by the National Natural Science Foundation of China(Grant Nos.40331002,40621063 and 40506014)the Fok Ying Tung Education Foundation(Grant No.101018)+2 种基金the Doctoral Program of Higher Education(Grant No.20060247032)the Excellent Young Teachers Program and the Program for New Century Excellent Talents in University of the Ministry of Education of China(GrantNo.NCET-04-0372)and the Laboratory of Marginal Sea Geology Grant of theChinese Academy of Sciences(Grant No.BYH03A08)
文摘Clay minerals have played a significant role in the study of the East Asian monsoon evolution in the South China Sea by being able to track oceanic current variations and to reveal contemporaneous pa- leoclimatic changes prevailing in continental source areas.As one of the most important rivers input- ting terrigenous matters to the northern South China Sea,the Pearl River was not previously paid at- tention to from the viewpoint of clay mineralogy.This paper presents a detailed study on clay minerals in surface sediments collected from the Pearl River drainage basin(including all three main channels, various branches,and the Lingdingyang in the estuary)by using the X-ray diffraction(XRD)method. The results indicate that the clay mineral assemblage consists dominantly of kaolinite(35%-65%), lesser abundance of chlorite(20%-35%)and illite(12%-42%),and very scare smectite occurrences (generally<5%).Their respective distribution does not present any obvious difference throughout the Pearl River drainage basin.However,downstream the Pearl River to the northern South China Sea,the clay mineral assemblage varies significantly:kaolinite decreases gradually,smectite and illite increase gradually.Additionally,illite chemistry index steps down and illite crystallinity steps up.These varia- tions indicate the contribution of major kaolinite,lesser illite and chlorite,and very scarce smectite to the northern South China Sea from the Pearl River drainage basin.The maximum contribution of clay minerals from the Pearl River is 72%to the northern margin and only 15%to the northern slope of the South China Sea.In both glacials and interglacials,kaolinite indicates that the ability of mechanical erosion occurred in the Pearl River drainage basin.
文摘The use of ultra-high intensity laser beams to achieve extreme material states in the laboratory has become almost routine with the development of the petawatt laser. Petawatt class lasers have been constructed for specific research activities,including particle acceleration, inertial confinement fusion and radiation therapy, and for secondary source generation(x-rays, electrons, protons, neutrons and ions). They are also now routinely coupled, and synchronized, to other large scale facilities including megajoule scale lasers, ion and electron accelerators, x-ray sources and z-pinches. The authors of this paper have tried to compile a comprehensive overview of the current status of petawatt class lasers worldwide.The definition of ‘petawatt class' in this context is a laser that delivers >200 TW.
基金Supported by the National Key Basic Research Special Foundation Project of China (Grant No. 2007CB815906)the National Natural Science Foundation of China (Grant Nos. 40321603 and 40331002)+3 种基金the Fok Ying Tung Education Foundation (Grant No. 101018)the Doctoral Program of Higher Education (Grant No. 20060247032)the Sino-Netherlands Science Cooperation Project (Grant No. 2004CB720506)the Program for New Century Excellent Talents in University of the Ministry of Education of China (Grant No. NCET-04-0372)
文摘High-resolution clay mineral records combined with oxygen isotopic stratigraphy over the past 450 ka during late Quaternary from Core MD05-2901 off Middle Vietnam in the western South China Sea are re-ported to reconstruct a history of East Asian monsoon evolution. Variations in Illite, chlorite, and kaolinite contents indicate a strong glacial-interglacial cyclicity, while changes in smectite content present a higher frequency cyclicity. The provenance analysis indicates a mixture of individual clay minerals from various sources surrounding the South China Sea. Smectite derived mainly from the Sunda shelf and its major source area of the Indonesian islands. Illite and chlorite originated mainly from the Mekong and Red rivers. Kaolinite was provided mainly by the Pearl River. Spectral analysis of the kaolin-ite/(illite+chlorite) ratio displays a strong eccentricity period of 100 ka, implying the ice sheet-forced win-ter monsoon evolution; whereas higher frequency changes in the smectite content show an ice sheet-forced obliquity period of 41 ka, and precession periods of 23 and 19 ka and a semi-precession period of 13 ka as well, implying the tropical-forced summer monsoon evolution. The winter monsoon evolution is generally in coherence with the glacial-interglacial cyclicity, with intensified winter monsoon winds during glacials and weakened winter monsoon winds during interglacials; whereas the summer monsoon evolution provides an almost linear response to the summer insolation of low latitude in the Northern Hemisphere, with strengthened summer monsoon during higher insolation and weakened summer monsoon during lower insolation. The result suggests that the high-latitude ice sheet and low-latitude tropical factor could drive the late Quaternary evolution of East Asian winter and summer monsoons, respectively, implying their diplex and self-contained forcing mechanism.
基金supported by the National Natural Science Foundation of China (40925008,40876024 and 40776027)the National Basic Research Program of China (2007CB815906)+1 种基金the Shanghai Shuguang Program (07SG23)the Shanghai Subject Chief Scientist Program (10XD1406300)
文摘High-resolution clay mineralogical analysis of Core MD05-2904 in the northern South China Sea(SCS) covering the period since the Last Glacial Maximum shows that illite(29%-48%),smectite(14%-45%),chlorite(17%-28%),and minor kaolinite(6%-14%) comprise the clay mineral assemblage,and that time series variation does not present glacial-interglacial cyclicity.Provenance analysis indicates three end-member sources:almost all smectite derives from Luzon,all kaolinite is sourced from the Pearl River,and illite and chlorite originate from both the Pearl River and Taiwan.By comparing clay mineral compositions in surface sediments from the three major source areas and of the SCS,we reconstructed a time series of clay mineral contribution from the major provenances to the northern slope of the SCS using the linear separation method for illite crystallinity.There were three stages of provenance change.(1) During 24.1-17.5 ka BP,contributions from Taiwan and Luzon were similar(30%-40%),while that from the Pearl River was only 25%.(2) During 17.5-14.0 ka BP,the contribution from Luzon decreased rapidly to 20%-25%,while that from Taiwan increased to 35% from an average of 25% at 18 ka BP,and that from the Pearl River increased largely to 40%.(3) During the Holocene,differences in contributions from the three major provenances increased:the contribution from Luzon increased slightly and then remained at 27%-35%,that from Taiwan increased rapidly and then remained at 55%-60%,and that from the Pearl River decreased to 15%.The change in clay mineral contributions from different provenances is influenced mainly by clay mineral production,monsoon rainfall denudation,oceanic current transport,and sea-level change.
文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy.
