Coal gangue is the main pollution source of mining areas.When coal gangue is stacked and recycled,the heavy metal elements contained in it are released by natural weathering and leaching,which causes damage to the sur...Coal gangue is the main pollution source of mining areas.When coal gangue is stacked and recycled,the heavy metal elements contained in it are released by natural weathering and leaching,which causes damage to the surrounding ecological environment.In this study,the leaching and precipitation characteristics of heavy metals in low-sulfur coal gangue under different environmental conditions were simulated by indoor dynamic leaching experiments,which provided a theoretical basis for environmental restoration of the mining area.The conclusions are as follows:higher heavy metal content in low-sulfur coal gangue is associated with greater,leaching of heavy metals;acidic conditions promote the release of heavy metals in low-sulfur coal gangue;and more precipitation is associated with better release of heavy metals from the low-sulfur coal gangue.展开更多
Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current...Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet （HFD） to dams during lactation and to pups after weaning. We also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity. Results showed that feeding with HFD induces fat deposition and obesity in pups. Furthermore, HFD more potently increased the body weight （BW） of male than female pups. HFD-fed female pups were obese, underwent precocious puberty, and showed increased kisspeptin expression in the hypothalamus. However, parental obesity and precocious puberty exerted no synergistic effects on the HFD-induced postnatal weight gain and puberty onset of the pups. Interestingly, some HFD-fed litters with normal BW also exhibited precocious puberty. This finding suggested that diet composition but not BW triggers puberty onset. Our model suggests good construction validity of obesity and precocious puberty. Furthermore, our model can also be used to explore the mutual interactions between diet-induced postnatal childhood obesity and puberty.展开更多
Obtaining comprehensive and accurate information is very important in intelligent tragic system （ITS）. In ITS, the GPS floating car system is an important approach for traffic data acquisition. However, in this syst...Obtaining comprehensive and accurate information is very important in intelligent tragic system （ITS）. In ITS, the GPS floating car system is an important approach for traffic data acquisition. However, in this system, the GPS blind areas caused by tall buildings or tunnels could affect the acquisition of tragic information and depress the system performance. Aiming at this problem, a novel method employing a back propagation （BP） neural network is developed to estimate the traffic speed in the GPS blind areas. When the speed of one road section is lost, the speed of its related road sections can be used to estimate its speed. The complete historical data of these road sections are used to train the neural network, using Levenberg-Marquardt learning algorithm. Then, the current speed of the related roads is used by the trained neural network to get the speed of the road section without GPS signal. We compare the speed of the road section estimated by our method with the real speed of this road section, and the experimental results show that the proposed method of traffic speed estimation is very effective.展开更多
Abnormal approach-avoidance behavior has been linked to deficits in the mesolimbic dopamine（DA）system of the brain. Recently, increasing evidence has indicated that toll-like receptor 4（TLR4）, an important pattern...Abnormal approach-avoidance behavior has been linked to deficits in the mesolimbic dopamine（DA）system of the brain. Recently, increasing evidence has indicated that toll-like receptor 4（TLR4）, an important pattern-recognition receptor in the innate immune system,can be directly activated by substances of abuse, resulting in an increase of the extracellular DA level in the nucleus accumbens. We thus hypothesized that TLR4-dependent signaling might regulate approach-avoidance behavior. To test this hypothesis, we compared the novelty-seeking and social interaction behaviors of TLR4-deficient（TLR4^（-/-））and wild-type（WT） mice in an approach-avoidance conflict situation in which the positive motivation to explore a novel object or interact with an unfamiliar mouse was counteracted by the negative motivation to hide in exposed,large spaces. We found that TLR4^（-/-）mice exhibitedreduced novelty-seeking and social interaction in the large open spaces. In less stressful test apparatuses similar in size to the mouse cage, however, TLR4^（-/-）mice performed normally in both novelty-seeking and social interaction tests. The reduced exploratory behaviors under approachavoidance conflict were not due to a high anxiety level or an enhanced fear response in the TLR4^（-/-）mice, as these mice showed normal anxiety and fear responses in the open field and passive avoidance tests, respectively. Importantly,the novelty-seeking behavior in the large open field induced a higher level of c-Fos activation in the nucleus accumbens shell（NAc Sh） in TLR4^（-/-）mice than in WT mice. Partially inactivating the NAc Sh via infusion of GABA receptor agonists restored the novelty-seeking behavior of TLR4^（-/-）mice. These data suggested that TLR4 is crucial for positive motivational behavior under approach-avoidance conflict. TLR4-dependent activation of neurons in the NAc Sh may contribute to this phenomenon.展开更多
A new compressor thermodynamic model is set up. Artificial neural networks(ANN) which have self adjusting functions are adopted to calculate volumetric efficiency and electrical efficiency of a compressor. The new co...A new compressor thermodynamic model is set up. Artificial neural networks(ANN) which have self adjusting functions are adopted to calculate volumetric efficiency and electrical efficiency of a compressor. The new compressor model composed of the theoretical model and ANN reaches more precise results than traditional ones. Furthermore, the new compressor model is of better flexibility in a large scale.展开更多
Peach(Prunus persica Batsch‘Yuhualu’)fruit are sensitive to chilling injury(CI).Proline,polyamine(PA),and nitric oxide(NO)are important small regulators of various metabolic pathways under chilling stress that mitig...Peach(Prunus persica Batsch‘Yuhualu’)fruit are sensitive to chilling injury(CI).Proline,polyamine(PA),and nitric oxide(NO)are important small regulators of various metabolic pathways under chilling stress that mitigate CI.Ethylene is known to promote senescence and CI,while 1-methylcyclopropene(1-MCP)is an antagonist that inhibits the effects of ethylene.However,how1-MCP and ethylene affect proline,PA,and NO levels under chilling stress remains unclear.To address these questions,1-MCP(1μL·L^(−1))and ethylene(1μL·L^(−1))treatments were applied to peach fruit.Fruit were stored at 4°C for 28 d,then moved to 25°C for 3 d immediately after cold storage.Peach fruit exhibited CI symptoms after 7 d of cold storage with enhanced electrolyte leakage and malondialdehyde contents.The 1-MCP treatment significantly(P<0.05)restrained peach CI,and fruit did not exhibit CI symptoms until 14 d of cold storage.Proline and PAs in peach under chilling stress weremostly synthesized from glutamate and arginine,which were catalyzed by1-pyrroline-5-carboxylate synthetase and arginine decarboxylase,respectively.1-MCPtreated fruit exhibited higher proline and PA contents and enhanced chilling tolerance compared to the control,while ethylene-treated fruit had lower proline and PA contents and reduced chilling tolerance.Ethylene-treated fruit,which exhibited more severe CI symptoms compared to the control,had significantly(P<0.05)lower NO contents and NO synthase activities.However,NOmay not be a direct acting factor in 1-MCPinduced chilling tolerance,as 1-MCP-treated fruit had lower NO contents and NO synthase activities compared to the control.In conclusion,proline and PA clearly played direct and important roles in 1-MCP-induced peach chilling tolerance,while NO may not be actively involved.展开更多
OBJECTIVE: To predict the targets of Bufei Huoxue capsule( 补肺活血胶囊, BFHX) using network pharmacology analysis and to explore its effects and functional targets in a silicotic rat model. METHODS: The drug and dise...OBJECTIVE: To predict the targets of Bufei Huoxue capsule( 补肺活血胶囊, BFHX) using network pharmacology analysis and to explore its effects and functional targets in a silicotic rat model. METHODS: The drug and disease targets were correlated through network pharmacology analysis to explore the targets and signaling pathways of BFHX affecting silicosis. NR8383 cells were cultured to verify the core genes and pathways. A rat model of silicosis was established to verify whether the mechanism behind SiO2-caused pulmonary fibrosis was alleviated by BFHX(0.82 g/kg) and how it affected key targets and pathways. RESULTS: Overlapping BFHX and silicotic gene targets produced 159 interactive targets, and 55 were screened by network topology analysis. The results of gene ontology and Kyoto encyclopedia of genes and genomes enrichment analyses suggested that BFHX could affect silicosis through the nucleotide-like receptor containing pyrin domain 3(NLRP3) inflammasome. In NR8383 cells, the expression of core genes related to the NLRP3 inflammasome could be inhibited by BFHX treatment. BFHX reduced the degree of alveolitis and collagen deposition, attenuating pulmonary fibrosis in Si O2-induced rat model. Pulmonary macrophage pyroptosis after SiO2 exposure was observed under transmission electron microscopy. BFHX alleviated the morphological characteristics of pyroptosis. BFHX also reduced the expression of NLRP3, caspase-1, interleukin-1 beta(IL-1β), IL-18, IL-6, and tumor necrosis factor-alpha in lung tissues of silicotic rat model. BFHX affected the K ion content in bronchoalveolar lavage fluid when assessed by energy dispersive spectrometer testing. The expression of CD68+ and CD206+ were also reduced after BFHX intervention. CONCLUSION: NOD-like receptor signaling is vital for BFHX's effects on silicosis. It exerts anti-pulmonary fibrosis effects by inhibiting pulmonary macrophage pyroptosis and polarization through NLRP3 inflammasome activation.展开更多
Hepatocellular carcinoma(HCC)is a common cancer,and the body’s immune responses greatly affect its progression and the prognosis of patients.Immunological suppression and the maintenance of self-tolerance in the tumo...Hepatocellular carcinoma(HCC)is a common cancer,and the body’s immune responses greatly affect its progression and the prognosis of patients.Immunological suppression and the maintenance of self-tolerance in the tumor microenvironment are essential responses,and these form part of the theoretical foundations of immunotherapy.In this review,we first discuss the tumor microenvironment of HCC,describe immunosuppression in HCC,and review the major biomarkers used to track HCC progression and response to treatment.We then examine antibody-based therapies,with a focus on immune checkpoint inhibitors(ICIs),monoclonal antibodies that target key proteins in the immune response(programmed cell death protein 1,anti-cytotoxic T-lymphocyte associated protein 4,and programmed deathligand 1)which have transformed the treatment of HCC and other cancers.ICIs may be used alone or in conjunction with various targeted therapies for patients with advanced HCC who are receiving first-line treatments or subsequent treatments.We also discuss the use of different cellular immunotherapies,including T cell receptor(TCR)T cell therapy and chimeric antigen receptor(CAR)T cell therapy.We then review the use of HCC vaccines,adjuvant immunotherapy,and oncolytic virotherapy,and describe the goals of future research in the development of treatments for HCC.展开更多
Fibrosis resulting from pathological repair secondary to recurrent or persistent tissue damage often leads to organ failure and mortality.Biliary fibrosis is a crucial but easily neglected pathological feature in hepa...Fibrosis resulting from pathological repair secondary to recurrent or persistent tissue damage often leads to organ failure and mortality.Biliary fibrosis is a crucial but easily neglected pathological feature in hepatobiliary disorders,which may promote the development and progression of benign and malignant biliary diseases through pathological healing mechanisms secondary to biliary tract injuries.Elucidating the etiology and pathogenesis of biliary fibrosis is beneficial to the prevention and treatment of biliary diseases.In this review,we emphasized the importance of biliary fibrosis in cholangiopathies and summarized the clinical manifestations,epidemiology,and aberrant cellular composition involving the biliary ductules,cholangiocytes,immune system,fibroblasts,and the microbiome.We also focused on pivotal signaling pathways and offered insights into ongoing clinical trials and proposing a strategic approach for managing biliary fibrosis-related cholangiopathies.This review will offer a comprehensive perspective on biliary fibrosis and provide an important reference for future mechanism research and innovative therapy to prevent or reverse fibrosis.展开更多
To the Editor:Pancreatoduodenectomy(PD),distal pancreatectomy(DP),and central pancreatectomy(CP)usually lead to an undesirable loss of functional pancreatic parenchyma,disruption of the continuity of the digestive tra...To the Editor:Pancreatoduodenectomy(PD),distal pancreatectomy(DP),and central pancreatectomy(CP)usually lead to an undesirable loss of functional pancreatic parenchyma,disruption of the continuity of the digestive tract,and high incidence of complications.In recent years,traditional pancreatic enucleation(TPE)has been increasingly performed for small benign and lowgrade malignant pancreatic lesions>2 mm away from the main duct(MD)as it can maximize the preservation of functional pancreatic parenchyma and retain the continuity of the digestive tract.Cases with a too short distance(≤2 mm)are not good candidates,as a too short distance may damage the MD when TPE is performed.[1]Herein,a novel pancreatic enucleation procedure,the main-ductfirst approach pancreatic enucleation(MDFAPE),was introduced for small benign and low-grade malignant lesions≤2 mm away from the MD.展开更多
In order to obtain liquefied products with higher yields of aromatic molecules to produce mesophase pitch,a good understanding of the relevant reaction mechanisms is required.Reactive molecular dynamics simulations we...In order to obtain liquefied products with higher yields of aromatic molecules to produce mesophase pitch,a good understanding of the relevant reaction mechanisms is required.Reactive molecular dynamics simulations were used to study the thermal reactions of pyrene,1-methylpyrene,7,8,9,10-tetrahydrobenzopyrene,and mixtures of pyrene with 1-octene,cyclohexene,or styrene.The reactant conversion rates,reaction rates,and product distributions were calculated and compared,and the mechanisms were analyzed and discussed.The results demonstrated that methyl and naphthenic structures in aromatics might improve the conversion rates of reactants in hydrogen transfer processes,but their steric hindrances prohibited the generation of high polymers.The naphthenic structures could generate more free radicals and presented a more obvious inhibition effect on the condensation of polymers compared with the methyl side chains.It was discovered that when different olefins were mixed with pyrene,1-octene primarily underwent pyrolysis reactions,whereas cyclohexene mainly underwent hydrogen transfer reactions with pyrene and styrene,mostly producing superconjugated biradicals through condensation reactions with pyrene.In the mixture systems,the olefins scattered aromatic molecules,hindering the formation of pyrene trimers and higher polymers.According to the reactive molecular dynamics simulations,styrene may enhance the yield of dimer and enable the controlled polycondensation of pyrene.展开更多
Molecular simulations were performed to investigate the molecular structural effects on needle coke mesophase stacking.The simulation results showed that the stacking states of anthracene trimer and tetramer accumulat...Molecular simulations were performed to investigate the molecular structural effects on needle coke mesophase stacking.The simulation results showed that the stacking states of anthracene trimer and tetramer accumulations were orderly,while the stacking states of anthracene dimer,pentamer,and hexamer accumulations were disorderly.Anthracene trimer and tetramer in the model compounds were two of the most ideal needle coke mesophase constituents.It was also found that the introduction of methyl side chains in anthracene trimer derivatives was not conducive to the formation of a mesophase crystal.To sum up,the molecules which had similar structures to anthracene trimer or tetramer with no alkyl chains are ideal constituents of needle coke mesophase.展开更多
An analytic model for working fluids flowing through capillary tubes has been established with the approximate integral method. All the possible flow regimes in the capillary tubes,including subcooled, two-phase and s...An analytic model for working fluids flowing through capillary tubes has been established with the approximate integral method. All the possible flow regimes in the capillary tubes,including subcooled, two-phase and superheated regimes, are covered in the model, and different analytic solutions are given respectively for each flow regime. As examples, the mass flow rates of refrigerants R12, R134a and R600a through capillary tubes are predicted by the model,and compared with those evaluated by a general distributed-parameter model. The mean bias falls into 1% and the maximum bias is 2.2%, while the computation speed of the new model is more than one order of magnitude higher than that of the distributed-parameter one.展开更多
Molecular simulations were carried out to investigate the self-diffusion coefficient of asphaltene in asphaltene-xylene systems,used as heavy oil models.The self-diffusion behavior of asphaltene in the asphaltene-xyle...Molecular simulations were carried out to investigate the self-diffusion coefficient of asphaltene in asphaltene-xylene systems,used as heavy oil models.The self-diffusion behavior of asphaltene in the asphaltene-xylene equilibrium system was mainly affected by the interaction between asphaltene molecules,with stronger interactions corresponding to a slower diffusion of asphaltene.The interactions between asphaltene molecules mainly includedπ-πinteractions between aromatic rings and hydrogen bonds between strongly electronegative heteroatoms.These results are expected to provide theoretical guidance for reducing the viscosity of heavy oil.展开更多
As energy storage systems are typically not installed with residential solar photovoltaic (PV) systems,any “excess” solar energy exceeding the house load remains unharvested or is exported to the grid.This paper int...As energy storage systems are typically not installed with residential solar photovoltaic (PV) systems,any “excess” solar energy exceeding the house load remains unharvested or is exported to the grid.This paper introduces an approach towards a system design for improved PV self-consumptionand self-sufficiency. As a result, a polyvalent heat pump, offering heating, cooling and domestic hotwater, is considered alongside water storage tanks and batteries. Our method of system analysisbegins with annual hourly thermal loads for heating and cooling a typical Australian house inGeelong, Victoria. These hourly heating and cooling loads are determined using Transient SystemSimulation (TRNSYS) software. The house’s annual hourly electricity consumption is analysed usingsmart meter data downloaded from the power supplier and PV generation data measured with aPV system controller. The results reveal that the proposed system could increase PV self-consumptionand self-sufficiency to 41.96% and 86.34%, respectively, resulting in the annual imported energybeing reduced by about 74%. The paper also provides sensitivity analyses for the hot and coldstorage tank sizes, the coefficient of performance of the heat pump, solar PV and battery sizes.After establishing the limits of thermal storage size, a significant impact on self-efficiency can berealised through battery storage. This study demonstrates the feasibility of using a polyvalent heatpump together with water storage tanks and, ultimately, batteries to increase PV self-consumptionand self-sufficiency. Future work will concentrate on determining a best-fit approach to systemsizing embedded within the TRNSYS simulation tool.展开更多
In order to investigate the influence of hydrogenation degree and structural variety on reaction trend of polyaro- matic hydrocarbons (PAHs) in resins and asphaltenes portion of heavy oil, a series of PAHs with differ...In order to investigate the influence of hydrogenation degree and structural variety on reaction trend of polyaro- matic hydrocarbons (PAHs) in resins and asphaltenes portion of heavy oil, a series of PAHs with different hydrogenation degree were selected as model compounds to simulate their different hydrogenation stage, and the PAHs thermal cracking reaction was simulated based on free radical mechanism by the density functional theory (DFT) to search for reactions'transition state. By comparing the dynamic data obtained from reaction simulation, it is showed that processing difficulty could rise with increasing condensed aromatic ring number, and hydrogenation could promote ring cleavage reaction, but excessive hydrogenation would decrease the oil conversion rate to reduce light-end products. In conclusion, proper hydrogenation was quite critical in promoting light-end products conversion efficiency and saving the processing cost as well. Operational instructions were given based on both PAHs hydrogenation performance and conclusions were drawn up from reaction simulation results.展开更多
Mesozoic and Cenozoic magma activity in the Wolong Lake mining area of Huaibei is frequent,and the degree of magma intrusion into coal seams remarkable.On the one hand,magma intrusion affects the utilization of coal r...Mesozoic and Cenozoic magma activity in the Wolong Lake mining area of Huaibei is frequent,and the degree of magma intrusion into coal seams remarkable.On the one hand,magma intrusion affects the utilization of coal resources;on the other hand,the macro and trace elements in coal are redistributed to form new mineral types.This study uses the Wolong Lake magma intrusion coal seam as a research object.The mineral paragenesis for igneous rock,coke,and thermally-altered coal in an igneous intrusion zone is studied using SEM,XRD,and Raman spectroscopy.During igneous intrusion,the temperature and pressure of igneous rock metamorphose ambient low-rank coal to high-rank coal and coke.The response mechanism of minerals and trace elements to magmatic intrusion is discussed.The results are:①SEM analysis shows that ankerite and pyrite are formed from magma intrusion.Both minerals are strongly developed in the magma-coal contact zone,and less well developed in thermally-altered coal.②XRD analysis shows that igneous intrusion strongly influences the types and content of minerals in coke and thermally-altered coal.In addition to the increase amounts of ankerite and pyrite,chlorite,serpentine,and muscovite,and other secondary minerals,are generated following igneous intrusion.③Raman analysis suggests that thermally-altered coal possesses the characteristics of both pyrite and coke.Coke from the magma-coal boundary zone possesses the typical characteristics of pyrite.Igneous rock contains a mineral similar to pyrite,confirmed by both having similar Raman peaks.The scattering intensity of Ag indicates that the formation pressure of pyrite increases from thermally-altered coal via the boundary between the coke zone and the igneous rock.展开更多
The fuzzy method is introduced to the calculation of thermal performance of refrigeration compressors. A compound model combining classical thermodynamic theory and fuzzy theory is presented and compared with a simple...The fuzzy method is introduced to the calculation of thermal performance of refrigeration compressors. A compound model combining classical thermodynamic theory and fuzzy theory is presented and compared with a simple fuzzy model without classical thermodynamic fundamentals. Case study of refrigeration compressors shows that the compound fuzzy model and the simple fuzzy model are both more efficient than the classical thermodynamic method. However, the compound fuzzy model is of better precision and adaptability.展开更多
Edible fungi are rich in nutrition,but they are susceptible to spoilage,and often prolonged by drying.RF and microwave energy drying have the advantages of short drying time,high energy efficiency and good process con...Edible fungi are rich in nutrition,but they are susceptible to spoilage,and often prolonged by drying.RF and microwave energy drying have the advantages of short drying time,high energy efficiency and good process control.However,to develop an effective dielectric drying method,it is important to understand dielectric properties,the major factor characterizing the interaction between the electromagnetic energy and the food.At present,there is a lack of research on dielectric properties of edible fungi.In this study,a vector network analyzer and an open-ended coaxial-line probe were employed to measure the dielectric parameters.The dielectric parameters were observed at different temperatures(25–85°C)for edible fungi powder with moisture content ranging from 5 to 30%wet basis over a frequency range of 1–3000 MHz.The relationship between the dielectric properties and frequency,temperature,and moisture content were obtained via regression analysis.Further,the dielectric penetration depth was calculated,and the effects of frequency,moisture content,and temperature on the penetration depth were also analyzed.The results showed that the dielectric properties of edible fungi powder increased with an increase in moisture content and temperature,while they decreased with increasing frequency.At high moisture content and temperature,the increase in dielectric properties was slightly larger than that at low moisture content and temperature.The dielectric properties changed more evidently at lower radio frequencies than at higher radio frequencies.The penetration depth decreased with an increase in temperature,moisture content,and frequency.It can be concluded that a large penetration depth at radio frequencies below 100 MHz could be used to dry edible fungi on a large scale,whereas microwave energy could be employed for drying edible fungi on a small scale.展开更多
基金the National Natural Science Fund Project of China(41373108)the Mining Group Project of Huaibei(K160139078)。
文摘Coal gangue is the main pollution source of mining areas.When coal gangue is stacked and recycled,the heavy metal elements contained in it are released by natural weathering and leaching,which causes damage to the surrounding ecological environment.In this study,the leaching and precipitation characteristics of heavy metals in low-sulfur coal gangue under different environmental conditions were simulated by indoor dynamic leaching experiments,which provided a theoretical basis for environmental restoration of the mining area.The conclusions are as follows:higher heavy metal content in low-sulfur coal gangue is associated with greater,leaching of heavy metals;acidic conditions promote the release of heavy metals in low-sulfur coal gangue;and more precipitation is associated with better release of heavy metals from the low-sulfur coal gangue.
文摘Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet （HFD） to dams during lactation and to pups after weaning. We also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity. Results showed that feeding with HFD induces fat deposition and obesity in pups. Furthermore, HFD more potently increased the body weight （BW） of male than female pups. HFD-fed female pups were obese, underwent precocious puberty, and showed increased kisspeptin expression in the hypothalamus. However, parental obesity and precocious puberty exerted no synergistic effects on the HFD-induced postnatal weight gain and puberty onset of the pups. Interestingly, some HFD-fed litters with normal BW also exhibited precocious puberty. This finding suggested that diet composition but not BW triggers puberty onset. Our model suggests good construction validity of obesity and precocious puberty. Furthermore, our model can also be used to explore the mutual interactions between diet-induced postnatal childhood obesity and puberty.
基金funded by National Key Technology R&D Program of China (No.2006BAG01A03)
文摘Obtaining comprehensive and accurate information is very important in intelligent tragic system （ITS）. In ITS, the GPS floating car system is an important approach for traffic data acquisition. However, in this system, the GPS blind areas caused by tall buildings or tunnels could affect the acquisition of tragic information and depress the system performance. Aiming at this problem, a novel method employing a back propagation （BP） neural network is developed to estimate the traffic speed in the GPS blind areas. When the speed of one road section is lost, the speed of its related road sections can be used to estimate its speed. The complete historical data of these road sections are used to train the neural network, using Levenberg-Marquardt learning algorithm. Then, the current speed of the related roads is used by the trained neural network to get the speed of the road section without GPS signal. We compare the speed of the road section estimated by our method with the real speed of this road section, and the experimental results show that the proposed method of traffic speed estimation is very effective.
基金supported by the National Basic Research Development Program(973 Program)of China(2013CB530902)the National Natural Science Foundation of China(91132712,81571125,81221003 and 81300979)+2 种基金the Natural Science Foundation of Zhejiang Province,China(LR12C09001 and Q13C090002)the Fundamental Research Funds for the Central Universities of China(2014FZA7008)partly supported by a Chinese Postdoctoral Science Foundation grant(2015M570501)
文摘Abnormal approach-avoidance behavior has been linked to deficits in the mesolimbic dopamine（DA）system of the brain. Recently, increasing evidence has indicated that toll-like receptor 4（TLR4）, an important pattern-recognition receptor in the innate immune system,can be directly activated by substances of abuse, resulting in an increase of the extracellular DA level in the nucleus accumbens. We thus hypothesized that TLR4-dependent signaling might regulate approach-avoidance behavior. To test this hypothesis, we compared the novelty-seeking and social interaction behaviors of TLR4-deficient（TLR4^（-/-））and wild-type（WT） mice in an approach-avoidance conflict situation in which the positive motivation to explore a novel object or interact with an unfamiliar mouse was counteracted by the negative motivation to hide in exposed,large spaces. We found that TLR4^（-/-）mice exhibitedreduced novelty-seeking and social interaction in the large open spaces. In less stressful test apparatuses similar in size to the mouse cage, however, TLR4^（-/-）mice performed normally in both novelty-seeking and social interaction tests. The reduced exploratory behaviors under approachavoidance conflict were not due to a high anxiety level or an enhanced fear response in the TLR4^（-/-）mice, as these mice showed normal anxiety and fear responses in the open field and passive avoidance tests, respectively. Importantly,the novelty-seeking behavior in the large open field induced a higher level of c-Fos activation in the nucleus accumbens shell（NAc Sh） in TLR4^（-/-）mice than in WT mice. Partially inactivating the NAc Sh via infusion of GABA receptor agonists restored the novelty-seeking behavior of TLR4^（-/-）mice. These data suggested that TLR4 is crucial for positive motivational behavior under approach-avoidance conflict. TLR4-dependent activation of neurons in the NAc Sh may contribute to this phenomenon.
文摘A new compressor thermodynamic model is set up. Artificial neural networks(ANN) which have self adjusting functions are adopted to calculate volumetric efficiency and electrical efficiency of a compressor. The new compressor model composed of the theoretical model and ANN reaches more precise results than traditional ones. Furthermore, the new compressor model is of better flexibility in a large scale.
基金This work was supported by the Natural Science Foundation of Jiangsu Province of China(Grant No.BK20140483)China Postdoctoral Science Foundation(Grant No.2014M560451).
文摘Peach(Prunus persica Batsch‘Yuhualu’)fruit are sensitive to chilling injury(CI).Proline,polyamine(PA),and nitric oxide(NO)are important small regulators of various metabolic pathways under chilling stress that mitigate CI.Ethylene is known to promote senescence and CI,while 1-methylcyclopropene(1-MCP)is an antagonist that inhibits the effects of ethylene.However,how1-MCP and ethylene affect proline,PA,and NO levels under chilling stress remains unclear.To address these questions,1-MCP(1μL·L^(−1))and ethylene(1μL·L^(−1))treatments were applied to peach fruit.Fruit were stored at 4°C for 28 d,then moved to 25°C for 3 d immediately after cold storage.Peach fruit exhibited CI symptoms after 7 d of cold storage with enhanced electrolyte leakage and malondialdehyde contents.The 1-MCP treatment significantly(P<0.05)restrained peach CI,and fruit did not exhibit CI symptoms until 14 d of cold storage.Proline and PAs in peach under chilling stress weremostly synthesized from glutamate and arginine,which were catalyzed by1-pyrroline-5-carboxylate synthetase and arginine decarboxylase,respectively.1-MCPtreated fruit exhibited higher proline and PA contents and enhanced chilling tolerance compared to the control,while ethylene-treated fruit had lower proline and PA contents and reduced chilling tolerance.Ethylene-treated fruit,which exhibited more severe CI symptoms compared to the control,had significantly(P<0.05)lower NO contents and NO synthase activities.However,NOmay not be a direct acting factor in 1-MCPinduced chilling tolerance,as 1-MCP-treated fruit had lower NO contents and NO synthase activities compared to the control.In conclusion,proline and PA clearly played direct and important roles in 1-MCP-induced peach chilling tolerance,while NO may not be actively involved.
基金Jiangsu Natural Science Foundation Youth Program:Regulation of Alveolar Macrophage Pyroptosis based on (Never in Mitosis Gene A)-Related Kinase 7/Nucleotide-like Receptor Containing Pyrin Domain 3 Inflammasome to Explore the Mechanism of Bufei Huoxue Capsule on Pulmonary Fibrosis in Silicosis (No. BK20220236)Key Research and Development Project of Xuzhou City:Evaluation of Pyroptosis Induced by Nucleotide-like Receptor Containing Pyrin Domain 3 Inflammasome Activation in Pneumoconiosis Patients by Bronchoalveolar Lavage Fluid Ion Assay Combined with High-Resolution Computed Tomography Quantitative Analysis (KC22212)Youth Medical Science and Technology Innovation Project of Xuzhou Municipal Health Commission and Development Fund of Affiliated Hospital of Xuzhou Medical University:Study on the Regulation of Various Cytokines and the Effect of c-Jun Activation Domain-Binding Protein 1 on Immune Response in Lung Cancer (XWKYHT20210565, XYFY2020051)。
文摘OBJECTIVE: To predict the targets of Bufei Huoxue capsule( 补肺活血胶囊, BFHX) using network pharmacology analysis and to explore its effects and functional targets in a silicotic rat model. METHODS: The drug and disease targets were correlated through network pharmacology analysis to explore the targets and signaling pathways of BFHX affecting silicosis. NR8383 cells were cultured to verify the core genes and pathways. A rat model of silicosis was established to verify whether the mechanism behind SiO2-caused pulmonary fibrosis was alleviated by BFHX(0.82 g/kg) and how it affected key targets and pathways. RESULTS: Overlapping BFHX and silicotic gene targets produced 159 interactive targets, and 55 were screened by network topology analysis. The results of gene ontology and Kyoto encyclopedia of genes and genomes enrichment analyses suggested that BFHX could affect silicosis through the nucleotide-like receptor containing pyrin domain 3(NLRP3) inflammasome. In NR8383 cells, the expression of core genes related to the NLRP3 inflammasome could be inhibited by BFHX treatment. BFHX reduced the degree of alveolitis and collagen deposition, attenuating pulmonary fibrosis in Si O2-induced rat model. Pulmonary macrophage pyroptosis after SiO2 exposure was observed under transmission electron microscopy. BFHX alleviated the morphological characteristics of pyroptosis. BFHX also reduced the expression of NLRP3, caspase-1, interleukin-1 beta(IL-1β), IL-18, IL-6, and tumor necrosis factor-alpha in lung tissues of silicotic rat model. BFHX affected the K ion content in bronchoalveolar lavage fluid when assessed by energy dispersive spectrometer testing. The expression of CD68+ and CD206+ were also reduced after BFHX intervention. CONCLUSION: NOD-like receptor signaling is vital for BFHX's effects on silicosis. It exerts anti-pulmonary fibrosis effects by inhibiting pulmonary macrophage pyroptosis and polarization through NLRP3 inflammasome activation.
基金supported by the Natural Science Foundation of Gansu Province(21JR7RA374,20JR10RA674)Gansu Provincial Major Science and Technology Project(23ZDWA003)+1 种基金the Provincial-level special funds for military-civilian integration development from the Department of Finance of Gansu Province,the First Hospital of Lanzhou University Intramural Fund(ldyyyn2020-20,ldyyyn2019-45)the National Natural Science Foundation of China(82060119).
文摘Hepatocellular carcinoma(HCC)is a common cancer,and the body’s immune responses greatly affect its progression and the prognosis of patients.Immunological suppression and the maintenance of self-tolerance in the tumor microenvironment are essential responses,and these form part of the theoretical foundations of immunotherapy.In this review,we first discuss the tumor microenvironment of HCC,describe immunosuppression in HCC,and review the major biomarkers used to track HCC progression and response to treatment.We then examine antibody-based therapies,with a focus on immune checkpoint inhibitors(ICIs),monoclonal antibodies that target key proteins in the immune response(programmed cell death protein 1,anti-cytotoxic T-lymphocyte associated protein 4,and programmed deathligand 1)which have transformed the treatment of HCC and other cancers.ICIs may be used alone or in conjunction with various targeted therapies for patients with advanced HCC who are receiving first-line treatments or subsequent treatments.We also discuss the use of different cellular immunotherapies,including T cell receptor(TCR)T cell therapy and chimeric antigen receptor(CAR)T cell therapy.We then review the use of HCC vaccines,adjuvant immunotherapy,and oncolytic virotherapy,and describe the goals of future research in the development of treatments for HCC.
基金supported by the National Key Research and Development Program of China (2022YFC2407405)the Joint Research Fund Major Project of Gansu Province (23JRRA1488)the Medical Innovation and Development Project of Lanzhou University (lzuyxcx-2022-157).
文摘Fibrosis resulting from pathological repair secondary to recurrent or persistent tissue damage often leads to organ failure and mortality.Biliary fibrosis is a crucial but easily neglected pathological feature in hepatobiliary disorders,which may promote the development and progression of benign and malignant biliary diseases through pathological healing mechanisms secondary to biliary tract injuries.Elucidating the etiology and pathogenesis of biliary fibrosis is beneficial to the prevention and treatment of biliary diseases.In this review,we emphasized the importance of biliary fibrosis in cholangiopathies and summarized the clinical manifestations,epidemiology,and aberrant cellular composition involving the biliary ductules,cholangiocytes,immune system,fibroblasts,and the microbiome.We also focused on pivotal signaling pathways and offered insights into ongoing clinical trials and proposing a strategic approach for managing biliary fibrosis-related cholangiopathies.This review will offer a comprehensive perspective on biliary fibrosis and provide an important reference for future mechanism research and innovative therapy to prevent or reverse fibrosis.
基金funded by the Key Research and Development Projects in Sichuan Province(No.2023YFS0316)Key R&D project of Science and Technology Department of Sichuan Province(No.2021YFS0107)
文摘To the Editor:Pancreatoduodenectomy(PD),distal pancreatectomy(DP),and central pancreatectomy(CP)usually lead to an undesirable loss of functional pancreatic parenchyma,disruption of the continuity of the digestive tract,and high incidence of complications.In recent years,traditional pancreatic enucleation(TPE)has been increasingly performed for small benign and lowgrade malignant pancreatic lesions>2 mm away from the main duct(MD)as it can maximize the preservation of functional pancreatic parenchyma and retain the continuity of the digestive tract.Cases with a too short distance(≤2 mm)are not good candidates,as a too short distance may damage the MD when TPE is performed.[1]Herein,a novel pancreatic enucleation procedure,the main-ductfirst approach pancreatic enucleation(MDFAPE),was introduced for small benign and low-grade malignant lesions≤2 mm away from the MD.
基金financially supported by the National Natural Science Foundation of China(Approval No.42172168).
文摘In order to obtain liquefied products with higher yields of aromatic molecules to produce mesophase pitch,a good understanding of the relevant reaction mechanisms is required.Reactive molecular dynamics simulations were used to study the thermal reactions of pyrene,1-methylpyrene,7,8,9,10-tetrahydrobenzopyrene,and mixtures of pyrene with 1-octene,cyclohexene,or styrene.The reactant conversion rates,reaction rates,and product distributions were calculated and compared,and the mechanisms were analyzed and discussed.The results demonstrated that methyl and naphthenic structures in aromatics might improve the conversion rates of reactants in hydrogen transfer processes,but their steric hindrances prohibited the generation of high polymers.The naphthenic structures could generate more free radicals and presented a more obvious inhibition effect on the condensation of polymers compared with the methyl side chains.It was discovered that when different olefins were mixed with pyrene,1-octene primarily underwent pyrolysis reactions,whereas cyclohexene mainly underwent hydrogen transfer reactions with pyrene and styrene,mostly producing superconjugated biradicals through condensation reactions with pyrene.In the mixture systems,the olefins scattered aromatic molecules,hindering the formation of pyrene trimers and higher polymers.According to the reactive molecular dynamics simulations,styrene may enhance the yield of dimer and enable the controlled polycondensation of pyrene.
基金Funding provided by the Molecular Simulation Key Laboratory at SINOPEC Research Institute of Petroleum Processing is gratefully acknowledged.
文摘Molecular simulations were performed to investigate the molecular structural effects on needle coke mesophase stacking.The simulation results showed that the stacking states of anthracene trimer and tetramer accumulations were orderly,while the stacking states of anthracene dimer,pentamer,and hexamer accumulations were disorderly.Anthracene trimer and tetramer in the model compounds were two of the most ideal needle coke mesophase constituents.It was also found that the introduction of methyl side chains in anthracene trimer derivatives was not conducive to the formation of a mesophase crystal.To sum up,the molecules which had similar structures to anthracene trimer or tetramer with no alkyl chains are ideal constituents of needle coke mesophase.
文摘An analytic model for working fluids flowing through capillary tubes has been established with the approximate integral method. All the possible flow regimes in the capillary tubes,including subcooled, two-phase and superheated regimes, are covered in the model, and different analytic solutions are given respectively for each flow regime. As examples, the mass flow rates of refrigerants R12, R134a and R600a through capillary tubes are predicted by the model,and compared with those evaluated by a general distributed-parameter model. The mean bias falls into 1% and the maximum bias is 2.2%, while the computation speed of the new model is more than one order of magnitude higher than that of the distributed-parameter one.
基金This work is financially supported by the National Natural Science Foundation of China(Grant No.41872168).
文摘Molecular simulations were carried out to investigate the self-diffusion coefficient of asphaltene in asphaltene-xylene systems,used as heavy oil models.The self-diffusion behavior of asphaltene in the asphaltene-xylene equilibrium system was mainly affected by the interaction between asphaltene molecules,with stronger interactions corresponding to a slower diffusion of asphaltene.The interactions between asphaltene molecules mainly includedπ-πinteractions between aromatic rings and hydrogen bonds between strongly electronegative heteroatoms.These results are expected to provide theoretical guidance for reducing the viscosity of heavy oil.
文摘As energy storage systems are typically not installed with residential solar photovoltaic (PV) systems,any “excess” solar energy exceeding the house load remains unharvested or is exported to the grid.This paper introduces an approach towards a system design for improved PV self-consumptionand self-sufficiency. As a result, a polyvalent heat pump, offering heating, cooling and domestic hotwater, is considered alongside water storage tanks and batteries. Our method of system analysisbegins with annual hourly thermal loads for heating and cooling a typical Australian house inGeelong, Victoria. These hourly heating and cooling loads are determined using Transient SystemSimulation (TRNSYS) software. The house’s annual hourly electricity consumption is analysed usingsmart meter data downloaded from the power supplier and PV generation data measured with aPV system controller. The results reveal that the proposed system could increase PV self-consumptionand self-sufficiency to 41.96% and 86.34%, respectively, resulting in the annual imported energybeing reduced by about 74%. The paper also provides sensitivity analyses for the hot and coldstorage tank sizes, the coefficient of performance of the heat pump, solar PV and battery sizes.After establishing the limits of thermal storage size, a significant impact on self-efficiency can berealised through battery storage. This study demonstrates the feasibility of using a polyvalent heatpump together with water storage tanks and, ultimately, batteries to increase PV self-consumptionand self-sufficiency. Future work will concentrate on determining a best-fit approach to systemsizing embedded within the TRNSYS simulation tool.
基金sapported by China Petro-chemical Corporation(SINOPEC)(Contact No.112101)
文摘In order to investigate the influence of hydrogenation degree and structural variety on reaction trend of polyaro- matic hydrocarbons (PAHs) in resins and asphaltenes portion of heavy oil, a series of PAHs with different hydrogenation degree were selected as model compounds to simulate their different hydrogenation stage, and the PAHs thermal cracking reaction was simulated based on free radical mechanism by the density functional theory (DFT) to search for reactions'transition state. By comparing the dynamic data obtained from reaction simulation, it is showed that processing difficulty could rise with increasing condensed aromatic ring number, and hydrogenation could promote ring cleavage reaction, but excessive hydrogenation would decrease the oil conversion rate to reduce light-end products. In conclusion, proper hydrogenation was quite critical in promoting light-end products conversion efficiency and saving the processing cost as well. Operational instructions were given based on both PAHs hydrogenation performance and conclusions were drawn up from reaction simulation results.
基金This work was supported by the National Natural Science Foundation of China(No.41373108 and 41702176)Natural Science Foundation of Anhui Province(No.1608085QD79)+1 种基金the Scientific and Technological Project of Huaibei Mining Industry(Group)Co.Ltd.(HK-2018-1)the Scientific and Technological Project of Anhui Traffic and Aviation Engineering(Group)Co.Ltd.We acknowledge the editors and reviewers for polishing the language and providing in-depth discussion.
文摘Mesozoic and Cenozoic magma activity in the Wolong Lake mining area of Huaibei is frequent,and the degree of magma intrusion into coal seams remarkable.On the one hand,magma intrusion affects the utilization of coal resources;on the other hand,the macro and trace elements in coal are redistributed to form new mineral types.This study uses the Wolong Lake magma intrusion coal seam as a research object.The mineral paragenesis for igneous rock,coke,and thermally-altered coal in an igneous intrusion zone is studied using SEM,XRD,and Raman spectroscopy.During igneous intrusion,the temperature and pressure of igneous rock metamorphose ambient low-rank coal to high-rank coal and coke.The response mechanism of minerals and trace elements to magmatic intrusion is discussed.The results are:①SEM analysis shows that ankerite and pyrite are formed from magma intrusion.Both minerals are strongly developed in the magma-coal contact zone,and less well developed in thermally-altered coal.②XRD analysis shows that igneous intrusion strongly influences the types and content of minerals in coke and thermally-altered coal.In addition to the increase amounts of ankerite and pyrite,chlorite,serpentine,and muscovite,and other secondary minerals,are generated following igneous intrusion.③Raman analysis suggests that thermally-altered coal possesses the characteristics of both pyrite and coke.Coke from the magma-coal boundary zone possesses the typical characteristics of pyrite.Igneous rock contains a mineral similar to pyrite,confirmed by both having similar Raman peaks.The scattering intensity of Ag indicates that the formation pressure of pyrite increases from thermally-altered coal via the boundary between the coke zone and the igneous rock.
文摘The fuzzy method is introduced to the calculation of thermal performance of refrigeration compressors. A compound model combining classical thermodynamic theory and fuzzy theory is presented and compared with a simple fuzzy model without classical thermodynamic fundamentals. Case study of refrigeration compressors shows that the compound fuzzy model and the simple fuzzy model are both more efficient than the classical thermodynamic method. However, the compound fuzzy model is of better precision and adaptability.
基金support provided by the National Key R&D Program of China(No.2018YFD0400200)China National Natural Science Foundation(No.31601484)Jiangsu Agricultural Scientific and Technological Self-Innovation Foundation[CX(18)3037].
文摘Edible fungi are rich in nutrition,but they are susceptible to spoilage,and often prolonged by drying.RF and microwave energy drying have the advantages of short drying time,high energy efficiency and good process control.However,to develop an effective dielectric drying method,it is important to understand dielectric properties,the major factor characterizing the interaction between the electromagnetic energy and the food.At present,there is a lack of research on dielectric properties of edible fungi.In this study,a vector network analyzer and an open-ended coaxial-line probe were employed to measure the dielectric parameters.The dielectric parameters were observed at different temperatures(25–85°C)for edible fungi powder with moisture content ranging from 5 to 30%wet basis over a frequency range of 1–3000 MHz.The relationship between the dielectric properties and frequency,temperature,and moisture content were obtained via regression analysis.Further,the dielectric penetration depth was calculated,and the effects of frequency,moisture content,and temperature on the penetration depth were also analyzed.The results showed that the dielectric properties of edible fungi powder increased with an increase in moisture content and temperature,while they decreased with increasing frequency.At high moisture content and temperature,the increase in dielectric properties was slightly larger than that at low moisture content and temperature.The dielectric properties changed more evidently at lower radio frequencies than at higher radio frequencies.The penetration depth decreased with an increase in temperature,moisture content,and frequency.It can be concluded that a large penetration depth at radio frequencies below 100 MHz could be used to dry edible fungi on a large scale,whereas microwave energy could be employed for drying edible fungi on a small scale.
