Solid-state lithium metal batteries are one of the most promising options for next-generation batteries pursuing high-energy density and high-safety.However,the inevitable volatilization of lithium compounds during si...Solid-state lithium metal batteries are one of the most promising options for next-generation batteries pursuing high-energy density and high-safety.However,the inevitable volatilization of lithium compounds during sintering leads to low relative density and low ionic conductivity of solid-state electrolytes.Herein,the dynamic lithium-compensation mechanism is proposed to facilitate the densification of Ta-substituted garnet-type electrolyte(Li_(6.5)La_(3)Zr_(1.5)Ta_(0.5)O_(12)(LLZT))through the reversible manipulating of Li_(2)O atmosphere.Li_(2)ZrO_(3)is used as mother powder additive,which reacts with Li_(2)O in sintering atmosphere and forms Li_(6)Zr_(2)O_(7).Li_(2)ZrO_(3)/Li_(6)Zr_(2)O_(7)buffer pair manipulates the sintering Li_(2)O atmosphere,which is vital for LLZT,within the Li_(2)O partial pressure range corresponding to Li_(2)ZrO_(3)and Li_(6)Zr_(2)O_(7).Furthermore,the reversibility mechanism of buffer pair for Li_(2)O absorption and release is revealed.The obtained LLZT exhibits a relative density of over 96%and an ionic conductivity exceeding 7×10^(−4)S·cm^(−1)with no abnormal grain growth.The symmetric cell demonstrates an excellent lithium dendrite suppressing ability(stable cycling at a current density of 0.3 mA·cm^(−2)for over 1000 h).Such dynamic lithium-compensation strategy has been successfully applied in atmosphere manipulation of LLZT sintering process,which reduces the dependence of LLZT on the Li_(2)O atmosphere,making it conducive to large-scale preparation of electrolyte ceramics.展开更多
We propose a low-threshold soliton fiber laser passively mode locked with two different types of film-like saturable absorbers, one of which is fabricated by mixing Bi2Te3 with de-ionized water, as well as polyvinyl a...We propose a low-threshold soliton fiber laser passively mode locked with two different types of film-like saturable absorbers, one of which is fabricated by mixing Bi2Te3 with de-ionized water, as well as polyvinyl alcohol（PVA）, and then evaporating them in a Petri dish, and the other of which is prepared by directly dropping Bi2Te3 solution on the PVA film. Both Bi2Te3–PVA films exhibit outstanding features of low loss, high flexibility, and easy synthesis. By incorporating Bi2Te3–PVA films into fiber lasers, stable single-soliton emissions are obtained at a low pump power of 13 mW. Our results suggest that the Bi2Te3 can work as a promising mode locker for ultrafast lasers,while PVA is an excellent host for fabricating high-performance film-based saturable absorbers.展开更多
apoptosis plays regulatory roles in the pathogenesis of immunosuppression and organ failure.We previously reported that adenosine deaminases acting on RNA-1(ADAR1)reduced intestinal and splenic inflammatory damage dur...apoptosis plays regulatory roles in the pathogenesis of immunosuppression and organ failure.We previously reported that adenosine deaminases acting on RNA-1(ADAR1)reduced intestinal and splenic inflammatory damage during sepsis.However,the roles and mechanism of ADAR1 in sepsis-induced liver injury remain unclear.Methods:We performed transcriptome and single-cell RNA sequencing of peripheral blood mononuclear cells(PBMCs)from patients with sepsis to investigate the effects of ADAR1 on immune cell activities.We also employed a cecal ligation and puncture(CLP)sepsis mouse model to evaluate the roles of ADAR1 in sepsisinduced liver injury.Finally,we treated murine RAW 264.7 macrophages with lipopolysaccharide to explore the underlying ADAR1-mediated mechanisms in sepsis.Results:PBMCs from patients with sepsis had obvious apoptotic morphological features.Single-cell RNA sequencing indicated that apoptosis-related pathways were enriched in monocytes,with significantly elevated ADAR1 and BCL2A1 expression in severe sepsis.CLP-induced septic mice had aggravated liver injury and Kupffer cell apoptosis that were largely alleviated by ADAR1 overexpression.ADAR1 directly bound to premiR-122 to modulate miR-122 biosynthesis.miR-122 was an upstream regulator of BCL2A1.Furthermore,ADAR1 also reduced macrophage apoptosis in mice with CLP-induced sepsis through the miR-122/BCL2A1 signaling pathway and protected against sepsis-induced liver injury.Conclusions:The findings show that ADAR1 alleviates macrophage apoptosis and sepsis-induced liver damage through the miR-122/BCL2A1 signaling pathway.The study provides novel insights into the development of therapeutic interventions in sepsis.展开更多
基金financially supported by the National Key Research and Development Program of China(No.2022YFB3807700)the National Natural Science Foundation of China(Nos.U20A20248 and U1930208)+1 种基金the Key-Area Research and Development Program of Guangdong Province(No.2020B090919001)the Shanghai Engineering Research Center of Inorganic Energy Materials and Electric Power Sources(No.18DZ2280800).
文摘Solid-state lithium metal batteries are one of the most promising options for next-generation batteries pursuing high-energy density and high-safety.However,the inevitable volatilization of lithium compounds during sintering leads to low relative density and low ionic conductivity of solid-state electrolytes.Herein,the dynamic lithium-compensation mechanism is proposed to facilitate the densification of Ta-substituted garnet-type electrolyte(Li_(6.5)La_(3)Zr_(1.5)Ta_(0.5)O_(12)(LLZT))through the reversible manipulating of Li_(2)O atmosphere.Li_(2)ZrO_(3)is used as mother powder additive,which reacts with Li_(2)O in sintering atmosphere and forms Li_(6)Zr_(2)O_(7).Li_(2)ZrO_(3)/Li_(6)Zr_(2)O_(7)buffer pair manipulates the sintering Li_(2)O atmosphere,which is vital for LLZT,within the Li_(2)O partial pressure range corresponding to Li_(2)ZrO_(3)and Li_(6)Zr_(2)O_(7).Furthermore,the reversibility mechanism of buffer pair for Li_(2)O absorption and release is revealed.The obtained LLZT exhibits a relative density of over 96%and an ionic conductivity exceeding 7×10^(−4)S·cm^(−1)with no abnormal grain growth.The symmetric cell demonstrates an excellent lithium dendrite suppressing ability(stable cycling at a current density of 0.3 mA·cm^(−2)for over 1000 h).Such dynamic lithium-compensation strategy has been successfully applied in atmosphere manipulation of LLZT sintering process,which reduces the dependence of LLZT on the Li_(2)O atmosphere,making it conducive to large-scale preparation of electrolyte ceramics.
基金supported by the Fundamental Research Funds for the Central Universities (Grant Nos. 3102014JCQ01101, 3102014JCQ01099, and 3102014JCQ01085)the 973 Program (Grant No. 2012CB921900)the National Natural Science Foundation of China (Grant Nos. 61405161, 11404263, and 61377035)
文摘We propose a low-threshold soliton fiber laser passively mode locked with two different types of film-like saturable absorbers, one of which is fabricated by mixing Bi2Te3 with de-ionized water, as well as polyvinyl alcohol（PVA）, and then evaporating them in a Petri dish, and the other of which is prepared by directly dropping Bi2Te3 solution on the PVA film. Both Bi2Te3–PVA films exhibit outstanding features of low loss, high flexibility, and easy synthesis. By incorporating Bi2Te3–PVA films into fiber lasers, stable single-soliton emissions are obtained at a low pump power of 13 mW. Our results suggest that the Bi2Te3 can work as a promising mode locker for ultrafast lasers,while PVA is an excellent host for fabricating high-performance film-based saturable absorbers.
基金supported by the Basic research program of Natural Science in Shaanxi Province(No.2020JQ-466)Key research and development program of Shaanxi Province(No.2021SF-014)+2 种基金University Supporting Grant(No.2020rcfczr)Basic research project of the Logistics Support Department of the Chinese Military Commission(No.BWS21J002)National Natural Science Foundation of China(No.81871587).
文摘apoptosis plays regulatory roles in the pathogenesis of immunosuppression and organ failure.We previously reported that adenosine deaminases acting on RNA-1(ADAR1)reduced intestinal and splenic inflammatory damage during sepsis.However,the roles and mechanism of ADAR1 in sepsis-induced liver injury remain unclear.Methods:We performed transcriptome and single-cell RNA sequencing of peripheral blood mononuclear cells(PBMCs)from patients with sepsis to investigate the effects of ADAR1 on immune cell activities.We also employed a cecal ligation and puncture(CLP)sepsis mouse model to evaluate the roles of ADAR1 in sepsisinduced liver injury.Finally,we treated murine RAW 264.7 macrophages with lipopolysaccharide to explore the underlying ADAR1-mediated mechanisms in sepsis.Results:PBMCs from patients with sepsis had obvious apoptotic morphological features.Single-cell RNA sequencing indicated that apoptosis-related pathways were enriched in monocytes,with significantly elevated ADAR1 and BCL2A1 expression in severe sepsis.CLP-induced septic mice had aggravated liver injury and Kupffer cell apoptosis that were largely alleviated by ADAR1 overexpression.ADAR1 directly bound to premiR-122 to modulate miR-122 biosynthesis.miR-122 was an upstream regulator of BCL2A1.Furthermore,ADAR1 also reduced macrophage apoptosis in mice with CLP-induced sepsis through the miR-122/BCL2A1 signaling pathway and protected against sepsis-induced liver injury.Conclusions:The findings show that ADAR1 alleviates macrophage apoptosis and sepsis-induced liver damage through the miR-122/BCL2A1 signaling pathway.The study provides novel insights into the development of therapeutic interventions in sepsis.
