Autophagy is a highly conserved bulk degradation mechanism that degrades damaged organelles,aged proteins and intracellular contents to maintain the homeostasis of the intracellular microenvironment.Activation of auto...Autophagy is a highly conserved bulk degradation mechanism that degrades damaged organelles,aged proteins and intracellular contents to maintain the homeostasis of the intracellular microenvironment.Activation of autophagy can be observed during myocardial injury,during which inflammatory responses are strongly triggered.Autophagy can inhibit the inflammatory response and regulate the inflammatory microenvironment by removing invading pathogens and damaged mitochondria.In addition,autophagy may enhance the clearance of apoptotic and necrotic cells to promote the repair of damaged tissue.In this paper,we briefly review the role of autophagy in different cell types in the inflammatory microenvironment of myocardial injury and discuss the molecular mechanism of autophagy in regulating the inflammatory response in a series of myocardial injury conditions,including myocardial ischemia,ischemia/reperfusion injury and sepsis cardiomyopathy.展开更多
Application of silicon in high capacity electrodes of lithium ion battery suffers from stress effects and, in turn, affects voltage performance of battery. This paper established a reaction-diffusion-stress coupled mo...Application of silicon in high capacity electrodes of lithium ion battery suffers from stress effects and, in turn, affects voltage performance of battery. This paper established a reaction-diffusion-stress coupled model and investigated the stress induced voltage hysteresis with consideration of diffusion induced stress, surface effects and interparticle compression. It was found stress and stress induced voltage hysteresis depended on particle size. In big particles, diffusion induced stress is dominant and leads to significant hysteresis in both stress and voltage, indicating energy dissipation due to stress effects. In small particles, e.g.,radius of dozens nanometers, diffusion induced stress was negligible while surface effects played dominant role, leading to nearly vanished voltage hysteresis shifting away from equilibrium potential. According to calculation, particle sizes around 100 nm are appropriate choice for electrode design as both diffusion induced stress and surface effects are insignificant. Finally,interparticle compression pushed the stress hysteresis to compressive side and led to early termination of lithiation at cut-off voltage. Denser electrode would enhance this effect. It indicated that there must be a limit of mixing ratio of silicon because higher interparticle compressive stress due to more introduced silicon would impede the battery from fully charged.展开更多
It is important for high-quality trials to be conducted in compliance with GCP principles and the CONSORT statement.We showed an example of such trial.A double-blind,randomized,placebo-controlled trial was conducted,a...It is important for high-quality trials to be conducted in compliance with GCP principles and the CONSORT statement.We showed an example of such trial.A double-blind,randomized,placebo-controlled trial was conducted,aimed to evaluate the effectiveness and safety of formula PSORI-CM01 for psoriasis.A pilot study was performed to assess the feasibility of the trial.For展开更多
We conducted series studies to assess the effectiveness and safety of Chinese herbal formula PSORI-CM01 for psoriasis vulgaris(PV),and indicate mechanisms and ingredients of the formula.An observational study,experime...We conducted series studies to assess the effectiveness and safety of Chinese herbal formula PSORI-CM01 for psoriasis vulgaris(PV),and indicate mechanisms and ingredients of the formula.An observational study,experimental study and a pilot randomized controlled trial was performed.To define the chemical profiles and control the quality of PSORICM01,UHPLC-ESI-LTQ/Orbitrap-MS method展开更多
基金supported by the National Natural Science Foundation of China(82104495 and 82174161)Shenzhen Fundamental Research Program(No.SGDX20210823103804030)+8 种基金Science and Technology Development Fund,Macao SAR(No.0025/2022/A1)University of Macao grants(No.MYRG2019-00129-ICMS)Macao Youth Scholars Program(AM2021023)Guangdong Basic and Applied Basic Research Foundation(2022A1515010395 and 2021A1515012573)Science and Technology Foundation of Guangzhou City(202102010257)State Key Laboratory of Dampness Syndrome of Chinese Medicine Research Foundation(SZ2021ZZ21 and SZ2022QN02)Scientific Research Projects of Guangdong Bureau of Traditional Chinese Medicine(Nos.20212088)TCM Research Fund of Guangdong Provincial Hospital of Chinese Medicine(YN2020MS13)The 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund(Guangdong-Hong Kong-Macao Joint Lab,No.2020B1212030006 and MY2022KF05).
文摘Autophagy is a highly conserved bulk degradation mechanism that degrades damaged organelles,aged proteins and intracellular contents to maintain the homeostasis of the intracellular microenvironment.Activation of autophagy can be observed during myocardial injury,during which inflammatory responses are strongly triggered.Autophagy can inhibit the inflammatory response and regulate the inflammatory microenvironment by removing invading pathogens and damaged mitochondria.In addition,autophagy may enhance the clearance of apoptotic and necrotic cells to promote the repair of damaged tissue.In this paper,we briefly review the role of autophagy in different cell types in the inflammatory microenvironment of myocardial injury and discuss the molecular mechanism of autophagy in regulating the inflammatory response in a series of myocardial injury conditions,including myocardial ischemia,ischemia/reperfusion injury and sepsis cardiomyopathy.
基金the financial supports of the National Natural Science Foundation of China (Grant Nos. 11672170, 11332005, 11702166)the Natural Science Foundation of Shanghai (Grant No. 16ZR1412200)+1 种基金the support provided by the 2017 Monash University Malaysia Strategic Large Grant Scheme (Grant No. LG-2017-04-ENG)Advanced Engineering Programme Cluster funding
文摘Application of silicon in high capacity electrodes of lithium ion battery suffers from stress effects and, in turn, affects voltage performance of battery. This paper established a reaction-diffusion-stress coupled model and investigated the stress induced voltage hysteresis with consideration of diffusion induced stress, surface effects and interparticle compression. It was found stress and stress induced voltage hysteresis depended on particle size. In big particles, diffusion induced stress is dominant and leads to significant hysteresis in both stress and voltage, indicating energy dissipation due to stress effects. In small particles, e.g.,radius of dozens nanometers, diffusion induced stress was negligible while surface effects played dominant role, leading to nearly vanished voltage hysteresis shifting away from equilibrium potential. According to calculation, particle sizes around 100 nm are appropriate choice for electrode design as both diffusion induced stress and surface effects are insignificant. Finally,interparticle compression pushed the stress hysteresis to compressive side and led to early termination of lithiation at cut-off voltage. Denser electrode would enhance this effect. It indicated that there must be a limit of mixing ratio of silicon because higher interparticle compressive stress due to more introduced silicon would impede the battery from fully charged.
文摘It is important for high-quality trials to be conducted in compliance with GCP principles and the CONSORT statement.We showed an example of such trial.A double-blind,randomized,placebo-controlled trial was conducted,aimed to evaluate the effectiveness and safety of formula PSORI-CM01 for psoriasis.A pilot study was performed to assess the feasibility of the trial.For
文摘We conducted series studies to assess the effectiveness and safety of Chinese herbal formula PSORI-CM01 for psoriasis vulgaris(PV),and indicate mechanisms and ingredients of the formula.An observational study,experimental study and a pilot randomized controlled trial was performed.To define the chemical profiles and control the quality of PSORICM01,UHPLC-ESI-LTQ/Orbitrap-MS method
