AIM: To study the effects of danhong huayu koufuye (DHK) on fasting blood glucose (FBG) and diabetic retinopathy (DR) in streptozotocin (517)-induced type 1 diabetic rats to facilitate the rational usage of this drug....AIM: To study the effects of danhong huayu koufuye (DHK) on fasting blood glucose (FBG) and diabetic retinopathy (DR) in streptozotocin (517)-induced type 1 diabetic rats to facilitate the rational usage of this drug. METHODS: Diabetic rats were induced by injection of a single dose of STZ intraperitoneally at 50mg/kg. Flash electroretinogram (FERG) and oscillatory potentials (OPs) were used to measure retinal function. The microvascular perfusion of ears was performed to study the microcirculation in rats. FBG, body-weight, and 24-h urine volume, water intake and diet intake were also assessed. RESULTS: DHK had no effect on FBG in normal rats. However, STZ + DHK group were significantly different from those of Model and moved toward those of normal control. It reversed the increase in diet intake (P <= 0.05 vs model control) and the loss in body-weight (P <= 0.05 vs model control) in diabetic rats. DHK decreased the FBG of diabetic rats by 25.6% (P <= 0.05) and 37.9% P <= 0.01) after 14 and 21 days administration as compared with the model control, respectively. Moreover, DHK significantly increased the FERG b-wave amplitude by 80% (P <= 0.05 vs model control) and decreased the FERG b-wave latency by 15.3% (P <= 0.01 vs model control) after 24 days administration. The OP(1) and OP(2) amplitudes in DHK group were 2.6 (P <= 0.01) and 2.0 (P <= 0.01) times of model group after 24 days of DHK treatment, respectively. At the same time, OP(1) and OP(2) latencies in DHK group reduced by 16.0% (P <= 0.001) and 14.7% (P <= 0.001) as compared with the model control, respectively. Furthermore, the microvascular perfusion of DHK group was 2.4 times of model group (P <= 0.001) after 21 days administration. CONCLUSION: DHK had no effect on normal FBG. But it had antihyperglycemic activity, and had a preventive and therapeutic effect on DR in diabetic rats.展开更多
[Objective] The aim was to study the mechanism of the removal effect of methylene blue(MB) by rice husk ash(RHA).[Method] The effects of contact time and pH on the adsorption of MB by rice husk ash were investigated,a...[Objective] The aim was to study the mechanism of the removal effect of methylene blue(MB) by rice husk ash(RHA).[Method] The effects of contact time and pH on the adsorption of MB by rice husk ash were investigated,and the mechanism was discussed.[Result] RHA exhibited a remarkable ability on the adsorption of MB.The process of adsorption reached the equilibrium after 30 min,at about pH 9.The adsorption effect was explored with the aid of ion beam etching technique,which displayed that there were two main adsorption manners.One was the electrostatic interactions,through which the negatively charged RHA could adsorb the positively charged MB,the other was the porous effect due to the huge specific surface area of the micro/nano-scale porous silica in RHA,and MB could be adsorbed and deposited into the pores.[Conclusion] RHA could be used in the treatment of textile wastewater.Ion beam technology might be used as an effective way to investigate the adsorption effect.展开更多
文摘AIM: To study the effects of danhong huayu koufuye (DHK) on fasting blood glucose (FBG) and diabetic retinopathy (DR) in streptozotocin (517)-induced type 1 diabetic rats to facilitate the rational usage of this drug. METHODS: Diabetic rats were induced by injection of a single dose of STZ intraperitoneally at 50mg/kg. Flash electroretinogram (FERG) and oscillatory potentials (OPs) were used to measure retinal function. The microvascular perfusion of ears was performed to study the microcirculation in rats. FBG, body-weight, and 24-h urine volume, water intake and diet intake were also assessed. RESULTS: DHK had no effect on FBG in normal rats. However, STZ + DHK group were significantly different from those of Model and moved toward those of normal control. It reversed the increase in diet intake (P <= 0.05 vs model control) and the loss in body-weight (P <= 0.05 vs model control) in diabetic rats. DHK decreased the FBG of diabetic rats by 25.6% (P <= 0.05) and 37.9% P <= 0.01) after 14 and 21 days administration as compared with the model control, respectively. Moreover, DHK significantly increased the FERG b-wave amplitude by 80% (P <= 0.05 vs model control) and decreased the FERG b-wave latency by 15.3% (P <= 0.01 vs model control) after 24 days administration. The OP(1) and OP(2) amplitudes in DHK group were 2.6 (P <= 0.01) and 2.0 (P <= 0.01) times of model group after 24 days of DHK treatment, respectively. At the same time, OP(1) and OP(2) latencies in DHK group reduced by 16.0% (P <= 0.001) and 14.7% (P <= 0.001) as compared with the model control, respectively. Furthermore, the microvascular perfusion of DHK group was 2.4 times of model group (P <= 0.001) after 21 days administration. CONCLUSION: DHK had no effect on normal FBG. But it had antihyperglycemic activity, and had a preventive and therapeutic effect on DR in diabetic rats.
基金Supported by National Natural Science Foundation of China (No.10975154)State Key Lab of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry,CAS (SKLEA 201104)
文摘[Objective] The aim was to study the mechanism of the removal effect of methylene blue(MB) by rice husk ash(RHA).[Method] The effects of contact time and pH on the adsorption of MB by rice husk ash were investigated,and the mechanism was discussed.[Result] RHA exhibited a remarkable ability on the adsorption of MB.The process of adsorption reached the equilibrium after 30 min,at about pH 9.The adsorption effect was explored with the aid of ion beam etching technique,which displayed that there were two main adsorption manners.One was the electrostatic interactions,through which the negatively charged RHA could adsorb the positively charged MB,the other was the porous effect due to the huge specific surface area of the micro/nano-scale porous silica in RHA,and MB could be adsorbed and deposited into the pores.[Conclusion] RHA could be used in the treatment of textile wastewater.Ion beam technology might be used as an effective way to investigate the adsorption effect.
