Background： Liver abscess is a serious complication following transcatheter arterial chemoembolization （TACE）. Much attention has been paid to this condition as it may interfere with the treatment process and resul...Background： Liver abscess is a serious complication following transcatheter arterial chemoembolization （TACE）. Much attention has been paid to this condition as it may interfere with the treatment process and result in a poor prognosis of the patient. This study aimed to analyze the causes of liver abscess, a complication, after TACE for hepatic tumors and to summarize management approaches. Methods： From June 2012 to June 2014, of 1480 consecutive patients who underwent TACE at our hospital, five patients developed liver abscess alier TACE procedures for hepatic tumors. Of the five patients, each receiving conventional TACE, one underwent three sessions, two underwent two sessions, and the remaining two underwent one session of TACE. Demographic and clinical characteristics, together with management approaches and prognosis, were collected through a review of medical records. Results： These five patients were confirmed to have post-TACE liver abscess through clinical manifestations, laboratory, and imaging tests. Aiier percutaneous drainage and anti-inflammatory treatments, the symptoms present in four patients with liver abscess significantly improved as evidenced by shrinkage or disappearance of the abscess cavity, and the patients recovered completely after sufficient drainage. The remaining patient experienced recurrent symptoms and abdominal abscess, achieved no significant improvement after treatment, and eventually died of severe infection and multiple organ failures. Conclusions： TACE must be implemented with extreme caution to avoid liver abscess. An effective management relies on an early diagnosis, prompt use of sufficient doses of appropriate antibiotics, and active implementation of abscess incision, drainage, and aspiration.展开更多
A new adenosine biosensor based on aptamer probe is introduced in this article. An amino-labeled aptamer probe was immobilized on the gold electrode modified with an o-phenylenediamine electropolymerized film. When ad...A new adenosine biosensor based on aptamer probe is introduced in this article. An amino-labeled aptamer probe was immobilized on the gold electrode modified with an o-phenylenediamine electropolymerized film. When adenosine is bound specifically to the aptamer probe, the interface of the biosensor is changed, resulting in the decrement of the peak current. The response current is proportional to the amount of adenosine in sample. The used electrode can be easily regenerated in hot water. The proposed biosensor represents a linear response to adenosine over a concentration range of 1.0x 10^-7-l.0x10^-4 mol/L with a detection limit of 1.0xl0^-8 mol/L. The presented biosensor exhibits a nice specificity towards adenosine. It offers a promising approach for adenosine assay due to its excellent electrochemical properties that are believed to be very attractive for electrochemical studies and electroanalytical applications.展开更多
Achievement of a‘clinical cure’in chronic hepatitis B(CHB)implies sustained virological suppression and immunological control over the infection,which is the ideal treatment goal according to domestic and internatio...Achievement of a‘clinical cure’in chronic hepatitis B(CHB)implies sustained virological suppression and immunological control over the infection,which is the ideal treatment goal according to domestic and international CHB management guidelines.Clinical practice has shown encouraging results for specific patient cohorts using tailored treatment regimens.These regimens incorporate either nucleos(t)ide analogs,immunomodulatory agents such as pegylated interferonα,or a strategic combination of both,sequentially or concurrently administered.Despite these advancements in the clinical handling of hepatitis B,achieving a clinical cure remains elusive for a considerable subset of patients due to the number of challenges that preclude the realization of optimal treatment outcomes.These include,but are not limited to,the emergence of antiviral resistance,incomplete immune recovery,and the persistence of covalently closed circular DNA.Moreover,the variance in response to interferon therapy and the lack of definitive biomarkers for treatment cessation also contribute to the complexity of achieving a clinical cure.This article briefly overviews the current research progress and existing issues in pursuing a clinical cure for hepatitis B.展开更多
Circular RNAs(circRNAs)are a new and large group of non-coding RNA molecules that are abundantly expressed in the central nervous system.However,very little is known about their roles in traumatic brain injury.In this...Circular RNAs(circRNAs)are a new and large group of non-coding RNA molecules that are abundantly expressed in the central nervous system.However,very little is known about their roles in traumatic brain injury.In this study,we firstly screened differentially expressed circ RNAs in normal and injured brain tissues of mice after traumatic brain injury.We found that the expression of circ Lphn3 was substantially decreased in mouse models of traumatic brain injury and in hemin-treated b End.3(mouse brain cell line)cells.After overexpressing circ Lphn3 in b End.3 cells,the expression of the tight junction proteins,ZO-1,ZO-2,and occludin,was upregulated,and the expression of mi R-185-5 p was decreased.In b End.3 cells transfected with mi R-185-5 p mimics,the expression of ZO-1 was decreased.Dual-luciferase reporter assays showed that circ Lphn3 bound to mi R-185-5 p,and that mi R-185-5 p bound to ZO-1.Additionally,circ Lphn3 overexpression attenuated the hemin-induced high permeability of the in vitro b End.3 cell model of the blood-brain barrier,while mi R-185-5 p transfection increased the permeability.These findings suggest that circ Lphn3,as a molecular sponge of mi R-185-5 p,regulates tight junction proteins'expression after traumatic brain injury,and it thereby improves the permeability of the blood-brain barrier.This study was approved by the Animal Care and Use Committee of Chongqing Medical University of China(approval No.2021-177)on March 22,2021.展开更多
To investigate decay law of acoustic emission and microseismic activities caused by disturbances associated with multilevel loading and mining blast,a new exponential decay(ED)law was proposed.The results show that th...To investigate decay law of acoustic emission and microseismic activities caused by disturbances associated with multilevel loading and mining blast,a new exponential decay(ED)law was proposed.The results show that the micro-fracture activity decay law after multistage stress loading and blasting disturbance conforms to the ED model,in which the sum of A and n represents the number of initial micro-fracture events,and n represents the level of background micro-fracture events.The ED model can describe the number of initial micro-fracture events with a deviation less than 10%.The ED model outperforms the traditional aftershock models in describing the micro-fracture event decay law in the three cases considered.The ED model can provide a reference for selecting the blasting interval in mines,which is of great significance to maintain the stability of the surrounding rock and ensure safe production in metal mines.展开更多
Background:To evaluate the efficacy of traditional Chinese medicine(TCM)in treating Acquired Immune Deficiency Syndrome(AIDS)related diarrhoea.Methods:Chinese and English databases(CBM,CNKI,Wanfang Database,PubMed,Web...Background:To evaluate the efficacy of traditional Chinese medicine(TCM)in treating Acquired Immune Deficiency Syndrome(AIDS)related diarrhoea.Methods:Chinese and English databases(CBM,CNKI,Wanfang Database,PubMed,Web of Science,Cochrane Library)were searched up to November 2021.Studies that compared TCM with western medicine were included.RevMan 5.4,Stata 17,and Grading of Recommendations Assessment Development and Evaluation system were used for data analyses.The inclusion and exclusion criteria,quality assessment process,and potential biases were specified.Result:24 randomized controlled trial with a total of 1,766 participants of TCM compared with western medicine were included,12 of which reported random assignment methods.Meta-analyses showed that,TCM was more effective than western medicine in treating AIDS-related diarrhoea[RR=1.32,95%CI(1.26,1.39),P<0.01],internal treatment of TCM[RR=1.37,95%CI(1.28,1.46),P<0.01],external treatment of TCM[RR=1.27,95%CI(1.17,1.39)],internal and external treatment of TCM[RR=1.21,95%CI(1.07,1.37),P<0.01],Shenlingbaizhu Powder/Pill[RR=1.25,95%CI(1.13,1.39),P<0.01],Xielikang Capsules[RR=1.57,95%CI(1.33,1.84),P<0.01],Jianpizhixie Recipe[RR=1.31,95%CI(1.05,1.65),P<0.01],Moxibustion[RR=1.19,95%CI(1.07,1.32),P<0.01],Ginger Moxibustion[RR=1.24,95%CI(1.04,1.47),P<0.01],when compared to using western medicine alone and with significant differences.Conclusion:Shenlingbaizhu Powder/Pill,Xielikang Capsules,Jianpizhixie Recipe,Moxibustion and Ginger Moxibustion had certain advantages in improving the effective rate of AIDS-related diarrhoea,they needed to be further validated by high quality clinical trials.展开更多
The question of the power-law exponent of exponential growth networks is studied here.In a discrete case,the degree distribution is defined as the probability distribution of the discrete variable.Based on this,the de...The question of the power-law exponent of exponential growth networks is studied here.In a discrete case,the degree distribution is defined as the probability distribution of the discrete variable.Based on this,the degree distribution of the pseudofractal scale-free web,an exponential growth network,is obtained.The power-law exponent ln3/ln2 is analyzed according to the maximum likelihood principle.It satisfies consistency and is good for small generations of the network.For many exponential growth networks,their power-law exponent needs to be tested.The work provides a new view on the power-law exponent of an exponential growth network.展开更多
It is of great importance to determine an unknown quantum state for fundamental studies of quantum mechanics,yet it is still difficult to characterize systems of large dimensions in practice.Although the scan-free dir...It is of great importance to determine an unknown quantum state for fundamental studies of quantum mechanics,yet it is still difficult to characterize systems of large dimensions in practice.Although the scan-free direct measurement approach based on a weak measurement scheme was proposed to measure a high-dimensional photonic state,how weak the interaction should be to give a correct estimation remains unclear.Here we propose and experimentally demonstrate a technique that measures a high-dimensional quantum state with the combination of scan-free measurement and direct strong measurement.The procedure involves sequential strong measurement,in which case no approximation is made similarly to the conventional direct weak measurement.We use this method to measure a transverse state of a photon with effective dimensionality of 65000 without the time-consumed scanning process.Furthermore,the high fidelity of the result and the simplicity of the experimental apparatus show that our approach can be readily used to measure the complex field of a beam in diverse applications such as wavefront sensing and quantitative phase imaging.展开更多
文章以Web of Science数据库2010~2020年收录的学习投入度方面的1355条文献数据为样本,通过知识图谱进行可视化分析,探究国际教育领域学习投入度研究的焦点与未来转向,结果发现:国际教育领域学习投入度研究主要围绕学习投入度内涵分析...文章以Web of Science数据库2010~2020年收录的学习投入度方面的1355条文献数据为样本,通过知识图谱进行可视化分析,探究国际教育领域学习投入度研究的焦点与未来转向,结果发现:国际教育领域学习投入度研究主要围绕学习投入度内涵分析和本质探索、学习投入度作用机制的实证研究、提升学习投入度的方式和路径探究、学习投入度的测量和评估四个焦点问题;随着学习科学、脑科学、智能技术等的兴起,学习投入度研究将转向寻求学习投入度研究的跨学科与本土化平衡、人工智能技术赋能学习投入度的研究、重视学习投入度多源数据分析及其影响因素研究等三个方面。研究有助于从整体上了解教育领域学习投入度的国际进展和前沿趋势,以期为我国教育领域的学习投入度创新发展提供参考。展开更多
目的评价三级公立医院绩效考核背景下医院推行加速康复外科(Enhanced Recovery After Surgery,ERAS)整合管理效果。方法基于结直肠癌根治术患者数据,采用回顾性历史对照研究试点病区实行ERAS整合管理前后运营效率指标变化。结果试点病...目的评价三级公立医院绩效考核背景下医院推行加速康复外科(Enhanced Recovery After Surgery,ERAS)整合管理效果。方法基于结直肠癌根治术患者数据,采用回顾性历史对照研究试点病区实行ERAS整合管理前后运营效率指标变化。结果试点病区实行ERAS整合管理后医疗服务收入占比30.29%,住院次均药品费用降幅11.91%,住院次均费用增幅2.16%,达到国家卫生健康委2020年公布指标满分值,上述指标前后对比均有显著性差异。结论 ERAS整合管理模式有助于医院提升运营管理效率,符合三级公立医院绩效考核要求。展开更多
文摘Background： Liver abscess is a serious complication following transcatheter arterial chemoembolization （TACE）. Much attention has been paid to this condition as it may interfere with the treatment process and result in a poor prognosis of the patient. This study aimed to analyze the causes of liver abscess, a complication, after TACE for hepatic tumors and to summarize management approaches. Methods： From June 2012 to June 2014, of 1480 consecutive patients who underwent TACE at our hospital, five patients developed liver abscess alier TACE procedures for hepatic tumors. Of the five patients, each receiving conventional TACE, one underwent three sessions, two underwent two sessions, and the remaining two underwent one session of TACE. Demographic and clinical characteristics, together with management approaches and prognosis, were collected through a review of medical records. Results： These five patients were confirmed to have post-TACE liver abscess through clinical manifestations, laboratory, and imaging tests. Aiier percutaneous drainage and anti-inflammatory treatments, the symptoms present in four patients with liver abscess significantly improved as evidenced by shrinkage or disappearance of the abscess cavity, and the patients recovered completely after sufficient drainage. The remaining patient experienced recurrent symptoms and abdominal abscess, achieved no significant improvement after treatment, and eventually died of severe infection and multiple organ failures. Conclusions： TACE must be implemented with extreme caution to avoid liver abscess. An effective management relies on an early diagnosis, prompt use of sufficient doses of appropriate antibiotics, and active implementation of abscess incision, drainage, and aspiration.
基金Supported by the National Natural Science Foundation of China(Nos20675028, 20435010 and 20375012)the Science Commission of Hunan Province, China
文摘A new adenosine biosensor based on aptamer probe is introduced in this article. An amino-labeled aptamer probe was immobilized on the gold electrode modified with an o-phenylenediamine electropolymerized film. When adenosine is bound specifically to the aptamer probe, the interface of the biosensor is changed, resulting in the decrement of the peak current. The response current is proportional to the amount of adenosine in sample. The used electrode can be easily regenerated in hot water. The proposed biosensor represents a linear response to adenosine over a concentration range of 1.0x 10^-7-l.0x10^-4 mol/L with a detection limit of 1.0xl0^-8 mol/L. The presented biosensor exhibits a nice specificity towards adenosine. It offers a promising approach for adenosine assay due to its excellent electrochemical properties that are believed to be very attractive for electrochemical studies and electroanalytical applications.
基金Supported by National Key Research and Development Program of China 2023,No:2023YFC2308100.
文摘Achievement of a‘clinical cure’in chronic hepatitis B(CHB)implies sustained virological suppression and immunological control over the infection,which is the ideal treatment goal according to domestic and international CHB management guidelines.Clinical practice has shown encouraging results for specific patient cohorts using tailored treatment regimens.These regimens incorporate either nucleos(t)ide analogs,immunomodulatory agents such as pegylated interferonα,or a strategic combination of both,sequentially or concurrently administered.Despite these advancements in the clinical handling of hepatitis B,achieving a clinical cure remains elusive for a considerable subset of patients due to the number of challenges that preclude the realization of optimal treatment outcomes.These include,but are not limited to,the emergence of antiviral resistance,incomplete immune recovery,and the persistence of covalently closed circular DNA.Moreover,the variance in response to interferon therapy and the lack of definitive biomarkers for treatment cessation also contribute to the complexity of achieving a clinical cure.This article briefly overviews the current research progress and existing issues in pursuing a clinical cure for hepatitis B.
基金supported by the National Natural Science Foundation of ChinaNo.81771355+1 种基金the Natural Science Foundation of Chongqing of ChinaNo.CSTC2015jcyj A10096(both to ZBL)。
文摘Circular RNAs(circRNAs)are a new and large group of non-coding RNA molecules that are abundantly expressed in the central nervous system.However,very little is known about their roles in traumatic brain injury.In this study,we firstly screened differentially expressed circ RNAs in normal and injured brain tissues of mice after traumatic brain injury.We found that the expression of circ Lphn3 was substantially decreased in mouse models of traumatic brain injury and in hemin-treated b End.3(mouse brain cell line)cells.After overexpressing circ Lphn3 in b End.3 cells,the expression of the tight junction proteins,ZO-1,ZO-2,and occludin,was upregulated,and the expression of mi R-185-5 p was decreased.In b End.3 cells transfected with mi R-185-5 p mimics,the expression of ZO-1 was decreased.Dual-luciferase reporter assays showed that circ Lphn3 bound to mi R-185-5 p,and that mi R-185-5 p bound to ZO-1.Additionally,circ Lphn3 overexpression attenuated the hemin-induced high permeability of the in vitro b End.3 cell model of the blood-brain barrier,while mi R-185-5 p transfection increased the permeability.These findings suggest that circ Lphn3,as a molecular sponge of mi R-185-5 p,regulates tight junction proteins'expression after traumatic brain injury,and it thereby improves the permeability of the blood-brain barrier.This study was approved by the Animal Care and Use Committee of Chongqing Medical University of China(approval No.2021-177)on March 22,2021.
基金financial supports from the National Natural Science Foundation of China(Nos.51704056,51974059)the China Postdoctoral Science Foundation(No.2017M621152)the Fundamental Research Funds for the Central University of China(Nos.N160103006,N180115010,N2001001)。
文摘To investigate decay law of acoustic emission and microseismic activities caused by disturbances associated with multilevel loading and mining blast,a new exponential decay(ED)law was proposed.The results show that the micro-fracture activity decay law after multistage stress loading and blasting disturbance conforms to the ED model,in which the sum of A and n represents the number of initial micro-fracture events,and n represents the level of background micro-fracture events.The ED model can describe the number of initial micro-fracture events with a deviation less than 10%.The ED model outperforms the traditional aftershock models in describing the micro-fracture event decay law in the three cases considered.The ED model can provide a reference for selecting the blasting interval in mines,which is of great significance to maintain the stability of the surrounding rock and ensure safe production in metal mines.
基金Supported by National Major Science and Technology Projects of China During the 13th Five-year Plan Period:New Adjuvant Strategies of Traditional Chinese Medicine on Immune Reconstruction for Long-term ART-treated People Living with HIV(No.2017ZX10205501)Science and Technology Project of Hebei Education Department(No.QN2020272)Research Project of Hebei Provincial Administration of Traditional Chinese Medicine(No.2021176).
文摘Background:To evaluate the efficacy of traditional Chinese medicine(TCM)in treating Acquired Immune Deficiency Syndrome(AIDS)related diarrhoea.Methods:Chinese and English databases(CBM,CNKI,Wanfang Database,PubMed,Web of Science,Cochrane Library)were searched up to November 2021.Studies that compared TCM with western medicine were included.RevMan 5.4,Stata 17,and Grading of Recommendations Assessment Development and Evaluation system were used for data analyses.The inclusion and exclusion criteria,quality assessment process,and potential biases were specified.Result:24 randomized controlled trial with a total of 1,766 participants of TCM compared with western medicine were included,12 of which reported random assignment methods.Meta-analyses showed that,TCM was more effective than western medicine in treating AIDS-related diarrhoea[RR=1.32,95%CI(1.26,1.39),P<0.01],internal treatment of TCM[RR=1.37,95%CI(1.28,1.46),P<0.01],external treatment of TCM[RR=1.27,95%CI(1.17,1.39)],internal and external treatment of TCM[RR=1.21,95%CI(1.07,1.37),P<0.01],Shenlingbaizhu Powder/Pill[RR=1.25,95%CI(1.13,1.39),P<0.01],Xielikang Capsules[RR=1.57,95%CI(1.33,1.84),P<0.01],Jianpizhixie Recipe[RR=1.31,95%CI(1.05,1.65),P<0.01],Moxibustion[RR=1.19,95%CI(1.07,1.32),P<0.01],Ginger Moxibustion[RR=1.24,95%CI(1.04,1.47),P<0.01],when compared to using western medicine alone and with significant differences.Conclusion:Shenlingbaizhu Powder/Pill,Xielikang Capsules,Jianpizhixie Recipe,Moxibustion and Ginger Moxibustion had certain advantages in improving the effective rate of AIDS-related diarrhoea,they needed to be further validated by high quality clinical trials.
基金Supported by the National Natural Science Foundation of China under Grant No 10774035the Foundation of Inner Mongolia University of Technology under Grant No X200937.
文摘The question of the power-law exponent of exponential growth networks is studied here.In a discrete case,the degree distribution is defined as the probability distribution of the discrete variable.Based on this,the degree distribution of the pseudofractal scale-free web,an exponential growth network,is obtained.The power-law exponent ln3/ln2 is analyzed according to the maximum likelihood principle.It satisfies consistency and is good for small generations of the network.For many exponential growth networks,their power-law exponent needs to be tested.The work provides a new view on the power-law exponent of an exponential growth network.
基金Supported by the National Natural Science Foundation of China(Grant Nos.11574291,11774334,11774335,11674306 and 61590932)the Strategic Priority Research Program(B)of the Chinese Academy of Sciences(Grant No.XDB01030200)+2 种基金the National Key Research and Development Program of China(Grant Nos.2016YFA0301300,2016YFA0301700 and 2017YFA0304100)the Key Research Program of Frontier Science,CAS(Grant No.QYZDY-SSW-SLH003)Anhui Initiative in Quantum Information Technologies.
文摘It is of great importance to determine an unknown quantum state for fundamental studies of quantum mechanics,yet it is still difficult to characterize systems of large dimensions in practice.Although the scan-free direct measurement approach based on a weak measurement scheme was proposed to measure a high-dimensional photonic state,how weak the interaction should be to give a correct estimation remains unclear.Here we propose and experimentally demonstrate a technique that measures a high-dimensional quantum state with the combination of scan-free measurement and direct strong measurement.The procedure involves sequential strong measurement,in which case no approximation is made similarly to the conventional direct weak measurement.We use this method to measure a transverse state of a photon with effective dimensionality of 65000 without the time-consumed scanning process.Furthermore,the high fidelity of the result and the simplicity of the experimental apparatus show that our approach can be readily used to measure the complex field of a beam in diverse applications such as wavefront sensing and quantitative phase imaging.
文摘文章以Web of Science数据库2010~2020年收录的学习投入度方面的1355条文献数据为样本,通过知识图谱进行可视化分析,探究国际教育领域学习投入度研究的焦点与未来转向,结果发现:国际教育领域学习投入度研究主要围绕学习投入度内涵分析和本质探索、学习投入度作用机制的实证研究、提升学习投入度的方式和路径探究、学习投入度的测量和评估四个焦点问题;随着学习科学、脑科学、智能技术等的兴起,学习投入度研究将转向寻求学习投入度研究的跨学科与本土化平衡、人工智能技术赋能学习投入度的研究、重视学习投入度多源数据分析及其影响因素研究等三个方面。研究有助于从整体上了解教育领域学习投入度的国际进展和前沿趋势,以期为我国教育领域的学习投入度创新发展提供参考。
文摘目的评价三级公立医院绩效考核背景下医院推行加速康复外科(Enhanced Recovery After Surgery,ERAS)整合管理效果。方法基于结直肠癌根治术患者数据,采用回顾性历史对照研究试点病区实行ERAS整合管理前后运营效率指标变化。结果试点病区实行ERAS整合管理后医疗服务收入占比30.29%,住院次均药品费用降幅11.91%,住院次均费用增幅2.16%,达到国家卫生健康委2020年公布指标满分值,上述指标前后对比均有显著性差异。结论 ERAS整合管理模式有助于医院提升运营管理效率,符合三级公立医院绩效考核要求。
