<strong>Introduction:</strong> Epilepsy is considered a chronic neurological condition that manifests itself with seizures, where 30% - 40% of patients do not achieve control of their seizures despite prop...<strong>Introduction:</strong> Epilepsy is considered a chronic neurological condition that manifests itself with seizures, where 30% - 40% of patients do not achieve control of their seizures despite proper management. Seizures represent a significant limitation in the patient’s daily activities and are often accompanied by emotional and relational difficulties that have a great impact on the quality of life of the patient and their families. Cannabidiol (CBD) has been found to be effective in controlling seizures and may also improve cognitive and behavioral abilities. <strong>Material and Methods:</strong> The Quality of Life of the Patient with Epilepsy (CAVE) scale was applied to patients with refractory epilepsies who use Cannabidiol (CBD) added to their base therapy, before the use of CBD and after 12 months of follow-up. The presentation of collateral effects was also evaluated. <strong>Results:</strong> Out of 34 patients, 26 (76.5%) increased their CAVE value at the end of the study and only 1 (2.9%) decreased. 19 (55.9%) improved in learning and behavior, 55.8% in the frequency of seizures and 79.4% reported a decrease in the intensity of seizures. There were other positive side effects such as improvement in alertness, language, sleep and behavior. The main side effects were mild and transitory, including drowsiness, and constipation. There was a correlation between the global perception of improvement and seizure control. <strong>Conclusions:</strong> This study shows that in the long term CBD improves the quality of life of patients with refractory epilepsies, through the control of seizures and the improvement of cognitive and behavioral functions.展开更多
当加利福尼亚州州长杰里·布朗（Jerry Brown）10月7日签署州参议院350号法案时，看起来像是石油业者的一次重大胜利。这项法案的原始版本有一条强制性规定，耍在2030年前将加州的石油消费量减半。但就在州参议院进行这项法案投票...当加利福尼亚州州长杰里·布朗（Jerry Brown）10月7日签署州参议院350号法案时，看起来像是石油业者的一次重大胜利。这项法案的原始版本有一条强制性规定，耍在2030年前将加州的石油消费量减半。但就在州参议院进行这项法案投票的前几天，州参议院议长，同时也是法案主要提案人凯文·德莱昂（Kevin de Leon）宣布，为了做出向加州产油区的民主党人让步的姿态，他决定放弃上述强制性规定。展开更多
文摘<strong>Introduction:</strong> Epilepsy is considered a chronic neurological condition that manifests itself with seizures, where 30% - 40% of patients do not achieve control of their seizures despite proper management. Seizures represent a significant limitation in the patient’s daily activities and are often accompanied by emotional and relational difficulties that have a great impact on the quality of life of the patient and their families. Cannabidiol (CBD) has been found to be effective in controlling seizures and may also improve cognitive and behavioral abilities. <strong>Material and Methods:</strong> The Quality of Life of the Patient with Epilepsy (CAVE) scale was applied to patients with refractory epilepsies who use Cannabidiol (CBD) added to their base therapy, before the use of CBD and after 12 months of follow-up. The presentation of collateral effects was also evaluated. <strong>Results:</strong> Out of 34 patients, 26 (76.5%) increased their CAVE value at the end of the study and only 1 (2.9%) decreased. 19 (55.9%) improved in learning and behavior, 55.8% in the frequency of seizures and 79.4% reported a decrease in the intensity of seizures. There were other positive side effects such as improvement in alertness, language, sleep and behavior. The main side effects were mild and transitory, including drowsiness, and constipation. There was a correlation between the global perception of improvement and seizure control. <strong>Conclusions:</strong> This study shows that in the long term CBD improves the quality of life of patients with refractory epilepsies, through the control of seizures and the improvement of cognitive and behavioral functions.
文摘当加利福尼亚州州长杰里·布朗（Jerry Brown）10月7日签署州参议院350号法案时，看起来像是石油业者的一次重大胜利。这项法案的原始版本有一条强制性规定，耍在2030年前将加州的石油消费量减半。但就在州参议院进行这项法案投票的前几天，州参议院议长，同时也是法案主要提案人凯文·德莱昂（Kevin de Leon）宣布，为了做出向加州产油区的民主党人让步的姿态，他决定放弃上述强制性规定。
