BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and t...BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.展开更多
AIM: To evaluate the association of known copy number variations(CNVs) in ulcerative colitis(UC) progressing to colorectal cancer.METHODS: Microsatellite instability analysis using the National Cancer Institute's ...AIM: To evaluate the association of known copy number variations(CNVs) in ulcerative colitis(UC) progressing to colorectal cancer.METHODS: Microsatellite instability analysis using the National Cancer Institute's panel of markers, and CNV association studies using Agilent 2 × 105 k arrays were done in tissue samples from four patient groups with UC: those at low risk(LR) or high risk of developing colorectal cancer, those with premalignant dysplastic lesions, and those with colitis-associated colorectal cancer(CAC). DNA from tissue samples of these groups were independently hybridized on arrays and analyzed. The data obtained were further subjected to downstream bioinformatics enrichment analysis to examine the correlation with CAC progression.RESULTS: Microarray analysis highlighted a progressive increase in the total number of CNVs [LR(n = 178) vs CAC(n = 958), 5.3-fold], gains and losses [LR(n = 37 and 141) vs CAC(n = 495 and 463), 13.4- and 3.3-fold, respectively], size [LR(964.2 kb) vs CAC(10540 kb), 10.9-fold] and the number of genes in such regions [LR(n = 119) vs CAC(n = 455), 3.8-fold]. Chromosomewise analysis of CNVs also showed an increase in the number of CNVs across each chromosome. There were 38 genes common to all four groups in the study; 13 of these were common to cancer genes from the Genetic Disease Association dataset. The gene set enrichment analysis and ontology analysis highlighted many cancerassociated genes. All the samples in the different groupswere microsatellite stable.CONCLUSION: Increasing numbers of CNVs are associated with the progression of UC to CAC, and warrant further detailed exploration.展开更多
This is a continuity of a series of taxonomic and phylogenetic papers on the fungi where materials were collected from many countries,examined and described.In addition to extensive morphological descriptions and appr...This is a continuity of a series of taxonomic and phylogenetic papers on the fungi where materials were collected from many countries,examined and described.In addition to extensive morphological descriptions and appropriate asexual and sexual connections,DNA sequence data are also analysed from concatenated datasets to infer phylogenetic relationships and substantiate systematic positions of taxa within appropriate ranks.Wherever new species or combinations are proposed,we apply an integrative approach using morphological and molecular data as well as ecological features wherever applicable.Notes on 112 fungal taxa are compiled in this paper including Biatriosporaceae and Roussoellaceae,Didysimulans gen.nov.,81 new species,18 new host records and new country records,five reference specimens,two new combinations,and three sexual and asexual morph reports.The new species are Amanita cornelii,A.emodotrygon,Angustimassarina alni,A.arezzoensis,A.italica,A.lonicerae,A.premilcurensis,Ascochyta italica,A.rosae,Austroboletus appendiculatus,Barriopsis thailandica,Berkleasmium ariense,Calophoma petasitis,Camarosporium laburnicola,C.moricola,C.grisea,C.ossea,C.paraincrustata,Colletotrichum sambucicola,Coprinopsis cerkezii,Cytospora gelida,Dacrymyces chiangraiensis,Didysimulans italica,D.mezzanensis,Entodesmium italica,Entoloma magnum,Evlachovaea indica,Exophiala italica,Favolus gracilisporus,Femsjonia monospora,Fomitopsis flabellata,F.roseoalba,Gongronella brasiliensis,Helvella crispoides,Hermatomyces chiangmaiensis,H.chromolaenae,Hysterium centramurum,Inflatispora caryotae,Inocybe brunneosquamulosa,I.luteobrunnea,I.rubrobrunnea,Keissleriella cirsii,Lepiota cylindrocystidia,L.flavocarpa,L.maerimensis,Lophiotrema guttulata,Marasmius luculentus,Morenoina calamicola,Moelleriella thanathonensis,Mucor stercorarius,Myrmecridium fluviae,Myrothecium septentrionale,Neosetophoma garethjonesii,Nigrograna cangshanensis,Nodulosphaeria guttulatum,N.multiseptata,N.sambuci,Panus subfasciatus,Paraleptosphaeria padi,Paraphaeosphaeri展开更多
Aim: To determine the relationship of carotid plaque, intima media thickness (IMT), resistivity index (RI) and pulsatility index (PI) and prevalence of different risk factors with acute ischemic stroke and stroke subt...Aim: To determine the relationship of carotid plaque, intima media thickness (IMT), resistivity index (RI) and pulsatility index (PI) and prevalence of different risk factors with acute ischemic stroke and stroke subtypes in both diabetic and non-diabetic subjects. Materials and methods: 80 cases of acute ischemic strokes and 40 healthy controls were included in the study. The plaque, IMT, RI and PI were measured by carotid duplex ultrasound. Results: 31 subjects were Type 2 diabetic, 54 hypertensive while 25 were both diabetic and hypertensive. 23 cases (28.75%) had lacunar stroke (LACI), 32 (40%) stroke involving partial anterior circulation(PACI), 10(12.5%) stroke in posterior circulation (PACI) and 15(18.75%) stroke involving total anterior circulation(TACI) respectively. The mean IMT (0.88 ± 0.19mm), RI(0.76 ± 0.05) and PI(1.71 ± 0.19) of patients and mean IMT (0.6±0.09mm), RI (0.61 ± 0.06) and PI (1.53 ± 0.11) of controls were statistically significant (p-0.000). The mean values of IMT, PI and RI were significantly higher in diabetics (IMT-0.90 ± 0.16 VS 0.64 ± 0.11, p-0.013;PI-1.76 ± 0.20 VS 1.49 ± 0.09, P-0.000 and RI-0.76 ± 0.04 VS 0.59 ± 0.06, P-0.000) and similarly the mean values for IMT, PI and RI in hypertensives as compared to controls (IMT-0.88 ± 0.16 vs 0.65 ± 0.10, P-0.006;PI1.69 ± 0.18 vs 1.49 ± 0.09, P-0.000 and RI 0.76 ± 0.04 vs 0.59 ± 0.06, P-0.000). The mean IMT, PI and RI were increased significantly in smokers compared to controls (IMT-0.93 ± 0.20 vs 0.63 ± 0.06, P-0.000;PI-1.82 ± 0.22 vs 1.49 ± 0.09, P-0.000 and RI-0.77 ± 0.04 vs 0.59 ± 0.06, P-0.000). Type 3 plaque accounted for 27 (56.2%) cases and Type 2 plaque 12 (25%) cases. The total number of plaques in patients as compared to controls were significantly more (P-0.0034) and the mean plaque area was 46 mm2 for cases and 20 mm2 for control (P-0.0001). TACI was the most common type of ischemic stroke seen in DM (60%), HTN (66.6%) and smokers (66.7%). Plaques (73.3%), IMT (0.90 ± 0.12), PI(1.72 ± 0.14) and RI展开更多
Mining operations result in the generation of barren land and spoil heaps which are subject to high erosion rate during the rainy season. The present study uses the Revised Universal Soil Loss Equation (RUSLE) and SCS...Mining operations result in the generation of barren land and spoil heaps which are subject to high erosion rate during the rainy season. The present study uses the Revised Universal Soil Loss Equation (RUSLE) and SCS-CN (Soil Conservation Service - Curve Number) process to estimate in Kiruburu and Meghahatuburu mining sites areas. The geospatial model of annual average soil loss rate was determined by integrating environmental variables parameters in a raster pixels-based GIS framework. GIS layers with, rainfall passivity and runoff erosivity (R), soil erodibility (K), slope length and steepness (LS), cover management(C) and conservation practice (P) factors were calculated to determine their effects on annual soil erosion in the study area. The coefficient of determination (r2) was 0.834, which indicates a strong correlation of soil loss with runoff and rainfall. Sub -watersheds 5,9,10 and 2 experienced high level of highly runoff. Average annual soil loss was calculated (30*30 m raster grid cell) to determine the critical soil loss areas (Sub-watershed 9 and 5). Total soil erosion area was classified into five class, slight (10,025 ha), moderate (3125 ha), high (973 ha), very high (260 ha) and severe (53 ha). The resulting map shows greatest soil erosion of >40 t h-1 y-1 (severe) through connection to grassland, degraded and open forestry on the erect mining side-escutcheon. The Landsat pan sharpening image and DGPS survey field data were used in the verification of soil erosion results.展开更多
In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry(eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be rep...In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry(eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020 s.展开更多
A comparative study of Frequency Ratio(FR)and Analytic Hierarchy Process(AHP)models are performed for forest fire risk(FFR)mapping in Melghat Tiger Reserve forest,central India.Identification of FFR depends on various...A comparative study of Frequency Ratio(FR)and Analytic Hierarchy Process(AHP)models are performed for forest fire risk(FFR)mapping in Melghat Tiger Reserve forest,central India.Identification of FFR depends on various hydrometeorological parameters altitude,slope,aspect,topographic position index,normalized differential vegetation index,rainfall,air temperature,land surface temperature,wind speed,distance to settlements,and distance by road are integrated using a GIS platform.The results from FR and AHP show similar trends.The FR model was significantly higher accurate(overall accuracy of 81.3%,kappa statistic 0.78)than the AHP model(overall accuracy 79.3%,kappa statistic 0.75).The FR model total forest fire risk areas were classified into five classes:very low(7.1%),low(22.2%),moderate(32.3%),high(26.9%),and very high(11.5%).The AHP fire risk classes were very low(6.7%),low(21.7%),moderate(34.0%),high(26.7%),and very high(10.9%).Sensitivity analyses were performed for AHP and FR models.The results of the two different models are compared and justified concerning the forest fire sample points(Forest Survey of India)and burn images(2010-2016).These results help in designing more effective fire management plans to improve the allocation of resources across a landscape framework.展开更多
BACKGROUND The prognostic significance of lymph nodes(LNs)metastases and the optimum number of LN yield in gastroenteropancreatic neuroendocrine tumours(GEP NETs)undergoing curative resection is still debatable.Many s...BACKGROUND The prognostic significance of lymph nodes(LNs)metastases and the optimum number of LN yield in gastroenteropancreatic neuroendocrine tumours(GEP NETs)undergoing curative resection is still debatable.Many studies have demonstrated that cure rate for patients with GEP NETs can be improved by the resection of the primary tumour and regional lymphadenectomy AIM To evaluate the effect of lymph node(LN)status and yield on relapse-free survival(RFS)and overall survival(OS)in patients with resected GEP NETs.METHODS Data on patients who underwent curative resection for GEP NETs between January 2002 and March 2017 were analysed retrospectively.Grade 3 tumours(Ki67>20%)were excluded.Univariate Cox proportional hazard models were computed for RFS and OS and assessed alongside cut-point analysis to distinguish a suitable binary categorisation of total LNs retrieved associated with RFS.RESULTS A total of 217 patients were included in the study.The median age was 59 years(21-97 years)and 51%(n=111)were male.Primary tumour sites were small bowel(42%),pancreas(25%),appendix(18%),rectum(7%),colon(3%),gastric(2%),others(2%).Median follow up times for all patients were 41 mo(95%CI:36-51)and 71 mo(95%CI:63–76)for RFS and OS respectively;50 relapses and 35 deaths were reported.LNs were retrieved in 151 patients.Eight or more LNs were harvested in 106 patients and LN positivity reported in 114 patients.Three or more positive LNs were detected in 62 cases.The result of univariate analysis suggested perineural invasion(P=0.0023),LN positivity(P=0.033),LN retrieval of≥8(P=0.047)and localisation(P=0.0049)have a statistically significant association with shorter RFS,but there was no effect of LN ratio on RFS:P=0.1 or OS:P=0.75.Tumour necrosis(P=0.021)and perineural invasion(P=0.016)were the only two variables significantly associated with worse OS.In the final multivariable analysis,localisation(pancreas HR=27.33,P=0.006,small bowel HR=32.44,P=0.005),and retrieval of≥8 LNs(HR=2.7,P=0.036)were independent prognostic factors展开更多
Objective:To determine the relationship of the capacity to produce interferon gamma(IFN-γ) in whole blood,bacteriological,hematological,radiographic and clinical presentations in new,HIV seronegative cases of pulmona...Objective:To determine the relationship of the capacity to produce interferon gamma(IFN-γ) in whole blood,bacteriological,hematological,radiographic and clinical presentations in new,HIV seronegative cases of pulmonary tuberculosis(TB).Methods:80 cases and 50 control subjects aged 15 years onwards,representative of Kasturba Hospital and Nursing schools of Wardha district of Maharashtra state in India were examined for their health condition with standard methodology.Results:Among these TB patients,73.8%were Quantiferon-TB gold (QFT) positive with IFN-γconcentration as 0.35 IU or more and there was none in healthy controls.The mean IFN-γconcentrations varied between 9.58 IU(50-59 yrs) and 2.58 IU(≥60 yrs),showing no trend.The differences in positivity and mean IFN-γconcentrations were statistically insignificant.Both the QFT positivity and IFN-γconcentrations were higher in normal lymphocyte percent as compared to below and above normal,but differences were not statistically significant.Conclusions:The IFN-γconcentrations are not correlated with any of the predictors of disease severity studied,the levels are significantly higher in observation group as compared to healthy group.展开更多
Pocket switched Network (PSN) is an emerging research magnet that has been attracting researchers. This paper provides an introduction to PSN and covers some of its basic features and challenges. Continuous connectivi...Pocket switched Network (PSN) is an emerging research magnet that has been attracting researchers. This paper provides an introduction to PSN and covers some of its basic features and challenges. Continuous connectivity is difficult in infrastructure independent communication. In this paper, we will see how PSN provides an effective alternative. We also explain some routing protocols that can be incorporated for effective data forwarding. This paper also discusses possible applications and areas where PSN can be effectively used and some ideas that may foster future research in PSN routing.展开更多
We made comparative studies of three tropical ox-bow lakes in India with different trophic states.The species number of zooplanktons was negatively correlated with the degree of water eutrophication,and lakes of simil...We made comparative studies of three tropical ox-bow lakes in India with different trophic states.The species number of zooplanktons was negatively correlated with the degree of water eutrophication,and lakes of similar trophic status had higher similarity of species.The most significant differences of species composition were observed with rotifers and zoobenthos.The density and biomass of phytoplankton,rotifers,oligochaetes and chironomids tended to increase with increasing nutrients.We observed a significant difference of dominant species in different waters,especially the eutrophic lake,which was dominated by a few species of oligochaetes.The abundance of Tanypus bilobatus showed a highly significant correlation with the degree of eutrophication.Rotifers and zoobenthos showed considerably lower biodiversity in the eutrophic lake.展开更多
Objective:To study the extent of undernutrition at district level and the socio-economic determinants of underweight children aged 0-71 months in West Bengal.Methods:The data were accessed from the Reproductive and Ch...Objective:To study the extent of undernutrition at district level and the socio-economic determinants of underweight children aged 0-71 months in West Bengal.Methods:The data were accessed from the Reproductive and Child Health Survey(RCHS-II),which contained information of 7 SSO children and their parents.Information of socio-economic variables about the associated families of these children had also been taken for our study.This study computed weight-for-age z-scores to assess the nutritional status of the children using WHO(2006) reference.Results:The prevalence of underweight varied over the districts.Districts with very high prevalence of underweight children were Murshidabad,Burdwan,Purulia,Medinipur, Howrah and South 24 Parganas.High prevalent districts for both boys and girls were Jalpaiguri and Coochbihar.Low prevalent districts for both boys and girls were South Dinajpur,Nadia and Kolkata.The percentage of underweight children were more in rural areas among Muslim families with illiterate parents and low standard of living.In Murshidabad,Bankura,Nadia, Medinipur and South 24 Parganas districts,i.e.,where prevalence of underweight children were higher,the rural and urban differences were less.The characteristics like religion,parents’ educational status and standard of living index showed significant effect on the children’s weights.Conclusions:Public intervention programs on the parent’s education and the standard of living of the households at district level should be given high priority to combat the children’s undernutrition problems so far as weight for age is concerned.展开更多
Objective:To estimate the antidepressant,anxiolytic and antinociceptive activities of ethanol extract of Steudnera colocasiifolia K.Koch(S.colocasiifolia)leaves.Methods:Swiss albino mice treated with 1%Tween solution,...Objective:To estimate the antidepressant,anxiolytic and antinociceptive activities of ethanol extract of Steudnera colocasiifolia K.Koch(S.colocasiifolia)leaves.Methods:Swiss albino mice treated with 1%Tween solution,standard drugs and ethanol extract of S.colocasiifolia,respectively,were subjected to the neurological and antinociceptive investigations.The tail suspension test and forced swimming test were used for testing antidepressant activity,where the parameter is the measurement of immobility time.Anxiolytic activity was evaluated by hole board model.Anti-nociceptive potential of the extract was also screened for centrally acting analgesic activity by using formalin induced licking response model and acetic acid induced writhing test was used for testing peripheral analgesic action.Results:Ethanol extract of S.colocasiifolia significantly decreased the period of immobility in both tested models(tail suspension and forced swimming models)of antidepressant activity.In the hole board model,there was a dose dependant(at 100 and 200 mg/kg)and a significant increase in the number of head dipping by comparing with control(1%Tween solution)(P<0.05 and P<0.001).In formalin induced licking model,a significant inhibition of pain compared to standard diclofenac sodium was observed(P<0.05 and P<0.001).In acetic acid induced test,there was a significant reduction of writhing response and pain in mice treated with leaves extract of S.colocasiifolia at 200 mg/kg body weight(P<0.05 and P<0.001).Conclusions:The results proofed the prospective antidepressant,anxiolytic and antinociceptive activities of ethanol extract of S.colocasiifolia leaves.展开更多
An Ultra Wideband (UWB) microstrip diamond slotted patch antenna with enhanced bandwidth is presented in this paper. The proposed antenna is simulated in CST Microwave Studio and fabricated for measurements. Its simul...An Ultra Wideband (UWB) microstrip diamond slotted patch antenna with enhanced bandwidth is presented in this paper. The proposed antenna is simulated in CST Microwave Studio and fabricated for measurements. Its simulated result displays impedance bandwidth from 3.28 GHz to 19.64 GHz, whereas the measured result displays the frequency region from 2.01 GHz to 18.67 GHz. The antenna complies with the return loss of S11 < –10 dB and Voltage Standing Wave Ratio (VSWR) < 2 throughout the impedance bandwidth. Details of the antenna design and related results such as phase angle, input impedance and radiation patterns are discussed in this paper. This antenna has surpassed the bandwidth of UWB requirement, which is from 3.1 GHz to 10.6 GHz, and exhibits good UWB characteristics.展开更多
Objective:To examine hypoglycemic and antibacterial activity against some Gram-positive and Gram-negative bacteria of organic extracts of four Bangladeshi plants.Methods:An in vivo hypoglycemic effect on mice model wa...Objective:To examine hypoglycemic and antibacterial activity against some Gram-positive and Gram-negative bacteria of organic extracts of four Bangladeshi plants.Methods:An in vivo hypoglycemic effect on mice model was used to check the hypoglycemic effect of four Bangladeshi herbal organic extracts viz.,roots of Curculigo recurvata W.T.Aiton(Satipata)(C.recurvata),leaf of Amorphophallus bulbifer Roxb.(Olkachu)(A.bulbifer),whole plant of Thunbergia grandiflora Roxb.(Nillata)(T.grandiflora)and leaf of Steudnera colocasiifolia K.Koch(Yunnan)(S.colocasiifolia)using glibenclamide as a positive control and water as a negative control.They were also tested for antibacterial activity on three Grampositive and four Gram-negative bacteria by disk diffusion method.C.recurvata,A.bulbifer and T.grandiflora were extracted with methanol and S.colocasiifolia was extracted with ethanol.Results:Among all the plant extract,only ethanol extract of S.colocasiifolia leaves at 800 mg/kg dose significantly(P<0.01)reduced fasting glucose level in normal mice as compared to standard drug glibenclamide(5 mg/kg).Ethanol extract of S.colocasiifolia leaves at 800 mg/kg dose decreased 20.28%of blood glucose level after 2 h of administration in normal mice,where glibenclamide decreased 39.63%.Methanol extract of T.grandiflora didn’t show any zone of inhibition against the tested bacteria,but other three extracts showed a wide range of zone of inhibition.However,none of the extract showed antibacterial activity against all the tested bacteria.Methanol extract of C.recurvata showed maximum zone of inhibition against Bacillus cereus[(10.50±0.50)mm],Salmonella typhi[(16.20±1.26)mm],Escherichia coli[(13.00±1.00)mm]and ethanol extract of S.colocasiifolia showed maximum zone of inhibition against Staphylococcus aureus[(11.20±1.26)mm],Bacillus subtilis[(12.00±0.50)mm],Salmonella paratyphi[(10.80±0.29)mm].Only methanol extract of A.bulbifer showed(8.50±0.50)mm and(7.20±0.76)mm zone of inhibition against Pseudomomas aeruginosa at 1000 and 800�展开更多
Objective:To search adequate epidemiological data on periodontal conditions for the planning of oral health programs in Indian population,and to determine the prevalence of periodontal diseases,in regards to age and g...Objective:To search adequate epidemiological data on periodontal conditions for the planning of oral health programs in Indian population,and to determine the prevalence of periodontal diseases,in regards to age and gender of urban and rural population in West Bengal.India. Methods:22 542 subjects aged 15 years onwards,representative of rural and urban areas of West Bengal were examined for their periodontal conditions using the community periodontal index(CPI).Results:Supra and/or sub gingival calculus dominated as the most frequent score (score 2) among males(76.51%) and females(76.58%),which was least affected in young age group and higher in rural population.Severity of highest score were significant(P【0.001) according to their gender,age group and habitation and had independent effects(P【0.001) on it. Mean number of sextants affected by scores 1,2,3,& 4 were more in the rural areas.Assessed treatment needed was predominantly typeⅡ(Scaling and improved oral hygiene).Conclusions: The severe periodontal condition(Score 2,3 and 4) is observed among rural males in older age group more than its urban counterparts of West Bengal,India.展开更多
A three Higgs-doublet model exhibiting S_(3)-symmetry can predict the observed pattern of quark masses and their mixings. However, the same symmetry also introduces potential flavor-changing neutral currents(FCNCs)at ...A three Higgs-doublet model exhibiting S_(3)-symmetry can predict the observed pattern of quark masses and their mixings. However, the same symmetry also introduces potential flavor-changing neutral currents(FCNCs)at the tree level. In this study, we assume that the scalar potential contains appropriate soft S_(3)-breaking terms to maintain flexible choices of scalar masses. We identify the parameters in the Yukawa Lagrangian of the quark sector responsible for such FCNCs and constrain them using data from flavor physics observables, such as meson-decays and meson-mixings. We also validate the corresponding model parameter space via renormalization group evaluation.展开更多
Background: Curculigo recurvata(C. recurvata) is an enthnomedicinally important herb reported to have significant medicinal values. The present study aimed to explore the in vivo and in silico anti-nociceptive and ant...Background: Curculigo recurvata(C. recurvata) is an enthnomedicinally important herb reported to have significant medicinal values. The present study aimed to explore the in vivo and in silico anti-nociceptive and anti-diarrheal effects of a C. recurvate rhizome methanol extract(Me-RCR).Methods: The analgesic effects of Me-RCR were assessed using acetic acid-induced writhing and the formalin-induced flicking test. The drugs were administered intraperitoneally(IP) at doses of 200 and 400 mg/kg body weight(bw). Anti-diarrheal activity was evaluated by assessing intestinal motility, hypersecretion, and fecal score in mice at oral doses of 200 and 400 mg/kg·bw. Computer facilitated analyses for anti-nociceptive and anti-diarrheal activities of three isolated compounds from C. recurvata were undertaken to identify the best-fit phytoconstituents.Results: The Me-RCR showed significant(P <.05) peripheral anti-nociception at the highest dose. The extract inhibited both early and late phases of nociception in the formalin-induced writhing test. In the castor oil-induced diarrhoea model, the extract significantly(P <.05) prolonged the onset time of diarrhoea, inhibited percentage of diarrhoea, and decreased both the volume and weight of intestinal contents. Rates of intestinal fluid accumulation inhibition were(33.61 ± 1.00)% and(46.44 ± 0.89)% at Me-RCR doses of 200 and 400 mg/kg·bw, respectively. Moreover, a significant(P <.05) reduction in gastrointestinal motility was observed. An absorption, distribution, metabolism, excretion and/or toxicity(ADME/T) test showed that the selected compounds yielded promising results, satisfying Lipinski's rule of five for predicting drug-like potential. Notably, of the three phytoconstituents curculigine and isocurculigine possessed the highest affinity for the COX-1 and COX-2. Isocurculigine was also identified as the most effective anti-diarrheal compound in the computer-facilitated model.Conclusion: An extract of the plant C. recurvata showed potential analgesic and antidiarrheal展开更多
文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.
基金Supported by Grants from Department of Biotechnology(BT/01/COE/06/02/07)TIFAC-CORE in Pharmacogenomics,Government of India
文摘AIM: To evaluate the association of known copy number variations(CNVs) in ulcerative colitis(UC) progressing to colorectal cancer.METHODS: Microsatellite instability analysis using the National Cancer Institute's panel of markers, and CNV association studies using Agilent 2 × 105 k arrays were done in tissue samples from four patient groups with UC: those at low risk(LR) or high risk of developing colorectal cancer, those with premalignant dysplastic lesions, and those with colitis-associated colorectal cancer(CAC). DNA from tissue samples of these groups were independently hybridized on arrays and analyzed. The data obtained were further subjected to downstream bioinformatics enrichment analysis to examine the correlation with CAC progression.RESULTS: Microarray analysis highlighted a progressive increase in the total number of CNVs [LR(n = 178) vs CAC(n = 958), 5.3-fold], gains and losses [LR(n = 37 and 141) vs CAC(n = 495 and 463), 13.4- and 3.3-fold, respectively], size [LR(964.2 kb) vs CAC(10540 kb), 10.9-fold] and the number of genes in such regions [LR(n = 119) vs CAC(n = 455), 3.8-fold]. Chromosomewise analysis of CNVs also showed an increase in the number of CNVs across each chromosome. There were 38 genes common to all four groups in the study; 13 of these were common to cancer genes from the Genetic Disease Association dataset. The gene set enrichment analysis and ontology analysis highlighted many cancerassociated genes. All the samples in the different groupswere microsatellite stable.CONCLUSION: Increasing numbers of CNVs are associated with the progression of UC to CAC, and warrant further detailed exploration.
基金Saowaluck Tibpromma would like to thank the Molecular Biology Experimental Center at Kunming Institute of Botany for facilities for molecular work,the Mushroom Research Foundation(MRF)Chiang Rai,Thailand for the financial support of her study and Shaun Pennycook is thanked for nomenclatural advice.K.D.Hyde would like to thank the Thailand Research Fund Grant No.RSA5980068 entitled“Biodiversity,phylogeny and role of fungal endophytes on above parts of Rhizophora apiculata and Nypa fruticans”+6 种基金the Chinese Academy of Sciences,Project Number 2013T2S0030for the award of Visiting Professorship for Senior International Scientists at Kunming Institute of Botany and National Research Council of Thailand(Mae Fah Luang University)for a grants“Biodiversity,phylogeny and role of fungal endophytes of Pandanaceae”(Grant No.:592010200112)“Diseases of mangrove trees and maintenance of good forestry practice”(Grant No.:60201000201)for supporting this study.S.C.Karunarathna,P.E.Mortimer and J.C.Xu would like to thank the World Agroforestry Centre,East and Central Asia OfficeKey Laboratory for Plant Diversity and Biogeography of East Asia,Kunming Institute of Botany,Chinese Academy of Sciencethe ChineseMinistry of Science and Technology,under the 12th 5-year National Key Technology Support Program(NKTSP)2013 BAB07B06 integration and comprehensive demonstration of key technologies on Green Phosphate-mountaion Construction and the CGIAR Research Program 6:Forest,Trees and Agroforestry for partial funding.The authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for funding this research group NO(RG-1436-025)Financial support by the German Academic Exchange Service(DAAD)and the Thai Royal Golden Ph.D.Jubilee-Industry program(RGJ)for a joint TRFDAAD PPP(2012-2014)academic exchange grant to K.D.Hyde and M.Stadler,and the RGJ for a personal grant to B.Thongbai(No.Ph.D/0138/2553 in 4.S.MF/53/A.3)is gratefully acknowledged.Chayanard Phukhamsakda(PHD/0020/25
文摘This is a continuity of a series of taxonomic and phylogenetic papers on the fungi where materials were collected from many countries,examined and described.In addition to extensive morphological descriptions and appropriate asexual and sexual connections,DNA sequence data are also analysed from concatenated datasets to infer phylogenetic relationships and substantiate systematic positions of taxa within appropriate ranks.Wherever new species or combinations are proposed,we apply an integrative approach using morphological and molecular data as well as ecological features wherever applicable.Notes on 112 fungal taxa are compiled in this paper including Biatriosporaceae and Roussoellaceae,Didysimulans gen.nov.,81 new species,18 new host records and new country records,five reference specimens,two new combinations,and three sexual and asexual morph reports.The new species are Amanita cornelii,A.emodotrygon,Angustimassarina alni,A.arezzoensis,A.italica,A.lonicerae,A.premilcurensis,Ascochyta italica,A.rosae,Austroboletus appendiculatus,Barriopsis thailandica,Berkleasmium ariense,Calophoma petasitis,Camarosporium laburnicola,C.moricola,C.grisea,C.ossea,C.paraincrustata,Colletotrichum sambucicola,Coprinopsis cerkezii,Cytospora gelida,Dacrymyces chiangraiensis,Didysimulans italica,D.mezzanensis,Entodesmium italica,Entoloma magnum,Evlachovaea indica,Exophiala italica,Favolus gracilisporus,Femsjonia monospora,Fomitopsis flabellata,F.roseoalba,Gongronella brasiliensis,Helvella crispoides,Hermatomyces chiangmaiensis,H.chromolaenae,Hysterium centramurum,Inflatispora caryotae,Inocybe brunneosquamulosa,I.luteobrunnea,I.rubrobrunnea,Keissleriella cirsii,Lepiota cylindrocystidia,L.flavocarpa,L.maerimensis,Lophiotrema guttulata,Marasmius luculentus,Morenoina calamicola,Moelleriella thanathonensis,Mucor stercorarius,Myrmecridium fluviae,Myrothecium septentrionale,Neosetophoma garethjonesii,Nigrograna cangshanensis,Nodulosphaeria guttulatum,N.multiseptata,N.sambuci,Panus subfasciatus,Paraleptosphaeria padi,Paraphaeosphaeri
文摘Aim: To determine the relationship of carotid plaque, intima media thickness (IMT), resistivity index (RI) and pulsatility index (PI) and prevalence of different risk factors with acute ischemic stroke and stroke subtypes in both diabetic and non-diabetic subjects. Materials and methods: 80 cases of acute ischemic strokes and 40 healthy controls were included in the study. The plaque, IMT, RI and PI were measured by carotid duplex ultrasound. Results: 31 subjects were Type 2 diabetic, 54 hypertensive while 25 were both diabetic and hypertensive. 23 cases (28.75%) had lacunar stroke (LACI), 32 (40%) stroke involving partial anterior circulation(PACI), 10(12.5%) stroke in posterior circulation (PACI) and 15(18.75%) stroke involving total anterior circulation(TACI) respectively. The mean IMT (0.88 ± 0.19mm), RI(0.76 ± 0.05) and PI(1.71 ± 0.19) of patients and mean IMT (0.6±0.09mm), RI (0.61 ± 0.06) and PI (1.53 ± 0.11) of controls were statistically significant (p-0.000). The mean values of IMT, PI and RI were significantly higher in diabetics (IMT-0.90 ± 0.16 VS 0.64 ± 0.11, p-0.013;PI-1.76 ± 0.20 VS 1.49 ± 0.09, P-0.000 and RI-0.76 ± 0.04 VS 0.59 ± 0.06, P-0.000) and similarly the mean values for IMT, PI and RI in hypertensives as compared to controls (IMT-0.88 ± 0.16 vs 0.65 ± 0.10, P-0.006;PI1.69 ± 0.18 vs 1.49 ± 0.09, P-0.000 and RI 0.76 ± 0.04 vs 0.59 ± 0.06, P-0.000). The mean IMT, PI and RI were increased significantly in smokers compared to controls (IMT-0.93 ± 0.20 vs 0.63 ± 0.06, P-0.000;PI-1.82 ± 0.22 vs 1.49 ± 0.09, P-0.000 and RI-0.77 ± 0.04 vs 0.59 ± 0.06, P-0.000). Type 3 plaque accounted for 27 (56.2%) cases and Type 2 plaque 12 (25%) cases. The total number of plaques in patients as compared to controls were significantly more (P-0.0034) and the mean plaque area was 46 mm2 for cases and 20 mm2 for control (P-0.0001). TACI was the most common type of ischemic stroke seen in DM (60%), HTN (66.6%) and smokers (66.7%). Plaques (73.3%), IMT (0.90 ± 0.12), PI(1.72 ± 0.14) and RI
文摘Mining operations result in the generation of barren land and spoil heaps which are subject to high erosion rate during the rainy season. The present study uses the Revised Universal Soil Loss Equation (RUSLE) and SCS-CN (Soil Conservation Service - Curve Number) process to estimate in Kiruburu and Meghahatuburu mining sites areas. The geospatial model of annual average soil loss rate was determined by integrating environmental variables parameters in a raster pixels-based GIS framework. GIS layers with, rainfall passivity and runoff erosivity (R), soil erodibility (K), slope length and steepness (LS), cover management(C) and conservation practice (P) factors were calculated to determine their effects on annual soil erosion in the study area. The coefficient of determination (r2) was 0.834, which indicates a strong correlation of soil loss with runoff and rainfall. Sub -watersheds 5,9,10 and 2 experienced high level of highly runoff. Average annual soil loss was calculated (30*30 m raster grid cell) to determine the critical soil loss areas (Sub-watershed 9 and 5). Total soil erosion area was classified into five class, slight (10,025 ha), moderate (3125 ha), high (973 ha), very high (260 ha) and severe (53 ha). The resulting map shows greatest soil erosion of >40 t h-1 y-1 (severe) through connection to grassland, degraded and open forestry on the erect mining side-escutcheon. The Landsat pan sharpening image and DGPS survey field data were used in the verification of soil erosion results.
基金support from ERC Starting (Grant No. 639217 CSINEUTRONSTAR)support from a Netherlands Organization for Scientific Research (NWO) Vidi Fellowship+2 种基金suported by the European Union Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Global Fellowship (Grant No. 703916)supported in part by the DFG through Grant SFB 1245 and the ERC (Grant No. 307986 STRONGINT)support of the Chinese Academy of Sciences through the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDA15020100)
文摘In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry(eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020 s.
文摘A comparative study of Frequency Ratio(FR)and Analytic Hierarchy Process(AHP)models are performed for forest fire risk(FFR)mapping in Melghat Tiger Reserve forest,central India.Identification of FFR depends on various hydrometeorological parameters altitude,slope,aspect,topographic position index,normalized differential vegetation index,rainfall,air temperature,land surface temperature,wind speed,distance to settlements,and distance by road are integrated using a GIS platform.The results from FR and AHP show similar trends.The FR model was significantly higher accurate(overall accuracy of 81.3%,kappa statistic 0.78)than the AHP model(overall accuracy 79.3%,kappa statistic 0.75).The FR model total forest fire risk areas were classified into five classes:very low(7.1%),low(22.2%),moderate(32.3%),high(26.9%),and very high(11.5%).The AHP fire risk classes were very low(6.7%),low(21.7%),moderate(34.0%),high(26.7%),and very high(10.9%).Sensitivity analyses were performed for AHP and FR models.The results of the two different models are compared and justified concerning the forest fire sample points(Forest Survey of India)and burn images(2010-2016).These results help in designing more effective fire management plans to improve the allocation of resources across a landscape framework.
文摘BACKGROUND The prognostic significance of lymph nodes(LNs)metastases and the optimum number of LN yield in gastroenteropancreatic neuroendocrine tumours(GEP NETs)undergoing curative resection is still debatable.Many studies have demonstrated that cure rate for patients with GEP NETs can be improved by the resection of the primary tumour and regional lymphadenectomy AIM To evaluate the effect of lymph node(LN)status and yield on relapse-free survival(RFS)and overall survival(OS)in patients with resected GEP NETs.METHODS Data on patients who underwent curative resection for GEP NETs between January 2002 and March 2017 were analysed retrospectively.Grade 3 tumours(Ki67>20%)were excluded.Univariate Cox proportional hazard models were computed for RFS and OS and assessed alongside cut-point analysis to distinguish a suitable binary categorisation of total LNs retrieved associated with RFS.RESULTS A total of 217 patients were included in the study.The median age was 59 years(21-97 years)and 51%(n=111)were male.Primary tumour sites were small bowel(42%),pancreas(25%),appendix(18%),rectum(7%),colon(3%),gastric(2%),others(2%).Median follow up times for all patients were 41 mo(95%CI:36-51)and 71 mo(95%CI:63–76)for RFS and OS respectively;50 relapses and 35 deaths were reported.LNs were retrieved in 151 patients.Eight or more LNs were harvested in 106 patients and LN positivity reported in 114 patients.Three or more positive LNs were detected in 62 cases.The result of univariate analysis suggested perineural invasion(P=0.0023),LN positivity(P=0.033),LN retrieval of≥8(P=0.047)and localisation(P=0.0049)have a statistically significant association with shorter RFS,but there was no effect of LN ratio on RFS:P=0.1 or OS:P=0.75.Tumour necrosis(P=0.021)and perineural invasion(P=0.016)were the only two variables significantly associated with worse OS.In the final multivariable analysis,localisation(pancreas HR=27.33,P=0.006,small bowel HR=32.44,P=0.005),and retrieval of≥8 LNs(HR=2.7,P=0.036)were independent prognostic factors
文摘Objective:To determine the relationship of the capacity to produce interferon gamma(IFN-γ) in whole blood,bacteriological,hematological,radiographic and clinical presentations in new,HIV seronegative cases of pulmonary tuberculosis(TB).Methods:80 cases and 50 control subjects aged 15 years onwards,representative of Kasturba Hospital and Nursing schools of Wardha district of Maharashtra state in India were examined for their health condition with standard methodology.Results:Among these TB patients,73.8%were Quantiferon-TB gold (QFT) positive with IFN-γconcentration as 0.35 IU or more and there was none in healthy controls.The mean IFN-γconcentrations varied between 9.58 IU(50-59 yrs) and 2.58 IU(≥60 yrs),showing no trend.The differences in positivity and mean IFN-γconcentrations were statistically insignificant.Both the QFT positivity and IFN-γconcentrations were higher in normal lymphocyte percent as compared to below and above normal,but differences were not statistically significant.Conclusions:The IFN-γconcentrations are not correlated with any of the predictors of disease severity studied,the levels are significantly higher in observation group as compared to healthy group.
文摘Pocket switched Network (PSN) is an emerging research magnet that has been attracting researchers. This paper provides an introduction to PSN and covers some of its basic features and challenges. Continuous connectivity is difficult in infrastructure independent communication. In this paper, we will see how PSN provides an effective alternative. We also explain some routing protocols that can be incorporated for effective data forwarding. This paper also discusses possible applications and areas where PSN can be effectively used and some ideas that may foster future research in PSN routing.
文摘We made comparative studies of three tropical ox-bow lakes in India with different trophic states.The species number of zooplanktons was negatively correlated with the degree of water eutrophication,and lakes of similar trophic status had higher similarity of species.The most significant differences of species composition were observed with rotifers and zoobenthos.The density and biomass of phytoplankton,rotifers,oligochaetes and chironomids tended to increase with increasing nutrients.We observed a significant difference of dominant species in different waters,especially the eutrophic lake,which was dominated by a few species of oligochaetes.The abundance of Tanypus bilobatus showed a highly significant correlation with the degree of eutrophication.Rotifers and zoobenthos showed considerably lower biodiversity in the eutrophic lake.
文摘Objective:To study the extent of undernutrition at district level and the socio-economic determinants of underweight children aged 0-71 months in West Bengal.Methods:The data were accessed from the Reproductive and Child Health Survey(RCHS-II),which contained information of 7 SSO children and their parents.Information of socio-economic variables about the associated families of these children had also been taken for our study.This study computed weight-for-age z-scores to assess the nutritional status of the children using WHO(2006) reference.Results:The prevalence of underweight varied over the districts.Districts with very high prevalence of underweight children were Murshidabad,Burdwan,Purulia,Medinipur, Howrah and South 24 Parganas.High prevalent districts for both boys and girls were Jalpaiguri and Coochbihar.Low prevalent districts for both boys and girls were South Dinajpur,Nadia and Kolkata.The percentage of underweight children were more in rural areas among Muslim families with illiterate parents and low standard of living.In Murshidabad,Bankura,Nadia, Medinipur and South 24 Parganas districts,i.e.,where prevalence of underweight children were higher,the rural and urban differences were less.The characteristics like religion,parents’ educational status and standard of living index showed significant effect on the children’s weights.Conclusions:Public intervention programs on the parent’s education and the standard of living of the households at district level should be given high priority to combat the children’s undernutrition problems so far as weight for age is concerned.
基金Supported by a research grant from Managing Committee of the Department of Pharmacy,International Islamic University Chittagong,Bangladesh(Grant No.Pharm-P&D 71/09-15/54).
文摘Objective:To estimate the antidepressant,anxiolytic and antinociceptive activities of ethanol extract of Steudnera colocasiifolia K.Koch(S.colocasiifolia)leaves.Methods:Swiss albino mice treated with 1%Tween solution,standard drugs and ethanol extract of S.colocasiifolia,respectively,were subjected to the neurological and antinociceptive investigations.The tail suspension test and forced swimming test were used for testing antidepressant activity,where the parameter is the measurement of immobility time.Anxiolytic activity was evaluated by hole board model.Anti-nociceptive potential of the extract was also screened for centrally acting analgesic activity by using formalin induced licking response model and acetic acid induced writhing test was used for testing peripheral analgesic action.Results:Ethanol extract of S.colocasiifolia significantly decreased the period of immobility in both tested models(tail suspension and forced swimming models)of antidepressant activity.In the hole board model,there was a dose dependant(at 100 and 200 mg/kg)and a significant increase in the number of head dipping by comparing with control(1%Tween solution)(P<0.05 and P<0.001).In formalin induced licking model,a significant inhibition of pain compared to standard diclofenac sodium was observed(P<0.05 and P<0.001).In acetic acid induced test,there was a significant reduction of writhing response and pain in mice treated with leaves extract of S.colocasiifolia at 200 mg/kg body weight(P<0.05 and P<0.001).Conclusions:The results proofed the prospective antidepressant,anxiolytic and antinociceptive activities of ethanol extract of S.colocasiifolia leaves.
文摘An Ultra Wideband (UWB) microstrip diamond slotted patch antenna with enhanced bandwidth is presented in this paper. The proposed antenna is simulated in CST Microwave Studio and fabricated for measurements. Its simulated result displays impedance bandwidth from 3.28 GHz to 19.64 GHz, whereas the measured result displays the frequency region from 2.01 GHz to 18.67 GHz. The antenna complies with the return loss of S11 < –10 dB and Voltage Standing Wave Ratio (VSWR) < 2 throughout the impedance bandwidth. Details of the antenna design and related results such as phase angle, input impedance and radiation patterns are discussed in this paper. This antenna has surpassed the bandwidth of UWB requirement, which is from 3.1 GHz to 10.6 GHz, and exhibits good UWB characteristics.
基金Supported by Department of Pharmacy,International Islamic University Chittagong,Bangladesh with a research grant to accomplish the study(Grant No.Pharm-P&D 71/09-15/09).
文摘Objective:To examine hypoglycemic and antibacterial activity against some Gram-positive and Gram-negative bacteria of organic extracts of four Bangladeshi plants.Methods:An in vivo hypoglycemic effect on mice model was used to check the hypoglycemic effect of four Bangladeshi herbal organic extracts viz.,roots of Curculigo recurvata W.T.Aiton(Satipata)(C.recurvata),leaf of Amorphophallus bulbifer Roxb.(Olkachu)(A.bulbifer),whole plant of Thunbergia grandiflora Roxb.(Nillata)(T.grandiflora)and leaf of Steudnera colocasiifolia K.Koch(Yunnan)(S.colocasiifolia)using glibenclamide as a positive control and water as a negative control.They were also tested for antibacterial activity on three Grampositive and four Gram-negative bacteria by disk diffusion method.C.recurvata,A.bulbifer and T.grandiflora were extracted with methanol and S.colocasiifolia was extracted with ethanol.Results:Among all the plant extract,only ethanol extract of S.colocasiifolia leaves at 800 mg/kg dose significantly(P<0.01)reduced fasting glucose level in normal mice as compared to standard drug glibenclamide(5 mg/kg).Ethanol extract of S.colocasiifolia leaves at 800 mg/kg dose decreased 20.28%of blood glucose level after 2 h of administration in normal mice,where glibenclamide decreased 39.63%.Methanol extract of T.grandiflora didn’t show any zone of inhibition against the tested bacteria,but other three extracts showed a wide range of zone of inhibition.However,none of the extract showed antibacterial activity against all the tested bacteria.Methanol extract of C.recurvata showed maximum zone of inhibition against Bacillus cereus[(10.50±0.50)mm],Salmonella typhi[(16.20±1.26)mm],Escherichia coli[(13.00±1.00)mm]and ethanol extract of S.colocasiifolia showed maximum zone of inhibition against Staphylococcus aureus[(11.20±1.26)mm],Bacillus subtilis[(12.00±0.50)mm],Salmonella paratyphi[(10.80±0.29)mm].Only methanol extract of A.bulbifer showed(8.50±0.50)mm and(7.20±0.76)mm zone of inhibition against Pseudomomas aeruginosa at 1000 and 800�
文摘Objective:To search adequate epidemiological data on periodontal conditions for the planning of oral health programs in Indian population,and to determine the prevalence of periodontal diseases,in regards to age and gender of urban and rural population in West Bengal.India. Methods:22 542 subjects aged 15 years onwards,representative of rural and urban areas of West Bengal were examined for their periodontal conditions using the community periodontal index(CPI).Results:Supra and/or sub gingival calculus dominated as the most frequent score (score 2) among males(76.51%) and females(76.58%),which was least affected in young age group and higher in rural population.Severity of highest score were significant(P【0.001) according to their gender,age group and habitation and had independent effects(P【0.001) on it. Mean number of sextants affected by scores 1,2,3,& 4 were more in the rural areas.Assessed treatment needed was predominantly typeⅡ(Scaling and improved oral hygiene).Conclusions: The severe periodontal condition(Score 2,3 and 4) is observed among rural males in older age group more than its urban counterparts of West Bengal,India.
基金support from DST,India,under Grant Number IFA19-PH237(INSPIRE Faculty Award)support from DST,India,under grant number IFA18-PH214(INSPIRE Faculty Award)。
文摘A three Higgs-doublet model exhibiting S_(3)-symmetry can predict the observed pattern of quark masses and their mixings. However, the same symmetry also introduces potential flavor-changing neutral currents(FCNCs)at the tree level. In this study, we assume that the scalar potential contains appropriate soft S_(3)-breaking terms to maintain flexible choices of scalar masses. We identify the parameters in the Yukawa Lagrangian of the quark sector responsible for such FCNCs and constrain them using data from flavor physics observables, such as meson-decays and meson-mixings. We also validate the corresponding model parameter space via renormalization group evaluation.
基金Center for Research and Publication,Grant/Award Number 180111International Islamic University Chittagong。
文摘Background: Curculigo recurvata(C. recurvata) is an enthnomedicinally important herb reported to have significant medicinal values. The present study aimed to explore the in vivo and in silico anti-nociceptive and anti-diarrheal effects of a C. recurvate rhizome methanol extract(Me-RCR).Methods: The analgesic effects of Me-RCR were assessed using acetic acid-induced writhing and the formalin-induced flicking test. The drugs were administered intraperitoneally(IP) at doses of 200 and 400 mg/kg body weight(bw). Anti-diarrheal activity was evaluated by assessing intestinal motility, hypersecretion, and fecal score in mice at oral doses of 200 and 400 mg/kg·bw. Computer facilitated analyses for anti-nociceptive and anti-diarrheal activities of three isolated compounds from C. recurvata were undertaken to identify the best-fit phytoconstituents.Results: The Me-RCR showed significant(P <.05) peripheral anti-nociception at the highest dose. The extract inhibited both early and late phases of nociception in the formalin-induced writhing test. In the castor oil-induced diarrhoea model, the extract significantly(P <.05) prolonged the onset time of diarrhoea, inhibited percentage of diarrhoea, and decreased both the volume and weight of intestinal contents. Rates of intestinal fluid accumulation inhibition were(33.61 ± 1.00)% and(46.44 ± 0.89)% at Me-RCR doses of 200 and 400 mg/kg·bw, respectively. Moreover, a significant(P <.05) reduction in gastrointestinal motility was observed. An absorption, distribution, metabolism, excretion and/or toxicity(ADME/T) test showed that the selected compounds yielded promising results, satisfying Lipinski's rule of five for predicting drug-like potential. Notably, of the three phytoconstituents curculigine and isocurculigine possessed the highest affinity for the COX-1 and COX-2. Isocurculigine was also identified as the most effective anti-diarrheal compound in the computer-facilitated model.Conclusion: An extract of the plant C. recurvata showed potential analgesic and antidiarrheal
