Due to the high incidence of bone fractures in the population, it became necessary to produce scaffolds that are able to assist in tissue regeneration. It is necessary to find an appropriate balance between the mechan...Due to the high incidence of bone fractures in the population, it became necessary to produce scaffolds that are able to assist in tissue regeneration. It is necessary to find an appropriate balance between the mechanical and biological properties, in order to mimic the natural tissue, these properties are directly related to the architecture and their degree of porosity, as well as the size of their pores and their interconnectivity. In this perspective, the 3D printing stands out, where the structure is obtained layer by layer, according to a predetermined computational model which provides a greater control of architecture and scaffold geometry and overcomes, in this way, the limitations of traditional techniques of scaffolds manufacturing. In this way, the objective of this seminar is to present the state of the art of the polymer scaffolds produced by 3D printing and applied to bone tissue regeneration, highlighting the advantages and limitations of this process.展开更多
3D printing is a valuable resource that allows flexibility in the production of objects based on a virtual file. When it is combined with nanotechnology, new features can be added to existing materials. Thus, form and...3D printing is a valuable resource that allows flexibility in the production of objects based on a virtual file. When it is combined with nanotechnology, new features can be added to existing materials. Thus, form and function can be associated to achieve a specific goal, such as the development of support structures for cell growth applicable to systems aiding tissue regeneration. Based on this rationale, the present work proposes a system composed of ABS and graphene nanoparticles solubilized in acetone to be 3D impressed using solvent casting technique. Our main goal was to develop a biocompatible and non-degradable material that fully makes use of the design versatility of 3D printing, to enable new practical employments in the future, for example in the medical field. In this study, different characterization techniques were used—such as microscopy, TGA, DSC, and others—to understand the features and properties of the material obtained, as well as the viability of its use and diffusion. Moreover, the artifacts impressed proved to be non-cytotoxic and promoted cellular adhesion to the cellular lineage of fibroblasts L929. In sum, we believe that the technology described in this article has the potential to serve as a basis for the development of future biocompatible materials that take advantage of their three-dimensional design to perform their functions.展开更多
文摘Due to the high incidence of bone fractures in the population, it became necessary to produce scaffolds that are able to assist in tissue regeneration. It is necessary to find an appropriate balance between the mechanical and biological properties, in order to mimic the natural tissue, these properties are directly related to the architecture and their degree of porosity, as well as the size of their pores and their interconnectivity. In this perspective, the 3D printing stands out, where the structure is obtained layer by layer, according to a predetermined computational model which provides a greater control of architecture and scaffold geometry and overcomes, in this way, the limitations of traditional techniques of scaffolds manufacturing. In this way, the objective of this seminar is to present the state of the art of the polymer scaffolds produced by 3D printing and applied to bone tissue regeneration, highlighting the advantages and limitations of this process.
文摘3D printing is a valuable resource that allows flexibility in the production of objects based on a virtual file. When it is combined with nanotechnology, new features can be added to existing materials. Thus, form and function can be associated to achieve a specific goal, such as the development of support structures for cell growth applicable to systems aiding tissue regeneration. Based on this rationale, the present work proposes a system composed of ABS and graphene nanoparticles solubilized in acetone to be 3D impressed using solvent casting technique. Our main goal was to develop a biocompatible and non-degradable material that fully makes use of the design versatility of 3D printing, to enable new practical employments in the future, for example in the medical field. In this study, different characterization techniques were used—such as microscopy, TGA, DSC, and others—to understand the features and properties of the material obtained, as well as the viability of its use and diffusion. Moreover, the artifacts impressed proved to be non-cytotoxic and promoted cellular adhesion to the cellular lineage of fibroblasts L929. In sum, we believe that the technology described in this article has the potential to serve as a basis for the development of future biocompatible materials that take advantage of their three-dimensional design to perform their functions.
