Myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with sepsis.Recent studies reported that reactive oxygen species(ROS)-mediated ferroptosis plays a criti...Myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with sepsis.Recent studies reported that reactive oxygen species(ROS)-mediated ferroptosis plays a critical role in the development of heart diseases.Therefore,we hypothesized that anti-ferroptosis agent might be a novel potential therapeutic strategy for sepsis-induced cardiac injury.Herein,we demonstrated that a small biocompatible and MRI-visible melanin nanoparticles(MMPP)improves myocardial function by inhibiting ROS-related ferroptosis signaling pathway.In LPS-induced murine sepsis model,after a single dose intravenously injection of MMPP treatment,MMPP markedly alleviated the myocardial injury including cardiac function and heart structure disorder through suppressing iron-accumulation induced ferroptosis.In vitro,MMPP inhibited cardiomyocyte death by attenuating oxidative stress,inflammation and maintaining mitochondrial homeostasis.Collectively,our findings demonstrated that MMPP protected heart against sepsis-induced myocardial injury via inhibiting ferroptosis and inflammation,which might be a novel therapeutic approach in future.展开更多
Cervical eropion,a pathological change associated with chronic cervicitis,is a common condition that is difficult to cure.M any pa tients particularly those with mild or medium infection and those preparing for pregna...Cervical eropion,a pathological change associated with chronic cervicitis,is a common condition that is difficult to cure.M any pa tients particularly those with mild or medium infection and those preparing for pregnancy require a simple but effective medication.In this study,extracts of an empirical herbal prescription composed of six Chinese traditional drugs viz Cortex Phellodendri,Rhizoma Coptidis,Olibanum,Myrrha,borneol and catechu were formulated to facilitate intravaginal administration and improve efficacy.An extract of the first four components was formulated with borneol as a thermosensitive gel(TG)while an extract of catechu used to prepare a regular gel(CG)because of a chemical incompatibility.The optimized TG was prepared using poloxamer 407 and poloxamer 188.The CG was prepared using glycerin,carbopol and triethanolamine.The gels were characterized in vitro in terms of release of berberine(TG)and total catechins(CG)and in vivo in a rat model of cervical erosion.Trea tment by once daily application of the TG for 7 days followed by once daily application of the CG for 3 days produced a restoration of normal tissues.Gel formulation of the empirical Chinese traditional remedy appears to provide a promising treatment for cervical erosion.展开更多
Explorati on of adva need an ode materials for sodium-i on batteries(SIBs)is still a big challe nge due to the large radius of sodium.In this work,the hierarchical architectures assembled from N-doped carbon-coated Co...Explorati on of adva need an ode materials for sodium-i on batteries(SIBs)is still a big challe nge due to the large radius of sodium.In this work,the hierarchical architectures assembled from N-doped carbon-coated Co_(0.5)Ni_(0.5)Se_(2)(Co_(0.5)Ni_(0.5)Se_(2)@NC)nanoparticles encapsulated into cross-stacked nano sheets have been successfully prepared from the cobalt-nickel bin ary-metal organic frameworks(CoNi-MOF)by two steps of the solid-state sele nizati on and carb on coating processes.Imports ntly,the resulta nt hierarchical Co0.5Nio:5Se2@NC architecture can achieve a satisfactory electrochemical performance,maintaining a high-rate capacity of 330 mA-h-g^(-1)1 at 3 A·g^(-1) and a stable cyclability of 100 cycles without obvious capacity decay at 0.2 A·g^(-1).The design of distinct superstructure can not only be applied to other electrode materials but also boost the forward development of energy storage systems.展开更多
The precise syntheses of transition-rare-earth metal clusters with desired structures remain a great challenge.Herein,by utilizing SO_(4)^(2-)anion released by in-situ decomposition of sodium dodecyl sulfate(SDS)as a ...The precise syntheses of transition-rare-earth metal clusters with desired structures remain a great challenge.Herein,by utilizing SO_(4)^(2-)anion released by in-situ decomposition of sodium dodecyl sulfate(SDS)as a template,a series of novel high-nuclearity 3d-4f clusters,formulated as[Ni_(24)Pr_(22)(μ_(3)-OH)_(31)(pida)_(24)(SO_(4))_(4)(NO_(3))_(9)(CH_(3)COO)_(3)]·Br_(4)·(NO_(3))_(11)·_(16)H_(2)O·25CH_(3)OH(1,H_(2)pida=N-phenyliminodiacetic acid),[Ni_(24)Nd_(22)(μ3-OH)_(31)(pida)_(24)(SO_(4))_(4)(NO_(3))_(9)(CH_(3)COO)_(3)]·Br_(4)·(NO_(3))_(11)·14H_(2)O·24CH_(3)OH(2)and[Ni_(24)Gd_(22)(μ3-OH)_(36)(bida)_(24)(SO_(4))_(7)(NO_(3))_(3)(CH_(3)COO)_(3)]·(SO_(4))·Br_(4)·(NO_(3))_(4)·31H_(2)O·32CH_(3)OH(3,H_(2)bida=N-benzyliminodiacetic acid),have been successfully isolated.X-ray crystal structure analyses reveal that all the cationic{Ni_(24)RE_(22)}cores in 1-3 possess a ball-like structure with C_(3v)symmetry,and can be viewed as consisting of an inner{RE_(22)}core and an outer{Ni_(24)}shell.From 1 and 2 to 3,due to the lanthanide contraction effect,the coordination numbers for rare-earth metal centers in{RE_(22)}are different,resulting in different number of SO_(4)^(2-)and NO_(3)^(-)anions to support and stabilize the skeleton structures.Meanwhile,the magnetic properties of complexes 1-3 were also studied.The result revealed that complexes 1-3 show antiferromagnetic/ferrimagnetic interactions,and 3 exhibits magneto-caloric effect at ultralow temperatures with a maximum-ΔSm(magnetic entropy change)value of 33.03 J·kg^(−1)·K^(−1)at 3.0 K and 7 T.展开更多
Herein,a flexible ZIF-67/PAN hybrid membrane was successfully prepared by the incorporation of ZIF-67 nanoparticles and PAN nanofibers through electrospinning method.The hybrid membrane presented tomatoes on sticks st...Herein,a flexible ZIF-67/PAN hybrid membrane was successfully prepared by the incorporation of ZIF-67 nanoparticles and PAN nanofibers through electrospinning method.The hybrid membrane presented tomatoes on sticks structures with one single PAN fiber stringing series of ZIF-67 nanoparticles.The morphology,electrolyte wettability,heat resistance,flexibility,and electrochemical properties of the electrospun ZIF-67/PAN membranes were discussed.Among the membranes prepared with different percentage of ZIF-67,the 30% ZIF-67/PAN membrane exhibited outstanding heat shrinkage resistance(remained intact at 200℃ for 1 h),excellent electrolyte uptake(556.39%),wide electrochemical window(~5.25 V)and high ionic conductivity(2.98 mS cm^(−1)).When used as lithium-ion batteries(LIBs)separators,the cells assembled by 30% ZIF-67/PAN membrane presented excellent rate capacity and high capacity retention of 86.9% after 300 cycles at 1C.More importantly,the cells assembled with ZIF-67/PAN membranes repeated bent for 1000 times also exhibited high rate performance and maintained capacity retention of 92% after 100 cycles at 1 C.The characterization and the electrochemical testing suggest the electrospinning prepared ZIF-67/PAN flexible membranes can be expected to be used as potential separator for advanced batteries with high safety and high performance.展开更多
Twelve novel transition-rare-earth metal clusters,formulated as [Ni_(18)Pr_(14)(μ_(3)OH)_(14)(dmpa)_(10)(mmt)_(10)(SO_(4))_(4)(CH_(3)COO)_(16)]·9CH_(3)OH·5H_(2)O(1,H_(3)dmpa=dimethylolpropionic acid,and Hmm...Twelve novel transition-rare-earth metal clusters,formulated as [Ni_(18)Pr_(14)(μ_(3)OH)_(14)(dmpa)_(10)(mmt)_(10)(SO_(4))_(4)(CH_(3)COO)_(16)]·9CH_(3)OH·5H_(2)O(1,H_(3)dmpa=dimethylolpropionic acid,and Hmmt=2-me rcapto-5-methyl-1,3,4-thiadiazole) [Ni_(36)RE_(102)(OH)_(138)(mmt)_(18)(Hdmpa)_(30)(H_(2)dmpa)_(12)(CH_(3)COO)_(72)(NO_(3))_(36)(SO_(4))_(18)(H_(2)O)_(30)]·Br_(6)(RE=Nd(2),Sm(3),Eu(4) and Gd(5))[Ni_(12)RE_(10)(μ_(3)-OH)_(10)(dmpa)_(8)(mmt)_(8)(S(_(4))2(CH_(3)COO)_(8)(H_(2)O)_(4)]·8CH_(3)OH·7H_(2)O(RE = Tb(6),Dy(7),Ho(8),Er(9) and Y(10)) [Ni_(8)Pr_(8)(μ_(3)-OH)_(8)(mmt)_(8)(Hdpga)_(16)(CH3COO)_(8)]·8CH_(3)OH(11,H_(2)dpga=diphe nyl-glycolic acid),and [Ni_(16)Tb_(6)(μ_(3)-OH)_(24)(mmt)_(8)(Hdpga)_(4)(dpga)_(4)(CH_(3)COO)_(2)(NO_(3))_(4)(H_(2)O)_(2)]·12CH_(3)OH·5H_(2)O(12),were synthesized solvothermally by using different ligand combinations and rare earth nitrates.X-ray crystal structure analyses reveal that complexes 1 and 12 possess sandwich-like structure.Compounds 2-5 are isostructural and feature a hexagonal structure,shaped like a "Star of David".Isostructural 6-10 present ring-like structure,as well as the cluster 11.The structural variations of these complexes can be attributed to the effect of lanthanide contraction.Moreover,the template effect of SO_(4)^(2-) anion derived from the slow decomposition of Hmmt ligand also plays a significant role in the formation of cluster skeletons.The insitu mechanism for the generation of sulfate anion is briefly discussed.Meanwhile,the magnetic properties of complexes 2-11 were studied which show typical antiferromagnetic interactions.展开更多
基金supported by grants of the National Natural Science Foundation of China to YS(82272221,32071263),ZQ(81971887,82172170)and CL(82202403)the Tianjin Natural Science Foundation to ZQ(20JCYBJC01260,20JCYBJC01230)+3 种基金the Key Laboratory of Emergency and Trauma(Hainan Medical University),Ministry of Education to YS(KLET-202018)the Fundamental Research Funds for the Central Universities,Nankai University to ZQ(63211140)the Scientific Research Project of Tianjin Education Commission to CL(2020KJ206)National College Students’Innovative Entrepreneurial Training Plan Program to RL(202210062001).
文摘Myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with sepsis.Recent studies reported that reactive oxygen species(ROS)-mediated ferroptosis plays a critical role in the development of heart diseases.Therefore,we hypothesized that anti-ferroptosis agent might be a novel potential therapeutic strategy for sepsis-induced cardiac injury.Herein,we demonstrated that a small biocompatible and MRI-visible melanin nanoparticles(MMPP)improves myocardial function by inhibiting ROS-related ferroptosis signaling pathway.In LPS-induced murine sepsis model,after a single dose intravenously injection of MMPP treatment,MMPP markedly alleviated the myocardial injury including cardiac function and heart structure disorder through suppressing iron-accumulation induced ferroptosis.In vitro,MMPP inhibited cardiomyocyte death by attenuating oxidative stress,inflammation and maintaining mitochondrial homeostasis.Collectively,our findings demonstrated that MMPP protected heart against sepsis-induced myocardial injury via inhibiting ferroptosis and inflammation,which might be a novel therapeutic approach in future.
基金This study was supported as a Key Project by the Bureau of Zhejiang Traditional Chinese Medicine,China(No.2008ZA010).
文摘Cervical eropion,a pathological change associated with chronic cervicitis,is a common condition that is difficult to cure.M any pa tients particularly those with mild or medium infection and those preparing for pregnancy require a simple but effective medication.In this study,extracts of an empirical herbal prescription composed of six Chinese traditional drugs viz Cortex Phellodendri,Rhizoma Coptidis,Olibanum,Myrrha,borneol and catechu were formulated to facilitate intravaginal administration and improve efficacy.An extract of the first four components was formulated with borneol as a thermosensitive gel(TG)while an extract of catechu used to prepare a regular gel(CG)because of a chemical incompatibility.The optimized TG was prepared using poloxamer 407 and poloxamer 188.The CG was prepared using glycerin,carbopol and triethanolamine.The gels were characterized in vitro in terms of release of berberine(TG)and total catechins(CG)and in vivo in a rat model of cervical erosion.Trea tment by once daily application of the TG for 7 days followed by once daily application of the CG for 3 days produced a restoration of normal tissues.Gel formulation of the empirical Chinese traditional remedy appears to provide a promising treatment for cervical erosion.
基金supported by the National Natural Science Foundation of China(No.51563002)the"100-level"Innovative Talents Project of Guizhou Province China(No.[2016]5653)the Scie nee and Tech no logy Planning Project of Guan gzhou Province(No.202102010373).
文摘Explorati on of adva need an ode materials for sodium-i on batteries(SIBs)is still a big challe nge due to the large radius of sodium.In this work,the hierarchical architectures assembled from N-doped carbon-coated Co_(0.5)Ni_(0.5)Se_(2)(Co_(0.5)Ni_(0.5)Se_(2)@NC)nanoparticles encapsulated into cross-stacked nano sheets have been successfully prepared from the cobalt-nickel bin ary-metal organic frameworks(CoNi-MOF)by two steps of the solid-state sele nizati on and carb on coating processes.Imports ntly,the resulta nt hierarchical Co0.5Nio:5Se2@NC architecture can achieve a satisfactory electrochemical performance,maintaining a high-rate capacity of 330 mA-h-g^(-1)1 at 3 A·g^(-1) and a stable cyclability of 100 cycles without obvious capacity decay at 0.2 A·g^(-1).The design of distinct superstructure can not only be applied to other electrode materials but also boost the forward development of energy storage systems.
基金support of National Natural Science Foundation of China(22375157 and 22271228)Special Support Plan of Shaanxi Province for Young Top-notch Talent,State Key Laboratory of Electrical Insulation and Power Equipment(No.EIPE23402)+1 种基金"Scientists+Engineers"Team Building Project of Qin Chuang Yuan(2022KXJ-088)the Medical-Engineering Cross Project of the First Affiliated Hospital of XJTU(QYJCO2).
文摘The precise syntheses of transition-rare-earth metal clusters with desired structures remain a great challenge.Herein,by utilizing SO_(4)^(2-)anion released by in-situ decomposition of sodium dodecyl sulfate(SDS)as a template,a series of novel high-nuclearity 3d-4f clusters,formulated as[Ni_(24)Pr_(22)(μ_(3)-OH)_(31)(pida)_(24)(SO_(4))_(4)(NO_(3))_(9)(CH_(3)COO)_(3)]·Br_(4)·(NO_(3))_(11)·_(16)H_(2)O·25CH_(3)OH(1,H_(2)pida=N-phenyliminodiacetic acid),[Ni_(24)Nd_(22)(μ3-OH)_(31)(pida)_(24)(SO_(4))_(4)(NO_(3))_(9)(CH_(3)COO)_(3)]·Br_(4)·(NO_(3))_(11)·14H_(2)O·24CH_(3)OH(2)and[Ni_(24)Gd_(22)(μ3-OH)_(36)(bida)_(24)(SO_(4))_(7)(NO_(3))_(3)(CH_(3)COO)_(3)]·(SO_(4))·Br_(4)·(NO_(3))_(4)·31H_(2)O·32CH_(3)OH(3,H_(2)bida=N-benzyliminodiacetic acid),have been successfully isolated.X-ray crystal structure analyses reveal that all the cationic{Ni_(24)RE_(22)}cores in 1-3 possess a ball-like structure with C_(3v)symmetry,and can be viewed as consisting of an inner{RE_(22)}core and an outer{Ni_(24)}shell.From 1 and 2 to 3,due to the lanthanide contraction effect,the coordination numbers for rare-earth metal centers in{RE_(22)}are different,resulting in different number of SO_(4)^(2-)and NO_(3)^(-)anions to support and stabilize the skeleton structures.Meanwhile,the magnetic properties of complexes 1-3 were also studied.The result revealed that complexes 1-3 show antiferromagnetic/ferrimagnetic interactions,and 3 exhibits magneto-caloric effect at ultralow temperatures with a maximum-ΔSm(magnetic entropy change)value of 33.03 J·kg^(−1)·K^(−1)at 3.0 K and 7 T.
基金This work was supported by the National Natural Science Foundation of China(51563002,52101243)the“100-level”Innovative Talents Project of Guizhou Province China([2016]5653)+1 种基金Natural Science Foundation of Guangdong Province(2020A1515010886)the Science and Technology Planning Project of Guangzhou(202102010373).
文摘Herein,a flexible ZIF-67/PAN hybrid membrane was successfully prepared by the incorporation of ZIF-67 nanoparticles and PAN nanofibers through electrospinning method.The hybrid membrane presented tomatoes on sticks structures with one single PAN fiber stringing series of ZIF-67 nanoparticles.The morphology,electrolyte wettability,heat resistance,flexibility,and electrochemical properties of the electrospun ZIF-67/PAN membranes were discussed.Among the membranes prepared with different percentage of ZIF-67,the 30% ZIF-67/PAN membrane exhibited outstanding heat shrinkage resistance(remained intact at 200℃ for 1 h),excellent electrolyte uptake(556.39%),wide electrochemical window(~5.25 V)and high ionic conductivity(2.98 mS cm^(−1)).When used as lithium-ion batteries(LIBs)separators,the cells assembled by 30% ZIF-67/PAN membrane presented excellent rate capacity and high capacity retention of 86.9% after 300 cycles at 1C.More importantly,the cells assembled with ZIF-67/PAN membranes repeated bent for 1000 times also exhibited high rate performance and maintained capacity retention of 92% after 100 cycles at 1 C.The characterization and the electrochemical testing suggest the electrospinning prepared ZIF-67/PAN flexible membranes can be expected to be used as potential separator for advanced batteries with high safety and high performance.
基金Project supported by the National Natural Science Foundation of China (21971203)Support Plan of Shaanxi Province for Young Topnotch TalentFundamental Research Funds for Central Universities。
文摘Twelve novel transition-rare-earth metal clusters,formulated as [Ni_(18)Pr_(14)(μ_(3)OH)_(14)(dmpa)_(10)(mmt)_(10)(SO_(4))_(4)(CH_(3)COO)_(16)]·9CH_(3)OH·5H_(2)O(1,H_(3)dmpa=dimethylolpropionic acid,and Hmmt=2-me rcapto-5-methyl-1,3,4-thiadiazole) [Ni_(36)RE_(102)(OH)_(138)(mmt)_(18)(Hdmpa)_(30)(H_(2)dmpa)_(12)(CH_(3)COO)_(72)(NO_(3))_(36)(SO_(4))_(18)(H_(2)O)_(30)]·Br_(6)(RE=Nd(2),Sm(3),Eu(4) and Gd(5))[Ni_(12)RE_(10)(μ_(3)-OH)_(10)(dmpa)_(8)(mmt)_(8)(S(_(4))2(CH_(3)COO)_(8)(H_(2)O)_(4)]·8CH_(3)OH·7H_(2)O(RE = Tb(6),Dy(7),Ho(8),Er(9) and Y(10)) [Ni_(8)Pr_(8)(μ_(3)-OH)_(8)(mmt)_(8)(Hdpga)_(16)(CH3COO)_(8)]·8CH_(3)OH(11,H_(2)dpga=diphe nyl-glycolic acid),and [Ni_(16)Tb_(6)(μ_(3)-OH)_(24)(mmt)_(8)(Hdpga)_(4)(dpga)_(4)(CH_(3)COO)_(2)(NO_(3))_(4)(H_(2)O)_(2)]·12CH_(3)OH·5H_(2)O(12),were synthesized solvothermally by using different ligand combinations and rare earth nitrates.X-ray crystal structure analyses reveal that complexes 1 and 12 possess sandwich-like structure.Compounds 2-5 are isostructural and feature a hexagonal structure,shaped like a "Star of David".Isostructural 6-10 present ring-like structure,as well as the cluster 11.The structural variations of these complexes can be attributed to the effect of lanthanide contraction.Moreover,the template effect of SO_(4)^(2-) anion derived from the slow decomposition of Hmmt ligand also plays a significant role in the formation of cluster skeletons.The insitu mechanism for the generation of sulfate anion is briefly discussed.Meanwhile,the magnetic properties of complexes 2-11 were studied which show typical antiferromagnetic interactions.
