由致病性拷贝数变异(pathogenic copy number variations,pCNV)导致的基因组病是出生缺陷的一个重要遗传学病因。近年来,随着基于孕妇血浆胎儿游离DNA高通量测序技术的发展、生物信息分析流程的完善以及大样本数据的积累,无创产前筛查(n...由致病性拷贝数变异(pathogenic copy number variations,pCNV)导致的基因组病是出生缺陷的一个重要遗传学病因。近年来,随着基于孕妇血浆胎儿游离DNA高通量测序技术的发展、生物信息分析流程的完善以及大样本数据的积累,无创产前筛查(noninvasive prenatal screening,NIPS)胎儿pCNV疾病已开始应用于临床,国内对此技术的规范应用亟需专业的指导意见。基于此,本组专家就筛查的目标疾病和全流程临床规范应用细节达成技术共识,以期达到NIPS筛查pCNV疾病规范应用的目的。展开更多
目的对我国护士人文关怀干预措施的实施效果进行系统评价,为提升护士人文关怀能力提供理论依据。方法检索Web of Science、知网、维普等数据库从建库至2022年9月的文献,经过去重、筛选、质量评价,分析讨论研究中的干预措施及其实施效果...目的对我国护士人文关怀干预措施的实施效果进行系统评价,为提升护士人文关怀能力提供理论依据。方法检索Web of Science、知网、维普等数据库从建库至2022年9月的文献,经过去重、筛选、质量评价,分析讨论研究中的干预措施及其实施效果。结果最终纳入11篇文献,人文关怀干预可提高护士关怀能力、关怀品质、共情能力及患者关怀感知度、满意度。结论人文关怀干预对护士人文关怀能力的提升具有促进作用,有必要在借鉴现有干预措施的基础上,积极开展护士人文关怀培训,实现护士人文关怀水平的整体提升。展开更多
Thermo-responsive random copolymers,poly(2-(2-methoxyethoxy)ethoxyethyl methacrylate-co-(ethylene glycol)methyl ether methacrylate)(P(EO_(2)-co-EO_(4/5)))and poly(2-(2-methoxyethoxy)ethoxyethyl methacrylate-co-ethylen...Thermo-responsive random copolymers,poly(2-(2-methoxyethoxy)ethoxyethyl methacrylate-co-(ethylene glycol)methyl ether methacrylate)(P(EO_(2)-co-EO_(4/5)))and poly(2-(2-methoxyethoxy)ethoxyethyl methacrylate-co-ethylene glycol methacrylate(P(EO2-co-EG4/5))are synthesized via atom transfer radical polymerization(ATRP).The successful synthesis and the narrow polydispersity index(PDI)of two copolymers are indicated by 1H nuclear magnetic resonance(1H-NMR)and gel permeation chromatography(GPC)analyses.The transition behaviors of polymers in the aqueous solution are demonstrated by changes in turbidity and particle sizes.The transition behavior of P(EO2-co-EG4/5)is found to be milder than that of P(EO2-co-EO4/5).Moreover,the presence of hydrogen bonds without thermo-responsive properties established by hydroxyl groups in the end-side chain of P(EO_(2)-co-EG_(4/5))hinders the dehydration at the transition temperature(TT).Attenuated total reflection Fourier transform infrared spectrometry(ATR-FTIR)analysis along with contact angle measurements reveals that both P(EO_(2)-co-EO_(4/5))and P(EO_(2)-co-EG_(4/5))films undergo phase transitions from hydrophilicity to hydrophobicity above TT.By examining the swelling and collapse behaviors of the polymer films during phase transitions,it can be concluded that the end hydroxyl groups may establish hydrogen bonds with neighboring ether groups within the films,which remain intact throughout the phase transition process due to their strong bonding interactions.This leads to an increase in steric hindrance within swollen films thereby impeding dehydration processes and inducing hysteresis during phase transitions.展开更多
文摘目的对我国护士人文关怀干预措施的实施效果进行系统评价,为提升护士人文关怀能力提供理论依据。方法检索Web of Science、知网、维普等数据库从建库至2022年9月的文献,经过去重、筛选、质量评价,分析讨论研究中的干预措施及其实施效果。结果最终纳入11篇文献,人文关怀干预可提高护士关怀能力、关怀品质、共情能力及患者关怀感知度、满意度。结论人文关怀干预对护士人文关怀能力的提升具有促进作用,有必要在借鉴现有干预措施的基础上,积极开展护士人文关怀培训,实现护士人文关怀水平的整体提升。
基金Fujian External Cooperation project of Natural Science Foundation,China(No.2022I0042)。
文摘Thermo-responsive random copolymers,poly(2-(2-methoxyethoxy)ethoxyethyl methacrylate-co-(ethylene glycol)methyl ether methacrylate)(P(EO_(2)-co-EO_(4/5)))and poly(2-(2-methoxyethoxy)ethoxyethyl methacrylate-co-ethylene glycol methacrylate(P(EO2-co-EG4/5))are synthesized via atom transfer radical polymerization(ATRP).The successful synthesis and the narrow polydispersity index(PDI)of two copolymers are indicated by 1H nuclear magnetic resonance(1H-NMR)and gel permeation chromatography(GPC)analyses.The transition behaviors of polymers in the aqueous solution are demonstrated by changes in turbidity and particle sizes.The transition behavior of P(EO2-co-EG4/5)is found to be milder than that of P(EO2-co-EO4/5).Moreover,the presence of hydrogen bonds without thermo-responsive properties established by hydroxyl groups in the end-side chain of P(EO_(2)-co-EG_(4/5))hinders the dehydration at the transition temperature(TT).Attenuated total reflection Fourier transform infrared spectrometry(ATR-FTIR)analysis along with contact angle measurements reveals that both P(EO_(2)-co-EO_(4/5))and P(EO_(2)-co-EG_(4/5))films undergo phase transitions from hydrophilicity to hydrophobicity above TT.By examining the swelling and collapse behaviors of the polymer films during phase transitions,it can be concluded that the end hydroxyl groups may establish hydrogen bonds with neighboring ether groups within the films,which remain intact throughout the phase transition process due to their strong bonding interactions.This leads to an increase in steric hindrance within swollen films thereby impeding dehydration processes and inducing hysteresis during phase transitions.
基金China Agriculture Research System(CARS-47-G26)Shanghai Promote Agriculture by Applying Scientific&Technological Advances Projects(2016No.1-1)+1 种基金Ability Promotion Project of Shanghai Municipal Science and Technology Commission Engineering Center(16DZ2280300)Public Service Platform Constuction Project for Shanghai Municipal Science and Technology Commission(17DZ2293400)
文摘为研究保压时间对超高压鲳鱼片冷藏期间品质变化的影响,以未做任何处理样品作为对照组(CK),研究在200MPa的超高压条件下,通过10min(HPP10)、20min(HPP20)与30min(HPP30)的保压时间处理后样品的品质变化,每隔2d分别对各组样品的微生物指标(Total Viable Count,TVC)、理化指标(pH值、总挥发性盐基氮(Total Volatile Base Nitrogen,TVB-N)、色差、持水力(Water Holding Capacity,WHC)与质构分析(Texture Profile Analysis,TPA)与感官分值进行测定。结果表明,样品经过超高压处理后,其在贮藏期间的微生物生长、蛋白质降解与汁液流失得到明显抑制,其质构特性得以保持。指标间相关性分析结果显示,ΔE、pH值、TVB-N和TVC等相关性好。经200MPa、30min超高压处理能使冷藏鲳鱼片的货架期由4d延至8～12d。
