Aconiti Lateralis Radix Praeparata(Fuzi) is a commonly used traditional Chinese medicine in clinic for its potency in restoring yang and rescuing from collapse. Aconiti alkaloids, mainly including monoester-diterpenoi...Aconiti Lateralis Radix Praeparata(Fuzi) is a commonly used traditional Chinese medicine in clinic for its potency in restoring yang and rescuing from collapse. Aconiti alkaloids, mainly including monoester-diterpenoidaconitines(MDAs) and diester-diterpenoidaconitines(DDAs), are considered to act as both bioactive and toxic constituents. In the present study, a feasible, economical, and accurate HPLC method for simultaneous determination of six alkaloid markers using the Single Standard for Determination of Multi-Components(SSDMC) method was developed and fully validated. Benzoylmesaconine was used as the unique reference standard. This method was proven as accurate(recovery varying between 97.5%-101.8%, RSD < 3%), precise(RSD 0.63%-2.05%), and linear(R > 0.999 9) over the concentration ranges, and subsequently applied to quantitative evaluation of 62 batches of samples, among which 45 batches were from good manufacturing practice(GMP) facilities and 17 batches from the drug market. The contents were then analyzed by principal component analysis(PCA) and homogeneity test. The present study provided valuable information for improving the quality standard of Aconiti Lateralis Radix Praeparata. The developed method also has the potential in analysis of other Aconitum species, such as Aconitum carmichaelii(prepared parent root) and Aconitum kusnezoffii(prepared root).展开更多
针对多模态遥感影像存在非线性辐射畸变的问题,本文提出了一种结合相位对称特征与基于排序局部自相似性的多模态遥感影像匹配方法.首先,利用影像的局部相位信息构造相位对称图,在此基础上利用加速分段测试特征提取算法(features from ac...针对多模态遥感影像存在非线性辐射畸变的问题,本文提出了一种结合相位对称特征与基于排序局部自相似性的多模态遥感影像匹配方法.首先,利用影像的局部相位信息构造相位对称图,在此基础上利用加速分段测试特征提取算法(features from accelerated segment test,FAST)对相位对称图进行特征提取.然后结合基于排序的局部自相似性与相位一致性构造一种新的特征描述符RPCLSS(combining rank,phase congruency and local self-similarity descriptor).最后利用快速抽样一致性算法(fast sample consensus,FSC)进行误匹配点剔除.将本文方法在公开的多源遥感影像数据集上与现有的5种先进匹配方法进行对比实验.实验结果表明,本文方法在正确匹配点数量、匹配精度和匹配正确率方面,优于现有的先进多模态遥感影像匹配方法.展开更多
1 Introduction Chronic kidney disease(CKD)often coexists with or is a complication of cardiovascular disease.Previous studies have shown that CKD increases the risk of cardiovascular death and all-cause death and was ...1 Introduction Chronic kidney disease(CKD)often coexists with or is a complication of cardiovascular disease.Previous studies have shown that CKD increases the risk of cardiovascular death and all-cause death and was considered to be a risk equivalent of coronary heart disease.[1,2]Adjusted for confounders,decreased glomerular filtration rate(GFR)and increased albuminuria are both independent risk factors for cardiovascular events.[3,4]The risk for cardiovascular death linearly increases with the decline of GFR in a certain range(<70 mL/min per 1.73 m^2)and the increase of albuminuria without a threshold effect[3].展开更多
Since the year of 2006, peer-to-peer （P2P） streaming media service has been developing rapidly, the user scale and income scale achieve synchronous growth. However, while people enjoying the benefits of the distribu...Since the year of 2006, peer-to-peer （P2P） streaming media service has been developing rapidly, the user scale and income scale achieve synchronous growth. However, while people enjoying the benefits of the distributed resources, a great deal of network bandwidth is consumed at the same time. Research on P2P streaming traffic characteristics and identification is essential to Internet service providers （ISPs） in terms of network planning and resource allocation. In this paper, we introduce the current common P2P traffic detection technology, and analyze the payload length distribution and payload length pattern in one flow of four popular P2P streaming media applications. Combining with the deep flow inspection and machine learning algorithm, a nearly real-time The experiments proved that this approach can achieve a high identification approach for P2P streaming media is proposed. accuracy with low false positives.展开更多
基金financially supported by the project of Standardization of Traditional Chinese Medicines/Indigenous Drugs sponsored by Chinese Academy of Sciences(No.KSZD-EW-Z-004-01)
文摘Aconiti Lateralis Radix Praeparata(Fuzi) is a commonly used traditional Chinese medicine in clinic for its potency in restoring yang and rescuing from collapse. Aconiti alkaloids, mainly including monoester-diterpenoidaconitines(MDAs) and diester-diterpenoidaconitines(DDAs), are considered to act as both bioactive and toxic constituents. In the present study, a feasible, economical, and accurate HPLC method for simultaneous determination of six alkaloid markers using the Single Standard for Determination of Multi-Components(SSDMC) method was developed and fully validated. Benzoylmesaconine was used as the unique reference standard. This method was proven as accurate(recovery varying between 97.5%-101.8%, RSD < 3%), precise(RSD 0.63%-2.05%), and linear(R > 0.999 9) over the concentration ranges, and subsequently applied to quantitative evaluation of 62 batches of samples, among which 45 batches were from good manufacturing practice(GMP) facilities and 17 batches from the drug market. The contents were then analyzed by principal component analysis(PCA) and homogeneity test. The present study provided valuable information for improving the quality standard of Aconiti Lateralis Radix Praeparata. The developed method also has the potential in analysis of other Aconitum species, such as Aconitum carmichaelii(prepared parent root) and Aconitum kusnezoffii(prepared root).
文摘针对多模态遥感影像存在非线性辐射畸变的问题,本文提出了一种结合相位对称特征与基于排序局部自相似性的多模态遥感影像匹配方法.首先,利用影像的局部相位信息构造相位对称图,在此基础上利用加速分段测试特征提取算法(features from accelerated segment test,FAST)对相位对称图进行特征提取.然后结合基于排序的局部自相似性与相位一致性构造一种新的特征描述符RPCLSS(combining rank,phase congruency and local self-similarity descriptor).最后利用快速抽样一致性算法(fast sample consensus,FSC)进行误匹配点剔除.将本文方法在公开的多源遥感影像数据集上与现有的5种先进匹配方法进行对比实验.实验结果表明,本文方法在正确匹配点数量、匹配精度和匹配正确率方面,优于现有的先进多模态遥感影像匹配方法.
基金the National Key Research and Development Programme of China(2018YFC1314003)the Education of Zhejiang Province(Y201328620).
文摘1 Introduction Chronic kidney disease(CKD)often coexists with or is a complication of cardiovascular disease.Previous studies have shown that CKD increases the risk of cardiovascular death and all-cause death and was considered to be a risk equivalent of coronary heart disease.[1,2]Adjusted for confounders,decreased glomerular filtration rate(GFR)and increased albuminuria are both independent risk factors for cardiovascular events.[3,4]The risk for cardiovascular death linearly increases with the decline of GFR in a certain range(<70 mL/min per 1.73 m^2)and the increase of albuminuria without a threshold effect[3].
基金supported by the National Natural Science Foundation of China (61072061)the National Science and Technology Major Project (2012ZX03002008003)+1 种基金the 111 Project of China (B08004)the Chinese Universities Scientific Fund(2011RC0116)
文摘Since the year of 2006, peer-to-peer （P2P） streaming media service has been developing rapidly, the user scale and income scale achieve synchronous growth. However, while people enjoying the benefits of the distributed resources, a great deal of network bandwidth is consumed at the same time. Research on P2P streaming traffic characteristics and identification is essential to Internet service providers （ISPs） in terms of network planning and resource allocation. In this paper, we introduce the current common P2P traffic detection technology, and analyze the payload length distribution and payload length pattern in one flow of four popular P2P streaming media applications. Combining with the deep flow inspection and machine learning algorithm, a nearly real-time The experiments proved that this approach can achieve a high identification approach for P2P streaming media is proposed. accuracy with low false positives.
