Behet’s disease (BD) is a chronic, multisystemic, inflammatory disorder characterized mainly by recurrent oral and genital aphthous ulcerations and uveitis. Our study aimed to determine the genetic damage in patien...Behet’s disease (BD) is a chronic, multisystemic, inflammatory disorder characterized mainly by recurrent oral and genital aphthous ulcerations and uveitis. Our study aimed to determine the genetic damage in patients with BD. The micronucleus(MN) frequency was counted in peripheral lymphocytes and exfoliated cells of the patients with BD. MN analysis was performed in peripheral lymphocytes of 30 patients with BD and in 20 healthy controls by the cytokinesis-block method, and on uncultured cells of the oral cavity in 10 patients and 9 healthy controls. We found significantly higher MN rates in lymphocytes of the patients than the control subjects (P = 0.000). There were no significant differences between the patients with or without treatment (P=0.860). The MN frequency in exfoliated cells of the patients was higher than in those of healthy controls(P=0.013), and there was no significant difference between the exfoliated cells of the treated and untreated patients (P=0.201). Our results indicate that genetic damage may play a secondary but important part in the aetiology of BD and that treatment with colchicine does not induce MN.展开更多
Background:disease(BD)is a systemic inflammatory vasculitis of young adults with unknown etiology.Objective:The aim of this study was to determine the clinical features and outcome of BD in childhood.Patients and meth...Background:disease(BD)is a systemic inflammatory vasculitis of young adults with unknown etiology.Objective:The aim of this study was to determine the clinical features and outcome of BD in childhood.Patients and methods:Seventeen patients with BD within a pediatric age group were studied since 1997.Results:Boys :girls ratio was 12:5.Familial cases were very frequent(45%).Oral aphthous ulcers were presentin all patients(100%),genital aphthous ulcers were present in 16(94%),ocular lesions in 4(24%),erythema nodosum in 3(18%),papulopustules in 8(47%),joint symptoms in 13(76%),mild gastrointestinal symptoms in 2(12%),neurological involvement in 2(12%),positive pathergy reactions in 13(76%),and thrombophlebitis in 1(6%).We used colchicine,system iccorticosteroids,cyclosporine,nonsteroidal anti-inflammatory drugs,sulfasalazine,and topical agents for the treatment of children with BD.Conclusion:The findings of BD in children are similar as in adults,but the frequency of familial cases is significantly higher.展开更多
文摘Behet’s disease (BD) is a chronic, multisystemic, inflammatory disorder characterized mainly by recurrent oral and genital aphthous ulcerations and uveitis. Our study aimed to determine the genetic damage in patients with BD. The micronucleus(MN) frequency was counted in peripheral lymphocytes and exfoliated cells of the patients with BD. MN analysis was performed in peripheral lymphocytes of 30 patients with BD and in 20 healthy controls by the cytokinesis-block method, and on uncultured cells of the oral cavity in 10 patients and 9 healthy controls. We found significantly higher MN rates in lymphocytes of the patients than the control subjects (P = 0.000). There were no significant differences between the patients with or without treatment (P=0.860). The MN frequency in exfoliated cells of the patients was higher than in those of healthy controls(P=0.013), and there was no significant difference between the exfoliated cells of the treated and untreated patients (P=0.201). Our results indicate that genetic damage may play a secondary but important part in the aetiology of BD and that treatment with colchicine does not induce MN.
文摘Background:disease(BD)is a systemic inflammatory vasculitis of young adults with unknown etiology.Objective:The aim of this study was to determine the clinical features and outcome of BD in childhood.Patients and methods:Seventeen patients with BD within a pediatric age group were studied since 1997.Results:Boys :girls ratio was 12:5.Familial cases were very frequent(45%).Oral aphthous ulcers were presentin all patients(100%),genital aphthous ulcers were present in 16(94%),ocular lesions in 4(24%),erythema nodosum in 3(18%),papulopustules in 8(47%),joint symptoms in 13(76%),mild gastrointestinal symptoms in 2(12%),neurological involvement in 2(12%),positive pathergy reactions in 13(76%),and thrombophlebitis in 1(6%).We used colchicine,system iccorticosteroids,cyclosporine,nonsteroidal anti-inflammatory drugs,sulfasalazine,and topical agents for the treatment of children with BD.Conclusion:The findings of BD in children are similar as in adults,but the frequency of familial cases is significantly higher.
