BACKGROUND: Stent failure is more likely in the lipid rich and thrombus laden culprit lesions underlying ST-segment elevation myocardial infarction(STEMI).This study assessed the effectiveness of post-dilatation in pr...BACKGROUND: Stent failure is more likely in the lipid rich and thrombus laden culprit lesions underlying ST-segment elevation myocardial infarction(STEMI).This study assessed the effectiveness of post-dilatation in primary percutaneous coronary intervention(pPCI) for acute STEMI.METHODS: The multi-center POST-STEMI trial enrolled 41 consecutive STEMI patients with symptom onset <12 hours undergoing manual thrombus aspiration and Promus Element stent implantation.Patients were randomly assigned to control group(n=20) or post-dilatation group(n=21) in which a non-compliant balloon was inflated to >16 atm pressure.Strut apposition and coverage were evaluated by optical coherence tomography(OCT) after intracoronary verapamil administration via thrombus aspiration catheter, post pPCI and at 7-month follow-up.The primary endpoint was rate of incomplete strut apposition(ISA) at 7 months after pPCI.RESULTS: There were similar baseline characteristics except for stent length(21.9 [SD 6.5] mm vs.26.0 [SD 5.8] mm, respectively, P=0.03).In post-dilatation vs.control group, ISA rate was lower(2.5% vs.4.5%, P=0.04) immediately after pPCI without affecting final TIMI flow 3 rate(95.2% vs.95.0%, P>0.05) or corrected TIMI frame counts(22.6±9.4 vs.22.0±9.7, P>0.05); and at 7-month follow-up(0.7% vs.1.8%, P<0.0001), the primary study endpoint, with similar strut coverage(98.5% vs.98.4%, P=0.63) and 1-year rate of major adverse cardiovascular events(MACE).CONCLUSION: In STEMI patients, post-dilatation after stent implantation and thrombus aspiration improved strut apposition up to 7 months without affecting coronary blood flow or 1-year MACE rate.Larger and longer term studies are warranted to further assess safety(Clinical Trials.gov identifier: NCT02121223).展开更多
We propose a trellis-compressed maximum likelihood sequence estimation(TC-MLSE)-assisted sliding-block decision feedback equalizer(DFE)to suppress the error propagation resulting from the DFE in high-speed systems.We ...We propose a trellis-compressed maximum likelihood sequence estimation(TC-MLSE)-assisted sliding-block decision feedback equalizer(DFE)to suppress the error propagation resulting from the DFE in high-speed systems.We use an out-ofrange detector to detect the end of burst errors from the DFE and activate the optional TC-MLSE to correct burst errors.We conduct experiments to transmit a 201-Gbit/s PAM-8 signal.The results show that the proposed method achieves a bit error rate of 3.65×10^(-3),which is close to that of MLSE.The optional MLSE is only activated when needed and processes 11.4%of the total symbols.Moreover,the proposed method compresses the maximum length of burst errors from 19 to 5.展开更多
基金funded by grants from National Natural Science Foundation of China(81100141 and 81570322 for JJ,81320108003 for JW)jointly supported by Boston Scientific
文摘BACKGROUND: Stent failure is more likely in the lipid rich and thrombus laden culprit lesions underlying ST-segment elevation myocardial infarction(STEMI).This study assessed the effectiveness of post-dilatation in primary percutaneous coronary intervention(pPCI) for acute STEMI.METHODS: The multi-center POST-STEMI trial enrolled 41 consecutive STEMI patients with symptom onset <12 hours undergoing manual thrombus aspiration and Promus Element stent implantation.Patients were randomly assigned to control group(n=20) or post-dilatation group(n=21) in which a non-compliant balloon was inflated to >16 atm pressure.Strut apposition and coverage were evaluated by optical coherence tomography(OCT) after intracoronary verapamil administration via thrombus aspiration catheter, post pPCI and at 7-month follow-up.The primary endpoint was rate of incomplete strut apposition(ISA) at 7 months after pPCI.RESULTS: There were similar baseline characteristics except for stent length(21.9 [SD 6.5] mm vs.26.0 [SD 5.8] mm, respectively, P=0.03).In post-dilatation vs.control group, ISA rate was lower(2.5% vs.4.5%, P=0.04) immediately after pPCI without affecting final TIMI flow 3 rate(95.2% vs.95.0%, P>0.05) or corrected TIMI frame counts(22.6±9.4 vs.22.0±9.7, P>0.05); and at 7-month follow-up(0.7% vs.1.8%, P<0.0001), the primary study endpoint, with similar strut coverage(98.5% vs.98.4%, P=0.63) and 1-year rate of major adverse cardiovascular events(MACE).CONCLUSION: In STEMI patients, post-dilatation after stent implantation and thrombus aspiration improved strut apposition up to 7 months without affecting coronary blood flow or 1-year MACE rate.Larger and longer term studies are warranted to further assess safety(Clinical Trials.gov identifier: NCT02121223).
基金This work was supported by the National Natural Science Foundation of China(NSFC)(Nos.62301128,61871082,and 62111530150)the Open Fund of IPOC(BUPT)(No.IPOC2020A011)+1 种基金the STCSM(No.SKLSFO2021-01)the Fundamental Research Funds for the Central Universities(Nos.ZYGX2020ZB043 and ZYGX2019J008).
文摘We propose a trellis-compressed maximum likelihood sequence estimation(TC-MLSE)-assisted sliding-block decision feedback equalizer(DFE)to suppress the error propagation resulting from the DFE in high-speed systems.We use an out-ofrange detector to detect the end of burst errors from the DFE and activate the optional TC-MLSE to correct burst errors.We conduct experiments to transmit a 201-Gbit/s PAM-8 signal.The results show that the proposed method achieves a bit error rate of 3.65×10^(-3),which is close to that of MLSE.The optional MLSE is only activated when needed and processes 11.4%of the total symbols.Moreover,the proposed method compresses the maximum length of burst errors from 19 to 5.
基金supported by the National Natural Science Foundation of China (Grant Nos.12192210 and 12192214)the independent project of State Key Laboratory of Traction Power (Grant No.2022TPL-T05).
基金supported by the National Key Research and Development Program of China(2022YFB3505101)the National Science Foundation for Excellent Young Scholars(52222107)+2 种基金the National Science Foundation for Distinguished Young Scholars(51925605)the Research Projects of Ganjiang Innovation Academy,Chinese Academy of Sciences(E055B002)the Doctoral Postgraduate Innovation Funding project of Hebei Province(CXZZBS2023032)。
基金supported by the National Natural Science Foundation of China(52172171,52090022,11725210,and 91963115)the Natural Science Foundation of Hebei Province of China(E2022203109)Dr.Nie A appreciates the support of the Natural Science Foundation for Distinguished Young Scholars of Hebei Province(E2020203085)。
基金supported by the National Key Research and Development Program of China(2020YFA0712102)the National Natural Science Foundation of China(52022094,22020102003,and 52072142)+1 种基金the Program of Science and Technology Development Plan of Jilin Province of China(20210101111JC and 20230508071RC)the Youth Innovation Promotion Association of Chinese Academy of Sciences(2019232)。
基金supported by the Natural Science Foundation of Hebei Province of China(E2020203085,E2022203109)the National Natural Science Foundation of China(52090022,52288102)。
