Imbalanced application of nitrogen(N) and phosphorus(P) fertilizers can result in reduced crop yield,low nutrient use efficiency,and high loss of nutrients and soil nitrate nitrogen(NO_3^--N) accumulation decreases wh...Imbalanced application of nitrogen(N) and phosphorus(P) fertilizers can result in reduced crop yield,low nutrient use efficiency,and high loss of nutrients and soil nitrate nitrogen(NO_3^--N) accumulation decreases when N is applied with P and/or manure;however,the effect of applications of N with P and/or manure on root growth and distribution in the soil profile is not fully understood.The aim of this study was to investigate the combined effects of different N and P fertilizer application rates with or without manure on maize(Zea mays L.) yield,N uptake,root growth,apparent N surplus,Olsen-P concentration,and mineral N(N_(min)) accumulation in a fluvo-aquic calcareous soil from a long-term(28-year) experiment.The experiment comprised twelve combinations of chemical N and P fertilizers,either with or without chicken manure,as treatments in four replicates.The yield of maize grain was 82%higher,the N uptake 100%higher,and the N_(min) accumulation 39%lower in the treatments with combined N and P in comparison to N fertilizer only.The maize root length density in the 30-60 cm layer was three times greater in the treatments with N and P fertilizers than with N fertilizer only.Manure addition increased maize yield by 50%and N uptake by 43%,and reduced N_(min)(mostly NO_3^--N) accumulation in the soil by 46%.The long-term application of manure and P fertilizer resulted in significant increases in soil Olsen-P concentration when no N fertilizer was applied.Manure application reduced the apparent N surplus for all treatments.These results suggest that combined N and P fertilizer applications could enhance maize grain yield and nutrient uptake via stimulating root growth,leading to reduced accumulation of potentially leachable NO_3^--N in soil,and manure application was a practical way to improve degraded soils in China and the rest of the world.展开更多
Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin...Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinical展开更多
There is promising indication of helium-rich natural gas in Weihe Basin.However,the lack of a detailed investigation on the origin and the spatial distribution of helium source rocks(mainly Yanshanian granites)limits ...There is promising indication of helium-rich natural gas in Weihe Basin.However,the lack of a detailed investigation on the origin and the spatial distribution of helium source rocks(mainly Yanshanian granites)limits the helium potentiality evaluation in Weihe Basin(WB).We performed three-dimensional(3 D)inversions of magnetic data in Weihe Basin and its adjacent areas to figure out the crustal thermal structure and the temporal-spatial distribution of deep granite in the basin.Based on this,we have proposed a geological model of helium accumulation and predicted the potential area of helium distribution.The results of 3 D magnetic inversion indicate that the granites in the deep Weihe Basin are mostly located at the central and southern parts of the basin,which are connected spatially with the granites in the North Qinling Orogenic Belt.These granites were all derived from largescale intra-continental orogeny in the Qinling area during the mid-Mesozoic,providing a good material basis for crust-derived helium in the basin.The local uplift of the Curie surface makes the thermal fluid more actively,which contributes to helium accumulation.The faults developed in the WB are the migration pathway of crust-derived helium and the upward migration of the mantle-derived helium.The wells with high percentage helium are mostly located near the Weihe fault and the areas on the south of it.The Wugong-Xi’an-Lantian area in the central and the Lintong-Weinan-Tongguan area in the eastern Weihe Basin are the most promising helium distribution areas.Furthermore,the region from the north of Taibai Mountain to Baoji City in the western Weihe Basin may also be another potential area of Helium resource.展开更多
The High Altitude Detection of Astronomical Radiation(HADAR)experiment is a refracting terrestrial telescope array based on the atmospheric Cherenkov imaging technique.It focuses the Cherenkov light emitted by extensi...The High Altitude Detection of Astronomical Radiation(HADAR)experiment is a refracting terrestrial telescope array based on the atmospheric Cherenkov imaging technique.It focuses the Cherenkov light emitted by extensive air showers through a large aperture water-lens system for observing very-high-energyγ-rays and cosmic rays.With the advantages of a large field-of-view(FOV)and low energy threshold,the HADAR experiment operates in a large-scale sky scanning mode to observe galactic sources.This study presents the prospects of using the HADAR experiment for the sky survey of TeVγ-ray sources from TeVCat and provids a one-year survey of statistical significance.Results from the simulation show that a total of 23 galactic point sources,including five supernova remnant sources and superbubbles,four pulsar wind nebula sources,and 14 unidentified sources,were detected in the HADAR FOV with a significance greater than 5 standard deviations(σ).The statistical significance for the Crab Nebula during one year of operation reached 346.0σand the one-year integral sensitivity of HADAR above 1 TeV was~1.3%–2.4%of the flux from the Crab Nebula.展开更多
基金supported by the Beijing Higher Education Young Elite Teacher Project (No. YETP0313)the Chinese Universities Scientific Fund (No. 2014JD073)+1 种基金the National Natural Science Foundation of China (Nos. 31330070, 30925024, 31121062, 41173083, and 41473068)the Introducing International Advanced Agricultural Science and Technology Program of the Ministry of Agriculture of China (948 Program) (No. 2011-G18)
文摘Imbalanced application of nitrogen(N) and phosphorus(P) fertilizers can result in reduced crop yield,low nutrient use efficiency,and high loss of nutrients and soil nitrate nitrogen(NO_3^--N) accumulation decreases when N is applied with P and/or manure;however,the effect of applications of N with P and/or manure on root growth and distribution in the soil profile is not fully understood.The aim of this study was to investigate the combined effects of different N and P fertilizer application rates with or without manure on maize(Zea mays L.) yield,N uptake,root growth,apparent N surplus,Olsen-P concentration,and mineral N(N_(min)) accumulation in a fluvo-aquic calcareous soil from a long-term(28-year) experiment.The experiment comprised twelve combinations of chemical N and P fertilizers,either with or without chicken manure,as treatments in four replicates.The yield of maize grain was 82%higher,the N uptake 100%higher,and the N_(min) accumulation 39%lower in the treatments with combined N and P in comparison to N fertilizer only.The maize root length density in the 30-60 cm layer was three times greater in the treatments with N and P fertilizers than with N fertilizer only.Manure addition increased maize yield by 50%and N uptake by 43%,and reduced N_(min)(mostly NO_3^--N) accumulation in the soil by 46%.The long-term application of manure and P fertilizer resulted in significant increases in soil Olsen-P concentration when no N fertilizer was applied.Manure application reduced the apparent N surplus for all treatments.These results suggest that combined N and P fertilizer applications could enhance maize grain yield and nutrient uptake via stimulating root growth,leading to reduced accumulation of potentially leachable NO_3^--N in soil,and manure application was a practical way to improve degraded soils in China and the rest of the world.
基金China National Major Project for New Drug Innovation,Grant/Award Number:2017ZX09304015Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(CIFMS),Grant/Award Number:2016-I2M-1-001。
文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinical
基金supported by the National Natural Science Foundation of China(No.41904115)the Natural Science Basic Research Plan in Shaanxi Province of China(No.2018JQ4034)。
文摘There is promising indication of helium-rich natural gas in Weihe Basin.However,the lack of a detailed investigation on the origin and the spatial distribution of helium source rocks(mainly Yanshanian granites)limits the helium potentiality evaluation in Weihe Basin(WB).We performed three-dimensional(3 D)inversions of magnetic data in Weihe Basin and its adjacent areas to figure out the crustal thermal structure and the temporal-spatial distribution of deep granite in the basin.Based on this,we have proposed a geological model of helium accumulation and predicted the potential area of helium distribution.The results of 3 D magnetic inversion indicate that the granites in the deep Weihe Basin are mostly located at the central and southern parts of the basin,which are connected spatially with the granites in the North Qinling Orogenic Belt.These granites were all derived from largescale intra-continental orogeny in the Qinling area during the mid-Mesozoic,providing a good material basis for crust-derived helium in the basin.The local uplift of the Curie surface makes the thermal fluid more actively,which contributes to helium accumulation.The faults developed in the WB are the migration pathway of crust-derived helium and the upward migration of the mantle-derived helium.The wells with high percentage helium are mostly located near the Weihe fault and the areas on the south of it.The Wugong-Xi’an-Lantian area in the central and the Lintong-Weinan-Tongguan area in the eastern Weihe Basin are the most promising helium distribution areas.Furthermore,the region from the north of Taibai Mountain to Baoji City in the western Weihe Basin may also be another potential area of Helium resource.
基金support from the National Natural Science Foundation of China(Nos.11873005,11705103,12005120,12147218,U1831208,U1632104,11875264,and U2031110).
文摘The High Altitude Detection of Astronomical Radiation(HADAR)experiment is a refracting terrestrial telescope array based on the atmospheric Cherenkov imaging technique.It focuses the Cherenkov light emitted by extensive air showers through a large aperture water-lens system for observing very-high-energyγ-rays and cosmic rays.With the advantages of a large field-of-view(FOV)and low energy threshold,the HADAR experiment operates in a large-scale sky scanning mode to observe galactic sources.This study presents the prospects of using the HADAR experiment for the sky survey of TeVγ-ray sources from TeVCat and provids a one-year survey of statistical significance.Results from the simulation show that a total of 23 galactic point sources,including five supernova remnant sources and superbubbles,four pulsar wind nebula sources,and 14 unidentified sources,were detected in the HADAR FOV with a significance greater than 5 standard deviations(σ).The statistical significance for the Crab Nebula during one year of operation reached 346.0σand the one-year integral sensitivity of HADAR above 1 TeV was~1.3%–2.4%of the flux from the Crab Nebula.
