Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin...Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinical展开更多
A novel luminescent double-interpenetrated metal-organic framework(MOF),named{[In_(6)(O)_(3)(BTB)_(4)]·3H_(2)O}_(n)(1),is designed and synthesized using the tritopic linkers(1,3,5-tris(4-carboxyphenyl)benzene(H_(...A novel luminescent double-interpenetrated metal-organic framework(MOF),named{[In_(6)(O)_(3)(BTB)_(4)]·3H_(2)O}_(n)(1),is designed and synthesized using the tritopic linkers(1,3,5-tris(4-carboxyphenyl)benzene(H_(3)BTB))and tetranuclear clusters[In_(4)O_(2)(COO)_(8)].1 features 3,8-connected dual-wall"cage-in-cage"and exhibits excellent chemical stability owing to its high connectivity and double-interpenetrated architectures.Moreover,it could rapidly detect thiamphenicol(THI),nitrofurazone(NFZ),and nitrofurantoin(NFT)antibiotics in N,N-dime-thylformamide(DMF)with superior detection sensitivity(Ksv)and low detection limits(LOD)of 4.52×10^(3)M^(-1)and 348.6 ppm,1.43×10^(5)M^(-1)and 13.8 ppm,and 1.47×10^(5)M^(-1)and 12.1 ppm for THI,NFZ,and NFT,respectively.Additionally,compound 1 exhibits good selectivity and recyclability.It is also effectively used to detect NFT in the milk sample.Furthermore,the mechanism of luminescence quenching was revealed through the experimental results and the density functional theory calculations.The occurrence of photo-induced electron transfer(PET)affects the fluorescence quenching effect of NFT and NFZ.The design of indium-based MOFs has the potential to detect antibiotic residues in food.展开更多
Natural structural materials,such as spider silk,wood,and bone,are universally acknowledged as the gold standard for the ideal combinations of strength and toughness.The exceptional integrated performance of these bio...Natural structural materials,such as spider silk,wood,and bone,are universally acknowledged as the gold standard for the ideal combinations of strength and toughness.The exceptional integrated performance of these biological materials can be ascribed to their multiscale hierarchical architectures and components.Mimicking the hierarchical assembly feature of natural materials,artificial fibers,which are generated through the one-dimensional(1D)assembly of nanowires,have been widely reported with remarkable flexibility and functionality.Furthermore,the distinguishing feature of nanowires’1D assembly can bridge the unique properties of nanowires with their potential functional applications.This tutorial review summarizes the recent developments in the assembly of nanowires into macroscopic 1D fibers in the liquid state.We begin by introducing the general strategies and mechanisms for assembling nanowires in one direction and then,illustrate their potential applications in energy storage,sensors,biomedical engineering,etc.Finally,a brief summary and some personal perspectives on the future research directions of nanowires’1D assembly are also proposed.展开更多
基金China National Major Project for New Drug Innovation,Grant/Award Number:2017ZX09304015Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(CIFMS),Grant/Award Number:2016-I2M-1-001。
文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinical
基金supported by the National Science Foundation of China(21601115 and 22275118).
文摘A novel luminescent double-interpenetrated metal-organic framework(MOF),named{[In_(6)(O)_(3)(BTB)_(4)]·3H_(2)O}_(n)(1),is designed and synthesized using the tritopic linkers(1,3,5-tris(4-carboxyphenyl)benzene(H_(3)BTB))and tetranuclear clusters[In_(4)O_(2)(COO)_(8)].1 features 3,8-connected dual-wall"cage-in-cage"and exhibits excellent chemical stability owing to its high connectivity and double-interpenetrated architectures.Moreover,it could rapidly detect thiamphenicol(THI),nitrofurazone(NFZ),and nitrofurantoin(NFT)antibiotics in N,N-dime-thylformamide(DMF)with superior detection sensitivity(Ksv)and low detection limits(LOD)of 4.52×10^(3)M^(-1)and 348.6 ppm,1.43×10^(5)M^(-1)and 13.8 ppm,and 1.47×10^(5)M^(-1)and 12.1 ppm for THI,NFZ,and NFT,respectively.Additionally,compound 1 exhibits good selectivity and recyclability.It is also effectively used to detect NFT in the milk sample.Furthermore,the mechanism of luminescence quenching was revealed through the experimental results and the density functional theory calculations.The occurrence of photo-induced electron transfer(PET)affects the fluorescence quenching effect of NFT and NFZ.The design of indium-based MOFs has the potential to detect antibiotic residues in food.
基金supported by the National Natural Science Foundation of China(52202108,31771081)the Science and Technology Commission of Shanghai Municipality(22S31903300)+2 种基金S&T Innovation 2025 Major Special Program of Ningbo(2018B10040)the Fundamental Research Funds for the Central Universities(22120210582)China Postdoctoral Science Foundation(2021TQ0247,2022M712395).
文摘Natural structural materials,such as spider silk,wood,and bone,are universally acknowledged as the gold standard for the ideal combinations of strength and toughness.The exceptional integrated performance of these biological materials can be ascribed to their multiscale hierarchical architectures and components.Mimicking the hierarchical assembly feature of natural materials,artificial fibers,which are generated through the one-dimensional(1D)assembly of nanowires,have been widely reported with remarkable flexibility and functionality.Furthermore,the distinguishing feature of nanowires’1D assembly can bridge the unique properties of nanowires with their potential functional applications.This tutorial review summarizes the recent developments in the assembly of nanowires into macroscopic 1D fibers in the liquid state.We begin by introducing the general strategies and mechanisms for assembling nanowires in one direction and then,illustrate their potential applications in energy storage,sensors,biomedical engineering,etc.Finally,a brief summary and some personal perspectives on the future research directions of nanowires’1D assembly are also proposed.
