In the last few years,substantial experimental simulation and mumerical modelling hare been carried out in IMMPETUS to characterise the interfacial heat transfer and friction conditions during hot forging and rolling ...In the last few years,substantial experimental simulation and mumerical modelling hare been carried out in IMMPETUS to characterise the interfacial heat transfer and friction conditions during hot forging and rolling of steels. Emphasis has been placed on the influence of the oxide scale which forms on the steel workpiece. In the present paper, the experimental methods used for investigating interfacial heat transfer and friction conditions are described. Theses include hot flat rolling of steel slabs and hot axi- symmetric forging of steel cylinders and rings.Temperature measurements and computations demon- strate that for similar conditions, similar conditions, the effective interfacial heat transfer coefficients (IHTC) derived for hot rolling are significantly higher than those for forging, mainly due to the contribution of scale cracking during rolling. On the basis of experimental observations and numerical analysis,physical models for interfacial heat transfer in forging and rolling have been established. In addition, hot' sandwich' rolling and hot tensile tests with finite element modelling have been carried out to evaluate the hot ductility of the oxide scale.The results indicate that the defomation, cracking and decohesion behaviour of the oxide scale depend on deformation temperature, strain and relative strengths of the scale layer and scale - steel interface.Finaly, friction results from hot ring compression tests and from hot rolling with forward/backward slip measurements are reported.展开更多
To identify whether CpG island methylator phenotype (CIMP) is predictive of response to neoadjuvant chemoradiotherapy (NACRT) and outcomes in rectal cancer. METHODSPatients undergoing NACRT and surgical resection for ...To identify whether CpG island methylator phenotype (CIMP) is predictive of response to neoadjuvant chemoradiotherapy (NACRT) and outcomes in rectal cancer. METHODSPatients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status (high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined upon histological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed. RESULTSThere were 160 patients analysed with a median follow-up time of 46.4 mo. Twenty-one (13%) patients demonstrated high levels of CIMP methylation (CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion (EMVI) compared with CIMP-L [8/21 (38%) vs 15/99 (15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival (P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation (P = 0.01). There were 14 (9%) patients with a pathological complete response (pCR) compared to 116 (73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pCR had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant (P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced “T” stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence. CONCLUSIONWe report a novel association展开更多
文摘In the last few years,substantial experimental simulation and mumerical modelling hare been carried out in IMMPETUS to characterise the interfacial heat transfer and friction conditions during hot forging and rolling of steels. Emphasis has been placed on the influence of the oxide scale which forms on the steel workpiece. In the present paper, the experimental methods used for investigating interfacial heat transfer and friction conditions are described. Theses include hot flat rolling of steel slabs and hot axi- symmetric forging of steel cylinders and rings.Temperature measurements and computations demon- strate that for similar conditions, similar conditions, the effective interfacial heat transfer coefficients (IHTC) derived for hot rolling are significantly higher than those for forging, mainly due to the contribution of scale cracking during rolling. On the basis of experimental observations and numerical analysis,physical models for interfacial heat transfer in forging and rolling have been established. In addition, hot' sandwich' rolling and hot tensile tests with finite element modelling have been carried out to evaluate the hot ductility of the oxide scale.The results indicate that the defomation, cracking and decohesion behaviour of the oxide scale depend on deformation temperature, strain and relative strengths of the scale layer and scale - steel interface.Finaly, friction results from hot ring compression tests and from hot rolling with forward/backward slip measurements are reported.
文摘To identify whether CpG island methylator phenotype (CIMP) is predictive of response to neoadjuvant chemoradiotherapy (NACRT) and outcomes in rectal cancer. METHODSPatients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status (high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined upon histological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed. RESULTSThere were 160 patients analysed with a median follow-up time of 46.4 mo. Twenty-one (13%) patients demonstrated high levels of CIMP methylation (CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion (EMVI) compared with CIMP-L [8/21 (38%) vs 15/99 (15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival (P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation (P = 0.01). There were 14 (9%) patients with a pathological complete response (pCR) compared to 116 (73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pCR had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant (P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced “T” stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence. CONCLUSIONWe report a novel association
