Rat tail suspension offers a useful model to reproduce physiologic responses to weightlessness.The present study was conducted in the head-down-tilt(HDT) rat model to assess changes in metabolism of body tissues emp...Rat tail suspension offers a useful model to reproduce physiologic responses to weightlessness.The present study was conducted in the head-down-tilt(HDT) rat model to assess changes in metabolism of body tissues employing 3H-nicotine. Twelve male rats were used in the study. Half of the rats were tail suspended at 30°for two weeks on a 12/12 light/dark cycle. During this period,body weight, food and fluid intakes were measured. At term, animals were anesthetized and injected IV withe a solution contaming 4 microuries of micotine. After 90 min the animals were sacrificed, exsanguinated and tissues (brain,blood,trachea,salivary gland,lung,heart,esophagus,spleen, kidneys and testes) were harvested. The distribution of 3H-nicotine per gram of each tissue was determinded and ealeulated as percent of total injected radioactivity. Final body weights of suspended ammals were significantly (P < 0.0 5) lower than those of eontrols(309±21 vs 350±11g). 3HNicotine waw retained in greatest amounts by the kindneys, followed inorder by salivary glands, spleen, and gastrointestinal tissues. compared to non-suspended control, the tissue retention of nicotine in suspended animals was decreased in the following tissues:esphyagus (25 %), aorta (25%). fundus (25%), trachea (22%), adrenals (18%), spleen (17 %), and pancreas (12 %). The decreased retention of mcotine in tissues from suspended animals may be indicative of the fluid shifts and changes in blood flow to those tissue beds. The lack of differnces in nicotine retention in liver and kidney between control and suspended groups may implicate a normal metabolic function of these organs even under simulated weightlessness.展开更多
BACKGROUND: The prognosis of decompensated cirrhosis resulting from chronic hepatitis B is poor, and the benefits of treatment with interferon are ourweight serious sideeffects and the risk of fatal exacerbation of di...BACKGROUND: The prognosis of decompensated cirrhosis resulting from chronic hepatitis B is poor, and the benefits of treatment with interferon are ourweight serious sideeffects and the risk of fatal exacerbation of disease. Danshao Huaxian capsule rapidly reduces hepatitis B virus(HBV)-DNA in serum to undetectable levels. METHODS: A total of 35 patients with chronic hepatitis B and decompensated cirrhosis were treated with Danshao Huaxian 1.2g. po. tid daily. Before the treatment, HBVDNA in serum was positive in all patients. Ten patients had Child-Pugh class B and 25, class C hepatitis B. Seven patients underwent liver transplantation within 6 months of initial treatment. Of the 10 patients of class B, 5 died within 6 months, and the other 5 did not complete the treatment for some reasons; the 25 patients of class C were treated for at least 6 months (mean =19 months). RESULTS: In most of the 25 patients, liver function was improved slowly but markedly after 9 months of treatment, showing a decreased level of serum bilirubin from 67±13 to 30±4μmol/L (P<0.05, baseline vs.6 months), an increased level of serum albumin from 27±1 to 34±1 g/L(P<0.05) and a decreased level of Child-Pugh score from 10.3±0.4 to 7.5+0.5 (P<0.05). Three patients developed resistance to Danshao Huaxian because of a mutation in the YMDD motif, but liver function was not deteriorated. Inhibition of viral replication with Danshao Huaxian resulted in a significant improvement of liver function in patients with decompensated HBV cirrhosis, but the long-term results remain uncertain. CONCLUSION: Danshao Huaxian capsule is effective in inhibiting viral DNA replication in patients with decompensated cirrhosis and making clinical improvement.展开更多
Understanding P transformation in soils amended with poultry litter is important if water quality is to be protected.Our objectives were to determine the influence of method of litter application and temperature on P ...Understanding P transformation in soils amended with poultry litter is important if water quality is to be protected.Our objectives were to determine the influence of method of litter application and temperature on P availability. Poultry litter containing 20. 8g P/kg (dry weight) was either surface-applied or incorporated into Captina (fine-silty, siliceous, mesic Typic Fragiudult) and Nixa (loamy-skeletal,siliceous,Glossic Fragiudult) silt loams at rates of 0 or 10g/kg and incubated at 20℃ or 35℃ at a water potential of -40 kpa. Water soluble and available P (0.03 mol/L NH4F+0. 025mol/L HCl extraction) were determined during a 60d laboratory study. Results indicated that water soluble and available P levels in the soils initially decreased, then rapidly increased,and approached a steady state phase after approximately 20d. After 60d, water soluble P levels were significantly higher when litter was surface applied than when litter was incor porated. When the incubation was terminated, the net increase in available P in both soils was>100 mg P/kg.For efficient recycling of P and protection of water quality, application method and temperature should be considered when amending soils with poultry litter,展开更多
Java programming language is a major . new development which involves object-oriented programming and computer networking. Here, several examples of Java programs are presented. These examples show some major features...Java programming language is a major . new development which involves object-oriented programming and computer networking. Here, several examples of Java programs are presented. These examples show some major features that Java language provides, such as multi-thread, exception handling, network application writing, and the usage of Java applets. This article also shows some ways of setting up a Java language programming environment. All these examples are correct and ready to run.展开更多
We propose a multi-displacement continuum (MDC) model to characterize the local resonance presented in a lattice system. Dispersion curves in a mass-in-mass system are studied and compared to the single-displacement m...We propose a multi-displacement continuum (MDC) model to characterize the local resonance presented in a lattice system. Dispersion curves in a mass-in-mass system are studied and compared to the single-displacement model. It is shown that the dispersive relations and the local resonant band gap structures can be adequately described. The acoustic mode can be accurately predicted, while the optical mode is correctly predicted for certain frequency range, where the wave length is large enough. The single-displacement model fails to describe the bang gap structure inherent in the system due to local resonance.展开更多
Periodically ordered ZnO nanowire arrays were fabricated by a combination of soft templates created by electron beam lithography and an electrochemical process. Individual ZnO nanowires were precisely placed in desire...Periodically ordered ZnO nanowire arrays were fabricated by a combination of soft templates created by electron beam lithography and an electrochemical process. Individual ZnO nanowires were precisely placed in desired locations to form two-dimensional periodic structures with specific patterns. Scanning electron microscopy and light diffraction measurements confirmed the long-range ordered structures in the nanowire arrays. Variable temperature photoluminescence revealed both band edge and defect emissions. The obtained photonic structures may have potential applications in optical and optoelectronic devices.展开更多
In this paper, we will compute the transfer matrices to find the eigenfrequenciesfor the vibrations of the general non-collinear Euler-Bernoulli or Timoshenko beamstructure with dissipative joints. We will allow the s...In this paper, we will compute the transfer matrices to find the eigenfrequenciesfor the vibrations of the general non-collinear Euler-Bernoulli or Timoshenko beamstructure with dissipative joints. We will allow the structure to be three dimensional,and thus we must consider all types of vibrations simulaneously, including longitudinaland torsional vibrations. The general structure considered will consist of any number ofbeams joined end to end to form a chain. Many, different kinds of dampers areallowed, even within the same structure. We also will allow different materials withinthe structure as well as different beam widths. We then will show. that asymptotic estimates can be used to find the eigenfrequencies approximately.展开更多
Game theory is explored via a maze application where combinatorial optimization occurs with the objective of traversing through a defined maze with an aim to enhance decision support and locate the optimal travel sequ...Game theory is explored via a maze application where combinatorial optimization occurs with the objective of traversing through a defined maze with an aim to enhance decision support and locate the optimal travel sequence while minimizing computation time. This combinatorial optimization approach is initially demonstrated by utilizing a traditional genetic algorithm (GA), followed by the incorporation of artificial intelligence utilizing embedded rules based on domain-specific knowledge. The aim of this initiative is to compare the results of the traditional and rule-based optimization approaches with results acquired through an intelligent crossover methodology. The intelligent crossover approach encompasses a two-dimensional GA encoding where a second chromosome string is introduced within the GA, offering a sophisticated means for chromosome crossover amongst selected parents. Additionally, parent selection intelligence is incorporated where the best-traversed paths or population members are retained and utilized as potential parents to mate with parents selected within a traditional GA methodology. A further enhancement regarding the utilization of saved optimal population members as potential parents is mathematically explored within this literature.展开更多
An intelligent crossover methodology within the genetic algorithm (GA) is explored within both mathematical and finite element arenas improving both design and solution convergence time. This improved intelligent cros...An intelligent crossover methodology within the genetic algorithm (GA) is explored within both mathematical and finite element arenas improving both design and solution convergence time. This improved intelligent crossover outperforms the traditional genetic algorithm combined with a rule-based approach utilizing domain specific knowledge developed by Webb, et al. [1]. The encoding of the improved crossover consists of two chromosome strings within the genetic algorithm where the first string represents the design or solution string, and the second string represents chromosome crossover string intelligence. This improved crossover methodology saves the best population members or designs evaluated from each generation and applies crossover chromosome intelligence to the best saved population members paired with globally selected parents. Enhanced features of this crossover methodology employ the random selection of the best designs from the prior generation as a potential parent coupled with alternating intelligence pairing methods. In addition to this approach, two globally selected parents possess the ability to mate utilizing crossover chromosome string intelligence maintaining the integrity of a global GA search. Overall, the final population following crossover employs both global and best generation design chromosome strings to maximize creativity while enhancing the solution search. This is a modification to a conventional GA that can be translated into GA encoding. This technique is explored initially through a Base 10 mathematical application followed by the examination of plate structural optimization considering stress and displacement constraints. Results from crossover intelligence are compared with the conventional genetic algorithm and from Webb, et al. [1] which illustrates the outcome of a two phase genetic optimization algorithm.展开更多
Struvite (MgNH<sub>4</sub>PO<sub>4</sub>·6H<sub>2</sub>O) produced synthetically from a stock solution of known phosphorus (P) and nitrogen (N) concentrations has been shown to...Struvite (MgNH<sub>4</sub>PO<sub>4</sub>·6H<sub>2</sub>O) produced synthetically from a stock solution of known phosphorus (P) and nitrogen (N) concentrations has been shown to be an effective, alternative fertilizer-P source for various crops, but little is known about the potential agronomic effectiveness of struvite created from an actual municipal wastewater source. The objective of this study was to evaluate the effects of soil [i.e., Creldon silt loam (Oxyaquic Fragiudalf) and Calloway silt loam (Aquic Fraglossudalf) series], fertilizer-P source [i.e., synthetically produced electrochemically precipitated struvite (ECSTsyn), real-wastewater-derived ECST (ECSTreal), chemically precipitated struvite (CPST), monoammonium phosphate (MAP), and an unamended control (UC)], and irrigation water type (i.e., tapwater and struvite-removed wastewater) on corn (Zea mays L.) and soybean [Glycine max (L.) Merr.] growth and N, P, and magnesium (Mg) uptake in a 60-day, greenhouse potted-plant study. Crop growth and N, P, and Mg uptakes for the struvite treatments (i.e., CPST, ECSTsyn, and ECSTreal) were generally similar to or at least 1.2 times greater than MAP. The ECSTsyn material commonly had up to five times greater N, P, and Mg uptake in corn and soybean than any other fertilizer-P source. Struvite-removed wastewater resulted in at least 1.3 times lower dry matter and N, P, and Mg uptake than tapwater. Similar corn and soybean results from the struvite fertilizers among the various soil-water type combinations compared to MAP suggest that struvite generates similar crop responses as at least one widely used, commercially available, multi-nutrient fertilizer-P source.展开更多
文摘Rat tail suspension offers a useful model to reproduce physiologic responses to weightlessness.The present study was conducted in the head-down-tilt(HDT) rat model to assess changes in metabolism of body tissues employing 3H-nicotine. Twelve male rats were used in the study. Half of the rats were tail suspended at 30°for two weeks on a 12/12 light/dark cycle. During this period,body weight, food and fluid intakes were measured. At term, animals were anesthetized and injected IV withe a solution contaming 4 microuries of micotine. After 90 min the animals were sacrificed, exsanguinated and tissues (brain,blood,trachea,salivary gland,lung,heart,esophagus,spleen, kidneys and testes) were harvested. The distribution of 3H-nicotine per gram of each tissue was determinded and ealeulated as percent of total injected radioactivity. Final body weights of suspended ammals were significantly (P < 0.0 5) lower than those of eontrols(309±21 vs 350±11g). 3HNicotine waw retained in greatest amounts by the kindneys, followed inorder by salivary glands, spleen, and gastrointestinal tissues. compared to non-suspended control, the tissue retention of nicotine in suspended animals was decreased in the following tissues:esphyagus (25 %), aorta (25%). fundus (25%), trachea (22%), adrenals (18%), spleen (17 %), and pancreas (12 %). The decreased retention of mcotine in tissues from suspended animals may be indicative of the fluid shifts and changes in blood flow to those tissue beds. The lack of differnces in nicotine retention in liver and kidney between control and suspended groups may implicate a normal metabolic function of these organs even under simulated weightlessness.
基金This study is supported by a grant from the Primary Sciences and Technology Project of Guizhou Province, China (No. 961023).
文摘BACKGROUND: The prognosis of decompensated cirrhosis resulting from chronic hepatitis B is poor, and the benefits of treatment with interferon are ourweight serious sideeffects and the risk of fatal exacerbation of disease. Danshao Huaxian capsule rapidly reduces hepatitis B virus(HBV)-DNA in serum to undetectable levels. METHODS: A total of 35 patients with chronic hepatitis B and decompensated cirrhosis were treated with Danshao Huaxian 1.2g. po. tid daily. Before the treatment, HBVDNA in serum was positive in all patients. Ten patients had Child-Pugh class B and 25, class C hepatitis B. Seven patients underwent liver transplantation within 6 months of initial treatment. Of the 10 patients of class B, 5 died within 6 months, and the other 5 did not complete the treatment for some reasons; the 25 patients of class C were treated for at least 6 months (mean =19 months). RESULTS: In most of the 25 patients, liver function was improved slowly but markedly after 9 months of treatment, showing a decreased level of serum bilirubin from 67±13 to 30±4μmol/L (P<0.05, baseline vs.6 months), an increased level of serum albumin from 27±1 to 34±1 g/L(P<0.05) and a decreased level of Child-Pugh score from 10.3±0.4 to 7.5+0.5 (P<0.05). Three patients developed resistance to Danshao Huaxian because of a mutation in the YMDD motif, but liver function was not deteriorated. Inhibition of viral replication with Danshao Huaxian resulted in a significant improvement of liver function in patients with decompensated HBV cirrhosis, but the long-term results remain uncertain. CONCLUSION: Danshao Huaxian capsule is effective in inhibiting viral DNA replication in patients with decompensated cirrhosis and making clinical improvement.
文摘Understanding P transformation in soils amended with poultry litter is important if water quality is to be protected.Our objectives were to determine the influence of method of litter application and temperature on P availability. Poultry litter containing 20. 8g P/kg (dry weight) was either surface-applied or incorporated into Captina (fine-silty, siliceous, mesic Typic Fragiudult) and Nixa (loamy-skeletal,siliceous,Glossic Fragiudult) silt loams at rates of 0 or 10g/kg and incubated at 20℃ or 35℃ at a water potential of -40 kpa. Water soluble and available P (0.03 mol/L NH4F+0. 025mol/L HCl extraction) were determined during a 60d laboratory study. Results indicated that water soluble and available P levels in the soils initially decreased, then rapidly increased,and approached a steady state phase after approximately 20d. After 60d, water soluble P levels were significantly higher when litter was surface applied than when litter was incor porated. When the incubation was terminated, the net increase in available P in both soils was>100 mg P/kg.For efficient recycling of P and protection of water quality, application method and temperature should be considered when amending soils with poultry litter,
文摘Java programming language is a major . new development which involves object-oriented programming and computer networking. Here, several examples of Java programs are presented. These examples show some major features that Java language provides, such as multi-thread, exception handling, network application writing, and the usage of Java applets. This article also shows some ways of setting up a Java language programming environment. All these examples are correct and ready to run.
基金supported by the National Natural Science Foundation of China (Nos. 11072031, 10832002)
文摘We propose a multi-displacement continuum (MDC) model to characterize the local resonance presented in a lattice system. Dispersion curves in a mass-in-mass system are studied and compared to the single-displacement model. It is shown that the dispersive relations and the local resonant band gap structures can be adequately described. The acoustic mode can be accurately predicted, while the optical mode is correctly predicted for certain frequency range, where the wave length is large enough. The single-displacement model fails to describe the bang gap structure inherent in the system due to local resonance.
文摘Periodically ordered ZnO nanowire arrays were fabricated by a combination of soft templates created by electron beam lithography and an electrochemical process. Individual ZnO nanowires were precisely placed in desired locations to form two-dimensional periodic structures with specific patterns. Scanning electron microscopy and light diffraction measurements confirmed the long-range ordered structures in the nanowire arrays. Variable temperature photoluminescence revealed both band edge and defect emissions. The obtained photonic structures may have potential applications in optical and optoelectronic devices.
文摘In this paper, we will compute the transfer matrices to find the eigenfrequenciesfor the vibrations of the general non-collinear Euler-Bernoulli or Timoshenko beamstructure with dissipative joints. We will allow the structure to be three dimensional,and thus we must consider all types of vibrations simulaneously, including longitudinaland torsional vibrations. The general structure considered will consist of any number ofbeams joined end to end to form a chain. Many, different kinds of dampers areallowed, even within the same structure. We also will allow different materials withinthe structure as well as different beam widths. We then will show. that asymptotic estimates can be used to find the eigenfrequencies approximately.
文摘Game theory is explored via a maze application where combinatorial optimization occurs with the objective of traversing through a defined maze with an aim to enhance decision support and locate the optimal travel sequence while minimizing computation time. This combinatorial optimization approach is initially demonstrated by utilizing a traditional genetic algorithm (GA), followed by the incorporation of artificial intelligence utilizing embedded rules based on domain-specific knowledge. The aim of this initiative is to compare the results of the traditional and rule-based optimization approaches with results acquired through an intelligent crossover methodology. The intelligent crossover approach encompasses a two-dimensional GA encoding where a second chromosome string is introduced within the GA, offering a sophisticated means for chromosome crossover amongst selected parents. Additionally, parent selection intelligence is incorporated where the best-traversed paths or population members are retained and utilized as potential parents to mate with parents selected within a traditional GA methodology. A further enhancement regarding the utilization of saved optimal population members as potential parents is mathematically explored within this literature.
文摘An intelligent crossover methodology within the genetic algorithm (GA) is explored within both mathematical and finite element arenas improving both design and solution convergence time. This improved intelligent crossover outperforms the traditional genetic algorithm combined with a rule-based approach utilizing domain specific knowledge developed by Webb, et al. [1]. The encoding of the improved crossover consists of two chromosome strings within the genetic algorithm where the first string represents the design or solution string, and the second string represents chromosome crossover string intelligence. This improved crossover methodology saves the best population members or designs evaluated from each generation and applies crossover chromosome intelligence to the best saved population members paired with globally selected parents. Enhanced features of this crossover methodology employ the random selection of the best designs from the prior generation as a potential parent coupled with alternating intelligence pairing methods. In addition to this approach, two globally selected parents possess the ability to mate utilizing crossover chromosome string intelligence maintaining the integrity of a global GA search. Overall, the final population following crossover employs both global and best generation design chromosome strings to maximize creativity while enhancing the solution search. This is a modification to a conventional GA that can be translated into GA encoding. This technique is explored initially through a Base 10 mathematical application followed by the examination of plate structural optimization considering stress and displacement constraints. Results from crossover intelligence are compared with the conventional genetic algorithm and from Webb, et al. [1] which illustrates the outcome of a two phase genetic optimization algorithm.
文摘Struvite (MgNH<sub>4</sub>PO<sub>4</sub>·6H<sub>2</sub>O) produced synthetically from a stock solution of known phosphorus (P) and nitrogen (N) concentrations has been shown to be an effective, alternative fertilizer-P source for various crops, but little is known about the potential agronomic effectiveness of struvite created from an actual municipal wastewater source. The objective of this study was to evaluate the effects of soil [i.e., Creldon silt loam (Oxyaquic Fragiudalf) and Calloway silt loam (Aquic Fraglossudalf) series], fertilizer-P source [i.e., synthetically produced electrochemically precipitated struvite (ECSTsyn), real-wastewater-derived ECST (ECSTreal), chemically precipitated struvite (CPST), monoammonium phosphate (MAP), and an unamended control (UC)], and irrigation water type (i.e., tapwater and struvite-removed wastewater) on corn (Zea mays L.) and soybean [Glycine max (L.) Merr.] growth and N, P, and magnesium (Mg) uptake in a 60-day, greenhouse potted-plant study. Crop growth and N, P, and Mg uptakes for the struvite treatments (i.e., CPST, ECSTsyn, and ECSTreal) were generally similar to or at least 1.2 times greater than MAP. The ECSTsyn material commonly had up to five times greater N, P, and Mg uptake in corn and soybean than any other fertilizer-P source. Struvite-removed wastewater resulted in at least 1.3 times lower dry matter and N, P, and Mg uptake than tapwater. Similar corn and soybean results from the struvite fertilizers among the various soil-water type combinations compared to MAP suggest that struvite generates similar crop responses as at least one widely used, commercially available, multi-nutrient fertilizer-P source.
