The efficacy of insecticide-treated nets (ITNs) is increasingly compromised by the prevalence of malaria vectors resistant to pyrethroids. In response to this issue, a new generation of ITNs has been developed that in...The efficacy of insecticide-treated nets (ITNs) is increasingly compromised by the prevalence of malaria vectors resistant to pyrethroids. In response to this issue, a new generation of ITNs has been developed that incorporate synergistic components, such as piperonyl butoxide (PBO). The purpose of this study is to provide entomological evidence for the efficacy of a PBO-based ITN brand at the village level, serving as a basis for decision-making before large-scale net deployment. During the high malaria transmission period, ITNs were distributed in each group and vector sampling was conducted biweekly in selected households. Bionomic data were collected to assess the resistance of wild An. gambiae populations to various chemical insecticides. There was a significant disparity in total An. gambiae sl. collected between the ITN arms, the intervention arm (ITN arms), and the control arm (P = 0.003). An. coluzzi was identified as the predominant species in the study area, as confirmed by PCR analysis. Analysis of the blood-feeding inhibition rate revealed that 100% permethrin + PBO ITN exhibited significantly greater inhibition than 66.81% permethrin only ITN. According to the log-time probit regression analysis, permethrin exhibited a knockdown time of 256 min without synergists, while it decreased to 139 min (P = 0.001) when pre-exposed to PBO. The evidence from this trial supports the use of PBO ITNs over standard ITNs for pyrethroids to combat pyrethroid resistance and improve protection against malaria for both individuals and communities, particularly in areas with high pyrethroid resistance.展开更多
<b><span>Context:</span></b><span> The vector control is essential in malaria prevention strategies in several endemic countries in Africa including Burkina Faso. The high transmission of...<b><span>Context:</span></b><span> The vector control is essential in malaria prevention strategies in several endemic countries in Africa including Burkina Faso. The high transmission of malaria occurs during the period of high vector abundance (August to October) in Burkina Faso. Therefore, a vector control strategy based on the use of indoor residual spraying targeting this period should provide effective protection against malaria. This study aimed to evaluate the effect of bendiocarb applied in indoor residual spraying on entomological parameters of malaria transmission in a pyrethroid resistance area in southwestern, Burkina Faso.</span><span> </span><b><span>Methods:</span></b><span> CDC light trap and early morning collections by pyrethrum spray catches were performed monthly to determine the change in entomological parameter within malaria vector in sprayed (Diebougou) and unsprayed sites (Dano). The female’s malaria vectors collected by both methods were used to determine their blood feeding pattern, biting and sporozoites rates as well as the malaria transmission risk estimated by entomological inoculation rate. </span><b><span>Results:</span></b><span> A total of 26,276 mosquitoes (13,555 anopheline and 12</span><span>,</span><span>721 other culicines) were collected using both CDC light trap (9158 mosquitoes) and PSC collection methods (17,118 mosquitoes) from June to December 2012. </span><i><span>An. gambiae</span></i><span> complex was the predominant species collected. </span><i><span>An. gambiae</span></i><span> was the predominant species collected (P = 0.0005), comprising 88% of the total collected and the most infected species. Malaria vectors densities were significantly lower in sprayed villages (n = 4303) compared with unsprayed villages (n = 12,569) during post-spraying period (P = 0.0012). In addition, mean human biting rate of </span><i><span>An. gambiae</span></i><span> s.l. and </span><i><span>An. funestus </span></i><span>s.l. were significantly lower in sprayed areas com展开更多
<b><span style="font-family:Verdana;">Introduction:</span></b><span style="font-family:Verdana;"> Lymphatic filariasis (LF) and malaria are two vector-borne</span&g...<b><span style="font-family:Verdana;">Introduction:</span></b><span style="font-family:Verdana;"> Lymphatic filariasis (LF) and malaria are two vector-borne</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> diseases which parasites can simultaneously infect human or mosquito. In Burkina Faso, studies mainly focused on the control of these diseases independently. Hence, there is a lack of information on their co-transmission of to both human and vector. The present study aimed at providing baseline data </span><span style="font-family:Verdana;">from endemic areas in Burkina Faso towards a successful integrated man</span><span><span style="font-family:Verdana;">agement of both diseases. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> The study was carried out in six sites</span></span><span style="font-family:Verdana;"> dist</span><span style="font-family:Verdana;">ributed in the East, Center-East and South-West regions of Burkina Faso. </span><span style="font-family:Verdana;">Data were collected in August 2014 and September 2015. The infection rates in human and vector populations, vector diversity, trophic and resting behavior were investigated. To determine the disease prevalence nocturnal finger-</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">p</span><span style="font-family:Verdana;">rick blood sample and microscopic observations were performed. Vect</span><span style="font-family:Verdana;">ors </span><span style="font-family:Verdana;">collected by human landing catches and pyrethrum spray collections. Bio</span><span style="font-family:Verdana;">chemical and molecular analyses were performed to identify <i></i></span><i><i><span style="font-family:Verdana;">Anopheles gam</span><span><span style="font-family:Verdana;">biae </span><span style="font-family:Verdana;">sensu lato</span></span></i></i></span><b><span> </span></b><span style="font-family:Verdana;">si展开更多
文摘The efficacy of insecticide-treated nets (ITNs) is increasingly compromised by the prevalence of malaria vectors resistant to pyrethroids. In response to this issue, a new generation of ITNs has been developed that incorporate synergistic components, such as piperonyl butoxide (PBO). The purpose of this study is to provide entomological evidence for the efficacy of a PBO-based ITN brand at the village level, serving as a basis for decision-making before large-scale net deployment. During the high malaria transmission period, ITNs were distributed in each group and vector sampling was conducted biweekly in selected households. Bionomic data were collected to assess the resistance of wild An. gambiae populations to various chemical insecticides. There was a significant disparity in total An. gambiae sl. collected between the ITN arms, the intervention arm (ITN arms), and the control arm (P = 0.003). An. coluzzi was identified as the predominant species in the study area, as confirmed by PCR analysis. Analysis of the blood-feeding inhibition rate revealed that 100% permethrin + PBO ITN exhibited significantly greater inhibition than 66.81% permethrin only ITN. According to the log-time probit regression analysis, permethrin exhibited a knockdown time of 256 min without synergists, while it decreased to 139 min (P = 0.001) when pre-exposed to PBO. The evidence from this trial supports the use of PBO ITNs over standard ITNs for pyrethroids to combat pyrethroid resistance and improve protection against malaria for both individuals and communities, particularly in areas with high pyrethroid resistance.
文摘<b><span>Context:</span></b><span> The vector control is essential in malaria prevention strategies in several endemic countries in Africa including Burkina Faso. The high transmission of malaria occurs during the period of high vector abundance (August to October) in Burkina Faso. Therefore, a vector control strategy based on the use of indoor residual spraying targeting this period should provide effective protection against malaria. This study aimed to evaluate the effect of bendiocarb applied in indoor residual spraying on entomological parameters of malaria transmission in a pyrethroid resistance area in southwestern, Burkina Faso.</span><span> </span><b><span>Methods:</span></b><span> CDC light trap and early morning collections by pyrethrum spray catches were performed monthly to determine the change in entomological parameter within malaria vector in sprayed (Diebougou) and unsprayed sites (Dano). The female’s malaria vectors collected by both methods were used to determine their blood feeding pattern, biting and sporozoites rates as well as the malaria transmission risk estimated by entomological inoculation rate. </span><b><span>Results:</span></b><span> A total of 26,276 mosquitoes (13,555 anopheline and 12</span><span>,</span><span>721 other culicines) were collected using both CDC light trap (9158 mosquitoes) and PSC collection methods (17,118 mosquitoes) from June to December 2012. </span><i><span>An. gambiae</span></i><span> complex was the predominant species collected. </span><i><span>An. gambiae</span></i><span> was the predominant species collected (P = 0.0005), comprising 88% of the total collected and the most infected species. Malaria vectors densities were significantly lower in sprayed villages (n = 4303) compared with unsprayed villages (n = 12,569) during post-spraying period (P = 0.0012). In addition, mean human biting rate of </span><i><span>An. gambiae</span></i><span> s.l. and </span><i><span>An. funestus </span></i><span>s.l. were significantly lower in sprayed areas com
文摘<b><span style="font-family:Verdana;">Introduction:</span></b><span style="font-family:Verdana;"> Lymphatic filariasis (LF) and malaria are two vector-borne</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> diseases which parasites can simultaneously infect human or mosquito. In Burkina Faso, studies mainly focused on the control of these diseases independently. Hence, there is a lack of information on their co-transmission of to both human and vector. The present study aimed at providing baseline data </span><span style="font-family:Verdana;">from endemic areas in Burkina Faso towards a successful integrated man</span><span><span style="font-family:Verdana;">agement of both diseases. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> The study was carried out in six sites</span></span><span style="font-family:Verdana;"> dist</span><span style="font-family:Verdana;">ributed in the East, Center-East and South-West regions of Burkina Faso. </span><span style="font-family:Verdana;">Data were collected in August 2014 and September 2015. The infection rates in human and vector populations, vector diversity, trophic and resting behavior were investigated. To determine the disease prevalence nocturnal finger-</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">p</span><span style="font-family:Verdana;">rick blood sample and microscopic observations were performed. Vect</span><span style="font-family:Verdana;">ors </span><span style="font-family:Verdana;">collected by human landing catches and pyrethrum spray collections. Bio</span><span style="font-family:Verdana;">chemical and molecular analyses were performed to identify <i></i></span><i><i><span style="font-family:Verdana;">Anopheles gam</span><span><span style="font-family:Verdana;">biae </span><span style="font-family:Verdana;">sensu lato</span></span></i></i></span><b><span> </span></b><span style="font-family:Verdana;">si
