Background: Radiation therapy after breast conserving surgery is a standard part of treatment for invasive breast cancer. Based on radiobiological models, it was found that shorter radiation schedules offered the prom...Background: Radiation therapy after breast conserving surgery is a standard part of treatment for invasive breast cancer. Based on radiobiological models, it was found that shorter radiation schedules offered the promise of equivalent local control to standard radiation therapy by giving larger doses per fraction in shorter period of time. Methods: This study included 36 female patients with operable invasive stage I-II breast cancer. These patients underwent microscopic wide local excision of the primary tumor and lymph node dissection. They received adjuvant radiotherapy. The radiation dose was 40 Gy total dose in 15 fractions for whole breast and additional dose of 9 Gy in three consecutive fractions was delivered to tumour cavity simultaneously. Results: Mean age was 52 years (range: 30 - 67);most patients were of stage II disease and Grade II was the most common one. Invasive ductal carcinoma was reported in 94.4% and 72.2% of patients were hormone receptor positive. After median follow-up of 52 months, all patients were alive and ipsilateral local recurrence was reported in 1 case only. Grade IV radiation toxicity was not observed;moist desquamation was the most common acute reaction (61%) with grade III in 5.5% followed by dry desquamation in 55.6% of grade I only. Grade I erythema was recorded in 41.7% and grade II in 11%. Fibrosis was the most frequent late reaction (44.3%) with grade II in 11% followed by telengectesia then pigmentation (41.7%, 33.3% respectively). Conclusion: The regimen used in this study appears promising with acceptable acute toxicities and convenient for our patients and has the advantage of economic use of radiation facilities. However, larger number of patients and longer period of follow-up are needed for further evaluation.展开更多
<strong>Objective</strong><strong>:</strong><span style="font-family:""><span style="font-family:Verdana;"> To compare between the efficacy of the use of or...<strong>Objective</strong><strong>:</strong><span style="font-family:""><span style="font-family:Verdana;"> To compare between the efficacy of the use of oral sildenafil plus low dose aspirin versus the use of oral low dose aspirin alone in pregnancy as preventive measure in women at risk for preeclampsia (PE). </span><b><span style="font-family:Verdana;">Design: </span></b><span style="font-family:Verdana;">A randomized clinical trial. </span><b><span style="font-family:Verdana;">Setting: </span></b><span style="font-family:Verdana;">Outpatient Obstetric clinic of Ain Shams University Maternity Hospital. </span><b><span style="font-family:Verdana;">Population or sample: </span></b><span style="font-family:Verdana;">Women at gestational age of </span></span><span style="font-family:""><span style="font-family:Verdana;">≤</span><span><span style="font-family:Verdana;">16 weeks who at risk for PE between June 2018 and June 2019. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> Participants were randomly allocated into two groups: Group I Included 200 women who received a 25 mg tablet of oral sildenafil citrate tid until delivery plus 100 mg tablet of aspirin orally once daily until gestational age of 36 weeks, Group II Included 200 women who received a 100 mg tablet of aspirin orally once daily until gestational age of 36 weeks. </span><b><span style="font-family:Verdana;">Main Outcome Measures: </span></b><span style="font-family:Verdana;">Incidence of preeclampsia diagnosed per ACOG criteria. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The incidence of PE in both groups showed no statistically significant difference. The incidence of PE in the first group is 11.0%, and it is 12.0% in the second group (p-value 0.754). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The addition of sildenafil citrate to low dose aspirin had no impact on the prevention of展开更多
文摘Background: Radiation therapy after breast conserving surgery is a standard part of treatment for invasive breast cancer. Based on radiobiological models, it was found that shorter radiation schedules offered the promise of equivalent local control to standard radiation therapy by giving larger doses per fraction in shorter period of time. Methods: This study included 36 female patients with operable invasive stage I-II breast cancer. These patients underwent microscopic wide local excision of the primary tumor and lymph node dissection. They received adjuvant radiotherapy. The radiation dose was 40 Gy total dose in 15 fractions for whole breast and additional dose of 9 Gy in three consecutive fractions was delivered to tumour cavity simultaneously. Results: Mean age was 52 years (range: 30 - 67);most patients were of stage II disease and Grade II was the most common one. Invasive ductal carcinoma was reported in 94.4% and 72.2% of patients were hormone receptor positive. After median follow-up of 52 months, all patients were alive and ipsilateral local recurrence was reported in 1 case only. Grade IV radiation toxicity was not observed;moist desquamation was the most common acute reaction (61%) with grade III in 5.5% followed by dry desquamation in 55.6% of grade I only. Grade I erythema was recorded in 41.7% and grade II in 11%. Fibrosis was the most frequent late reaction (44.3%) with grade II in 11% followed by telengectesia then pigmentation (41.7%, 33.3% respectively). Conclusion: The regimen used in this study appears promising with acceptable acute toxicities and convenient for our patients and has the advantage of economic use of radiation facilities. However, larger number of patients and longer period of follow-up are needed for further evaluation.
文摘<strong>Objective</strong><strong>:</strong><span style="font-family:""><span style="font-family:Verdana;"> To compare between the efficacy of the use of oral sildenafil plus low dose aspirin versus the use of oral low dose aspirin alone in pregnancy as preventive measure in women at risk for preeclampsia (PE). </span><b><span style="font-family:Verdana;">Design: </span></b><span style="font-family:Verdana;">A randomized clinical trial. </span><b><span style="font-family:Verdana;">Setting: </span></b><span style="font-family:Verdana;">Outpatient Obstetric clinic of Ain Shams University Maternity Hospital. </span><b><span style="font-family:Verdana;">Population or sample: </span></b><span style="font-family:Verdana;">Women at gestational age of </span></span><span style="font-family:""><span style="font-family:Verdana;">≤</span><span><span style="font-family:Verdana;">16 weeks who at risk for PE between June 2018 and June 2019. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> Participants were randomly allocated into two groups: Group I Included 200 women who received a 25 mg tablet of oral sildenafil citrate tid until delivery plus 100 mg tablet of aspirin orally once daily until gestational age of 36 weeks, Group II Included 200 women who received a 100 mg tablet of aspirin orally once daily until gestational age of 36 weeks. </span><b><span style="font-family:Verdana;">Main Outcome Measures: </span></b><span style="font-family:Verdana;">Incidence of preeclampsia diagnosed per ACOG criteria. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The incidence of PE in both groups showed no statistically significant difference. The incidence of PE in the first group is 11.0%, and it is 12.0% in the second group (p-value 0.754). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The addition of sildenafil citrate to low dose aspirin had no impact on the prevention of
