Terrestrial mollusk fossil assemblages of the Luochuan loess section have been investigated so as to improve the reconstruction of environmental changes in the last 110ka. A total of 118 samples, taken at an interval ...Terrestrial mollusk fossil assemblages of the Luochuan loess section have been investigated so as to improve the reconstruction of environmental changes in the last 110ka. A total of 118 samples, taken at an interval of 10cm in the S0-S1 portion, have been analyzed. Results show that mollusk fossil assemblages have recorded detailed paleoclimatic and paleoecological changes. The Luochuan area bas experienced cold-dry and warm-humid alternations in the last 110 ka. However, even under the prevailing cold-dry condition, short-term or seasonal warm-humid climates frequently occurred in this area, reflecting the impact of summer monsoons temporarily. Comparison of mollusk records from the Luochuan loess sequence with those of grain-size and aridity index from RC 27-61 core in the Indian Ocean reveals obvious similarities in several time intervals, suggesting that climate variations in the Loess Plateau may have been also subjected to the influences of the Indian monsoon to a certain extent in the geological past. The presence of some specific cold-humid and cold-dry species represents deteriorated climate conditions, which might be the cooling events similar to the Heinrich events recorded in the Northern Atlantic. Six principal factors obtained by correspondence analysis and their related environmental significance have been discussed.展开更多
This note presents a new result of terrestrial mollusk study from the Luochuan loesssection since the last 250 ka. A total of 213 samples, taken at intervals of 10 cm in the S0-L3 portion, were analyzed for fossil mol...This note presents a new result of terrestrial mollusk study from the Luochuan loesssection since the last 250 ka. A total of 213 samples, taken at intervals of 10 cm in the S0-L3 portion, were analyzed for fossil mollusks. Generally, 150-600 individuals were counted in each sample. According to the distribution of mollusk fossil assemblages in the loess section, 11 mollusk fossil zones have been recognized, representing different climatic and ecological conditions. Three main ecological groups were identified according to the temperature and moisture requirements of each taxon. The cold-aridiphilous group shows maxima at about 240-220, 190-182, 150-140 and 74 -66 ka BP. The thermo-humidiphilous set has high abundances for at least 6 times in the section at about 246-240, 220-216, 170-158, 92-86, 60-44 and 10 kaBP. Our results show that variations in mollusk ecological groups are related with changes in the Earth orbital parameters at the 41 and 20 ka frequencies. Maxima in thermo-humidiphilous taxa展开更多
The first near continuous mollusk fossil record from the Qinan Miocene loess-soil se-quence is presented. Results show that mollusk species are abundant in the QA-I section between 22 and 6.2 Ma, and both loess layers...The first near continuous mollusk fossil record from the Qinan Miocene loess-soil se-quence is presented. Results show that mollusk species are abundant in the QA-I section between 22 and 6.2 Ma, and both loess layers and soil layers yield mollusk fossil individuals. All mollusk species are terrestrial and well preserved in the section. Most species are identical to those identified in the Quaternary loess-soil sequence of the Loess Plateau. The thermo-humidiphilous group generally is distributed in soil layers, whereas cold-aridiphilous group can be observed in loess layers. From the Miocene to Quaternary, the occurrence and divergence of new species of Metodontia and Cathaica correspond to the crucial periods of regional and global environmental changes, indicating that mol-lusk species are sensitive to environmental variations. Preliminary study on the QA-I mollusk record indicates that the Qinan Miocene loess-soil sequence may have a similar sedimentary environment to the Quaternary loess-soil sequence of the Loess Plateau.展开更多
We report an unusual case of spontaneous ovarian hyperstimulation syndrome and pituitary hyperplasia mimicking macroadenoma in an adult,non-pregnant woman.Her condition was triggered by unrecognized primary hypothyroi...We report an unusual case of spontaneous ovarian hyperstimulation syndrome and pituitary hyperplasia mimicking macroadenoma in an adult,non-pregnant woman.Her condition was triggered by unrecognized primary hypothyroidism,which regressed after thyroid hormone replacement therapy.This case highlights the need for clinicians and radiologists to familiarize themselves with the clinical and imaging features detected in case of these complications of primary hypothyroidism,which are not well known in the medical and radiological profession.Such improved knowledge will help avoid delays in diagnosis,progression to lifethreatening complications,and unnecessary surgery.展开更多
While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its ...While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely unknown.Hence,we sought to determine the effects of NOD1 on metastasis.NOD1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOD1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOD1.C12-iE-DAP,a highly selective NOD1 ligand derived from gram-negative bacteria,was used to activate NOD1.ML130,a specific NOD1 inhibitor,was used to block C12-iE-DAP stimulation.Stable knockdown(KD)of NOD1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus repeated.Lastly,the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase inhibitors.Our data demonstrate that NOD1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell lines.Clinically,we demonstrate that this increased NOD1 expression negatively impacts survival in patients with CRC.Subsequently,we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion,migration and metastasis.These effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)pathway.This is the first study implicating NOD1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target.展开更多
In some networks nodes belong to predefined groups （e.g., authors belong to institutions）. Common network cen- trality measures do not take this structure into account. Gefura measures are designed as indicators of ...In some networks nodes belong to predefined groups （e.g., authors belong to institutions）. Common network cen- trality measures do not take this structure into account. Gefura measures are designed as indicators of a node＇s brokerage role between such groups. They are defined as variants of betweeuness centrality and consider to what extent a node belongs to shortest paths between nodes from different groups. In this article we make the following new contributions to their study： （1） We systematically study unnormalized gefura measures and show that, next to the ＇structural＇ normalization that has hitherto been applied, a ＇basic＇ normalization procedure is possible. While the former normalizes at the level of groups, the latter normalizes at the level of nodes. （2） Treating undirected networks as equivalent to symmetric directed networks, we expand the definition of gefura measures to the directed case. （3） It is shown how Brandes＇ algorithm for betweenness centrality can be adjusted to cover these cases.展开更多
基金Projects supported by the CAS-CNRS exchange program and the National Natural Science Foundation of China.
文摘Terrestrial mollusk fossil assemblages of the Luochuan loess section have been investigated so as to improve the reconstruction of environmental changes in the last 110ka. A total of 118 samples, taken at an interval of 10cm in the S0-S1 portion, have been analyzed. Results show that mollusk fossil assemblages have recorded detailed paleoclimatic and paleoecological changes. The Luochuan area bas experienced cold-dry and warm-humid alternations in the last 110 ka. However, even under the prevailing cold-dry condition, short-term or seasonal warm-humid climates frequently occurred in this area, reflecting the impact of summer monsoons temporarily. Comparison of mollusk records from the Luochuan loess sequence with those of grain-size and aridity index from RC 27-61 core in the Indian Ocean reveals obvious similarities in several time intervals, suggesting that climate variations in the Loess Plateau may have been also subjected to the influences of the Indian monsoon to a certain extent in the geological past. The presence of some specific cold-humid and cold-dry species represents deteriorated climate conditions, which might be the cooling events similar to the Heinrich events recorded in the Northern Atlantic. Six principal factors obtained by correspondence analysis and their related environmental significance have been discussed.
文摘This note presents a new result of terrestrial mollusk study from the Luochuan loesssection since the last 250 ka. A total of 213 samples, taken at intervals of 10 cm in the S0-L3 portion, were analyzed for fossil mollusks. Generally, 150-600 individuals were counted in each sample. According to the distribution of mollusk fossil assemblages in the loess section, 11 mollusk fossil zones have been recognized, representing different climatic and ecological conditions. Three main ecological groups were identified according to the temperature and moisture requirements of each taxon. The cold-aridiphilous group shows maxima at about 240-220, 190-182, 150-140 and 74 -66 ka BP. The thermo-humidiphilous set has high abundances for at least 6 times in the section at about 246-240, 220-216, 170-158, 92-86, 60-44 and 10 kaBP. Our results show that variations in mollusk ecological groups are related with changes in the Earth orbital parameters at the 41 and 20 ka frequencies. Maxima in thermo-humidiphilous taxa
基金This work was supported by the National Basic Research Program of China(Grant No.2004CB720203)the National Natural Science Foundation of China(Grant Nos.40231001 and 40372083)the Chinese Academy of Sciences(Grant No.KZCX3-SW-139).
文摘The first near continuous mollusk fossil record from the Qinan Miocene loess-soil se-quence is presented. Results show that mollusk species are abundant in the QA-I section between 22 and 6.2 Ma, and both loess layers and soil layers yield mollusk fossil individuals. All mollusk species are terrestrial and well preserved in the section. Most species are identical to those identified in the Quaternary loess-soil sequence of the Loess Plateau. The thermo-humidiphilous group generally is distributed in soil layers, whereas cold-aridiphilous group can be observed in loess layers. From the Miocene to Quaternary, the occurrence and divergence of new species of Metodontia and Cathaica correspond to the crucial periods of regional and global environmental changes, indicating that mol-lusk species are sensitive to environmental variations. Preliminary study on the QA-I mollusk record indicates that the Qinan Miocene loess-soil sequence may have a similar sedimentary environment to the Quaternary loess-soil sequence of the Loess Plateau.
文摘We report an unusual case of spontaneous ovarian hyperstimulation syndrome and pituitary hyperplasia mimicking macroadenoma in an adult,non-pregnant woman.Her condition was triggered by unrecognized primary hypothyroidism,which regressed after thyroid hormone replacement therapy.This case highlights the need for clinicians and radiologists to familiarize themselves with the clinical and imaging features detected in case of these complications of primary hypothyroidism,which are not well known in the medical and radiological profession.Such improved knowledge will help avoid delays in diagnosis,progression to lifethreatening complications,and unnecessary surgery.
文摘While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely unknown.Hence,we sought to determine the effects of NOD1 on metastasis.NOD1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOD1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOD1.C12-iE-DAP,a highly selective NOD1 ligand derived from gram-negative bacteria,was used to activate NOD1.ML130,a specific NOD1 inhibitor,was used to block C12-iE-DAP stimulation.Stable knockdown(KD)of NOD1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus repeated.Lastly,the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase inhibitors.Our data demonstrate that NOD1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell lines.Clinically,we demonstrate that this increased NOD1 expression negatively impacts survival in patients with CRC.Subsequently,we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion,migration and metastasis.These effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)pathway.This is the first study implicating NOD1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target.
基金Project supported by the National Natural Science Foundation of China （No. 71173154）
文摘In some networks nodes belong to predefined groups （e.g., authors belong to institutions）. Common network cen- trality measures do not take this structure into account. Gefura measures are designed as indicators of a node＇s brokerage role between such groups. They are defined as variants of betweeuness centrality and consider to what extent a node belongs to shortest paths between nodes from different groups. In this article we make the following new contributions to their study： （1） We systematically study unnormalized gefura measures and show that, next to the ＇structural＇ normalization that has hitherto been applied, a ＇basic＇ normalization procedure is possible. While the former normalizes at the level of groups, the latter normalizes at the level of nodes. （2） Treating undirected networks as equivalent to symmetric directed networks, we expand the definition of gefura measures to the directed case. （3） It is shown how Brandes＇ algorithm for betweenness centrality can be adjusted to cover these cases.
