Purpose: To investigate transcleral delivery of ethacrynic acid (ECA) as an innovative drug delivery technique for glaucoma. To design an implant that delivers ECA close to it's site of action i.e. Schlemm's C...Purpose: To investigate transcleral delivery of ethacrynic acid (ECA) as an innovative drug delivery technique for glaucoma. To design an implant that delivers ECA close to it's site of action i.e. Schlemm's Canal. Methods: A polyglycolic acid polymer embedded with ethacrynic acid (Sigma) was formed展开更多
It is now almost forty years since Morton Grant first identified that the locus of abnormal (and normal) resistance to outflow of aqueous humor in the primary open angle glaucoma(s) is at, or just proximal, to the inn...It is now almost forty years since Morton Grant first identified that the locus of abnormal (and normal) resistance to outflow of aqueous humor in the primary open angle glaucoma(s) is at, or just proximal, to the inner wall of Schlemm's Canal (SC). Yet it is noteworthy and humbling that to date we have no specific medical therapies or surgical techniques that are targeted to展开更多
文摘Purpose: To investigate transcleral delivery of ethacrynic acid (ECA) as an innovative drug delivery technique for glaucoma. To design an implant that delivers ECA close to it's site of action i.e. Schlemm's Canal. Methods: A polyglycolic acid polymer embedded with ethacrynic acid (Sigma) was formed
文摘It is now almost forty years since Morton Grant first identified that the locus of abnormal (and normal) resistance to outflow of aqueous humor in the primary open angle glaucoma(s) is at, or just proximal, to the inner wall of Schlemm's Canal (SC). Yet it is noteworthy and humbling that to date we have no specific medical therapies or surgical techniques that are targeted to
