SARISTU was a big cooperation project granted by the European Commission,7th Framework Programme,carried out between 2011 and 2015.It dealt with smart aeronautic structures,both morphing and sensored;its main target w...SARISTU was a big cooperation project granted by the European Commission,7th Framework Programme,carried out between 2011 and 2015.It dealt with smart aeronautic structures,both morphing and sensored;its main target was to demonstrate the feasibility of designing,manufacturing and operating in representative environment,instrumented structures.Till now,it represents the major effort carried out within the European Union on the development of adaptive architectures for air systems.Inside that big activity,the realization of an Adaptive Trailing Edge Device(ATED)for wing camber adaptations aimed at compensating the weight reduction following the fuel consumption during cruise was addressed.It made the core of investigations target variable geometry aircraft components together with two other analyses concerning the development of shape-changing winglet and droop nose.ATED activities were conducted by the Italian Aerospace Research Centre(CIRA)in tight cooperation with the University of Napoli,"Federico II",who coordinated a group of 12 different partners from 8 different nations(France,Germany,Greece,the Netherlands,Israel,Spain,Turkey,and Italy).In this paper,an integral synthesis of that work is reported,with a focus on the definition and realization of the components of the presented device.The publication is in fact meant as the first part of a series that is aimed at overviewing the whole adaptive trailing edge development,till wind tunnel tests execution.Such a concise report is a critical and harmonized review of what have been performed by many colleagues spread all over Europe,all of which are duly recalled in the reported bibliography where the reader may access more detailed information and descriptions.In detail,the paper starts with a general introduction of the concept and its aims,to move to the specs definition immediately after.Then,it deals with a short but comprehensive description of the main ATED components:structural skeleton,skin,actuation and sensing systems.It is worth remarking that the pa展开更多
Self-centering earthquake-resistant structures have received increased attention due to their ability to reduce post-earthquake residual deformations and,thus,repair time and cost.This stimulated the development of re...Self-centering earthquake-resistant structures have received increased attention due to their ability to reduce post-earthquake residual deformations and,thus,repair time and cost.This stimulated the development of recentering shape memory alloy(SMA)dampers that use superelastic nitinol wires to dissipate energy and self-center the structure.However,there are still a few case studies applications on full-scale RC buildings in the literature.Moreover,general guidelines or even simplified approaches for the practical design of SMA damped braces are still lacking.This paper focuses on evaluating the effect of using self-centering shape memory alloy dampers for buckling-restrained braces applied for the seismic retrofit of a complex RC building structure.A design method originally proposed for elastoplastic dampers was implemented to size the SMA dampers to be placed on selected spans and stories of a building.The effectiveness of the design procedure was demonstrated by nonlinear time-history analyses under different sets of earthquake strong ground motions.The analysis results show that the recentering shape memory alloy bracing system is effective in limiting the maximum transient inter-story drifts and reducing the residual inter-story drifts after strong seismic events,due to its excellent recentering behavior together with its not negligible energy dissipation capacity.展开更多
Dear Editor, Testicular trauma is a frequent acquired cause o fin fertility; being accidents, work injuries and sport activities that are the most common causes of testicular traumas.1＇2 Strangely, the issue of manag...Dear Editor, Testicular trauma is a frequent acquired cause o fin fertility; being accidents, work injuries and sport activities that are the most common causes of testicular traumas.1＇2 Strangely, the issue of management of serious testicular trauma and fertility preservation has not been studied extensively before, existing only sporadic reports in international literature. Besides, no guidelines exist on fertility preservation in cases of important scrotal trauma when injury may result in irreparable damage to all testicular tissue （torsion of a solitary testis, bilateral synchronous testicular torsion,展开更多
Meplazumab,a humanized CD147 antibody,has shown favourable safety and efficacy in our previous clinical studies.In DEFLECT(NCT04586153),167 patients with severe COVID-19 were enroled and randomized to receive three do...Meplazumab,a humanized CD147 antibody,has shown favourable safety and efficacy in our previous clinical studies.In DEFLECT(NCT04586153),167 patients with severe COVID-19 were enroled and randomized to receive three dosages of meplazumab and a placebo.Meplazumab at 0.12 mg/kg,compared to the placebo group,showed clinical benefits in significantly reducing mortality by 83.6%(2.4%vs.14.6%,p=0.0150),increasing the proportion of patients alive and discharged without supplemental oxygen(82.9%vs.70.7%,p=0.0337)and increasing the proportion of patients who achieved sustained clinical improvement(41.5%vs.31.7%).The response rate in the 0.2 mg/kg group was relatively increased by 16.0%compared with the placebo group(53.7%vs.46.3%).Meplazumab also reduced the viral loads and multiple cytokine levels.Compare with the placebo group,the 0.3 mg/kg significantly increased the virus negative rate by 40.6%(p=0.0363)and reduced IL-8 level(p=0.0460);the 0.2 mg/kg increased the negative conversion rate by 36.9%,and reduced IL-4(p=0.0365)and IL-8 levels(p=0.0484).In this study,the adverse events occurred at a comparable rate across the four groups,with no unexpected safety findings observed.In conclusion,meplazumab promoted COVID-19 convalescence and reduced mortality,viral load,and cytokine levels in severe COVID-19 population with good safety profile.展开更多
基金The research herein reported did gratefully receive funding from Seventh Framework Programme of the European Union(FP7/2007-2013)under Grant Agreement N.284562,SARISTUThe project was prodigiously and effectively coordinated by Piet Christof Woelcken(Airbus)with the support of Michael Papadopoulos(EASN–European Aeronautic Science Network).
文摘SARISTU was a big cooperation project granted by the European Commission,7th Framework Programme,carried out between 2011 and 2015.It dealt with smart aeronautic structures,both morphing and sensored;its main target was to demonstrate the feasibility of designing,manufacturing and operating in representative environment,instrumented structures.Till now,it represents the major effort carried out within the European Union on the development of adaptive architectures for air systems.Inside that big activity,the realization of an Adaptive Trailing Edge Device(ATED)for wing camber adaptations aimed at compensating the weight reduction following the fuel consumption during cruise was addressed.It made the core of investigations target variable geometry aircraft components together with two other analyses concerning the development of shape-changing winglet and droop nose.ATED activities were conducted by the Italian Aerospace Research Centre(CIRA)in tight cooperation with the University of Napoli,"Federico II",who coordinated a group of 12 different partners from 8 different nations(France,Germany,Greece,the Netherlands,Israel,Spain,Turkey,and Italy).In this paper,an integral synthesis of that work is reported,with a focus on the definition and realization of the components of the presented device.The publication is in fact meant as the first part of a series that is aimed at overviewing the whole adaptive trailing edge development,till wind tunnel tests execution.Such a concise report is a critical and harmonized review of what have been performed by many colleagues spread all over Europe,all of which are duly recalled in the reported bibliography where the reader may access more detailed information and descriptions.In detail,the paper starts with a general introduction of the concept and its aims,to move to the specs definition immediately after.Then,it deals with a short but comprehensive description of the main ATED components:structural skeleton,skin,actuation and sensing systems.It is worth remarking that the pa
文摘Self-centering earthquake-resistant structures have received increased attention due to their ability to reduce post-earthquake residual deformations and,thus,repair time and cost.This stimulated the development of recentering shape memory alloy(SMA)dampers that use superelastic nitinol wires to dissipate energy and self-center the structure.However,there are still a few case studies applications on full-scale RC buildings in the literature.Moreover,general guidelines or even simplified approaches for the practical design of SMA damped braces are still lacking.This paper focuses on evaluating the effect of using self-centering shape memory alloy dampers for buckling-restrained braces applied for the seismic retrofit of a complex RC building structure.A design method originally proposed for elastoplastic dampers was implemented to size the SMA dampers to be placed on selected spans and stories of a building.The effectiveness of the design procedure was demonstrated by nonlinear time-history analyses under different sets of earthquake strong ground motions.The analysis results show that the recentering shape memory alloy bracing system is effective in limiting the maximum transient inter-story drifts and reducing the residual inter-story drifts after strong seismic events,due to its excellent recentering behavior together with its not negligible energy dissipation capacity.
文摘Dear Editor, Testicular trauma is a frequent acquired cause o fin fertility; being accidents, work injuries and sport activities that are the most common causes of testicular traumas.1＇2 Strangely, the issue of management of serious testicular trauma and fertility preservation has not been studied extensively before, existing only sporadic reports in international literature. Besides, no guidelines exist on fertility preservation in cases of important scrotal trauma when injury may result in irreparable damage to all testicular tissue （torsion of a solitary testis, bilateral synchronous testicular torsion,
基金The DEFLECT is supported by grants from National Natural Science Foundation of China(No.92169211).Jiangsu Pacific Meinuoke Biopharmaceuticals provided meplazumab.The views expressed in this article is the authors’opinion,not the opinion or policy of funder.
文摘Meplazumab,a humanized CD147 antibody,has shown favourable safety and efficacy in our previous clinical studies.In DEFLECT(NCT04586153),167 patients with severe COVID-19 were enroled and randomized to receive three dosages of meplazumab and a placebo.Meplazumab at 0.12 mg/kg,compared to the placebo group,showed clinical benefits in significantly reducing mortality by 83.6%(2.4%vs.14.6%,p=0.0150),increasing the proportion of patients alive and discharged without supplemental oxygen(82.9%vs.70.7%,p=0.0337)and increasing the proportion of patients who achieved sustained clinical improvement(41.5%vs.31.7%).The response rate in the 0.2 mg/kg group was relatively increased by 16.0%compared with the placebo group(53.7%vs.46.3%).Meplazumab also reduced the viral loads and multiple cytokine levels.Compare with the placebo group,the 0.3 mg/kg significantly increased the virus negative rate by 40.6%(p=0.0363)and reduced IL-8 level(p=0.0460);the 0.2 mg/kg increased the negative conversion rate by 36.9%,and reduced IL-4(p=0.0365)and IL-8 levels(p=0.0484).In this study,the adverse events occurred at a comparable rate across the four groups,with no unexpected safety findings observed.In conclusion,meplazumab promoted COVID-19 convalescence and reduced mortality,viral load,and cytokine levels in severe COVID-19 population with good safety profile.
