The discovery of microRNAs （miRNAs） is one of tbe most significant breakthroughs in recent decades, miRNAs are a class of small, endogenous, non-coding RNAs （19-24 nt） that negatively regulate the expression of ta...The discovery of microRNAs （miRNAs） is one of tbe most significant breakthroughs in recent decades, miRNAs are a class of small, endogenous, non-coding RNAs （19-24 nt） that negatively regulate the expression of target genes by binding to their 3＇ untranslated region and are involved in various biological processes. Three main approaches that are globally used for the detection of miRNA include direct cloning, forward genetics and computational approaches using bioinformatics.展开更多
文摘The discovery of microRNAs （miRNAs） is one of tbe most significant breakthroughs in recent decades, miRNAs are a class of small, endogenous, non-coding RNAs （19-24 nt） that negatively regulate the expression of target genes by binding to their 3＇ untranslated region and are involved in various biological processes. Three main approaches that are globally used for the detection of miRNA include direct cloning, forward genetics and computational approaches using bioinformatics.
