BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic pain.Although the term...BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic pain.Although the term cystitis suggests an inflammatory or infectious origin,no definite cause has been identified.It occurs in both sexes,but women are twice as much affected.AIM To systematically review evidence of psychiatric/psychological changes in persons with IC/BPS.METHODS Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search 36.Search on ClinicalTrials.gov produced 14 studies,of which none had available data.Eligible were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October 2023.These studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to catastrophizing.CONCLUSION Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/BPS.Such concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.展开更多
CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle envi...CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China).展开更多
AIM TO correlate Helicobacter pylori （H. pylorli）, EpsteinBarr virus （EBV） and human papillomavirus （HPV） with gastric cancer （GC） cases in Para State, Brazil.METHODS Tissue samples were obtained from 302 gast...AIM TO correlate Helicobacter pylori （H. pylorli）, EpsteinBarr virus （EBV） and human papillomavirus （HPV） with gastric cancer （GC） cases in Para State, Brazil.METHODS Tissue samples were obtained from 302 gastric adenocarcinomas. A rapid urease test was used to detect the presence of H. pylori, and the presence of the cagA gene in the HP-positive samples was confirmed by PCR. An RNA in situ hybridization test designed to complement Eberl RNA was used to detect the presence of EBV in the samples, and the L1 region of HPV was detected using nested PCR. Positive HPV samples were genotyped and analyzed for E6 and E7 viral gene expression. Infections were also correlated with the clinical and pathological characteristics of the patients.RESULTS The majority of the 302 samples analyzed were obtained from men （65%） aged 55 years or older （67%） and were classified as the intestinal subtype （55%）. All three pathogens were found in the samples analyzed in the present study （H. pylori： 87%, EBV： 20%, HPV： 3%）. Overall, 78% of the H. pylori-positive （H. pylorl＋） samples were cagA＋ （H. pylori-cagA＋）, and there was an association between the cytotoxic product of this gene and EBV. Coinfections of H. pylori-cagA＋ and EBV were correlated with the most advanced tumor stages. Although only 20% of the tumors were positive for EBV, infection with this virus was associated with distant metastasis. Only the HPV 16 and 18 strains were found in the samples, although no expression of the E6 and E7 oncoproteins was detected. The fundus of the stomach was the region least affected by the pathogens.CONCLUSION HPV was not involved in gastric tumorigenesis. Prophy- lactic and therapeutic measures against H. pylori and EBV may prevent the development of GC, especially the more aggressive forms.展开更多
Transition metal phosphides(TMPs)/carbonaceous matrices have gradually attracted attention in the field of energy storage.In this study,we presented nickel phosphide(Ni2P)nanoparticles anchored to nitrogen-doped carbo...Transition metal phosphides(TMPs)/carbonaceous matrices have gradually attracted attention in the field of energy storage.In this study,we presented nickel phosphide(Ni2P)nanoparticles anchored to nitrogen-doped carbon porous spheres(Ni2P/NC)by using metal-organic framework-Ni as the template.The comprehensive encapsulation architecture provides closer contact among the Ni2P nanoparticles and greatly improves the structural integrity as well as the electronic conductivity,resulting in excellent lithium storage performance.The reversible specific capacity of 286.4 mA hg^-1 has been obtained even at a high current density of 3.0 Ag^-1 and 450.4 mA hg^-1 is obtained after 800 cycles at 0.5 Ag^-1.Furthermore,full batteries based on LiNi1/3Co1/3Mn1/3O2||Ni2P/NC exhibit both good rate capability and cycling life.This study provides a powerful and indepth insight on new advanced electrodes in high-performance energy storage devices.展开更多
The scope of this work is to present a multidisciplinary study in order to propose a tool called DIMZAL. DIMZAL forecasts fuelbreak safety zone sizes. To evaluate a safety zone and to prevent injury, the Acceptable Sa...The scope of this work is to present a multidisciplinary study in order to propose a tool called DIMZAL. DIMZAL forecasts fuelbreak safety zone sizes. To evaluate a safety zone and to prevent injury, the Acceptable Safety Distance (ASD) between the fire and firefighters is required. This distance is usually set thanks to a general rule-of-thumb: it should be at least 4 times the maximum flame length. A common assumption considers an empirical relationship between fireline intensity and flame length. In the current work which follows on from an oral presentation held at the VII International Conference on Forest Fire Research in Coimbra in 2014, an alternative way is proposed: a closed physical model is applied in order to quantize the ASD. This model is integrated in a software tool, which uses a simulation framework based on Discrete EVent system Specification formalism (DEVS), a 3D physical real-time model of surface fires developed at the University of Corsica and a mobile application based on a Google SDK to display the展开更多
Objective.The study explored the hypothesis that spontaneous nystagmus (Ny) in migraine patients can be triggered or modulated by painful trigeminal stimulation, providing evidence of a functional connection between v...Objective.The study explored the hypothesis that spontaneous nystagmus (Ny) in migraine patients can be triggered or modulated by painful trigeminal stimulation, providing evidence of a functional connection between vestibular and trigeminal systems. Background.-Vertigo attacks are reported by subjects with migraine or a familiar history of migraine, also independently of headache episodes. Idiopathic vertigo is three times more frequent in migraine patients than in controls. Vestibular investigations in migraine patients have consistently demonstrated spontaneous Ny both of central and peripheral origin. Design.-In the first phase of the study 10 outpatients experiencing migraine without aura (MO) and 10 healthy volunteers were submitted to the registration of spontaneous primary-position Ny in the dark by Ulmer’s video-ocular-nystag-mographic equipment. Two electrodes for electrical stimulation were applied on the supraorbital point of one side of the head and the intensity of stimulation corresponding to pain threshold was calculated. Spontaneous ocular movements were recorded for 5 minutes at baseline and after a sequence of five electric pulses (square waves of .5 Hz frequency and 50 μs duration, at pain threshold intensity). Nystagmographic responses were expressed as latency after stimulation, direction of the quick phase, and duration. The second phase of the study explored, with the same procedure, the effects on Ny of supraorbital versus median nerve stimulation in other 10 MO patients. Responses to stimulation were considered the appearance of de novo Ny after stimulation in subjects without baseline Ny, or the change of the frequency (at last a 50%variation) or of the direction of Ny after stimulation in subjects with baseline Ny. The latency and the duration of responses to stimulation were also calculated. Results.-In the first series supraorbital painful electric stimulation was able to modify or to evoke Ny in 8 of 10 migraineurs and in none of 10 volunteers (Fisher’s exact test, P< .01). Bot展开更多
Asian dust comprises a large portion of the northern hemisphere atmospheric dust load,thereby exerting substantial influence on the Earth’s climate,global biogeochemistry and hydrological cycle through accelerated sn...Asian dust comprises a large portion of the northern hemisphere atmospheric dust load,thereby exerting substantial influence on the Earth’s climate,global biogeochemistry and hydrological cycle through accelerated snow and ice melt.Dust deposited on alpine glaciers encodes information on broad scale atmospheric-environmental processes.The(^(234)U/^(238)U)values of dust fine particulates can reflect the comminuting time and intermediate processes;thus,it provides a new method for the provenance of aeolian dust in the glacial snowpack/cryoconite.Here we present results from a comprehensive survey of uranium isotopic concentrations in dust collected from cryoconites on the glaciers of the northern Tibetan Plateau(TP).These results indicate significant spatial heterogeneity in the(^(234)U/^(238)U)values associated with snowpack/cryoconite dust over a broad range of glaciers in the northern TP.The values of the(^(234)U/^(238)U)ratio in the glaciers of western Qilian Mountains(Qiyi Glacier,Shiyi Glacier,Laohugou Glacier No.12)were the highest,followed by the Tanggula(Dunkemadi Glacier)and Kunlun Mountains(Yuzhufeng Glacier),whereas these values were the lowest in the eastern Qilian Mountains(Jingyangling Snowpack,Dabanshan Snowpack,Lenglongling Glacier).By including the analysis of Sr-Nd isotopic compositions,we find the spatial isotopic distribution reflects a combination of local dust,which is associated with short comminuting times,and dust transported over long ranges.Meteorological data indicate that the dust production in the west and north TP,Alxa arid lands and Gobi Deserts,may have a significant impact on the TP glaciers.Moreover,U-Sr-Nd isotopic composition and end-member mixing models(EMMA)were used in our study to find out the relative contribution of distinct Asian dust sources to the dust budget in the TP glaciers.The results reveal that snowpack/cryoconite dust is derived from both local sources(low comminution signatures)as well as other dust sources in the Asian region.Our study demonstrates the pote展开更多
AIM:To examine neuroretinal function by using the multifocal electroretinography(mf ERG)test in patients with neurofibromatosis type 1(NF1)without optic pathway gliomas(OPGs).METHODS:This study was conducted on 35 pat...AIM:To examine neuroretinal function by using the multifocal electroretinography(mf ERG)test in patients with neurofibromatosis type 1(NF1)without optic pathway gliomas(OPGs).METHODS:This study was conducted on 35 patients(35 eyes)with NF1 and 30 healthy subjects(30 eyes)for the control group.Each subject underwent a complete ophthalmological examination including spectral domainoptical coherence tomography(SD-OCT)and mf ERG.The 1.5-Tesla magnetic resonance imaging(MRI)scan of the brain was performed in NF1 patients to assess the presence of OPGs.All participants were recruited having a best corrected visual acuity(BCVA)of no less than 20/20 in each eye.The amplitude and implicit time of the P1 wave(first-order Kernel component)were evaluated on mf ERG.Data analysis was carried out in the two central degrees and in the four quadrants from two to 25 degrees of visual field.RESULTS:Statistically significant results were obtained for the P1 wave amplitudes in the 4 quadrants in NF1 patients compared to healthy controls,while the reduction was not significant in the 2 central degrees between the groups.A statistically significant difference was observed among the P1 wave amplitudes as recorded in the 4 quadrants within the NF1 group,with lower amplitudes detected in the nasal quadrants.No differences in the implicit times were recorded in the 2 central degrees and in the 4 quadrants as compared between NF1 patients and controls.CONCLUSION:Impaired neuroretinal function in NF1 patients is expressed in a decreased amplitude of the P1-wave between 2 and 25 central retinal degrees on mf ERG.Altered intracellular signal transduction due to abnormal neurofibromin-mediated cyclic adenosine monophosphate(c AMP)generation,can be involved.The possible use of mf ERG as subclinical retinal damage indicator has a potential utility in clinical practice for the follow-up of NF1 patients.展开更多
Short copper standing wave （SW） structures operating at an X-band frequency have been recently designed and manufactured at the Laboratori Nazionali di Frascati of the Istituto Nazionale di Fisica Nucleare （INFN） ...Short copper standing wave （SW） structures operating at an X-band frequency have been recently designed and manufactured at the Laboratori Nazionali di Frascati of the Istituto Nazionale di Fisica Nucleare （INFN） using the vacuum brazing technique. High power tests of the structures have been performed at the SLAC National Accelerator Laboratory. In this manuscript we report the results of these tests and the activity in progress to enhance the high gradient performance of the next generation of structures, particularly the technological characterization of high performance coatings obtained via molybdenum sputtering.展开更多
Due to the sodium abundance and availability,sodium-ion batteries(SIBs)have the potential to meet the worldwide growing demand of electrical energy storage.P2-type sodium transition-metal layer oxides with a high ener...Due to the sodium abundance and availability,sodium-ion batteries(SIBs)have the potential to meet the worldwide growing demand of electrical energy storage.P2-type sodium transition-metal layer oxides with a high energy density are considered as the most promising cathode materials for SIBs.We present here a detailed study of the enhanced rate capability and cyclic stability of the Ti-doped Na_(0.67)Ni_(0.33)Mn_(0.67)O_(2)cathode material.The combined analysis of ex-situ X-ray absorption fine structure(XAFS)spectroscopy,aberration-corrected high resolution transmission electron microscopy(AB-HRTEM)and X-ray diffraction(XRD)show that the strong Ti–O bond in the transition metal layers stabilizes the local structure,destroy the Na+-vacancy ordering and arrest the irreversible multiphase transformation that occurs during the intercalation/deintercalation process.Actually,Na_(0.67)Ni_(0.33)Mn_(0.52)Ti_(0.15)O_(2)exhibits a reversible capacity of 89.6 mA h g^(-1)even at 5 C,an excellent cyclability with 88.78%capacity retention after 200 cycles at 0.5 C.This study provides a better understanding in optimization of the design of high-energy cathode materials based on titanium doped layered oxides for SIBs.展开更多
Following a large-scale phylogenetic study of the lichenized genus Cora(Basidiomycota:Agaricales:Hygrophoraceae),we formally describe 70 new species,honouring the seventieth birthday of David Leslie Hawksworth,one of ...Following a large-scale phylogenetic study of the lichenized genus Cora(Basidiomycota:Agaricales:Hygrophoraceae),we formally describe 70 new species,honouring the seventieth birthday of David Leslie Hawksworth,one of the preeminent figures in mycology and lichenology in the past 50 years.Based on an updated phylogeny using the ITS fungal barcoding locus,we now recognize 189 taxa in a genus that until recently was considered to represent a single species;including this contribution,92 of these are formally recognized,including five taxa based on historical names or collections that have not been sequenced.Species of Cora can be recognized by a combination of morphological(size,colour,lobe configuration,surface hairs,hymenophore size and shape),anatomical(thallus thickness,cortex structure,photobiont type,hyphal papillae),and ecogeographical features(substrate,habitat,distribution),and a keytable allowing the identification of all accepted taxa is provided.The new species are:Cora accipiter Moncada,Madrin˜a´n&Lücking spec.nov.,C.applanata Moncada,Soto-Medina&Lücking spec.nov.,C.arachnodavidea Moncada,Dal Forno&Lücking spec.nov.,C.arborescens Dal Forno,Chaves&Lücking spec.nov.,C.arcabucana Moncada,C.Rodrı´guez&Lücking spec.nov.,C.aturucoa Lücking,Moncada&C.Vargas spec.nov.,C.auriculeslia Moncada,Ya´nez-Ayabaca&Lücking spec.nov.,C.barbifera Moncada,Patin˜o&Lücking spec.nov.,C.boleslia Lücking,E.Morales&Dal Forno spec.nov.,C.caliginosa Holgado,Rivas Plata&Perlmutter spec.nov.,C.campestris Dal Forno,Eliasaro&Spielmann spec.nov.,C.canari Nugra,Dal Forno&Lücking spec.nov.,C.caraana Lücking,Martins&Lucheta spec.nov.,C.casasolana Moncada,R.-E.Pe´rez&Lücking spec.nov.,C.caucensis Moncada,M.Gut.&Lücking spec.nov.,C.celestinoa Moncada,CabreraAmaya&Lücking spec.nov.,C.comaltepeca Moncada,R.-E.Pe´rez&Herrera-Camp.spec.nov.,C.corani Lücking,E.Morales&Dal Forno spec.nov.,C.corelleslia Moncada,A.Sua´rez-Corredor&Lücking spec.nov.,C.crispoleslia Moncada,J.Molina&Lücking spec.nov.,C.cuzcoensis Holgado,Rivas展开更多
Dear Editor, The cytosolic protein Tau is naturally present in human neurons, where it has a pivotal role in controlling microtubule stability. Hyperphosphorylation of Tau （observed during neurodegenerative diseases...Dear Editor, The cytosolic protein Tau is naturally present in human neurons, where it has a pivotal role in controlling microtubule stability. Hyperphosphorylation of Tau （observed during neurodegenerative diseases, such as Alzheimer＇s disease） impairs the protein＇s ability to bind microtubules. This results in microtubule disassembly and the formation of Tau aggregates, Tau protein is also widely expressed in peripheral tissues. In the male reproductive system, screening for Tau has focused solely on the rodent and bovine testis. In the present study, we used immunofluorescence and immunoenzymatic techniques （with a Tau-specific antibody） to investigate the presence of Tau protein in human ejaculated sperm and testicular tissue.展开更多
The consumption of beverages and processed foods, mainly soft drinks, has been incorporated into the usual diet of children, adolescents and adults frequently in recent years. The present study aimed to study the effe...The consumption of beverages and processed foods, mainly soft drinks, has been incorporated into the usual diet of children, adolescents and adults frequently in recent years. The present study aimed to study the effects of carbonated drinks on Wistar rats, based on the macroscopic and histological morphology of the esophagus. Fifteen Wistar rats were divided into three groups: control group;group fed with ration and cola-type refrigerant ad libitum and group fed with ration and gas industrialized water ad libitum, for a trial period of 90 days. For histopathology and morphology, the esophagus was removed, prepared in slides and stained with hematoxylineosin. Images of the sections were captured for analysis and classification of the inflammatory infiltrate. For morphometry, ten grid fields of 100 points were evaluated in the 40x eyepiece, totaling 3000 points per animal. The results demonstrate that the refrigerant treatment induced the following structural changes in the rats: significant reduction of weight in relation to the control group;inflammatory infiltrate predominantly diffuse mild to moderate and tissue edema. The rats treated with carbonated water had similar results to the control, besides signs of healing and tissue repair.展开更多
The first aim of this work is to provide an analytical expression to calculate the rate of spread of surface fires under no wind and no slope conditions. A previous simplified model was improved for this particular ca...The first aim of this work is to provide an analytical expression to calculate the rate of spread of surface fires under no wind and no slope conditions. A previous simplified model was improved for this particular case of fire propagation. The test of this proposed model was performed by using two complete sets of experimental results with several fuel beds and variable parameters such as moisture content or bulk density. The second aim of this article is to highlight two conditions that allow stopping a fire： the low leaf area and the high value of the moisture content.展开更多
Synchrotron radiation sources, whose number is steadily increasing, are undoubtedly the most powerful and brilliant sources in the X-ray range. Although the synchrotron emission covers with high brilliance also the in...Synchrotron radiation sources, whose number is steadily increasing, are undoubtedly the most powerful and brilliant sources in the X-ray range. Although the synchrotron emission covers with high brilliance also the infrared region, its use in this energy range has developed at a much slower rate. Nowadays, after a couple of decades of attempts, the aim of extending the unique performances of the synchrotron source to the infrared domain is achieved by several dedicated beamlines in different countries. With their high-brilliance, polarized and broad-band radiation one may perform experiments that are out of the range of conventional sources from the near-IR up to the far-IR range.展开更多
Study objective： to verify if the PAA （angle of the pubic arch） is a predictive data for the mode of delivery, the duration of labour and the expulsion period. Methods： we chose to measure the PAA in 100 women rec...Study objective： to verify if the PAA （angle of the pubic arch） is a predictive data for the mode of delivery, the duration of labour and the expulsion period. Methods： we chose to measure the PAA in 100 women recruited, chosen from the 38th to the 42th week of gestation. The method involves the use of two-dimensional transperineal ultrasound. Data collection took place over a period of time from May to September 2015. The ante-partum data taken into consideration were the patient’s name and surname, PAA, parity, age, height; those acquired in the post-partum provide for the calculation in minutes of the active phase of labor, the duration of the expulsion period, the execution of the amniorrhexis and the use of the synthetic oxytocin, the fetal cranial circumference, the fetal weight and the position of the presented part. Results： results discovered ultrasoundly 100 PAA, with an average value of 115.5° and we proceeded by evaluating 90 vaginal births. Infants at birth had a CC with an average value of 34.5 mm. By relating the two variables PAA and CC for the dependent variable “period expulsion in minutes”, confirming that the expulsive period depends on the relationship between PAA and CC. The average of the minutes of the expulsion period is 50＇ in women with a PAA 〉 111.5° and a CC 〉 34.5 mm while in women with an PAA 〉 111.5° the media time is 30＇ regardless of the CC. It has been shown that oxytocin and amniorrhexis reduce the minutes of the expulsion period only in a case of PAA 〉 111.5° and a CC 〉 34.5 mm bringing them from 60＇ to 23＇. Conclusion： the duration of the active phase of labor is not influenced by the PAA but it depends on external factors. In the case of the expulsion period, a predictability of the PAA on its duration is shown if the CC is taken into consideration; as regards the influence of the PAA on the method of delivery, it was not possible to carry out any analysis since all the useful cases had vaginal delivery.展开更多
A test is being realised by means of a network of wide band electromagnetic detectors that continuously records the electric components of the electromagnetic field, ranging from a few of Hz to tens of kHz. The networ...A test is being realised by means of a network of wide band electromagnetic detectors that continuously records the electric components of the electromagnetic field, ranging from a few of Hz to tens of kHz. The network has been operating in central Italy for more than ten years. The recorded signals from this network have been analysed in real time as well as their power spectrum contents. Time/frequency data have been saved for further analysis. The spectral contents have evidenced very distinct power spectrum signatures in ELF band that increase in intensity when strong seismic activity occurs near the stations, for example, at the time of Amatrice (M = 6) and Norcia (M = 6.5) earthquakes in 2016 when ten stations were operative, at the time of the Emilia (M = 6) earthquakes in 2012 when nine stations were operative, and at the time of the L’Aquila (M = 6.3) earthquakes in 2009 when only two stations were operative. Strong signals were also detected during the moderate Ancona (M = 5) earthquake in 2013 and by the recently installed Avigliano Umbro, Città di Castello and Gubbio stations in the Umbria region, during small seismic swarms (2 < M < 4) between 2013 and 2014. CIEN is presently composed of 16 stations and collect data from a multidisciplinary instrumentation.展开更多
Technological advancements are strongly required to fulfill the demands of new accelerator devices with the highest accelerating gradients and operation reliability for the future colliders. To this purpose an extensi...Technological advancements are strongly required to fulfill the demands of new accelerator devices with the highest accelerating gradients and operation reliability for the future colliders. To this purpose an extensive R^zD regarding molybdenum coatings on copper is in progress. In this contribution we describe chemical composition, deposition quality and resistivity properties of different molybdenum coatings obtained via sputtering. The deposited films are thick metallic disorder layers with different resistivity values above and below the molibdenum dioxide reference value. Chemical and electrical properties of these sputtered coatings have been characterized by Rutherford backscattering, XANES and photoemission spectroscopy. We will also consider multiple cells standing wave section coated by a molybdenum layer designed to improve the performance of X-Band accelerating systems.展开更多
文摘BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic pain.Although the term cystitis suggests an inflammatory or infectious origin,no definite cause has been identified.It occurs in both sexes,but women are twice as much affected.AIM To systematically review evidence of psychiatric/psychological changes in persons with IC/BPS.METHODS Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search 36.Search on ClinicalTrials.gov produced 14 studies,of which none had available data.Eligible were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October 2023.These studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to catastrophizing.CONCLUSION Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/BPS.Such concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.
基金supported by the Italian Space Agency in the framework of the“Accordo Attuativo n.2016-16-H0 Progetto Limadou Fase E/Scienza”(CUP F12F1600011005)
文摘CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China).
基金the National Council for scientific and technological development,No.(CNPq)402283/2013-9
文摘AIM TO correlate Helicobacter pylori （H. pylorli）, EpsteinBarr virus （EBV） and human papillomavirus （HPV） with gastric cancer （GC） cases in Para State, Brazil.METHODS Tissue samples were obtained from 302 gastric adenocarcinomas. A rapid urease test was used to detect the presence of H. pylori, and the presence of the cagA gene in the HP-positive samples was confirmed by PCR. An RNA in situ hybridization test designed to complement Eberl RNA was used to detect the presence of EBV in the samples, and the L1 region of HPV was detected using nested PCR. Positive HPV samples were genotyped and analyzed for E6 and E7 viral gene expression. Infections were also correlated with the clinical and pathological characteristics of the patients.RESULTS The majority of the 302 samples analyzed were obtained from men （65%） aged 55 years or older （67%） and were classified as the intestinal subtype （55%）. All three pathogens were found in the samples analyzed in the present study （H. pylori： 87%, EBV： 20%, HPV： 3%）. Overall, 78% of the H. pylori-positive （H. pylorl＋） samples were cagA＋ （H. pylori-cagA＋）, and there was an association between the cytotoxic product of this gene and EBV. Coinfections of H. pylori-cagA＋ and EBV were correlated with the most advanced tumor stages. Although only 20% of the tumors were positive for EBV, infection with this virus was associated with distant metastasis. Only the HPV 16 and 18 strains were found in the samples, although no expression of the E6 and E7 oncoproteins was detected. The fundus of the stomach was the region least affected by the pathogens.CONCLUSION HPV was not involved in gastric tumorigenesis. Prophy- lactic and therapeutic measures against H. pylori and EBV may prevent the development of GC, especially the more aggressive forms.
基金partly supported by the National Natural Science Foundation of China(11705015 and U1832147)the Foundation of Jiangsu Science and Technology Department(BA2016041)the Science and Technology Plan Project of Suzhou(SYG201738 and SZS201710)。
文摘Transition metal phosphides(TMPs)/carbonaceous matrices have gradually attracted attention in the field of energy storage.In this study,we presented nickel phosphide(Ni2P)nanoparticles anchored to nitrogen-doped carbon porous spheres(Ni2P/NC)by using metal-organic framework-Ni as the template.The comprehensive encapsulation architecture provides closer contact among the Ni2P nanoparticles and greatly improves the structural integrity as well as the electronic conductivity,resulting in excellent lithium storage performance.The reversible specific capacity of 286.4 mA hg^-1 has been obtained even at a high current density of 3.0 Ag^-1 and 450.4 mA hg^-1 is obtained after 800 cycles at 0.5 Ag^-1.Furthermore,full batteries based on LiNi1/3Co1/3Mn1/3O2||Ni2P/NC exhibit both good rate capability and cycling life.This study provides a powerful and indepth insight on new advanced electrodes in high-performance energy storage devices.
基金pported in part by the French Ministry of Research,the Corsican Region and the CNRS,under Grant CPER 2007-2013
文摘The scope of this work is to present a multidisciplinary study in order to propose a tool called DIMZAL. DIMZAL forecasts fuelbreak safety zone sizes. To evaluate a safety zone and to prevent injury, the Acceptable Safety Distance (ASD) between the fire and firefighters is required. This distance is usually set thanks to a general rule-of-thumb: it should be at least 4 times the maximum flame length. A common assumption considers an empirical relationship between fireline intensity and flame length. In the current work which follows on from an oral presentation held at the VII International Conference on Forest Fire Research in Coimbra in 2014, an alternative way is proposed: a closed physical model is applied in order to quantize the ASD. This model is integrated in a software tool, which uses a simulation framework based on Discrete EVent system Specification formalism (DEVS), a 3D physical real-time model of surface fires developed at the University of Corsica and a mobile application based on a Google SDK to display the
文摘Objective.The study explored the hypothesis that spontaneous nystagmus (Ny) in migraine patients can be triggered or modulated by painful trigeminal stimulation, providing evidence of a functional connection between vestibular and trigeminal systems. Background.-Vertigo attacks are reported by subjects with migraine or a familiar history of migraine, also independently of headache episodes. Idiopathic vertigo is three times more frequent in migraine patients than in controls. Vestibular investigations in migraine patients have consistently demonstrated spontaneous Ny both of central and peripheral origin. Design.-In the first phase of the study 10 outpatients experiencing migraine without aura (MO) and 10 healthy volunteers were submitted to the registration of spontaneous primary-position Ny in the dark by Ulmer’s video-ocular-nystag-mographic equipment. Two electrodes for electrical stimulation were applied on the supraorbital point of one side of the head and the intensity of stimulation corresponding to pain threshold was calculated. Spontaneous ocular movements were recorded for 5 minutes at baseline and after a sequence of five electric pulses (square waves of .5 Hz frequency and 50 μs duration, at pain threshold intensity). Nystagmographic responses were expressed as latency after stimulation, direction of the quick phase, and duration. The second phase of the study explored, with the same procedure, the effects on Ny of supraorbital versus median nerve stimulation in other 10 MO patients. Responses to stimulation were considered the appearance of de novo Ny after stimulation in subjects without baseline Ny, or the change of the frequency (at last a 50%variation) or of the direction of Ny after stimulation in subjects with baseline Ny. The latency and the duration of responses to stimulation were also calculated. Results.-In the first series supraorbital painful electric stimulation was able to modify or to evoke Ny in 8 of 10 migraineurs and in none of 10 volunteers (Fisher’s exact test, P< .01). Bot
基金funded by the National Natural Science Foundation of China(Grant No.42022002)the State Key Laboratory of Cryosphere Sciences(Grant No.SKLCS-ZZ-2022)+1 种基金funded through NSF Critical Zone Collaborative proposal#2011910the German Research Foundation(DFG)for funding through the Heisenberg Programme“Multiscale Simulation of Earth Surface Processes”.
文摘Asian dust comprises a large portion of the northern hemisphere atmospheric dust load,thereby exerting substantial influence on the Earth’s climate,global biogeochemistry and hydrological cycle through accelerated snow and ice melt.Dust deposited on alpine glaciers encodes information on broad scale atmospheric-environmental processes.The(^(234)U/^(238)U)values of dust fine particulates can reflect the comminuting time and intermediate processes;thus,it provides a new method for the provenance of aeolian dust in the glacial snowpack/cryoconite.Here we present results from a comprehensive survey of uranium isotopic concentrations in dust collected from cryoconites on the glaciers of the northern Tibetan Plateau(TP).These results indicate significant spatial heterogeneity in the(^(234)U/^(238)U)values associated with snowpack/cryoconite dust over a broad range of glaciers in the northern TP.The values of the(^(234)U/^(238)U)ratio in the glaciers of western Qilian Mountains(Qiyi Glacier,Shiyi Glacier,Laohugou Glacier No.12)were the highest,followed by the Tanggula(Dunkemadi Glacier)and Kunlun Mountains(Yuzhufeng Glacier),whereas these values were the lowest in the eastern Qilian Mountains(Jingyangling Snowpack,Dabanshan Snowpack,Lenglongling Glacier).By including the analysis of Sr-Nd isotopic compositions,we find the spatial isotopic distribution reflects a combination of local dust,which is associated with short comminuting times,and dust transported over long ranges.Meteorological data indicate that the dust production in the west and north TP,Alxa arid lands and Gobi Deserts,may have a significant impact on the TP glaciers.Moreover,U-Sr-Nd isotopic composition and end-member mixing models(EMMA)were used in our study to find out the relative contribution of distinct Asian dust sources to the dust budget in the TP glaciers.The results reveal that snowpack/cryoconite dust is derived from both local sources(low comminution signatures)as well as other dust sources in the Asian region.Our study demonstrates the pote
文摘AIM:To examine neuroretinal function by using the multifocal electroretinography(mf ERG)test in patients with neurofibromatosis type 1(NF1)without optic pathway gliomas(OPGs).METHODS:This study was conducted on 35 patients(35 eyes)with NF1 and 30 healthy subjects(30 eyes)for the control group.Each subject underwent a complete ophthalmological examination including spectral domainoptical coherence tomography(SD-OCT)and mf ERG.The 1.5-Tesla magnetic resonance imaging(MRI)scan of the brain was performed in NF1 patients to assess the presence of OPGs.All participants were recruited having a best corrected visual acuity(BCVA)of no less than 20/20 in each eye.The amplitude and implicit time of the P1 wave(first-order Kernel component)were evaluated on mf ERG.Data analysis was carried out in the two central degrees and in the four quadrants from two to 25 degrees of visual field.RESULTS:Statistically significant results were obtained for the P1 wave amplitudes in the 4 quadrants in NF1 patients compared to healthy controls,while the reduction was not significant in the 2 central degrees between the groups.A statistically significant difference was observed among the P1 wave amplitudes as recorded in the 4 quadrants within the NF1 group,with lower amplitudes detected in the nasal quadrants.No differences in the implicit times were recorded in the 2 central degrees and in the 4 quadrants as compared between NF1 patients and controls.CONCLUSION:Impaired neuroretinal function in NF1 patients is expressed in a decreased amplitude of the P1-wave between 2 and 25 central retinal degrees on mf ERG.Altered intracellular signal transduction due to abnormal neurofibromin-mediated cyclic adenosine monophosphate(c AMP)generation,can be involved.The possible use of mf ERG as subclinical retinal damage indicator has a potential utility in clinical practice for the follow-up of NF1 patients.
基金Supported by Technological Innovation Project of Institute of High Energy Physics
文摘Short copper standing wave （SW） structures operating at an X-band frequency have been recently designed and manufactured at the Laboratori Nazionali di Frascati of the Istituto Nazionale di Fisica Nucleare （INFN） using the vacuum brazing technique. High power tests of the structures have been performed at the SLAC National Accelerator Laboratory. In this manuscript we report the results of these tests and the activity in progress to enhance the high gradient performance of the next generation of structures, particularly the technological characterization of high performance coatings obtained via molybdenum sputtering.
基金the National Natural Science Foundation of China(No.11705015,U1832147)the Science and Technology Plan Project of Suzhou(Nos.SYG201738 and SZS201710)。
文摘Due to the sodium abundance and availability,sodium-ion batteries(SIBs)have the potential to meet the worldwide growing demand of electrical energy storage.P2-type sodium transition-metal layer oxides with a high energy density are considered as the most promising cathode materials for SIBs.We present here a detailed study of the enhanced rate capability and cyclic stability of the Ti-doped Na_(0.67)Ni_(0.33)Mn_(0.67)O_(2)cathode material.The combined analysis of ex-situ X-ray absorption fine structure(XAFS)spectroscopy,aberration-corrected high resolution transmission electron microscopy(AB-HRTEM)and X-ray diffraction(XRD)show that the strong Ti–O bond in the transition metal layers stabilizes the local structure,destroy the Na+-vacancy ordering and arrest the irreversible multiphase transformation that occurs during the intercalation/deintercalation process.Actually,Na_(0.67)Ni_(0.33)Mn_(0.52)Ti_(0.15)O_(2)exhibits a reversible capacity of 89.6 mA h g^(-1)even at 5 C,an excellent cyclability with 88.78%capacity retention after 200 cycles at 0.5 C.This study provides a better understanding in optimization of the design of high-energy cathode materials based on titanium doped layered oxides for SIBs.
基金This study was partially supported by three grants from the National Science Foundation:TICOLICHEN-The Costa Rican Lichen Biodiversity Inventory(DEB 0206125 to The Field MuseumPI Robert Lücking)+8 种基金Neotropical Epiphytic Microlichens-An Innovative Inventory of a Highly Diverse yet Little Known Group of Symbiotic Organisms(DEB 0715660 to The Field MuseumPI R.Lücking)Phylogenetic Diversity of Mycobionts and Photobionts in the Cyanolichen Genus Dictyonema,with Emphasis on the Neotropics and the Galapagos Islands(DEB 0841405 to George Mason UniversityPI J.LawreyCo-PIs:R.Lücking,P.Gillevet).The Verein der Freunde des Botanischen Gartens und Botanischen Museums Berlin-Dahlem e.V.(https://www.bgbm.org/de/BGBM/freunde/index.html)supported molecular sequencing work for specimens collected as part of the Pilotprojekt Kooperation mit dem Botanischen Garten Bogotá(BMBF,see below).The Universidad Distrital Francisco Jose´de Caldas,Bogota´,is thanked for the support to the lichen herbarium and the curatorial work of the UDBC collections.The Jardı´n Bota´nico de Bogota´Jose´Celestino Mutis organized field trips to Sumapaz,Pen˜a Blanca,and Pasquilla(Bogota´),by agreement with the Botanical Garden and Botanical Museum Berlin,partially financed through the German Federal Ministry of Education and Research(BMBFPilotprojekt Kooperation mit dem Botanischen Garten BogotáForderkennzeichen:01DN13030).The Universidad de los Andes,Bogota´,provided logistic support for field work in Chingaza.Fe´lix Fernandez,owner of El Secreto Private Reserve in Garagoa,Colombia,is thanked for providing access to the area.The Galapagos Lichen Inventory acknowledges support by successive science directors of the Charles Darwin Foundation(Alan Tye,Mark Gardener,Rodolfo Martinez,Ulf Hardter,and Noemi d’Ozouville)executive director Arturo Izurieta.Frank Bungartz and collaborators are further indebted to the Directorate of the Galapagos National Park(particular Galo Quezada and Victor Carrio´n,granting specimen export permits)This publi
文摘Following a large-scale phylogenetic study of the lichenized genus Cora(Basidiomycota:Agaricales:Hygrophoraceae),we formally describe 70 new species,honouring the seventieth birthday of David Leslie Hawksworth,one of the preeminent figures in mycology and lichenology in the past 50 years.Based on an updated phylogeny using the ITS fungal barcoding locus,we now recognize 189 taxa in a genus that until recently was considered to represent a single species;including this contribution,92 of these are formally recognized,including five taxa based on historical names or collections that have not been sequenced.Species of Cora can be recognized by a combination of morphological(size,colour,lobe configuration,surface hairs,hymenophore size and shape),anatomical(thallus thickness,cortex structure,photobiont type,hyphal papillae),and ecogeographical features(substrate,habitat,distribution),and a keytable allowing the identification of all accepted taxa is provided.The new species are:Cora accipiter Moncada,Madrin˜a´n&Lücking spec.nov.,C.applanata Moncada,Soto-Medina&Lücking spec.nov.,C.arachnodavidea Moncada,Dal Forno&Lücking spec.nov.,C.arborescens Dal Forno,Chaves&Lücking spec.nov.,C.arcabucana Moncada,C.Rodrı´guez&Lücking spec.nov.,C.aturucoa Lücking,Moncada&C.Vargas spec.nov.,C.auriculeslia Moncada,Ya´nez-Ayabaca&Lücking spec.nov.,C.barbifera Moncada,Patin˜o&Lücking spec.nov.,C.boleslia Lücking,E.Morales&Dal Forno spec.nov.,C.caliginosa Holgado,Rivas Plata&Perlmutter spec.nov.,C.campestris Dal Forno,Eliasaro&Spielmann spec.nov.,C.canari Nugra,Dal Forno&Lücking spec.nov.,C.caraana Lücking,Martins&Lucheta spec.nov.,C.casasolana Moncada,R.-E.Pe´rez&Lücking spec.nov.,C.caucensis Moncada,M.Gut.&Lücking spec.nov.,C.celestinoa Moncada,CabreraAmaya&Lücking spec.nov.,C.comaltepeca Moncada,R.-E.Pe´rez&Herrera-Camp.spec.nov.,C.corani Lücking,E.Morales&Dal Forno spec.nov.,C.corelleslia Moncada,A.Sua´rez-Corredor&Lücking spec.nov.,C.crispoleslia Moncada,J.Molina&Lücking spec.nov.,C.cuzcoensis Holgado,Rivas
文摘Dear Editor, The cytosolic protein Tau is naturally present in human neurons, where it has a pivotal role in controlling microtubule stability. Hyperphosphorylation of Tau （observed during neurodegenerative diseases, such as Alzheimer＇s disease） impairs the protein＇s ability to bind microtubules. This results in microtubule disassembly and the formation of Tau aggregates, Tau protein is also widely expressed in peripheral tissues. In the male reproductive system, screening for Tau has focused solely on the rodent and bovine testis. In the present study, we used immunofluorescence and immunoenzymatic techniques （with a Tau-specific antibody） to investigate the presence of Tau protein in human ejaculated sperm and testicular tissue.
文摘The consumption of beverages and processed foods, mainly soft drinks, has been incorporated into the usual diet of children, adolescents and adults frequently in recent years. The present study aimed to study the effects of carbonated drinks on Wistar rats, based on the macroscopic and histological morphology of the esophagus. Fifteen Wistar rats were divided into three groups: control group;group fed with ration and cola-type refrigerant ad libitum and group fed with ration and gas industrialized water ad libitum, for a trial period of 90 days. For histopathology and morphology, the esophagus was removed, prepared in slides and stained with hematoxylineosin. Images of the sections were captured for analysis and classification of the inflammatory infiltrate. For morphometry, ten grid fields of 100 points were evaluated in the 40x eyepiece, totaling 3000 points per animal. The results demonstrate that the refrigerant treatment induced the following structural changes in the rats: significant reduction of weight in relation to the control group;inflammatory infiltrate predominantly diffuse mild to moderate and tissue edema. The rats treated with carbonated water had similar results to the control, besides signs of healing and tissue repair.
文摘The first aim of this work is to provide an analytical expression to calculate the rate of spread of surface fires under no wind and no slope conditions. A previous simplified model was improved for this particular case of fire propagation. The test of this proposed model was performed by using two complete sets of experimental results with several fuel beds and variable parameters such as moisture content or bulk density. The second aim of this article is to highlight two conditions that allow stopping a fire： the low leaf area and the high value of the moisture content.
文摘Synchrotron radiation sources, whose number is steadily increasing, are undoubtedly the most powerful and brilliant sources in the X-ray range. Although the synchrotron emission covers with high brilliance also the infrared region, its use in this energy range has developed at a much slower rate. Nowadays, after a couple of decades of attempts, the aim of extending the unique performances of the synchrotron source to the infrared domain is achieved by several dedicated beamlines in different countries. With their high-brilliance, polarized and broad-band radiation one may perform experiments that are out of the range of conventional sources from the near-IR up to the far-IR range.
文摘Study objective： to verify if the PAA （angle of the pubic arch） is a predictive data for the mode of delivery, the duration of labour and the expulsion period. Methods： we chose to measure the PAA in 100 women recruited, chosen from the 38th to the 42th week of gestation. The method involves the use of two-dimensional transperineal ultrasound. Data collection took place over a period of time from May to September 2015. The ante-partum data taken into consideration were the patient’s name and surname, PAA, parity, age, height; those acquired in the post-partum provide for the calculation in minutes of the active phase of labor, the duration of the expulsion period, the execution of the amniorrhexis and the use of the synthetic oxytocin, the fetal cranial circumference, the fetal weight and the position of the presented part. Results： results discovered ultrasoundly 100 PAA, with an average value of 115.5° and we proceeded by evaluating 90 vaginal births. Infants at birth had a CC with an average value of 34.5 mm. By relating the two variables PAA and CC for the dependent variable “period expulsion in minutes”, confirming that the expulsive period depends on the relationship between PAA and CC. The average of the minutes of the expulsion period is 50＇ in women with a PAA 〉 111.5° and a CC 〉 34.5 mm while in women with an PAA 〉 111.5° the media time is 30＇ regardless of the CC. It has been shown that oxytocin and amniorrhexis reduce the minutes of the expulsion period only in a case of PAA 〉 111.5° and a CC 〉 34.5 mm bringing them from 60＇ to 23＇. Conclusion： the duration of the active phase of labor is not influenced by the PAA but it depends on external factors. In the case of the expulsion period, a predictability of the PAA on its duration is shown if the CC is taken into consideration; as regards the influence of the PAA on the method of delivery, it was not possible to carry out any analysis since all the useful cases had vaginal delivery.
文摘A test is being realised by means of a network of wide band electromagnetic detectors that continuously records the electric components of the electromagnetic field, ranging from a few of Hz to tens of kHz. The network has been operating in central Italy for more than ten years. The recorded signals from this network have been analysed in real time as well as their power spectrum contents. Time/frequency data have been saved for further analysis. The spectral contents have evidenced very distinct power spectrum signatures in ELF band that increase in intensity when strong seismic activity occurs near the stations, for example, at the time of Amatrice (M = 6) and Norcia (M = 6.5) earthquakes in 2016 when ten stations were operative, at the time of the Emilia (M = 6) earthquakes in 2012 when nine stations were operative, and at the time of the L’Aquila (M = 6.3) earthquakes in 2009 when only two stations were operative. Strong signals were also detected during the moderate Ancona (M = 5) earthquake in 2013 and by the recently installed Avigliano Umbro, Città di Castello and Gubbio stations in the Umbria region, during small seismic swarms (2 < M < 4) between 2013 and 2014. CIEN is presently composed of 16 stations and collect data from a multidisciplinary instrumentation.
文摘Technological advancements are strongly required to fulfill the demands of new accelerator devices with the highest accelerating gradients and operation reliability for the future colliders. To this purpose an extensive R^zD regarding molybdenum coatings on copper is in progress. In this contribution we describe chemical composition, deposition quality and resistivity properties of different molybdenum coatings obtained via sputtering. The deposited films are thick metallic disorder layers with different resistivity values above and below the molibdenum dioxide reference value. Chemical and electrical properties of these sputtered coatings have been characterized by Rutherford backscattering, XANES and photoemission spectroscopy. We will also consider multiple cells standing wave section coated by a molybdenum layer designed to improve the performance of X-Band accelerating systems.
