Pushover analysis is common because of its conceptual simplicity and computational attractiveness in computing seismic demand.Considering that traditional pushover analysis is restricted in underground structures due ...Pushover analysis is common because of its conceptual simplicity and computational attractiveness in computing seismic demand.Considering that traditional pushover analysis is restricted in underground structures due to the stark differences in the seismic response characteristics of surface structures,this paper proposes a pushover analysis method for underground structures and its application in seismic damage assessment.First,three types of force distribution are presented based on ground response analysis.Next,the target displacements and analysis models are established according to force-based and performance-based design.Then,the pushover analysis procedure for underground structures is described.Next,the applicability of pushover analysis to underground structures is verified by comparing the responses of a Chongwenmen subway station determined by the proposed procedure and by nonlinear response history analysis.In addition,two other points are made:that the inverted triangular distribution of effective earthquake acceleration is more practical than the other two distributions,and that performance-based design is more effective than force-based design.Finally,a cyclic reversal loading pattern based on one cycle of reversal loads as an earthquake event is presented and applied to the seismic damage assessment of underground structures.The results show that the proposed pushover analysis can be effectively applied to the seismic design and damage assessment of underground structures.展开更多
All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both natural and synthetic retinoids use specific nuclear receptors such as retinoic acid receptors and retinoid X receptors to a...All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both natural and synthetic retinoids use specific nuclear receptors such as retinoic acid receptors and retinoid X receptors to activate specific signaling pathways in the cells. Retinoic acid signaling is extremely important in the central nervous system. Impairment of retinoic acid signaling pathways causes severe pathological processes in the central nervous system, especially in the adult brain. Retinoids have major roles in neural patterning, differentiation, axon outgrowth in normal development, and function of the brain. Impaired retinoic acid signaling results in neuroinflammation, oxidative stress, mitochondrial malfunction, and neurodegeneration leading to progressive Alzheimer’s disease, which is pathologically characterized by extra-neuronal accumulation of amyloid plaques(aggregated amyloid-beta) and intra-neurofibrillary tangles(hyperphosphorylated tau protein) in the temporal lobe of the brain. Alzheimer’s disease is the most common cause of dementia and loss of memory in old adults. Inactive cholinergic neurotransmission is responsible for cognitive deficits in Alzheimer’s disease patients. Deficiency or deprivation of retinoic acid in mice is associated with loss of spatial learning and memory. Retinoids inhibit expression of chemokines and neuroinflammatory cytokines in microglia and astrocytes, which are activated in Alzheimer’s disease. Stimulation of retinoic acid receptors and retinoid X receptors slows down accumulation of amyloids, reduces neurodegeneration, and thereby prevents pathogenesis of Alzheimer’s disease in mice. In this review, we described chemistry and biochemistry of some natural and synthetic retinoids and potentials of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer’s disease.展开更多
The seismotectonic characteristics of ten repeated earthquake swarm sequence within a seismic cluster along Jiali Fault in eastern Himalayan Syntaxis(EHS) have been analysed.The swarms are spatially disposed in and ar...The seismotectonic characteristics of ten repeated earthquake swarm sequence within a seismic cluster along Jiali Fault in eastern Himalayan Syntaxis(EHS) have been analysed.The swarms are spatially disposed in and around Yigong Lake(a natural lake formed by blocking of Yigong River by landslide) and are characterized by low magnitude,crustal events with low to moderate b values.Ms:mb discriminant functions though indicate anomalous nature of the earthquakes within swarm but are considered as natural events that occurred under condition of high apparent stress and stress gradients.Composite fault plane solutions of selected swarms indicate strike-slip sense of shear on fault planes;solution parameters show low plunging compression and tensional axes along NW-SE and NE-SW respectively with causative fault plane oriented ENE-WSW.dipping steeply towards south or north.The fault plane is in excellent agreement with the disposition and tectonic movement registered by right lateral Jiali Fault.The process of pore pressure perturbation and resultant ’r—t plot’ with modelled diffusivity(D = 0.12 m^2/s) relates the diffusion of pore pressure to seismic sequence in a fractured poro-elastic fluid saturated medium at average crustal depth of 15-20 km.The low diffusivity depicts a highly fractured interconnected medium that is generated due to high stress activity near the eastern syntaxial bent of Himalaya.It is proposed that hydro fracturing with respect to periodic pore pressure variations is responsible for generation of swarms in the region.The fluid pressure generated due to shearing and infiltrations of surface water within dilated seismogenic fault(Jiali Fault) are causative factors.展开更多
Semiconductor nanowires （NW） possess several beneficial properties for efficient conversion of solar energy into electricity and chemical energy. Due to their efficient absorption of light, short distances for minor...Semiconductor nanowires （NW） possess several beneficial properties for efficient conversion of solar energy into electricity and chemical energy. Due to their efficient absorption of light, short distances for minority carriers to travel, high surface-to-volume ratios, and the availability of scalable synthesis methods, they provide a pathway to address the low cost-to-power requirements for widescale adaptation of solar energy conversion technologies. Here we highlight recent progress in our group towards implementation of NW components as photovoltaic and photoelectrochemical energy conversion devices. An emphasis is placed on the unique properties of these one-dimensional （1D） structures, which enable the use of abundant, low-cost materials and improved energy conversion efficiency compared to bulk devices.展开更多
In Bangladesh, Enteric fever is a persistent health issue throughout the year, occasionally reaching epidemic levels. The growing antibiotic resistance makes treatment increasingly challenging. Therefore, studying the...In Bangladesh, Enteric fever is a persistent health issue throughout the year, occasionally reaching epidemic levels. The growing antibiotic resistance makes treatment increasingly challenging. Therefore, studying the antibiotic resistance patterns within the population is crucial to ensure a more effective treatment strategy. This study was designed to determine the prevalence, antimicrobial susceptibility profile, and factors associated with Salmonella spp. infections among clinically suspected Enteric fever patients in Bangladesh. This study also aimed to investigate whether there has been a re-emergence in the susceptibility of bacterial strains to conventional drugs. Data were collected from February 2024 to July 2024, from patients suspected Enteric fever (fever less than seven days duration) in a Private Diagnostic Center of Bangladesh. A total of 195 blood samples were cultured, where 53.85% came out positive, among which 79.05% Salmonella typhi and 20.95% Salmonella paratyphi A were found. Prevalence of Typhoid fever was observed high among the school-going age group (0 - 15 years) patients. Both these organisms were susceptible to ceftazidime, cefixime, ceftriaxone and cefepime but resistant to nalidixic acid, ciprofloxacin and levofloxacin. Nalidixic Acid is resistant to all S. paratyphi A and sensitive to few S. typhi. Ciprofloxacin and levofloxacin showed delayed response (36.14% and 22.72% sensitive to S. typhi and S. paratyphi A, respectively) and resistance (63.85% and 77.27% resistant to S. typhi and S. paratyphi A, respectively). In case of S. typhi, the resistance was found against ampicillin (32.53%), chloramphenicol (27.71%), cotrimoxazole (24.09%) and the resistance of S. paratyphi A found against ampicillin (4.54%), chloramphenicol (0%) and cotrimoxazole (0%). This study will provide clinicians with alternative drug options and facilitate the effective treatment of Enteric fever.展开更多
Background: Left atrial myxoma (LAM) is the most common heart tumor in adults, requiring prompt surgical removal to prevent complications like valvular obstruction or embolization. Objectives: This study aimed to comp...Background: Left atrial myxoma (LAM) is the most common heart tumor in adults, requiring prompt surgical removal to prevent complications like valvular obstruction or embolization. Objectives: This study aimed to compare early postoperative outcomes between two surgical approaches—right mini-thoracotomy and median sternotomy—for the removal of isolated left atrial myxoma. Methods: We conducted a prospective observational study at the Department of Cardiac Surgery, National Heart Foundation Hospital & Research Institute (NHFH&RI), Mirpur, Dhaka, from March 2017 to August 2019. Twenty-eight patients undergoing surgery for isolated left atrial myxoma were included. The surgical approach was determined by the operating surgeon. We analyzed outcomes like intubation time, Intensive Care Unit (ICU) stay, pain levels (Visual Analogue Scale score), and overall hospital stay using SPSS. Statistical significance was set at p Results: Patients in the right mini-thoracotomy group had longer mean intubation times (11.43 vs. 5.93 hours, p Conclusion: Despite longer intubation and ICU times, the right mini-thoracotomy approach offers a minimally invasive alternative for isolated left atrial myxoma excision, with favorable outcomes overall.展开更多
The interaction of naringin with bovine serum albumin has been performed using fluorescence, circular dichroism and fourier transform infrared spectroscopy in 20 mM phosphate buffer of pH 7.0 as well as molecular dock...The interaction of naringin with bovine serum albumin has been performed using fluorescence, circular dichroism and fourier transform infrared spectroscopy in 20 mM phosphate buffer of pH 7.0 as well as molecular docking studies. The changes in enthalpy (ΔH°) and entropy (ΔS°) of the interaction were found to be +18.73 kJ/mol and +143.64 J mol-1 K-1 respectively, indicating that the interaction of naringin with bovine serum albumin occurred mainly through hydrophobic interactions. Negative values of free energy change (ΔG°) at different temperatures point toward the spontaneity of the interaction. Circular dichroism studies reveal that the helical content of bovine serum albumin decreased after interaction with naringin. According to the F?rster non-radiative energy transfer theory the distance between Trp 213 residue and naringin was found to be 3.25 nm. Displacement studies suggest that naringin binds to site 1 (subdomain IIA) of bovine serum albumin (BSA) which was also substantiated by molecular docking studies.展开更多
Unconsolidated siliciclastic sediments can undergo post-burial deformation, which leads to the formation of distinctive sedimentary structures, known as soft-sediment deformation structures(SSDS). The presence of a se...Unconsolidated siliciclastic sediments can undergo post-burial deformation, which leads to the formation of distinctive sedimentary structures, known as soft-sediment deformation structures(SSDS). The presence of a series of sand volcanoes confined to a particular lithostratigraphic horizon can represent a paleoseismic activity and, thereby, exemplifies the concept of “seismite”. The Kutch Basin has been a tectonically active region since the initiation of eastern Gondwana rifting followed by a tectonic inversion during the Cenozoic due to the collision of the Indian and Eurasian plates. A stratum-bound series of sand volcanoes belonging to the Khari Nadi Formation(KNF) is exposed along the banks of Khari River. They separate the shallow marine deposits below and non-marine deposits above with their characteristic marine and paleosol trace fossil suites, respectively. Although a seismogenic origin has been much debated for the SSDS,the ichnofabric analysis of the sand-volcano-bearing stratum unequivocally points toward such an origin under a shallow seafloor condition. In addition to the sedimentary regime change from an open shallow-marine setting to a continental depositional environment concomitant with basinal uplift, the behavior of the burrowing crustaceans testifies to a syn-depositional development of a fault network associated with the fluidization, sand volcanism, and the resilience of the trace-producers in surviving those processes until the sedimentary regime change in the overlying strata. Although the ichno-sedimentological evidence apparently differs from the previous works that proposed a continuous base-level rise from the beginning of deposition of the Khari Nadi Formation up to the middle part of the overlying Chhasra Formation, the paleoseismic activity,its ichnologic signature, and the depositional regime change refer to a higher-resolution(i.e., lower-order)sequence-stratigraphic change causing a short-duration regression within a longer-duration cycle of base-level rise.展开更多
Objective: Improvement in cancer survival over recent decades has not been accompanied by a narrowing of socioeconomic disparities. This study aimed to quantify the loss of life expectancy(LOLE) resulting from a cance...Objective: Improvement in cancer survival over recent decades has not been accompanied by a narrowing of socioeconomic disparities. This study aimed to quantify the loss of life expectancy(LOLE) resulting from a cancer diagnosis and examine disparities in LOLE based on area-level socioeconomic status(SES).Methods: Data were collected for all people between 50 and 89 years of age who were diagnosed with cancer, registered in the NSW Cancer Registry between 2001 and 2019, and underwent mortality follow-up evaluations until December 2020. Flexible parametric survival models were fitted to estimate the LOLE by gender and area-level SES for 12 common cancers.Results: Of 422,680 people with cancer, 24% and 18% lived in the most and least disadvantaged areas, respectively. Patients from the most disadvantaged areas had a significantly greater average LOLE than patients from the least disadvantaged areas for cancers with high survival rates, including prostate [2.9 years(95% CI: 2.5±3.2 years) vs. 1.6 years(95% CI: 1.3±1.9 years)] and breast cancer [1.6 years(95% CI: 1.4±1.8 years) vs. 1.2 years(95% CI: 1.0±1.4 years)]. The highest average LOLE occurred in males residing in the most disadvantaged areas with pancreatic [16.5 years(95% CI: 16.1±16.8 years) vs. 16.2 years(95% CI: 15.7±16.7 years)] and liver cancer [15.5 years(95% CI: 15.0±16.0 years) vs. 14.7 years(95% CI: 14.0±15.5 years)]. Females residing in the least disadvantaged areas with thyroid cancer [0.9 years(95% CI: 0.4±1.4 years) vs. 0.6 years(95% CI: 0.2±1.0 years)] or melanoma [0.9 years(95% CI: 0.8±1.1 years) vs. 0.7 years(95% CI: 0.5±0.8 years)] had the lowest average LOLE.Conclusions: Patients from the most disadvantaged areas had the highest LOLE with SES-based differences greatest for patients diagnosed with cancer at an early stage or cancers with higher survival rates, suggesting the need to prioritise early detection and reduce treatment-related barriers and survivorship challenges to improve life expectancy.展开更多
Objective:To evaluate the protective effect of benzydamine hydrochloride against ethanol-induced oxidative stress and inflammation in RAW 264.7 macrophages.Methods:RAW 264.7 macrophages were treated with ethanol(100 m...Objective:To evaluate the protective effect of benzydamine hydrochloride against ethanol-induced oxidative stress and inflammation in RAW 264.7 macrophages.Methods:RAW 264.7 macrophages were treated with ethanol(100 mM)and benzydamine hydrochloride(7.5μM).The imflammatory status was confirmed by measuring pro-(TNF-αand IL-6)and anti-inflammatory(IL-10)cytokines through ELISA and RT-PCR assays.Reactive oxygen species generation and mitochondrial membrane potential were investigated to study the protective role of benzydamine hydrochloride against ethanol-induced oxidative stress.Apoptosis detection was also investigated using flow cytometry and acridine orange/ethidium bromide staining.Results:Benzydamine hydrochloride significantly decreased the secretion of TNF-αand IL-6,as well as the generation of reactive oxygen species inside the cells,thereby stabilizing the mitochondrial membrane potential and reducing DNA fragmentation.The ethanol-induced cellular necrosis was also reversed by the administration of benzydamine hydrochloride.Conclusions:Benzydamine hydrochloride ameliorates ethanol-induced cell apoptosis and inflammation in RAW macrophages.展开更多
The Chhasra Formation(CF)of Kutch Basin exemplifies a typical mixed siliciclastic-carbonate system with alternations of biostromal carbonate and fine-grained siliciclastic beds.The CF is subdivided into two members:th...The Chhasra Formation(CF)of Kutch Basin exemplifies a typical mixed siliciclastic-carbonate system with alternations of biostromal carbonate and fine-grained siliciclastic beds.The CF is subdivided into two members:the lower Claystone(CM)and the upper Siltstone(SM)member.Three CM outcrops(P1-P3)comprising buried palaeosols that formed under a specific environmental set-up involving imperfectly to poorly drained conditions,are exposed along the Berwali River.The biostromal carbonate beds,alternating with the palaeosols,contain invertebrate bioclasts(bivalves,gastropods,echinoids,etc.)and are characterized by a paucispecific firmground Thalassinoides ichnofabric.At section P1,below the contact between the underlying palaeosol and overlying carbonate,Thalassinoides transforms into firmground Gyrolithes inside the palaeosol forming a compound ichnotaxon.The palaeosol intervals of sections P1 and P2 consist of a Vondrichnus-Termitichnus-root trace ichnofabric defining the Termitichnus ichnofacies.At section P3,lenses of fully bioturbated siltstones with a monospecific firmground Thalassinoides ichnofabric can be observed within an overall silty palaeosol horizon,thereby,locally cross-cutting the pedogenic features.The ichnofabrics of section P3 indicate polyphase pedogenesis with three stages:(1)initial stage:pedogenesis in siltstone of undefined depositional affinity which was obscured by pedogenic processes,(2)transient stage:recurring marine incursions and colonization by crustaceans within the lens-shaped palaeotopographic depressions overprinting the palaeosol,and(3)final stage:subaerial exposure and another preserved phase of pedogenesis.The CM shows an apparent low-order T-R(transgressive-regressive)cyclicity within a 3rd-order TST(transgressive systems tract)that is supported by pedogenic intensity,ichnofabrics,and reciprocal sedimentation near the Miocene basin margin,though the cyclicity can be the result of both autogenic and/or lowerorder allogenic changes.展开更多
Carnuba wax consists chiefly of myricyl cerotate (M<sub>W</sub> 817.4) and small quantities of free cerotic acid (C<sub>26</sub>H<sub>52</sub>O<sub>2</sub>, Mw 396.7) an...Carnuba wax consists chiefly of myricyl cerotate (M<sub>W</sub> 817.4) and small quantities of free cerotic acid (C<sub>26</sub>H<sub>52</sub>O<sub>2</sub>, Mw 396.7) and myricyl alcohol (C<sub>30</sub>H<sub>62</sub>O, mp 90°C). Of the two common extraction solvents, ethyl ether or petroleum ether, Lewkowitsch prefers the former. Concerning separation of phases, he advocates addition of small amounts of alcohol or caustic, and he also states that formation of a flocculant layer between the aqueous layer and the solvent does not interfere with the correct estimation of the unsaponifiable matter. These statements were not corroborated in the hands of this chemist. The “Unsaponifiable Matter” in oils or and fats, which consist mainly of hydrocarbons, sterols and aliphatic alcohols of high molecular mass that are not saponifiable by alkali hydroxides but are soluble in the ordinary fat solvents, and to products of saponification that are soluble in such solvents. Carnuba wax, a rather expensive wax, may be adulterated with less expensive paraffin by dishonest merchants. ASTM has a method for determining paraffinic material in carnuba wax. It uses heptanes at its boiling point to dissolve the wax, apply it to a silica gel column, and elute only the nonpolar (i.e. alkane) material. The method has the disadvantage of using a large volume of haptane, nor is it called for by either US Pharmacopeia/National Formulary (USP/NF) or Food Chemicals Codex (FCC). The test for unsaponifiable matter on pure carnuba wax will yield a result of 50.0% - 55.0%, while a higher result will betray the presence of paraffin adulterants.展开更多
IoT technology has emerged as a valuable tool in modern healthcare, providing real-time monitoring of patients, effective management of healthcare, and proper administration of patient information. The proposed system...IoT technology has emerged as a valuable tool in modern healthcare, providing real-time monitoring of patients, effective management of healthcare, and proper administration of patient information. The proposed system aims to develop a system that can prevent backward blood flow from stopping saline fluid, as well as monitor the temperature, heart rate, and oxygen level of patients by using multiple sensors like weight, temperature and heart rate, etc. Additionally, the proposed system can monitor the room temperature and humidity for contributing to the patient’s overall comfort. In emergency situations, it includes an emergency push button for quick alert medical staff and initiates timely interventions. It is designed to support nurses and doctors in monitoring patients and providing timely interventions to prevent complications.展开更多
The gastrointestinal tract(GIT) is a complex system, which changes in response to requirements of the body. GIT represents a barrier to the external environment. To achieve this, epithelial cells must renew rapidly. T...The gastrointestinal tract(GIT) is a complex system, which changes in response to requirements of the body. GIT represents a barrier to the external environment. To achieve this, epithelial cells must renew rapidly. This renewal of epithelial cells starts in the fetal life under the influence of many GIT peptides by swallowing amniotic fluid(AF). Development and maturation of GIT is a very complex cascade that begins long before birth and continues during infancy and childhood by breastfeeding. Many factors like genetic preprogramming, local and systemic endocrine secretions and many trophic factors(TF) from swallowed AF contribute and modulate the development and growth of the GIT. GIT morphogenesis, differentiation and functional development depend on the activity of various TF in the AF. This manuscript will review the role of AF borne TF in the development of GIT.展开更多
Rich genetic polymorphism is important for plants to adapt to changes because it enables the plant to make anatomical,physiological and biochemical changes in response to abiotic stress.Geomorphologic characteristics,...Rich genetic polymorphism is important for plants to adapt to changes because it enables the plant to make anatomical,physiological and biochemical changes in response to abiotic stress.Geomorphologic characteristics,demographic interference and a cumulative decrease in freshwater influx in the Indian Sundarbans region have proved detrimental to some economically important plants.In this study,genetic polymorphism of three mangrove species,Xylocarpus granatum,Excoecaria agallocha,and Phoenix paludosa,was assessed using RAPD and ISSR molecular markers.X.granatum,already in distress in the Sundarbans,had the least genetic polymorphism,14.56%in the RAPD analysis and 12.92% in the ISSR.Relatively higher genetic polymorphism was recorded for the profusely growing E.agallocha and P.paludosa: 24.66 and26.4% in RAPD; 24.87 and 20.32% in ISSR analysis respectively.A UPGMA dendrogram constructed using the similarity matrix from RAPD,ISSR and combined datashowed that for X.granatum,the least and highest salinity zones clustered together,whereas for E.agallocha and P.paludosa,higher and lower salinity areas clustered in different clades.Nei’s genetic diversity,calculated from RAPD and ISSR data,was also in accordance with 0.0637 and 0.0583 for X.granatum,respectively,much lower than0.0794 and 0.0818 for E.agallocha and 0.0799 and 0.0688 for P.paludosa.This opposing degree of polymorphism might be attributed to the profusely growing E.agallocha and P.paludosa and precarious status of X.granatum throughout the Indian Sundarbans.展开更多
In high seismic zone regions, slender reinforced concrete structural walls are commonly used in high-rise buildings as a main lateral load resisting element. These walls are very effective in limiting the lateral drif...In high seismic zone regions, slender reinforced concrete structural walls are commonly used in high-rise buildings as a main lateral load resisting element. These walls are very effective in limiting the lateral drift of the building due to their large in-plane stiffness. However, the presence of floor slabs influences the behavior of the shear wall. Also, the current design requirements do not account for the presence of floor slabs. To understand the behavior of wall-slab junctions and address the shortcomings of the current design requirements, the influence of two parameters, namely(a) aspect ratio and(b) longitudinal reinforcement ratio on the behavior is studied numerically. It is observed that the presence of floor slabs at different levels tends to partition the wall into squat wall panels between two consecutive floors. The wall-slab junctions show large stress concentrations arising from the strut action in the squat panels. It is also observed that the floor slabs can get significantly damaged near the wall-slab junction for lower vertical reinforcement ratios in the wall. Thus, the current codeprescribed minimum reinforcement in shear walls is not sufficient and needs to be revisited at for improved performance.展开更多
The interaction of baicalein with bovine serum albumin（BSA） was investigated with the help of spectroscopic and molecular docking studies.The binding affinity of baicalein towards BSA was estimated to be in order of...The interaction of baicalein with bovine serum albumin（BSA） was investigated with the help of spectroscopic and molecular docking studies.The binding affinity of baicalein towards BSA was estimated to be in order of 10~5 M^（-1） from fluorescence quenching studies.Negative ΔH°（-5.66 ＋ 0.14 kJ/mol） and positive（ΔS°）（＋ 79.96 ＋ 0.65J/mol K） indicate the presence of electrostatic interactions along with the hydrophobic forces that result in a positive ΔS°.The hydrophobic association of baicalein with BSA diminishes in the presence of sodium dodecyl sulfate（SDS） due to probable hydrophobic association of baicalein with SDS,resulting in a negative ΔS°（-40.65 ＋ 0.87 J/mol K）.Matrix-assisted laser desorption ionization/time of flight（MALDI-TOF） experiments indicate a 1：1 complexation between baicalein and BSA.The unfolding and refolding phenomena of BSA were investigated in the absence and presence of baicalein using steady-state and fluorescence lifetime measurements.It was observed that the presence of urea ruptured the non-covalent interaction between baicalein and BSA.The presence of metal ions（Ag~＋,Mg^（2＋）,Ni^（2＋）,Mn^（2＋）,Co^（2＋） and Zn^（2＋）） increased the binding affinity of ligand towards BSA.The changes in conformational aspects of BSA after ligand binding were also investigated using circular dichroism（CD） and Fourier transform infrared（FT-IR） spectroscopic techniques.Site selectivity studies following molecular docking analyses indicated the binding of baicalein to site 1（subdomain MA） of BSA.展开更多
Consumer adoption of Internet of Things devices is increasing rapidly. About 66% of consumers mean to buy an associated home gadget by 2019. Beacon technology helps in providing actionable insights to businesses throu...Consumer adoption of Internet of Things devices is increasing rapidly. About 66% of consumers mean to buy an associated home gadget by 2019. Beacon technology helps in providing actionable insights to businesses through visual heat maps generated by the consumers and these maps are further processed by machine learning algorithms. Google’s open source Eddystone beacon format released in 2015, mitigates the problem of high cost and provides an open source alternative for developers. The aim of the proposed work is to provide a low cost, reliable, flexible, scalable and open source alternative for small and medium scale enterprises. In the proposed work, an Internet of Things platform is configured and developed. The Raspberry Pi is configured as an Eddystone beacon through a NodeJs server. An android app is developed which is the front end of the platform and web services are deployed on the cloud.展开更多
基金supported by the Tsinghua Initiative Scientific Research Program(Grant No.2012THZ02-2)Beijing Natural Science Foundation(Grant No.8111001)+1 种基金National Basic Research Program of China(Grant No.2011CB013602)Major Research Plan of the National Natural Science Foundation of China(Grant No.91215301)
文摘Pushover analysis is common because of its conceptual simplicity and computational attractiveness in computing seismic demand.Considering that traditional pushover analysis is restricted in underground structures due to the stark differences in the seismic response characteristics of surface structures,this paper proposes a pushover analysis method for underground structures and its application in seismic damage assessment.First,three types of force distribution are presented based on ground response analysis.Next,the target displacements and analysis models are established according to force-based and performance-based design.Then,the pushover analysis procedure for underground structures is described.Next,the applicability of pushover analysis to underground structures is verified by comparing the responses of a Chongwenmen subway station determined by the proposed procedure and by nonlinear response history analysis.In addition,two other points are made:that the inverted triangular distribution of effective earthquake acceleration is more practical than the other two distributions,and that performance-based design is more effective than force-based design.Finally,a cyclic reversal loading pattern based on one cycle of reversal loads as an earthquake event is presented and applied to the seismic damage assessment of underground structures.The results show that the proposed pushover analysis can be effectively applied to the seismic design and damage assessment of underground structures.
基金supported in part by an award from the Soy Health Research Program(SHRP,United Soybean Board,Chesterfield,MO,USA)(to SKR)a grant(SCIRF-2015-I-01) from South Carolina Spinal Cord Injury Research Fund(Columbia,SC,USA)(to SKR)earlier R01 grants(CA-091460,and NS-057811)(to SKR) from the National Institutes of Health(Bethesda,MD,USA)
文摘All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both natural and synthetic retinoids use specific nuclear receptors such as retinoic acid receptors and retinoid X receptors to activate specific signaling pathways in the cells. Retinoic acid signaling is extremely important in the central nervous system. Impairment of retinoic acid signaling pathways causes severe pathological processes in the central nervous system, especially in the adult brain. Retinoids have major roles in neural patterning, differentiation, axon outgrowth in normal development, and function of the brain. Impaired retinoic acid signaling results in neuroinflammation, oxidative stress, mitochondrial malfunction, and neurodegeneration leading to progressive Alzheimer’s disease, which is pathologically characterized by extra-neuronal accumulation of amyloid plaques(aggregated amyloid-beta) and intra-neurofibrillary tangles(hyperphosphorylated tau protein) in the temporal lobe of the brain. Alzheimer’s disease is the most common cause of dementia and loss of memory in old adults. Inactive cholinergic neurotransmission is responsible for cognitive deficits in Alzheimer’s disease patients. Deficiency or deprivation of retinoic acid in mice is associated with loss of spatial learning and memory. Retinoids inhibit expression of chemokines and neuroinflammatory cytokines in microglia and astrocytes, which are activated in Alzheimer’s disease. Stimulation of retinoic acid receptors and retinoid X receptors slows down accumulation of amyloids, reduces neurodegeneration, and thereby prevents pathogenesis of Alzheimer’s disease in mice. In this review, we described chemistry and biochemistry of some natural and synthetic retinoids and potentials of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer’s disease.
文摘The seismotectonic characteristics of ten repeated earthquake swarm sequence within a seismic cluster along Jiali Fault in eastern Himalayan Syntaxis(EHS) have been analysed.The swarms are spatially disposed in and around Yigong Lake(a natural lake formed by blocking of Yigong River by landslide) and are characterized by low magnitude,crustal events with low to moderate b values.Ms:mb discriminant functions though indicate anomalous nature of the earthquakes within swarm but are considered as natural events that occurred under condition of high apparent stress and stress gradients.Composite fault plane solutions of selected swarms indicate strike-slip sense of shear on fault planes;solution parameters show low plunging compression and tensional axes along NW-SE and NE-SW respectively with causative fault plane oriented ENE-WSW.dipping steeply towards south or north.The fault plane is in excellent agreement with the disposition and tectonic movement registered by right lateral Jiali Fault.The process of pore pressure perturbation and resultant ’r—t plot’ with modelled diffusivity(D = 0.12 m^2/s) relates the diffusion of pore pressure to seismic sequence in a fractured poro-elastic fluid saturated medium at average crustal depth of 15-20 km.The low diffusivity depicts a highly fractured interconnected medium that is generated due to high stress activity near the eastern syntaxial bent of Himalaya.It is proposed that hydro fracturing with respect to periodic pore pressure variations is responsible for generation of swarms in the region.The fluid pressure generated due to shearing and infiltrations of surface water within dilated seismogenic fault(Jiali Fault) are causative factors.
文摘Semiconductor nanowires （NW） possess several beneficial properties for efficient conversion of solar energy into electricity and chemical energy. Due to their efficient absorption of light, short distances for minority carriers to travel, high surface-to-volume ratios, and the availability of scalable synthesis methods, they provide a pathway to address the low cost-to-power requirements for widescale adaptation of solar energy conversion technologies. Here we highlight recent progress in our group towards implementation of NW components as photovoltaic and photoelectrochemical energy conversion devices. An emphasis is placed on the unique properties of these one-dimensional （1D） structures, which enable the use of abundant, low-cost materials and improved energy conversion efficiency compared to bulk devices.
文摘In Bangladesh, Enteric fever is a persistent health issue throughout the year, occasionally reaching epidemic levels. The growing antibiotic resistance makes treatment increasingly challenging. Therefore, studying the antibiotic resistance patterns within the population is crucial to ensure a more effective treatment strategy. This study was designed to determine the prevalence, antimicrobial susceptibility profile, and factors associated with Salmonella spp. infections among clinically suspected Enteric fever patients in Bangladesh. This study also aimed to investigate whether there has been a re-emergence in the susceptibility of bacterial strains to conventional drugs. Data were collected from February 2024 to July 2024, from patients suspected Enteric fever (fever less than seven days duration) in a Private Diagnostic Center of Bangladesh. A total of 195 blood samples were cultured, where 53.85% came out positive, among which 79.05% Salmonella typhi and 20.95% Salmonella paratyphi A were found. Prevalence of Typhoid fever was observed high among the school-going age group (0 - 15 years) patients. Both these organisms were susceptible to ceftazidime, cefixime, ceftriaxone and cefepime but resistant to nalidixic acid, ciprofloxacin and levofloxacin. Nalidixic Acid is resistant to all S. paratyphi A and sensitive to few S. typhi. Ciprofloxacin and levofloxacin showed delayed response (36.14% and 22.72% sensitive to S. typhi and S. paratyphi A, respectively) and resistance (63.85% and 77.27% resistant to S. typhi and S. paratyphi A, respectively). In case of S. typhi, the resistance was found against ampicillin (32.53%), chloramphenicol (27.71%), cotrimoxazole (24.09%) and the resistance of S. paratyphi A found against ampicillin (4.54%), chloramphenicol (0%) and cotrimoxazole (0%). This study will provide clinicians with alternative drug options and facilitate the effective treatment of Enteric fever.
文摘Background: Left atrial myxoma (LAM) is the most common heart tumor in adults, requiring prompt surgical removal to prevent complications like valvular obstruction or embolization. Objectives: This study aimed to compare early postoperative outcomes between two surgical approaches—right mini-thoracotomy and median sternotomy—for the removal of isolated left atrial myxoma. Methods: We conducted a prospective observational study at the Department of Cardiac Surgery, National Heart Foundation Hospital & Research Institute (NHFH&RI), Mirpur, Dhaka, from March 2017 to August 2019. Twenty-eight patients undergoing surgery for isolated left atrial myxoma were included. The surgical approach was determined by the operating surgeon. We analyzed outcomes like intubation time, Intensive Care Unit (ICU) stay, pain levels (Visual Analogue Scale score), and overall hospital stay using SPSS. Statistical significance was set at p Results: Patients in the right mini-thoracotomy group had longer mean intubation times (11.43 vs. 5.93 hours, p Conclusion: Despite longer intubation and ICU times, the right mini-thoracotomy approach offers a minimally invasive alternative for isolated left atrial myxoma excision, with favorable outcomes overall.
文摘The interaction of naringin with bovine serum albumin has been performed using fluorescence, circular dichroism and fourier transform infrared spectroscopy in 20 mM phosphate buffer of pH 7.0 as well as molecular docking studies. The changes in enthalpy (ΔH°) and entropy (ΔS°) of the interaction were found to be +18.73 kJ/mol and +143.64 J mol-1 K-1 respectively, indicating that the interaction of naringin with bovine serum albumin occurred mainly through hydrophobic interactions. Negative values of free energy change (ΔG°) at different temperatures point toward the spontaneity of the interaction. Circular dichroism studies reveal that the helical content of bovine serum albumin decreased after interaction with naringin. According to the F?rster non-radiative energy transfer theory the distance between Trp 213 residue and naringin was found to be 3.25 nm. Displacement studies suggest that naringin binds to site 1 (subdomain IIA) of bovine serum albumin (BSA) which was also substantiated by molecular docking studies.
基金Science and Engineering Research Board (SERB), Government of India (Grant # CRG/2018/000259 to SDG)Industrial Research and Consultancy Centre (IRCC), IIT Bombay (Seed Grant # RD/0517-IRCCSH0-035 to SDG)Council of Scientific and Industrial Research (CSIR) (doctoral scholarship for AS),University Grants Commission (doctoral scholarship for KC),IIT Bombay and Ministry of Education of India (doctoral scholarship for MD)。
文摘Unconsolidated siliciclastic sediments can undergo post-burial deformation, which leads to the formation of distinctive sedimentary structures, known as soft-sediment deformation structures(SSDS). The presence of a series of sand volcanoes confined to a particular lithostratigraphic horizon can represent a paleoseismic activity and, thereby, exemplifies the concept of “seismite”. The Kutch Basin has been a tectonically active region since the initiation of eastern Gondwana rifting followed by a tectonic inversion during the Cenozoic due to the collision of the Indian and Eurasian plates. A stratum-bound series of sand volcanoes belonging to the Khari Nadi Formation(KNF) is exposed along the banks of Khari River. They separate the shallow marine deposits below and non-marine deposits above with their characteristic marine and paleosol trace fossil suites, respectively. Although a seismogenic origin has been much debated for the SSDS,the ichnofabric analysis of the sand-volcano-bearing stratum unequivocally points toward such an origin under a shallow seafloor condition. In addition to the sedimentary regime change from an open shallow-marine setting to a continental depositional environment concomitant with basinal uplift, the behavior of the burrowing crustaceans testifies to a syn-depositional development of a fault network associated with the fluidization, sand volcanism, and the resilience of the trace-producers in surviving those processes until the sedimentary regime change in the overlying strata. Although the ichno-sedimentological evidence apparently differs from the previous works that proposed a continuous base-level rise from the beginning of deposition of the Khari Nadi Formation up to the middle part of the overlying Chhasra Formation, the paleoseismic activity,its ichnologic signature, and the depositional regime change refer to a higher-resolution(i.e., lower-order)sequence-stratigraphic change causing a short-duration regression within a longer-duration cycle of base-level rise.
基金supported by National Health and Research Council of Australia Leadership Investigator Grants (NHMRCAPP1194679)+1 种基金the ACPCC has received equipment and a funding contribution from Roche Molecular Diagnostics USAco-PI on a major implementation programme Elimination of Cervical Cancer in the Western Pacific,which has received support from the Minderoo Foundation。
文摘Objective: Improvement in cancer survival over recent decades has not been accompanied by a narrowing of socioeconomic disparities. This study aimed to quantify the loss of life expectancy(LOLE) resulting from a cancer diagnosis and examine disparities in LOLE based on area-level socioeconomic status(SES).Methods: Data were collected for all people between 50 and 89 years of age who were diagnosed with cancer, registered in the NSW Cancer Registry between 2001 and 2019, and underwent mortality follow-up evaluations until December 2020. Flexible parametric survival models were fitted to estimate the LOLE by gender and area-level SES for 12 common cancers.Results: Of 422,680 people with cancer, 24% and 18% lived in the most and least disadvantaged areas, respectively. Patients from the most disadvantaged areas had a significantly greater average LOLE than patients from the least disadvantaged areas for cancers with high survival rates, including prostate [2.9 years(95% CI: 2.5±3.2 years) vs. 1.6 years(95% CI: 1.3±1.9 years)] and breast cancer [1.6 years(95% CI: 1.4±1.8 years) vs. 1.2 years(95% CI: 1.0±1.4 years)]. The highest average LOLE occurred in males residing in the most disadvantaged areas with pancreatic [16.5 years(95% CI: 16.1±16.8 years) vs. 16.2 years(95% CI: 15.7±16.7 years)] and liver cancer [15.5 years(95% CI: 15.0±16.0 years) vs. 14.7 years(95% CI: 14.0±15.5 years)]. Females residing in the least disadvantaged areas with thyroid cancer [0.9 years(95% CI: 0.4±1.4 years) vs. 0.6 years(95% CI: 0.2±1.0 years)] or melanoma [0.9 years(95% CI: 0.8±1.1 years) vs. 0.7 years(95% CI: 0.5±0.8 years)] had the lowest average LOLE.Conclusions: Patients from the most disadvantaged areas had the highest LOLE with SES-based differences greatest for patients diagnosed with cancer at an early stage or cancers with higher survival rates, suggesting the need to prioritise early detection and reduce treatment-related barriers and survivorship challenges to improve life expectancy.
基金supported by Indian Council of Medical Research(ICMR),the Government of India agency research grant(F.N.5/9/1328/2020-Nut).
文摘Objective:To evaluate the protective effect of benzydamine hydrochloride against ethanol-induced oxidative stress and inflammation in RAW 264.7 macrophages.Methods:RAW 264.7 macrophages were treated with ethanol(100 mM)and benzydamine hydrochloride(7.5μM).The imflammatory status was confirmed by measuring pro-(TNF-αand IL-6)and anti-inflammatory(IL-10)cytokines through ELISA and RT-PCR assays.Reactive oxygen species generation and mitochondrial membrane potential were investigated to study the protective role of benzydamine hydrochloride against ethanol-induced oxidative stress.Apoptosis detection was also investigated using flow cytometry and acridine orange/ethidium bromide staining.Results:Benzydamine hydrochloride significantly decreased the secretion of TNF-αand IL-6,as well as the generation of reactive oxygen species inside the cells,thereby stabilizing the mitochondrial membrane potential and reducing DNA fragmentation.The ethanol-induced cellular necrosis was also reversed by the administration of benzydamine hydrochloride.Conclusions:Benzydamine hydrochloride ameliorates ethanol-induced cell apoptosis and inflammation in RAW macrophages.
基金the following funding agencies for the research grants:Science and Engineering Research Board (SERB)Government ofIndia (grant#CRG/2018/000259 to SDG)+2 种基金Industrial Research and Consultancy Centre (IRCC)IIT Bombay (seed grant#RD/0517-IRCCSH0-035 to SDG)Council of Scientific&Industrial Research (CSIR) (doctoral scholarship for AS)。
文摘The Chhasra Formation(CF)of Kutch Basin exemplifies a typical mixed siliciclastic-carbonate system with alternations of biostromal carbonate and fine-grained siliciclastic beds.The CF is subdivided into two members:the lower Claystone(CM)and the upper Siltstone(SM)member.Three CM outcrops(P1-P3)comprising buried palaeosols that formed under a specific environmental set-up involving imperfectly to poorly drained conditions,are exposed along the Berwali River.The biostromal carbonate beds,alternating with the palaeosols,contain invertebrate bioclasts(bivalves,gastropods,echinoids,etc.)and are characterized by a paucispecific firmground Thalassinoides ichnofabric.At section P1,below the contact between the underlying palaeosol and overlying carbonate,Thalassinoides transforms into firmground Gyrolithes inside the palaeosol forming a compound ichnotaxon.The palaeosol intervals of sections P1 and P2 consist of a Vondrichnus-Termitichnus-root trace ichnofabric defining the Termitichnus ichnofacies.At section P3,lenses of fully bioturbated siltstones with a monospecific firmground Thalassinoides ichnofabric can be observed within an overall silty palaeosol horizon,thereby,locally cross-cutting the pedogenic features.The ichnofabrics of section P3 indicate polyphase pedogenesis with three stages:(1)initial stage:pedogenesis in siltstone of undefined depositional affinity which was obscured by pedogenic processes,(2)transient stage:recurring marine incursions and colonization by crustaceans within the lens-shaped palaeotopographic depressions overprinting the palaeosol,and(3)final stage:subaerial exposure and another preserved phase of pedogenesis.The CM shows an apparent low-order T-R(transgressive-regressive)cyclicity within a 3rd-order TST(transgressive systems tract)that is supported by pedogenic intensity,ichnofabrics,and reciprocal sedimentation near the Miocene basin margin,though the cyclicity can be the result of both autogenic and/or lowerorder allogenic changes.
文摘Carnuba wax consists chiefly of myricyl cerotate (M<sub>W</sub> 817.4) and small quantities of free cerotic acid (C<sub>26</sub>H<sub>52</sub>O<sub>2</sub>, Mw 396.7) and myricyl alcohol (C<sub>30</sub>H<sub>62</sub>O, mp 90°C). Of the two common extraction solvents, ethyl ether or petroleum ether, Lewkowitsch prefers the former. Concerning separation of phases, he advocates addition of small amounts of alcohol or caustic, and he also states that formation of a flocculant layer between the aqueous layer and the solvent does not interfere with the correct estimation of the unsaponifiable matter. These statements were not corroborated in the hands of this chemist. The “Unsaponifiable Matter” in oils or and fats, which consist mainly of hydrocarbons, sterols and aliphatic alcohols of high molecular mass that are not saponifiable by alkali hydroxides but are soluble in the ordinary fat solvents, and to products of saponification that are soluble in such solvents. Carnuba wax, a rather expensive wax, may be adulterated with less expensive paraffin by dishonest merchants. ASTM has a method for determining paraffinic material in carnuba wax. It uses heptanes at its boiling point to dissolve the wax, apply it to a silica gel column, and elute only the nonpolar (i.e. alkane) material. The method has the disadvantage of using a large volume of haptane, nor is it called for by either US Pharmacopeia/National Formulary (USP/NF) or Food Chemicals Codex (FCC). The test for unsaponifiable matter on pure carnuba wax will yield a result of 50.0% - 55.0%, while a higher result will betray the presence of paraffin adulterants.
文摘IoT technology has emerged as a valuable tool in modern healthcare, providing real-time monitoring of patients, effective management of healthcare, and proper administration of patient information. The proposed system aims to develop a system that can prevent backward blood flow from stopping saline fluid, as well as monitor the temperature, heart rate, and oxygen level of patients by using multiple sensors like weight, temperature and heart rate, etc. Additionally, the proposed system can monitor the room temperature and humidity for contributing to the patient’s overall comfort. In emergency situations, it includes an emergency push button for quick alert medical staff and initiates timely interventions. It is designed to support nurses and doctors in monitoring patients and providing timely interventions to prevent complications.
文摘The gastrointestinal tract(GIT) is a complex system, which changes in response to requirements of the body. GIT represents a barrier to the external environment. To achieve this, epithelial cells must renew rapidly. This renewal of epithelial cells starts in the fetal life under the influence of many GIT peptides by swallowing amniotic fluid(AF). Development and maturation of GIT is a very complex cascade that begins long before birth and continues during infancy and childhood by breastfeeding. Many factors like genetic preprogramming, local and systemic endocrine secretions and many trophic factors(TF) from swallowed AF contribute and modulate the development and growth of the GIT. GIT morphogenesis, differentiation and functional development depend on the activity of various TF in the AF. This manuscript will review the role of AF borne TF in the development of GIT.
基金funded by the Indian Statistical Institute,Kolkata
文摘Rich genetic polymorphism is important for plants to adapt to changes because it enables the plant to make anatomical,physiological and biochemical changes in response to abiotic stress.Geomorphologic characteristics,demographic interference and a cumulative decrease in freshwater influx in the Indian Sundarbans region have proved detrimental to some economically important plants.In this study,genetic polymorphism of three mangrove species,Xylocarpus granatum,Excoecaria agallocha,and Phoenix paludosa,was assessed using RAPD and ISSR molecular markers.X.granatum,already in distress in the Sundarbans,had the least genetic polymorphism,14.56%in the RAPD analysis and 12.92% in the ISSR.Relatively higher genetic polymorphism was recorded for the profusely growing E.agallocha and P.paludosa: 24.66 and26.4% in RAPD; 24.87 and 20.32% in ISSR analysis respectively.A UPGMA dendrogram constructed using the similarity matrix from RAPD,ISSR and combined datashowed that for X.granatum,the least and highest salinity zones clustered together,whereas for E.agallocha and P.paludosa,higher and lower salinity areas clustered in different clades.Nei’s genetic diversity,calculated from RAPD and ISSR data,was also in accordance with 0.0637 and 0.0583 for X.granatum,respectively,much lower than0.0794 and 0.0818 for E.agallocha and 0.0799 and 0.0688 for P.paludosa.This opposing degree of polymorphism might be attributed to the profusely growing E.agallocha and P.paludosa and precarious status of X.granatum throughout the Indian Sundarbans.
文摘In high seismic zone regions, slender reinforced concrete structural walls are commonly used in high-rise buildings as a main lateral load resisting element. These walls are very effective in limiting the lateral drift of the building due to their large in-plane stiffness. However, the presence of floor slabs influences the behavior of the shear wall. Also, the current design requirements do not account for the presence of floor slabs. To understand the behavior of wall-slab junctions and address the shortcomings of the current design requirements, the influence of two parameters, namely(a) aspect ratio and(b) longitudinal reinforcement ratio on the behavior is studied numerically. It is observed that the presence of floor slabs at different levels tends to partition the wall into squat wall panels between two consecutive floors. The wall-slab junctions show large stress concentrations arising from the strut action in the squat panels. It is also observed that the floor slabs can get significantly damaged near the wall-slab junction for lower vertical reinforcement ratios in the wall. Thus, the current codeprescribed minimum reinforcement in shear walls is not sufficient and needs to be revisited at for improved performance.
基金Department of Science and Technology(DST,Project no.SR/SO/BB-54/2007),Government of India for financial support
文摘The interaction of baicalein with bovine serum albumin（BSA） was investigated with the help of spectroscopic and molecular docking studies.The binding affinity of baicalein towards BSA was estimated to be in order of 10~5 M^（-1） from fluorescence quenching studies.Negative ΔH°（-5.66 ＋ 0.14 kJ/mol） and positive（ΔS°）（＋ 79.96 ＋ 0.65J/mol K） indicate the presence of electrostatic interactions along with the hydrophobic forces that result in a positive ΔS°.The hydrophobic association of baicalein with BSA diminishes in the presence of sodium dodecyl sulfate（SDS） due to probable hydrophobic association of baicalein with SDS,resulting in a negative ΔS°（-40.65 ＋ 0.87 J/mol K）.Matrix-assisted laser desorption ionization/time of flight（MALDI-TOF） experiments indicate a 1：1 complexation between baicalein and BSA.The unfolding and refolding phenomena of BSA were investigated in the absence and presence of baicalein using steady-state and fluorescence lifetime measurements.It was observed that the presence of urea ruptured the non-covalent interaction between baicalein and BSA.The presence of metal ions（Ag~＋,Mg^（2＋）,Ni^（2＋）,Mn^（2＋）,Co^（2＋） and Zn^（2＋）） increased the binding affinity of ligand towards BSA.The changes in conformational aspects of BSA after ligand binding were also investigated using circular dichroism（CD） and Fourier transform infrared（FT-IR） spectroscopic techniques.Site selectivity studies following molecular docking analyses indicated the binding of baicalein to site 1（subdomain MA） of BSA.
文摘Consumer adoption of Internet of Things devices is increasing rapidly. About 66% of consumers mean to buy an associated home gadget by 2019. Beacon technology helps in providing actionable insights to businesses through visual heat maps generated by the consumers and these maps are further processed by machine learning algorithms. Google’s open source Eddystone beacon format released in 2015, mitigates the problem of high cost and provides an open source alternative for developers. The aim of the proposed work is to provide a low cost, reliable, flexible, scalable and open source alternative for small and medium scale enterprises. In the proposed work, an Internet of Things platform is configured and developed. The Raspberry Pi is configured as an Eddystone beacon through a NodeJs server. An android app is developed which is the front end of the platform and web services are deployed on the cloud.
