目的探讨维持性血液透析患者疲劳状况与自我管理行为和生存质量的关系，为临床开展个性化护理，改善患者生存质量提供理论依据。方法采用疲劳评定量表（Fatigue Assessment Instrument，FAI）、血液透析患者自我管理量表和健康状况调查...目的探讨维持性血液透析患者疲劳状况与自我管理行为和生存质量的关系，为临床开展个性化护理，改善患者生存质量提供理论依据。方法采用疲劳评定量表（Fatigue Assessment Instrument，FAI）、血液透析患者自我管理量表和健康状况调查问卷（The MOS 36-item short-form health survey，SF-36）对2014年6月～2016年6月在该院长期进行血液透析治疗的患者140例进行调查。结果根据FAI疲劳评定量表因子1得分，本组患者“轻度疲劳”45例，“中度疲劳”73例，“重度疲劳”22例。除“轻度疲劳”和“中度疲劳”患者自我管理行为总分比较差异无统计学意义外（P〉0．05）；“轻度疲劳”、“中度疲劳”和“重度疲劳”患者自我管理行为总分、SF-36生理健康总分和SF-36心理健康总分均呈下降趋势，差异均有统计学意义（均P〈0．05）。Spearman相关分析结果显示，维持性血透患者各疲劳因子同自我管理行为总分、SF-36生理健康总分和SF-36心理健康总分呈负相关（P〈0．05）。结论维持性血液透析患者普遍处于疲劳状况，严重的疲劳状况不利于维持患者的自我管理行为，且会降低其生存质量。展开更多
目的:探讨甘精胰岛素联合格列吡嗪及二甲双胍治疗2型糖尿病的临床疗效。方法:140例2型糖尿病患者,按照随机数字表法分为对照组和治疗组,每组70例。对照组采用常规疗法口服降糖药(格列吡嗪控释片和二甲双胍片),治疗组在对照组的基础上加...目的:探讨甘精胰岛素联合格列吡嗪及二甲双胍治疗2型糖尿病的临床疗效。方法:140例2型糖尿病患者,按照随机数字表法分为对照组和治疗组,每组70例。对照组采用常规疗法口服降糖药(格列吡嗪控释片和二甲双胍片),治疗组在对照组的基础上加用甘精胰岛素注射治疗,治疗12周后观察并记录两组的糖代谢情况,血糖达标时间,发生低血糖次数。结果:140例患者经过12周治疗后,FPG(空腹血糖),2 h PG(早餐后2 h血糖)以及糖化血红蛋白(Hb A1c)均明显下降,FCP(空腹C肽)、2 h CP(餐后2 h C肽)均有所升高,与治疗前比较差异均有统计学意义(P<0.05);治疗组的FPG、2 h PG以及Hb A1c下降水平大于对照组,治疗组的FCP、2 h CP增加水平大于对照组,两组比较差异均有统计学意义(P<0.05);治疗组的达标时间短于对照组(P<0.05);治疗组不增加发生低血糖风险,两组的低血糖发生率均小于5.8%,无严重低血糖发生。结论:甘精胰岛素联合格列吡嗪及二甲双胍治疗2型糖尿病,降糖平稳,疗效确切,副作用小,值得临床推广应用。展开更多
Background The intravascular ultrasound(IVUS)-guided percutaneous coronary intervention(PCI)can benefit the treatment of coronary artery disease(CAD).However,the beneficial effect of IVUS-guided PCI in patients with a...Background The intravascular ultrasound(IVUS)-guided percutaneous coronary intervention(PCI)can benefit the treatment of coronary artery disease(CAD).However,the beneficial effect of IVUS-guided PCI in patients with acute myocardial infarction(AMI)remains controversial.Methods A total of 537 AMI patients were included in this study,divided into two groups:the angiography-guided group(n=289)and the IVUS-guided group(n=248)according to whether the IVUS was applied.The primary outcome was a composite of major adverse cardiovascular events(MACEs),including cardiovascular death,recurrent myocardial infarction(MI),and target lesion revascularization(TLR).The secondary outcome was procedural radiation exposure time.Results The IVUS-guided group was associated with a reduced incidence of MACEs(12.8%vs.8.5%,P=0.032).The results were consistent after adjusting for confounders in the multivariable Cox analysis,which showed that the absence of IVUS(HR 1.194,95%CI 1.061-1.323,P=0.011)was an independent predictor of MACEs.Additionally,the IVUS-guided group experienced significantly lower float time(893.3±265.2 min vs.623.2±137.3 min,P<0.001).Conclusions The use of IVUS was associated with better long-term cardiovascular outcomes.The use of IVUS in PCI should be considered for patients with AMI to optimize procedural outcomes and enhance long-term prognosis.展开更多
文摘目的探讨维持性血液透析患者疲劳状况与自我管理行为和生存质量的关系，为临床开展个性化护理，改善患者生存质量提供理论依据。方法采用疲劳评定量表（Fatigue Assessment Instrument，FAI）、血液透析患者自我管理量表和健康状况调查问卷（The MOS 36-item short-form health survey，SF-36）对2014年6月～2016年6月在该院长期进行血液透析治疗的患者140例进行调查。结果根据FAI疲劳评定量表因子1得分，本组患者“轻度疲劳”45例，“中度疲劳”73例，“重度疲劳”22例。除“轻度疲劳”和“中度疲劳”患者自我管理行为总分比较差异无统计学意义外（P〉0．05）；“轻度疲劳”、“中度疲劳”和“重度疲劳”患者自我管理行为总分、SF-36生理健康总分和SF-36心理健康总分均呈下降趋势，差异均有统计学意义（均P〈0．05）。Spearman相关分析结果显示，维持性血透患者各疲劳因子同自我管理行为总分、SF-36生理健康总分和SF-36心理健康总分呈负相关（P〈0．05）。结论维持性血液透析患者普遍处于疲劳状况，严重的疲劳状况不利于维持患者的自我管理行为，且会降低其生存质量。
文摘目的:探讨甘精胰岛素联合格列吡嗪及二甲双胍治疗2型糖尿病的临床疗效。方法:140例2型糖尿病患者,按照随机数字表法分为对照组和治疗组,每组70例。对照组采用常规疗法口服降糖药(格列吡嗪控释片和二甲双胍片),治疗组在对照组的基础上加用甘精胰岛素注射治疗,治疗12周后观察并记录两组的糖代谢情况,血糖达标时间,发生低血糖次数。结果:140例患者经过12周治疗后,FPG(空腹血糖),2 h PG(早餐后2 h血糖)以及糖化血红蛋白(Hb A1c)均明显下降,FCP(空腹C肽)、2 h CP(餐后2 h C肽)均有所升高,与治疗前比较差异均有统计学意义(P<0.05);治疗组的FPG、2 h PG以及Hb A1c下降水平大于对照组,治疗组的FCP、2 h CP增加水平大于对照组,两组比较差异均有统计学意义(P<0.05);治疗组的达标时间短于对照组(P<0.05);治疗组不增加发生低血糖风险,两组的低血糖发生率均小于5.8%,无严重低血糖发生。结论:甘精胰岛素联合格列吡嗪及二甲双胍治疗2型糖尿病,降糖平稳,疗效确切,副作用小,值得临床推广应用。
基金supported by the Zhaoqing City Science and Technology Innovation Guidance Project(No.2023010309025)。
文摘Background The intravascular ultrasound(IVUS)-guided percutaneous coronary intervention(PCI)can benefit the treatment of coronary artery disease(CAD).However,the beneficial effect of IVUS-guided PCI in patients with acute myocardial infarction(AMI)remains controversial.Methods A total of 537 AMI patients were included in this study,divided into two groups:the angiography-guided group(n=289)and the IVUS-guided group(n=248)according to whether the IVUS was applied.The primary outcome was a composite of major adverse cardiovascular events(MACEs),including cardiovascular death,recurrent myocardial infarction(MI),and target lesion revascularization(TLR).The secondary outcome was procedural radiation exposure time.Results The IVUS-guided group was associated with a reduced incidence of MACEs(12.8%vs.8.5%,P=0.032).The results were consistent after adjusting for confounders in the multivariable Cox analysis,which showed that the absence of IVUS(HR 1.194,95%CI 1.061-1.323,P=0.011)was an independent predictor of MACEs.Additionally,the IVUS-guided group experienced significantly lower float time(893.3±265.2 min vs.623.2±137.3 min,P<0.001).Conclusions The use of IVUS was associated with better long-term cardiovascular outcomes.The use of IVUS in PCI should be considered for patients with AMI to optimize procedural outcomes and enhance long-term prognosis.
