目的目前的研究已经证实骨质疏松症与牙周炎之间存在一定关联,但是二者之间的因果关联尚不清楚。同时,血清25-羟基维生素D状态也可改变牙周炎的发生风险。因此,本研究进行了孟德尔随机化(Mendelian randomization,MR)分析探究骨密度(Bon...目的目前的研究已经证实骨质疏松症与牙周炎之间存在一定关联,但是二者之间的因果关联尚不清楚。同时,血清25-羟基维生素D状态也可改变牙周炎的发生风险。因此,本研究进行了孟德尔随机化(Mendelian randomization,MR)分析探究骨密度(Bone mineral density,BMD)与牙周炎之间是否存在因果关联,以及是否由血清25-羟基维生素D介导。方法本研究采用骨密度、血清25-羟基维生素D以及牙周炎的全基因组关联研究(Genome wide association studies,GWAS)的汇总统计数据进行了两样本孟德尔随机化研究,以探究骨密度水平和牙周炎风险之间是否存在因果关联,以及是否由血清25-羟基维生素D介导。同时,本研究进行了敏感性分析,以确保结果的稳健性。结果在IVW固定效应模型下,遗传预测的骨密度与牙周炎风险之间存在因果关联并呈负相关(OR=0.921,95%CI:0.855-0.991,P=2.71e-02),最大似然法(OR=0.921,95%CI:0.856-0.991,P=2.84e-02)。对骨密度和血清25-羟基维生素D水平进行两样本孟德尔随机化研究,加权中位数结果显示,骨密度与血清25-羟基维生素D水平相关(OR=0.986,95%CI:0.973-0.999,P=3.44e-02),惩罚加权中位数分析(OR=0.983,95%CI:0.970-0.997,P=1.72e-02)。对血清25-羟基维生素D水平和牙周炎进行两样本孟德尔随机化研究,MR-Egger分析结果显示,血清25-羟基维生素D水平与牙周炎风险相关(OR=1.203,95%CI:1.012-1.430,P=3.95e-02)。结论MR分析研究显示,骨密度与牙周炎之间存在因果关联,并且可能由血清25-羟基维生素D介导。展开更多
We investigate the effect of impurities on the thermal entanglement in a spin-1/2 Ising-Heisenberg butterfly-shaped chain,where four interstitial Heisenberg spins are localized on the vertices of a rectangular plaquet...We investigate the effect of impurities on the thermal entanglement in a spin-1/2 Ising-Heisenberg butterfly-shaped chain,where four interstitial Heisenberg spins are localized on the vertices of a rectangular plaquette in a unit block.By using the transfer-matrix approach,we numerically calculate the partition function and the reduced density matrix of this model.The bipartite thermal entanglement between different Heisenberg spin pairs is quantified by the concurrence.We also discuss the fluctuations caused by the impurities through the uniform distribution and the Gaussian distribution.Considering the effects of the external magnetic field,temperature,Heisenberg and Ising interactions as well as the parameter of anisotropy on the thermal entanglement,our results show that comparing with the case of the clean model,in both the twoimpurity model and the impurity fluctuation model the entanglement is more robust within a certain range of anisotropic parameters and the region of the magnetic field where the entanglement occurred is also larger.展开更多
文摘目的目前的研究已经证实骨质疏松症与牙周炎之间存在一定关联,但是二者之间的因果关联尚不清楚。同时,血清25-羟基维生素D状态也可改变牙周炎的发生风险。因此,本研究进行了孟德尔随机化(Mendelian randomization,MR)分析探究骨密度(Bone mineral density,BMD)与牙周炎之间是否存在因果关联,以及是否由血清25-羟基维生素D介导。方法本研究采用骨密度、血清25-羟基维生素D以及牙周炎的全基因组关联研究(Genome wide association studies,GWAS)的汇总统计数据进行了两样本孟德尔随机化研究,以探究骨密度水平和牙周炎风险之间是否存在因果关联,以及是否由血清25-羟基维生素D介导。同时,本研究进行了敏感性分析,以确保结果的稳健性。结果在IVW固定效应模型下,遗传预测的骨密度与牙周炎风险之间存在因果关联并呈负相关(OR=0.921,95%CI:0.855-0.991,P=2.71e-02),最大似然法(OR=0.921,95%CI:0.856-0.991,P=2.84e-02)。对骨密度和血清25-羟基维生素D水平进行两样本孟德尔随机化研究,加权中位数结果显示,骨密度与血清25-羟基维生素D水平相关(OR=0.986,95%CI:0.973-0.999,P=3.44e-02),惩罚加权中位数分析(OR=0.983,95%CI:0.970-0.997,P=1.72e-02)。对血清25-羟基维生素D水平和牙周炎进行两样本孟德尔随机化研究,MR-Egger分析结果显示,血清25-羟基维生素D水平与牙周炎风险相关(OR=1.203,95%CI:1.012-1.430,P=3.95e-02)。结论MR分析研究显示,骨密度与牙周炎之间存在因果关联,并且可能由血清25-羟基维生素D介导。
基金Project supported by the National Natural Science Foundation of China(Grant No.12074101)the Science Fund for the New Century Excellent Talents in University of the Ministry of Education of China(Grant No.NCET-11-0960)the Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20134208110001).
文摘We investigate the effect of impurities on the thermal entanglement in a spin-1/2 Ising-Heisenberg butterfly-shaped chain,where four interstitial Heisenberg spins are localized on the vertices of a rectangular plaquette in a unit block.By using the transfer-matrix approach,we numerically calculate the partition function and the reduced density matrix of this model.The bipartite thermal entanglement between different Heisenberg spin pairs is quantified by the concurrence.We also discuss the fluctuations caused by the impurities through the uniform distribution and the Gaussian distribution.Considering the effects of the external magnetic field,temperature,Heisenberg and Ising interactions as well as the parameter of anisotropy on the thermal entanglement,our results show that comparing with the case of the clean model,in both the twoimpurity model and the impurity fluctuation model the entanglement is more robust within a certain range of anisotropic parameters and the region of the magnetic field where the entanglement occurred is also larger.
